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Cancer Incidence in C3H Mice Protected from Lethal Total-Body Radiation after Amifostine.

Cook JA, Naz S, Anver MR, Sowers AL, Fabre K, Krishna MC, Mitchell JB.

Radiat Res. 2018 Mar 12. doi: 10.1667/RR14987.1. [Epub ahead of print]


Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model.

Chung EJ, Sowers A, Thetford A, McKay-Corkum G, Chung SI, Mitchell JB, Citrin DE.

Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):857-866. doi: 10.1016/j.ijrobp.2016.07.026. Epub 2016 Jul 28.


SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.

Eytan DF, Snow GE, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers AL, Hernandez L, Mitchell JB, Annunziata CM, Chen Z, Van Waes C.

Cancer Res. 2016 Sep 15;76(18):5442-5454. doi: 10.1158/0008-5472.CAN-15-3317. Epub 2016 Jul 28.


Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cook JA, Chandramouli GV, Anver MR, Sowers AL, Thetford A, Krausz KW, Gonzalez FJ, Mitchell JB, Patterson AD.

Cancer Res. 2016 Mar 15;76(6):1569-77. doi: 10.1158/0008-5472.CAN-15-2416. Epub 2016 Feb 15.


NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay.

Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA.

Cancer Res. 2015 Jul 15;75(14):2788-99. doi: 10.1158/0008-5472.CAN-14-3011. Epub 2015 May 19.


The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE-/- mice.

Kim CH, Mitchell JB, Bursill CA, Sowers AL, Thetford A, Cook JA, van Reyk DM, Davies MJ.

Atherosclerosis. 2015 May;240(1):234-41. doi: 10.1016/j.atherosclerosis.2015.03.012. Epub 2015 Mar 16.


Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.

Leiker AJ, DeGraff W, Choudhuri R, Sowers AL, Thetford A, Cook JA, Van Waes C, Mitchell JB.

Clin Cancer Res. 2015 Jun 15;21(12):2792-801. doi: 10.1158/1078-0432.CCR-14-3279. Epub 2015 Feb 27.


Role of type II pneumocyte senescence in radiation-induced lung fibrosis.

Citrin DE, Shankavaram U, Horton JA, Shield W 3rd, Zhao S, Asano H, White A, Sowers A, Thetford A, Chung EJ.

J Natl Cancer Inst. 2013 Oct 2;105(19):1474-84. doi: 10.1093/jnci/djt212. Epub 2013 Sep 19.


PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer.

Herzog A, Bian Y, Vander Broek R, Hall B, Coupar J, Cheng H, Sowers AL, Cook JD, Mitchell JB, Chen Z, Kulkarni AB, Van Waes C.

Clin Cancer Res. 2013 Jul 15;19(14):3808-19. doi: 10.1158/1078-0432.CCR-12-2716. Epub 2013 May 2.


Metabolomics reveals that tumor xenografts induce liver dysfunction.

Li F, Patterson AD, Krausz KW, Jiang C, Bi H, Sowers AL, Cook JA, Mitchell JB, Gonzalez FJ.

Mol Cell Proteomics. 2013 Aug;12(8):2126-35. doi: 10.1074/mcp.M113.028324. Epub 2013 May 1.


Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis.

Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ.

Nat Med. 2013 Apr;19(4):421-8. doi: 10.1038/nm.3118. Epub 2013 Mar 10.


Inhibition of radiation-induced skin fibrosis with imatinib.

Horton JA, Chung EJ, Hudak KE, Sowers A, Thetford A, White AO, Mitchell JB, Citrin DE.

Int J Radiat Biol. 2013 Mar;89(3):162-70. doi: 10.3109/09553002.2013.741281. Epub 2012 Nov 19.


The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

Mitchell JB, Anver MR, Sowers AL, Rosenberg PS, Figueroa M, Thetford A, Krishna MC, Albert PS, Cook JA.

Cancer Res. 2012 Sep 15;72(18):4846-55. doi: 10.1158/0008-5472.CAN-12-1879. Epub 2012 Jul 17.


Pharmacological protection from radiation ± cisplatin-induced oral mucositis.

Cotrim AP, Yoshikawa M, Sunshine AN, Zheng C, Sowers AL, Thetford AD, Cook JA, Mitchell JB, Baum BJ.

Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1284-90. doi: 10.1016/j.ijrobp.2011.09.026. Epub 2011 Dec 22.


The effects of resveratrol and selected metabolites on the radiation and antioxidant response.

