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Items: 23


Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Emons G, Spitzner M, Reineke S, Möller J, Auslander N, Kramer F, Hu Y, Beissbarth T, Wolff HA, Rave-Fränk M, Heßmann E, Gaedcke J, Ghadimi BM, Johnsen SA, Ried T, Grade M.

Mol Cancer Res. 2017 Nov;15(11):1481-1490. doi: 10.1158/1541-7786.MCR-17-0205. Epub 2017 Aug 15.


Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation.

Hossan T, Nagarajan S, Baumgart SJ, Xie W, Magallanes RT, Hernandez C, Chiaroni PM, Indenbirken D, Spitzner M, Thomas-Chollier M, Grade M, Thieffry D, Grundhoff A, Wegwitz F, Johnsen SA.

Stem Cells. 2016 May;34(5):1369-76. doi: 10.1002/stem.2287. Epub 2016 Feb 13.


Diabetes increases pancreatitis induced systemic inflammation but has little effect on inflammation and cell death in the lung.

Zechner D, Spitzner M, Müller-Graff T, Vollmar B.

Int J Exp Pathol. 2014 Dec;95(6):411-7. doi: 10.1111/iep.12103. Epub 2014 Nov 17.


STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy.

Spitzner M, Ebner R, Wolff HA, Ghadimi BM, Wienands J, Grade M.

Cancers (Basel). 2014 Sep 29;6(4):1986-2011. doi: 10.3390/cancers6041986. Review.


In vivo cell biology in zebrafish - providing insights into vertebrate development and disease.

Vacaru AM, Unlu G, Spitzner M, Mione M, Knapik EW, Sadler KC.

J Cell Sci. 2014 Feb 1;127(Pt 3):485-95. doi: 10.1242/jcs.140194. Review.


STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M.

Int J Cancer. 2014 Feb 15;134(4):997-1007. doi: 10.1002/ijc.28429. Epub 2013 Sep 3.


Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, Kitz J, Kaulfuß S, Beißbarth T, Dobbelstein M, Ghadimi M, Grade M, Gaedcke J.

Radiother Oncol. 2013 Sep;108(3):451-7. doi: 10.1016/j.radonc.2013.06.032. Epub 2013 Aug 7.


Risk factors for pancreatic ductal adenocarcinoma specifically stimulate pancreatic duct glands in mice.

Bobrowski A, Spitzner M, Bethge S, Mueller-Graf F, Vollmar B, Zechner D.

Am J Pathol. 2013 Mar;182(3):965-74. doi: 10.1016/j.ajpath.2012.11.016. Erratum in: Am J Pathol. 2013 Jul;183(1):326.


Diabetes aggravates acute pancreatitis and inhibits pancreas regeneration in mice.

Zechner D, Spitzner M, Bobrowski A, Knapp N, Kuhla A, Vollmar B.

Diabetologia. 2012 May;55(5):1526-34. doi: 10.1007/s00125-012-2479-3. Epub 2012 Feb 12.


Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.

Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, Kramer F, Wolff HA, Becker H, Beissbarth T, Ebner R, Ghadimi BM, Pukrop T, Ried T, Grade M.

Carcinogenesis. 2011 Dec;32(12):1824-31. doi: 10.1093/carcin/bgr222. Epub 2011 Oct 8.


Historical sampling reveals dramatic demographic changes in western gorilla populations.

Thalmann O, Wegmann D, Spitzner M, Arandjelovic M, Guschanski K, Leuenberger C, Bergl RA, Vigilant L.

BMC Evol Biol. 2011 Apr 1;11:85. doi: 10.1186/1471-2148-11-85.


A gene expression signature for chemoradiosensitivity of colorectal cancer cells.

Spitzner M, Emons G, Kramer F, Gaedcke J, Rave-Fränk M, Scharf JG, Burfeind P, Becker H, Beissbarth T, Ghadimi BM, Ried T, Grade M.

Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1184-92. doi: 10.1016/j.ijrobp.2010.06.023.


A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

Grade M, Hummon AB, Camps J, Emons G, Spitzner M, Gaedcke J, Hoermann P, Ebner R, Becker H, Difilippantonio MJ, Ghadimi BM, Beissbarth T, Caplen NJ, Ried T.

Int J Cancer. 2011 Mar 1;128(5):1069-79. doi: 10.1002/ijc.25453.


Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice.

Koehl GE, Spitzner M, Ousingsawat J, Schreiber R, Geissler EK, Kunzelmann K.

Oncogene. 2010 Mar 11;29(10):1553-60. doi: 10.1038/onc.2009.435. Epub 2009 Dec 7.


Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells.

Aldehni F, Spitzner M, Martins JR, Barro-Soria R, Schreiber R, Kunzelmann K.

J Am Soc Nephrol. 2009 Jul;20(7):1556-64. doi: 10.1681/ASN.2008090987. Epub 2009 May 21.


Design of a multiplex nested PCR for genotyping of the NSP4 from group A rotavirus.

Rodríguez-Díaz J, Rubilar-Abreu E, Spitzner M, Hedlund KO, Liprandi F, Svensson L.

J Virol Methods. 2008 May;149(2):240-5. doi: 10.1016/j.jviromet.2008.01.030. Epub 2008 Mar 18.


Upregulation of colonic ion channels in APC ( Min/+ ) mice.

Ousingsawat J, Spitzner M, Schreiber R, Kunzelmann K.

Pflugers Arch. 2008 Aug;456(5):847-55. doi: 10.1007/s00424-008-0451-3. Epub 2008 Feb 5.


Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells.

Spitzner M, Martins JR, Soria RB, Ousingsawat J, Scheidt K, Schreiber R, Kunzelmann K.

J Biol Chem. 2008 Mar 21;283(12):7421-8. doi: 10.1074/jbc.M703758200. Epub 2008 Jan 25.


Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin?

Kunzelmann K, Milenkovic VM, Spitzner M, Soria RB, Schreiber R.

Pflugers Arch. 2007 Sep;454(6):879-89. Epub 2007 Mar 15. Review.


Control of ion transport in mouse proximal and distal colon by prolactin.

Puntheeranurak S, Schreiber R, Spitzner M, Ousingsawat J, Krishnamra N, Kunzelmann K.

Cell Physiol Biochem. 2007;19(1-4):77-88.


Expression of voltage-gated potassium channels in human and mouse colonic carcinoma.

Ousingsawat J, Spitzner M, Puntheeranurak S, Terracciano L, Tornillo L, Bubendorf L, Kunzelmann K, Schreiber R.

Clin Cancer Res. 2007 Feb 1;13(3):824-31.


Voltage-gated K+ channels support proliferation of colonic carcinoma cells.

Spitzner M, Ousingsawat J, Scheidt K, Kunzelmann K, Schreiber R.

FASEB J. 2007 Jan;21(1):35-44. Epub 2006 Nov 29.


Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia.

Barro Soria R, Spitzner M, Schreiber R, Kunzelmann K.

J Biol Chem. 2009 Oct 23;284(43):29405-12. Epub 2006 Sep 26.

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