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Gut microbiota modulate T cell trafficking into human colorectal cancer.

Cremonesi E, Governa V, Garzon JFG, Mele V, Amicarella F, Muraro MG, Trella E, Galati-Fournier V, Oertli D, Däster SR, Droeser RA, Weixler B, Bolli M, Rosso R, Nitsche U, Khanna N, Egli A, Keck S, Slotta-Huspenina J, Terracciano LM, Zajac P, Spagnoli GC, Eppenberger-Castori S, Janssen KP, Borsig L, Iezzi G.

Gut. 2018 Feb 6. pii: gutjnl-2016-313498. doi: 10.1136/gutjnl-2016-313498. [Epub ahead of print]


Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles.

Spagnoli G, Pouyanfard S, Cavazzini D, Canali E, Maggi S, Tommasino M, Bolchi A, Müller M, Ottonello S.

Sci Rep. 2017 Dec 21;7(1):18000. doi: 10.1038/s41598-017-18177-1.


Minor Capsid Protein L2 Polytope Induces Broad Protection against Oncogenic and Mucosal Human Papillomaviruses.

Pouyanfard S, Spagnoli G, Bulli L, Balz K, Yang F, Odenwald C, Seitz H, Mariz FC, Bolchi A, Ottonello S, Müller M.

J Virol. 2018 Jan 30;92(4). pii: e01930-17. doi: 10.1128/JVI.01930-17. Print 2018 Feb 15.


MAGE-A4 and MAGE-A1 Immunohistochemical Expression in High-grade Endometrial Cancer.

Srdelić S, Kuzmić-Prusac I, Spagnoli GC, Juretić A, Čapkun V.

Int J Gynecol Pathol. 2017 Nov 14. doi: 10.1097/PGP.0000000000000470. [Epub ahead of print]


mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition.

Xue G, Kohler R, Tang F, Hynx D, Wang Y, Orso F, Prêtre V, Ritschard R, Hirschmann P, Cron P, Roloff T, Dummer R, Mandalà M, Bichet S, Genoud C, Meyer AG, Muraro MG, Spagnoli GC, Taverna D, Rüegg C, Merghoub T, Massi D, Tang H, Levesque MP, Dirnhofer S, Zippelius A, Hemmings BA, Wicki A.

Oncotarget. 2017 May 25;8(41):69204-69218. doi: 10.18632/oncotarget.18213. eCollection 2017 Sep 19.


Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer.

Weixler B, Renetseder F, Facile I, Tosti N, Cremonesi E, Tampakis A, Delko T, Eppenberger-Castori S, Tzankov A, Iezzi G, Kettelhack C, Soysal SD, von Holzen U, Spagnoli GC, Terracciano L, Tornillo L, Droeser RA, Däster S.

Cell Oncol (Dordr). 2017 Dec;40(6):609-619. doi: 10.1007/s13402-017-0348-2. Epub 2017 Sep 21.


Ex-vivo assessment of drug response on breast cancer primary tissue with preserved microenvironments.

Muraro MG, Muenst S, Mele V, Quagliata L, Iezzi G, Tzankov A, Weber WP, Spagnoli GC, Soysal SD.

Oncoimmunology. 2017 May 30;6(7):e1331798. doi: 10.1080/2162402X.2017.1331798. eCollection 2017.


[Expression of cancer testis (CT) antigens in pediatric and adolescent melanomas].

Behrendt N, Schultewolter T, Busam K, Frosina D, Spagnoli G, Jungbluth A.

Pathologe. 2017 Jul;38(4):303-311. doi: 10.1007/s00292-017-0311-z. Review. German.


MAGE-A Antigens and Cancer Immunotherapy.

Zajac P, Schultz-Thater E, Tornillo L, Sadowski C, Trella E, Mengus C, Iezzi G, Spagnoli GC.

Front Med (Lausanne). 2017 Mar 8;4:18. doi: 10.3389/fmed.2017.00018. eCollection 2017.


Expression of Indoleamine 2,3-Dioxygenase Gene Is a Feature of Poorly Differentiated Non-muscle-invasive Urothelial Cell Bladder Carcinomas.