Fabre KM, Saito K, DeGraff W, Sowers AL, Thetford A, Cook JA, Krishna MC, Mitchell JB.

Cancer Biol Ther. 2011 Nov 15;12(10):915-23. doi: 10.4161/cbt.12.10.17714. Epub 2011 Nov 15.


Enhancement of 5-fluorouracil-induced in vitro and in vivo radiosensitization with MEK inhibition.

Urick ME, Chung EJ, Shield WP 3rd, Gerber N, White A, Sowers A, Thetford A, Camphausen K, Mitchell J, Citrin DE.

Clin Cancer Res. 2011 Aug 1;17(15):5038-47. doi: 10.1158/1078-0432.CCR-11-0358. Epub 2011 Jun 20.


A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.

Davis RM, Sowers AL, DeGraff W, Bernardo M, Thetford A, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2011 Aug 1;51(3):780-90. doi: 10.1016/j.freeradbiomed.2011.05.019. Epub 2011 May 25.


Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands.

Zheng C, Cotrim AP, Rowzee A, Swaim W, Sowers A, Mitchell JB, Baum BJ.

Clin Cancer Res. 2011 May 1;17(9):2842-51. doi: 10.1158/1078-0432.CCR-10-2982. Epub 2011 Mar 2.


Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes.

Matsumoto A, Matsumoto K, Matsumoto S, Hyodo F, Sowers AL, Koscielniak JW, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Biol Pharm Bull. 2011;34(1):142-5.


Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape.

Davis RM, Matsumoto S, Bernardo M, Sowers A, Matsumoto K, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2011 Feb 1;50(3):459-68. doi: 10.1016/j.freeradbiomed.2010.11.028. Epub 2010 Dec 1.


Inhibition of adipogenesis by Tempol in 3T3-L1 cells.

Samuni Y, Cook JA, Choudhuri R, Degraff W, Sowers AL, Krishna MC, Mitchell JB.

Free Radic Biol Med. 2010 Aug 15;49(4):667-73. doi: 10.1016/j.freeradbiomed.2010.05.028. Epub 2010 Jun 16.


Evaluation of the fullerene compound DF-1 as a radiation protector.

Brown AP, Chung EJ, Urick ME, Shield WP 3rd, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE.

Radiat Oncol. 2010 May 11;5:34. doi: 10.1186/1748-717X-5-34.


In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, Cook JA.

Clin Cancer Res. 2010 Apr 1;16(7):2076-84. doi: 10.1158/1078-0432.CCR-09-3277. Epub 2010 Mar 16.


Developmental effects of a municipal wastewater effluent on two generations of the fathead minnow, Pimephales promelas.

Sowers AD, Gaworecki KM, Mills MA, Roberts AP, Klaine SJ.

Aquat Toxicol. 2009 Nov 27;95(3):173-81. doi: 10.1016/j.aquatox.2009.08.012. Epub 2009 Sep 23.


The developmental effects of a municipal wastewater effluent on the northern leopard frog, Rana pipiens.

Sowers AD, Mills MA, Klaine SJ.

Aquat Toxicol. 2009 Aug 31;94(2):145-52. doi: 10.1016/j.aquatox.2009.06.013. Epub 2009 Jun 26.


Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands.

Zheng C, Cotrim AP, Sunshine AN, Sugito T, Liu L, Sowers A, Mitchell JB, Baum BJ.

Clin Cancer Res. 2009 Jul 15;15(14):4641-8. doi: 10.1158/1078-0432.CCR-09-0819. Epub 2009 Jul 7.


Halofuginone mediated protection against radiation-induced leg contracture.

Ishii H, Choudhuri R, Mathias A, Sowers AL, Flanders KC, Cook JA, Mitchell JB.

Int J Oncol. 2009 Aug;35(2):315-9.


TBI with lung dose reduction does not improve hematopoietic cell homing to BM during allogeneic transplantation.

Singh AK, Chen J, Calado R, Sowers A, Mitchell JB, Barrett AJ.

Bone Marrow Transplant. 2010 Jan;45(1):25-30. doi: 10.1038/bmt.2009.121. Epub 2009 Jun 15.


Biochemical and behavioral effects of diazinon exposure in hybrid striped bass.

Gaworecki KM, Roberts AP, Ellis N, Sowers AD, Klaine SJ.

Environ Toxicol Chem. 2009 Jan;28(1):105-12. doi: 10.1897/08-001.1.


Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging.

