Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 51


Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAFV600E inhibitors.

Kim T, Havighurst T, Kim K, Albertini M, Xu YG, Spiegelman VS.

Mol Carcinog. 2018 Jan 25. doi: 10.1002/mc.22786. [Epub ahead of print]


miFAST: A novel and rapid microRNA target capture method.

Poenitzsch Strong AM, Berry SM, Beebe DJ, Li JL, Spiegelman VS.

Mol Carcinog. 2018 Apr;57(4):559-566. doi: 10.1002/mc.22780. Epub 2018 Feb 12.


Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo.

Spiegelman VS, Elcheva IA.

J Invest Dermatol. 2017 Sep;137(9):1828-1830. doi: 10.1016/j.jid.2017.06.012. Review.


RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma.

Kim T, Havighurst T, Kim K, Hebbring SJ, Ye Z, Aylward J, Keles S, Xu YG, Spiegelman VS.

J Invest Dermatol. 2017 Mar;137(3):772-775. doi: 10.1016/j.jid.2016.10.042. Epub 2016 Nov 14. No abstract available.


Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.

Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK.

Mol Cancer Res. 2015 Nov;13(11):1478-86. doi: 10.1158/1541-7786.MCR-15-0224. Epub 2015 Jul 20.


Two Isoforms of the RNA Binding Protein, Coding Region Determinant-binding Protein (CRD-BP/IGF2BP1), Are Expressed in Breast Epithelium and Support Clonogenic Growth of Breast Tumor Cells.

Fakhraldeen SA, Clark RJ, Roopra A, Chin EN, Huang W, Castorino J, Wisinski KB, Kim T, Spiegelman VS, Alexander CM.

J Biol Chem. 2015 May 22;290(21):13386-400. doi: 10.1074/jbc.M115.655175. Epub 2015 Apr 10.


MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP).

Goswami S, Tarapore RS, Poenitzsch Strong AM, TeSlaa JJ, Grinblat Y, Setaluri V, Spiegelman VS.

J Biol Chem. 2015 Jan 2;290(1):384-95. doi: 10.1074/jbc.M114.590158. Epub 2014 Nov 20.


Sonic hedgehog signaling in Basal cell nevus syndrome.

Athar M, Li C, Kim AL, Spiegelman VS, Bickers DR.

Cancer Res. 2014 Sep 15;74(18):4967-75. doi: 10.1158/0008-5472.CAN-14-1666. Epub 2014 Aug 29. Review.


MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma.

Poenitzsch Strong AM, Setaluri V, Spiegelman VS.

Arch Biochem Biophys. 2014 Dec 1;563:118-24. doi: 10.1016/ Epub 2014 Jul 17.


Quantitative gene analysis of methylation and expression (Q-GAME) in fresh or fixed cells and tissues.

Wu J, Salva KA, Stutz N, Longley BJ, Spiegelman VS, Wood GS.

Exp Dermatol. 2014 May;23(5):304-9. doi: 10.1111/exd.12374.


Role of CRD-BP in the growth of human basal cell carcinoma cells.

Noubissi FK, Kim T, Kawahara TN, Aughenbaugh WD, Berg E, Longley BJ, Athar M, Spiegelman VS.

J Invest Dermatol. 2014 Jun;134(6):1718-1724. doi: 10.1038/jid.2014.17. Epub 2014 Jan 27.


The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling.

Tarapore RS, Siddiqui IA, Adhami VM, Spiegelman VS, Mukhtar H.

Mol Nutr Food Res. 2013 Nov;57(11):1950-8. doi: 10.1002/mnfr.201300155. Epub 2013 Jul 9.


IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts.

Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK.

Carcinogenesis. 2013 Nov;34(11):2647-54. doi: 10.1093/carcin/bgt217. Epub 2013 Jun 12.


Involvement of the mRNA binding protein CRD-BP in the regulation of metastatic melanoma cell proliferation and invasion by hypoxia.

Craig EA, Weber JD, Spiegelman VS.

J Cell Sci. 2012 Dec 15;125(Pt 24):5950-4. doi: 10.1242/jcs.115204. Epub 2012 Oct 4.


Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis.

Schmit TL, Nihal M, Ndiaye M, Setaluri V, Spiegelman VS, Ahmad N.

Cancer Res. 2012 Aug 1;72(15):3864-72. doi: 10.1158/0008-5472.CAN-12-0714. Epub 2012 May 16.


Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents.

Craig EA, Spiegelman VS.

Pigment Cell Melanoma Res. 2012 Jan;25(1):83-7. doi: 10.1111/j.1755-148X.2011.00921.x. Epub 2011 Oct 28.


Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions.

Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS.

Genes Cancer. 2010 Oct;1(10):1074-82. doi: 10.1177/1947601910395581.


(Mela)statin' the not so obvious: tumor suppressor hidden in intron.

Poenitzsch AM, Setaluri V, Spiegelman VS.

Pigment Cell Melanoma Res. 2011 Apr;24(2):263-5. No abstract available.


IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.

Mongroo PS, Noubissi FK, Cuatrecasas M, Kalabis J, King CE, Johnstone CN, Bowser MJ, Castells A, Spiegelman VS, Rustgi AK.

Cancer Res. 2011 Mar 15;71(6):2172-82. doi: 10.1158/0008-5472.CAN-10-3295. Epub 2011 Jan 20.


Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin.

Bhatia N, Demmer TA, Sharma AK, Elcheva I, Spiegelman VS.

Arch Biochem Biophys. 2011 Apr 15;508(2):178-84. doi: 10.1016/ Epub 2010 Dec 25.


Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol.

Tarapore RS, Siddiqui IA, Saleem M, Adhami VM, Spiegelman VS, Mukhtar H.

Carcinogenesis. 2010 Oct;31(10):1844-53. doi: 10.1093/carcin/bgq169. Epub 2010 Aug 23.


MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein.

Goswami S, Tarapore RS, Teslaa JJ, Grinblat Y, Setaluri V, Spiegelman VS.

J Biol Chem. 2010 Jul 2;285(27):20532-40. doi: 10.1074/jbc.M110.109298. Epub 2010 May 3. Retraction in: J Biol Chem. 2014 Apr 25;289(17):11859.


Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA.

Noubissi FK, Goswami S, Sanek NA, Kawakami K, Minamoto T, Moser A, Grinblat Y, Spiegelman VS.

Cancer Res. 2009 Nov 15;69(22):8572-8. doi: 10.1158/0008-5472.CAN-09-1500. Epub 2009 Nov 3.


CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation.

Elcheva I, Goswami S, Noubissi FK, Spiegelman VS.

Mol Cell. 2009 Jul 31;35(2):240-6. doi: 10.1016/j.molcel.2009.06.007.


Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells.

Schmit TL, Zhong W, Setaluri V, Spiegelman VS, Ahmad N.

J Invest Dermatol. 2009 Dec;129(12):2843-53. doi: 10.1038/jid.2009.172. Epub 2009 Jun 25.


Overexpression of mRNA-binding protein CRD-BP in malignant melanomas.

Elcheva I, Tarapore RS, Bhatia N, Spiegelman VS.

Oncogene. 2008 Aug 28;27(37):5069-74. doi: 10.1038/onc.2008.141. Epub 2008 May 5.


Inhibition of beta-TrCP function potentiates UVB-induced apoptosis in hTERT-immortalized normal human keratinocytes.

Bhatia N, Demmer TA, Spiegelman VS.

Photochem Photobiol. 2008 Mar-Apr;84(2):376-81. doi: 10.1111/j.1751-1097.2007.00272.x. Epub 2008 Jan 15.


Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.

Thiyagarajan S, Bhatia N, Reagan-Shaw S, Cozma D, Thomas-Tikhonenko A, Ahmad N, Spiegelman VS.

Cancer Res. 2007 Nov 15;67(22):10642-6.


S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9.

Saleem M, Kweon MH, Johnson JJ, Adhami VM, Elcheva I, Khan N, Bin Hafeez B, Bhat KM, Sarfaraz S, Reagan-Shaw S, Spiegelman VS, Setaluri V, Mukhtar H.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14825-30. Epub 2006 Sep 21.


Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells.

Syed DN, Afaq F, Kweon MH, Hadi N, Bhatia N, Spiegelman VS, Mukhtar H.

Oncogene. 2007 Feb 1;26(5):673-82. Epub 2006 Jul 24.


CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.

Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS.

Nature. 2006 Jun 15;441(7095):898-901.


Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

Bhatia N, Thiyagarajan S, Elcheva I, Saleem M, Dlugosz A, Mukhtar H, Spiegelman VS.