Hudolin T, Mengus C, Coulot J, Kastelan Z, El-Saleh A, Spagnoli GC.

Anticancer Res. 2017 Mar;37(3):1375-1380.


Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast.

Bosio MC, Fermi B, Spagnoli G, Levati E, Rubbi L, Ferrari R, Pellegrini M, Dieci G.

Nucleic Acids Res. 2017 May 5;45(8):4493-4506. doi: 10.1093/nar/gkx058.


MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy.

Laban S, Giebel G, Klümper N, Schröck A, Doescher J, Spagnoli G, Thierauf J, Theodoraki MN, Remark R, Gnjatic S, Krupar R, Sikora AG, Litjens G, Grabe N, Kristiansen G, Bootz F, Schuler PJ, Brunner C, Brägelmann J, Hoffmann TK, Perner S.

Oncotarget. 2017 Feb 28;8(9):14719-14735. doi: 10.18632/oncotarget.14830.


T-cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance.

Dasen B, Vlajnic T, Mengus C, Ruiz C, Bubendorf L, Spagnoli G, Wyler S, Erne P, Resink TJ, Philippova M.

J Pathol Clin Res. 2016 Nov 26;3(1):44-57. doi: 10.1002/cjp2.61. eCollection 2017 Jan.


The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer.

Governa V, Trella E, Mele V, Tornillo L, Amicarella F, Cremonesi E, Muraro MG, Xu H, Droeser R, Däster SR, Bolli M, Rosso R, Oertli D, Eppenberger-Castori S, Terracciano LM, Iezzi G, Spagnoli GC.

Clin Cancer Res. 2017 Jul 15;23(14):3847-3858. doi: 10.1158/1078-0432.CCR-16-2047. Epub 2017 Jan 20.


Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights.

Leavy M, Trottmann M, Liedl B, Reese S, Stief C, Freitag B, Baugh J, Spagnoli G, Kölle S.

Sci Rep. 2017 Jan 3;7:39931. doi: 10.1038/srep39931.


Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment.

Däster S, Amatruda N, Calabrese D, Ivanek R, Turrini E, Droeser RA, Zajac P, Fimognari C, Spagnoli GC, Iezzi G, Mele V, Muraro MG.

Oncotarget. 2017 Jan 3;8(1):1725-1736. doi: 10.18632/oncotarget.13857.


Influence of Photodynamic Therapy on the Expression of Cancer/Testis Antigens in Squamous Cell Carcinoma of the Head and Neck.

Theodoraki MN, Lorenz KJ, Schneider J, Thierauf JC, Spagnoli G, Schuler PJ, Hoffmann TK, Laban S.

Anticancer Res. 2016 Aug;36(8):3973-82.


Secretory production of designed multipeptides displayed on a thermostable bacterial thioredoxin scaffold in Pichia pastoris.

Spagnoli G, Bolchi A, Cavazzini D, Pouyanfard S, Müller M, Ottonello S.

Protein Expr Purif. 2017 Jan;129:150-157. doi: 10.1016/j.pep.2016.04.012. Epub 2016 Apr 29.


Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage.

Arriga R, Caratelli S, Coppola A, Spagnoli GC, Venditti A, Amadori S, Lanzilli G, Lauro D, Palomba P, Sconocchia T, Del Principe MI, Maurillo L, Buccisano F, Capuani B, Ferrone S, Sconocchia G.

Oncotarget. 2016 Jan 12;7(2):2070-9. doi: 10.18632/oncotarget.6529.


Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis.

Däster S, Eppenberger-Castori S, Hirt C, Soysal SD, Delko T, Nebiker CA, Weixler B, Amicarella F, Iezzi G, Governa V, Padovan E, Mele V, Sconocchia G, Heberer M, Terracciano L, Kettelhack C, Oertli D, Spagnoli GC, von Holzen U, Tornillo L, Droeser RA.

Oncoimmunology. 2015 May 29;4(12):e1050574. eCollection 2015 Dec.


CD40 ligand-expressing recombinant vaccinia virus promotes the generation of CD8(+) central memory T cells.

