Sort by
Items per page

Send to

Choose Destination

Search results

Items: 12


Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins.

Xu Y, Chandarajoti K, Zhang X, Pagadala V, Dou W, Hoppensteadt DM, Sparkenbaugh EM, Cooley B, Daily S, Key NS, Severynse-Stevens D, Fareed J, Linhardt RJ, Pawlinski R, Liu J.

Sci Transl Med. 2017 Sep 6;9(406). pii: eaan5954. doi: 10.1126/scitranslmed.aan5954.


Protective and detrimental effects of neuroectodermal cell-derived tissue factor in mouse models of stroke.

Wang S, Reeves B, Sparkenbaugh EM, Russell J, Soltys Z, Zhang H, Faber JE, Key NS, Kirchhofer D, Granger DN, Mackman N, Pawlinski R.

JCI Insight. 2016 Jul 21;1(11). pii: e86663.


Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

Sparkenbaugh EM, Chantrathammachart P, Chandarajoti K, Mackman N, Key NS, Pawlinski R.

Blood. 2016 Mar 10;127(10):1371-3. doi: 10.1182/blood-2015-11-681114. Epub 2016 Jan 27. No abstract available.


Excess of heme induces tissue factor-dependent activation of coagulation in mice.

Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R.

Haematologica. 2015 Mar;100(3):308-14. doi: 10.3324/haematol.2014.114728. Epub 2015 Jan 16.


Homogeneous low-molecular-weight heparins with reversible anticoagulant activity.

Xu Y, Cai C, Chandarajoti K, Hsieh PH, Li L, Pham TQ, Sparkenbaugh EM, Sheng J, Key NS, Pawlinski R, Harris EN, Linhardt RJ, Liu J.

Nat Chem Biol. 2014 Apr;10(4):248-50. doi: 10.1038/nchembio.1459. Epub 2014 Feb 23.


Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

Sparkenbaugh EM, Chantrathammachart P, Mickelson J, van Ryn J, Hebbel RP, Monroe DM, Mackman N, Key NS, Pawlinski R.

Blood. 2014 Mar 13;123(11):1747-56. doi: 10.1182/blood-2013-08-523936. Epub 2014 Jan 21.


Protease activated receptor-2 contributes to heart failure.

Antoniak S, Sparkenbaugh EM, Tencati M, Rojas M, Mackman N, Pawlinski R.

PLoS One. 2013 Nov 27;8(11):e81733. doi: 10.1371/journal.pone.0081733. eCollection 2013.


Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1α.

Sparkenbaugh EM, Ganey PE, Roth RA.

Am J Physiol Gastrointest Liver Physiol. 2012 Apr;302(7):G748-57. doi: 10.1152/ajpgi.00409.2011. Epub 2012 Jan 5.


The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.

Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2011 Aug;338(2):492-502. doi: 10.1124/jpet.111.180521. Epub 2011 May 16.


Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.

Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, Ganey PE.

J Pharmacol Exp Ther. 2009 Oct;331(1):114-21. doi: 10.1124/jpet.109.156331. Epub 2009 Jul 28.


Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.

Shaw PJ, Beggs KM, Sparkenbaugh EM, Dugan CM, Ganey PE, Roth RA.

Toxicol Sci. 2009 Oct;111(2):288-301. doi: 10.1093/toxsci/kfp163. Epub 2009 Jul 28.


Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.

Deng X, Liguori MJ, Sparkenbaugh EM, Waring JF, Blomme EA, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2008 Dec;327(3):634-44. doi: 10.1124/jpet.108.140335. Epub 2008 Sep 18.

Supplemental Content

Loading ...
Support Center