Hyodo F, Soule BP, Matsumoto K, Matusmoto S, Cook JA, Hyodo E, Sowers AL, Krishna MC, Mitchell JB.

J Pharm Pharmacol. 2008 Aug;60(8):1049-60. doi: 10.1211/jpp.60.8.0011. Review.


Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.

Flanders KC, Ho BM, Arany PR, Stuelten C, Mamura M, Paterniti MO, Sowers A, Mitchell JB, Roberts AB.

Am J Pathol. 2008 Jul;173(1):68-76. doi: 10.2353/ajpath.2008.070937. Epub 2008 May 23.


Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands.

Cotrim AP, Sowers A, Mitchell JB, Baum BJ.

Mol Ther. 2007 Dec;15(12):2101-6. Epub 2007 Aug 28.


Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging.

Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, Krishna MC, Mitchell JB.

Clin Cancer Res. 2007 Aug 15;13(16):4928-33.


Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD.

Br J Pharmacol. 2007 May;151(1):63-72. Epub 2007 Mar 12.


The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.

Matsumoto K, Szajek L, Krishna MC, Cook JA, Seidel J, Grimes K, Carson J, Sowers AL, English S, Green MV, Bacharach SL, Eckelman WC, Mitchell JB.

Int J Oncol. 2007 Apr;30(4):873-81.


Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo.

Cook JA, Chuang EY, Tsai MH, Coffin D, Degraff W, Sowers AL, Mitchell JB.

Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1263-72.


Hemolymph osmolality and cation concentrations in Litopenaeus vannamei during exposure to artificial sea salt or a mixed-ion solution: relationship to potassium flux.

Sowers AD, Young SP, Grosell M, Browdy CL, Tomasso JR.

Comp Biochem Physiol A Mol Integr Physiol. 2006 Oct;145(2):176-80. Epub 2006 Jun 10.


The influence of tumor oxygenation on (18)F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET).

Chan LW, Hapdey S, English S, Seidel J, Carson J, Sowers AL, Krishna MC, Green MV, Mitchell JB, Bacharach SL.

Radiat Oncol. 2006 Feb 28;1:3.


High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.

Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC.

Clin Cancer Res. 2006 Apr 15;12(8):2455-62.


Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR.

Matsumoto A, Matsumoto S, Sowers AL, Koscielniak JW, Trigg NJ, Kuppusamy P, Mitchell JB, Subramanian S, Krishna MC, Matsumoto K.

Magn Reson Med. 2005 Dec;54(6):1530-5.


Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model.

Cotrim AP, Sowers AL, Lodde BM, Vitolo JM, Kingman A, Russo A, Mitchell JB, Baum BJ.

Clin Cancer Res. 2005 Oct 15;11(20):7564-8.


Evaluation of radiation-induced oral mucositis by optical coherence tomography.

Muanza TM, Cotrim AP, McAuliffe M, Sowers AL, Baum BJ, Cook JA, Feldchtein F, Amazeen P, Coleman CN, Mitchell JB.

Clin Cancer Res. 2005 Jul 15;11(14):5121-7.


Influence of proton T1 on oxymetry using Overhauser enhanced magnetic resonance imaging.

Matsumoto S, Utsumi H, Aravalluvan T, Matsumoto K, Matsumoto A, Devasahayam N, Sowers AL, Mitchell JB, Subramanian S, Krishna MC.

Magn Reson Med. 2005 Jul;54(1):213-7.


Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.

Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.

Clin Cancer Res. 2004 Nov 15;10(22):7712-20.


CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

Mamura M, Lee W, Sullivan TJ, Felici A, Sowers AL, Allison JP, Letterio JJ.

Blood. 2004 Jun 15;103(12):4594-601. Epub 2004 Mar 11.


The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model.

Vitolo JM, Cotrim AP, Sowers AL, Russo A, Wellner RB, Pillemer SR, Mitchell JB, Baum BJ.

Clin Cancer Res. 2004 Mar 1;10(5):1807-12.


Influence of body temperature on the BOLD effect in murine SCC tumors.

Reijnders K, English SJ, Krishna MC, Cook JA, Sowers AL, Mitchell JB, Zhang Y.

Magn Reson Med. 2004 Feb;51(2):389-93.


Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A.

J Biol Chem. 2004 Apr 9;279(15):15167-76. Epub 2004 Jan 19.


Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D.

Cancer Res. 2003 Dec 15;63(24):8984-95.


Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin.

Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA, Mitchell JB, Russo A, Roberts AB.

Am J Pathol. 2003 Dec;163(6):2247-57.

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