Trella E, Raafat N, Mengus C, Traunecker E, Governa V, Heidtmann S, Heberer M, Oertli D, Spagnoli GC, Zajac P.

Eur J Immunol. 2016 Feb;46(2):420-31. doi: 10.1002/eji.201545554. Epub 2015 Dec 2.


OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer.

Weixler B, Cremonesi E, Sorge R, Muraro MG, Delko T, Nebiker CA, Däster S, Governa V, Amicarella F, Soysal SD, Kettelhack C, von Holzen UW, Eppenberger-Castori S, Spagnoli GC, Oertli D, Iezzi G, Terracciano L, Tornillo L, Sconocchia G, Droeser RA.

Oncotarget. 2015 Nov 10;6(35):37588-99. doi: 10.18632/oncotarget.5940.


Thioredoxin-Displayed Multipeptide Immunogens.

Bolchi A, Canali E, Santoni A, Spagnoli G, Viarisio D, Accardi R, Tommasino M, Müller M, Ottonello S.

Methods Mol Biol. 2015;1348:137-51. doi: 10.1007/978-1-4939-2999-3_14.


Why do infections cause cancer?

Antonelli G, Spagnoli GC.

Clin Microbiol Infect. 2015 Nov;21(11):967-8. doi: 10.1016/j.cmi.2015.07.008. Epub 2015 Jul 18. No abstract available.


Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo".

Hirt C, Papadimitropoulos A, Muraro MG, Mele V, Panopoulos E, Cremonesi E, Ivanek R, Schultz-Thater E, Droeser RA, Mengus C, Heberer M, Oertli D, Iezzi G, Zajac P, Eppenberger-Castori S, Tornillo L, Terracciano L, Martin I, Spagnoli GC.

Biomaterials. 2015 Sep;62:138-46. doi: 10.1016/j.biomaterials.2015.05.037. Epub 2015 May 20.


NK cells and T cells cooperate during the clinical course of colorectal cancer.

Sconocchia G, Eppenberger S, Spagnoli GC, Tornillo L, Droeser R, Caratelli S, Ferrelli F, Coppola A, Arriga R, Lauro D, Iezzi G, Terracciano L, Ferrone S.

Oncoimmunology. 2014 Aug 3;3(8):e952197. eCollection 2014.


High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer.

Däster S, Eppenberger-Castori S, Hirt C, Zlobec I, Delko T, Nebiker CA, Soysal SD, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Spagnoli GC, Kettelhack C, Terracciano L, Oertli D, von Holzen U, Tornillo L, Droeser RA.

Dis Markers. 2014;2014:792183. doi: 10.1155/2014/792183. Epub 2014 Dec 30.


Anti-inflammatory/tissue repair macrophages enhance the cartilage-forming capacity of human bone marrow-derived mesenchymal stromal cells.

Sesia SB, Duhr R, Medeiros da Cunha C, Todorov A, Schaeren S, Padovan E, Spagnoli G, Martin I, Barbero A.

J Cell Physiol. 2015 Jun;230(6):1258-69. doi: 10.1002/jcp.24861.


Expression and immune responses to MAGE antigens predict survival in epithelial ovarian cancer.

Daudi S, Eng KH, Mhawech-Fauceglia P, Morrison C, Miliotto A, Beck A, Matsuzaki J, Tsuji T, Groman A, Gnjatic S, Spagnoli G, Lele S, Odunsi K.

PLoS One. 2014 Aug 7;9(8):e104099. doi: 10.1371/journal.pone.0104099. eCollection 2014.


Microtubule-depolymerizing agents used in antibody-drug conjugates induce antitumor immunity by stimulation of dendritic cells.

Müller P, Martin K, Theurich S, Schreiner J, Savic S, Terszowski G, Lardinois D, Heinzelmann-Schwarz VA, Schlaak M, Kvasnicka HM, Spagnoli G, Dirnhofer S, Speiser DE, von Bergwelt-Baildon M, Zippelius A.

Cancer Immunol Res. 2014 Aug;2(8):741-55. doi: 10.1158/2326-6066.CIR-13-0198. Epub 2014 Apr 21.