J Biol Chem. 2006 Jul 14;281(28):19320-6. Epub 2006 May 1.


Stabilization of prolactin receptor in breast cancer cells.

Li Y, Clevenger CV, Minkovsky N, Kumar KG, Raghunath PN, Tomaszewski JE, Spiegelman VS, Fuchs SY.

Oncogene. 2006 Mar 23;25(13):1896-902.


Oncogenic beta-catenin signaling networks in colorectal cancer.

Fuchs SY, Ougolkov AV, Spiegelman VS, Minamoto T.

Cell Cycle. 2005 Nov;4(11):1522-39. Epub 2005 Dec 1. Review.


Activation of Wnt/beta-catenin/Tcf signaling in mouse skin carcinogenesis.

Bhatia N, Spiegelman VS.

Mol Carcinog. 2005 Apr;42(4):213-21.


Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells.

Tang W, Li Y, Yu D, Thomas-Tikhonenko A, Spiegelman VS, Fuchs SY.

Cancer Res. 2005 Mar 1;65(5):1904-8.


Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase.

Li Y, Kumar KG, Tang W, Spiegelman VS, Fuchs SY.

Mol Cell Biol. 2004 May;24(9):4038-48.


The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer.

Fuchs SY, Spiegelman VS, Kumar KG.

Oncogene. 2004 Mar 15;23(11):2028-36. Review.


Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.

Tang W, Pavlish OA, Spiegelman VS, Parkhitko AA, Fuchs SY.

J Biol Chem. 2003 Dec 5;278(49):48942-9. Epub 2003 Sep 30.


Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling.

Spiegelman VS, Tang W, Chan AM, Igarashi M, Aaronson SA, Sassoon DA, Katoh M, Slaga TJ, Fuchs SY.

J Biol Chem. 2002 Sep 27;277(39):36624-30. Epub 2002 Jul 31.


Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB.

Bhatia N, Herter JR, Slaga TJ, Fuchs SY, Spiegelman VS.

Oncogene. 2002 Feb 28;21(10):1501-9.


Inhibition of HOS expression and activities by Wnt pathway.

Spiegelman VS, Tang W, Katoh M, Slaga TJ, Fuchs SY.

Oncogene. 2002 Jan 24;21(5):856-60.


Induction of beta-transducin repeat-containing protein by JNK signaling and its role in the activation of NF-kappaB.

Spiegelman VS, Stavropoulos P, Latres E, Pagano M, Ronai Z, Slaga TJ, Fuchs SY.

J Biol Chem. 2001 Jul 20;276(29):27152-8. Epub 2001 May 24.


Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor.

Spiegelman VS, Slaga TJ, Pagano M, Minamoto T, Ronai Z, Fuchs SY.

Mol Cell. 2000 May;5(5):877-82.


Increased expression of p50-NF-kappaB and constitutive activation of NF-kappaB transcription factors during mouse skin carcinogenesis.

Budunova IV, Perez P, Vaden VR, Spiegelman VS, Slaga TJ, Jorcano JL.

Oncogene. 1999 Dec 9;18(52):7423-31.


Resistance of transformed mouse keratinocytes to growth inhibition by glucocorticoids.

Spiegelman VS, Budunova IV, Carbajal S, Slaga TJ.

Mol Carcinog. 1997 Sep;20(1):99-107.


The expression of insecticide resistance-related cytochrome P450 forms is regulated by molting hormone in Drosophila melanogaster.

Spiegelman VS, Fuchs SY, Belitsky GA.

Biochem Biophys Res Commun. 1997 Mar 17;232(2):304-7.


Inducibility of various cytochrome P450 isozymes by phenobarbital and some other xenobiotics in Drosophila melanogaster.

Fuchs SY, Spiegelman VS, Belitsky GA.

Biochem Pharmacol. 1994 May 18;47(10):1867-73.


The effect of the cytochrome P-450 system inducers on the development of Drosophila melanogaster.

Fuchs SYu, Spiegelman VS, Belitsky GA.

J Biochem Toxicol. 1993 Jun;8(2):83-8.


Xenobiotic-metabolizing enzymes and benzo[a]pyrene metabolism in the benzo[a]pyrene-sensitive mutant strain of Drosophila simulans.

Fuchs SYu, Spiegelman VS, Safaev RD, Belitsky GA.

Mutat Res. 1992 Oct;269(2):185-91.


Supplemental Content

Loading ...
Support Center