"In vitro" 3D models of tumor-immune system interaction.

Hirt C, Papadimitropoulos A, Mele V, Muraro MG, Mengus C, Iezzi G, Terracciano L, Martin I, Spagnoli GC.

Adv Drug Deliv Rev. 2014 Dec 15;79-80:145-54. doi: 10.1016/j.addr.2014.05.003. Epub 2014 May 9. Review.


A high-performance thioredoxin-based scaffold for peptide immunogen construction: proof-of-concept testing with a human papillomavirus epitope.

Canali E, Bolchi A, Spagnoli G, Seitz H, Rubio I, Pertinhez TA, Müller M, Ottonello S.

Sci Rep. 2014 Apr 22;4:4729. doi: 10.1038/srep04729.


GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer.

Nebiker CA, Han J, Eppenberger-Castori S, Iezzi G, Hirt C, Amicarella F, Cremonesi E, Huber X, Padovan E, Angrisani B, Droeser RA, Rosso R, Bolli M, Oertli D, von Holzen U, Adamina M, Muraro MG, Mengus C, Zajac P, Sconocchia G, Zuber M, Tornillo L, Terracciano L, Spagnoli GC.

Clin Cancer Res. 2014 Jun 15;20(12):3094-106. doi: 10.1158/1078-0432.CCR-13-2774. Epub 2014 Apr 15.


HLA class II antigen expression in colorectal carcinoma tumors as a favorable prognostic marker.

Sconocchia G, Eppenberger-Castori S, Zlobec I, Karamitopoulou E, Arriga R, Coppola A, Caratelli S, Spagnoli GC, Lauro D, Lugli A, Han J, Iezzi G, Ferrone C, Ferlosio A, Tornillo L, Droeser R, Rossi P, Attanasio A, Ferrone S, Terracciano L.

Neoplasia. 2014 Jan;16(1):31-42.


Co-expression of cancer testis antigens and topoisomerase 2-alpha in triple negative breast carcinomas.

Mrklić I, Spagnoli GC, Juretić A, Pogorelić Z, Tomić S.

Acta Histochem. 2014 Jun;116(5):740-6. doi: 10.1016/j.acthis.2014.01.003. Epub 2014 Feb 18.


Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer.

Laban S, Atanackovic D, Luetkens T, Knecht R, Busch CJ, Freytag M, Spagnoli G, Ritter G, Hoffmann TK, Knuth A, Sauter G, Wilczak W, Blessmann M, Borgmann K, Muenscher A, Clauditz TS.

Int J Cancer. 2014 Sep 1;135(5):1142-52. doi: 10.1002/ijc.28752. Epub 2014 Feb 11.


FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells.

Bocelli-Tyndall C, Trella E, Frachet A, Zajac P, Pfaff D, Geurts J, Heiler S, Barbero A, Mumme M, Resink TJ, Schaeren S, Spagnoli GC, Tyndall A.

Ann Rheum Dis. 2015 Jan;74(1):260-6. doi: 10.1136/annrheumdis-2013-204235. Epub 2013 Nov 18.


Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis.

Hirt C, Eppenberger-Castori S, Sconocchia G, Iezzi G, Tornillo L, Terracciano L, Spagnoli GC, Droeser RA.

Oncoimmunology. 2013 Oct 1;2(10):e25990. Epub 2013 Sep 12.


Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β.

Mele V, Muraro MG, Calabrese D, Pfaff D, Amatruda N, Amicarella F, Kvinlaug B, Bocelli-Tyndall C, Martin I, Resink TJ, Heberer M, Oertli D, Terracciano L, Spagnoli GC, Iezzi G.

Int J Cancer. 2014 Jun 1;134(11):2583-94. doi: 10.1002/ijc.28598. Epub 2014 Jan 30.


Characterization and clinical relevance of ALDHbright populations in prostate cancer.

Le Magnen C, Bubendorf L, Rentsch CA, Mengus C, Gsponer J, Zellweger T, Rieken M, Thalmann GN, Cecchini MG, Germann M, Bachmann A, Wyler S, Heberer M, Spagnoli GC.

Clin Cancer Res. 2013 Oct 1;19(19):5361-71. doi: 10.1158/1078-0432.CCR-12-2857. Epub 2013 Aug 22.


The role of 3D structure and protein conformation on the innate and adaptive immune responses to silk-based biomaterials.

Bhattacharjee M, Schultz-Thater E, Trella E, Miot S, Das S, Loparic M, Ray AR, Martin I, Spagnoli GC, Ghosh S.

Biomaterials. 2013 Nov;34(33):8161-71. doi: 10.1016/j.biomaterials.2013.07.018. Epub 2013 Jul 26.


High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor.

Droeser RA, Hirt C, Eppenberger-Castori S, Zlobec I, Viehl CT, Frey DM, Nebiker CA, Rosso R, Zuber M, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Tornillo L, Oertli D, Terracciano L, Spagnoli GC.

PLoS One. 2013 May 29;8(5):e64814. doi: 10.1371/journal.pone.0064814. Print 2013.


Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma.

Hudolin T, Kastelan Z, Ilic I, Levarda-Hudolin K, Basic-Jukic N, Rieken M, Spagnoli GC, Juretic A, Mengus C.

J Transl Med. 2013 May 16;11:123. doi: 10.1186/1479-5876-11-123.


Clinical impact of programmed cell death ligand 1 expression in colorectal cancer.

Droeser RA, Hirt C, Viehl CT, Frey DM, Nebiker C, Huber X, Zlobec I, Eppenberger-Castori S, Tzankov A, Rosso R, Zuber M, Muraro MG, Amicarella F, Cremonesi E, Heberer M, Iezzi G, Lugli A, Terracciano L, Sconocchia G, Oertli D, Spagnoli GC, Tornillo L.

Eur J Cancer. 2013 Jun;49(9):2233-42. doi: 10.1016/j.ejca.2013.02.015. Epub 2013 Mar 13.


T-cadherin loss promotes experimental metastasis of squamous cell carcinoma.

Philippova M, Pfaff D, Kyriakakis E, Buechner SA, Iezzi G, Spagnoli GC, Schoenenberger AW, Erne P, Resink TJ.

Eur J Cancer. 2013 May;49(8):2048-58. doi: 10.1016/j.ejca.2012.12.026. Epub 2013 Jan 29.


MAGE-A10 cancer/testis antigen is highly expressed in high-grade non-muscle-invasive bladder carcinomas.

Mengus C, Schultz-Thater E, Coulot J, Kastelan Z, Goluza E, Coric M, Spagnoli GC, Hudolin T.

Int J Cancer. 2013 May 15;132(10):2459-63. doi: 10.1002/ijc.27914. Epub 2012 Nov 16.


Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells.

Le Magnen C, Bubendorf L, Ruiz C, Zlobec I, Bachmann A, Heberer M, Spagnoli GC, Wyler S, Mengus C.

Eur J Cancer. 2013 Mar;49(4):955-63. doi: 10.1016/j.ejca.2012.09.023. Epub 2012 Oct 22.


Melanoma cells inhibit NK cell functions.

Sconocchia G, Arriga R, Tornillo L, Terracciano L, Ferrone S, Spagnoli GC.

Cancer Res. 2012 Oct 15;72(20):5428-9; author reply 5430. doi: 10.1158/0008-5472.CAN-12-1181. Epub 2012 Oct 9. No abstract available.


Cracks in dentin and enamel after cryopreservation.

Kühl S, Deyhle H, Zimmerli M, Spagnoli G, Beckmann F, Müller B, Filippi A.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Feb;113(2):e5-e10. doi: 10.1016/j.tripleo.2011.06.020. Epub 2012 Jan 20.


Differential patterns of large tumor antigen-specific immune responsiveness in patients with BK polyomavirus-positive prostate cancer or benign prostatic hyperplasia.

Sais G, Wyler S, Hudolin T, Banzola I, Mengus C, Bubendorf L, Wild PJ, Hirsch HH, Sulser T, Spagnoli GC, Provenzano M.

J Virol. 2012 Aug;86(16):8461-71. doi: 10.1128/JVI.00005-12. Epub 2012 May 30.

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