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Items: 1 to 50 of 159

1.
2.

Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics.

Moggridge S, Sorensen PH, Morin GB, Hughes CS.

J Proteome Res. 2018 Apr 6;17(4):1730-1740. doi: 10.1021/acs.jproteome.7b00913. Epub 2018 Mar 27.

PMID:
29565595
3.

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD.

Cell. 2018 Feb 22;172(5):1050-1062.e14. doi: 10.1016/j.cell.2018.01.038.

PMID:
29474906
4.

Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis.

Park J, Kim J, Park B, Yang KM, Sun EJ, Tognon CE, Sorensen PH, Kim SJ.

Oncogene. 2018 Feb 2. doi: 10.1038/s41388-017-0102-2. [Epub ahead of print]

PMID:
29391602
5.

Translational control of aberrant stress responses as a hallmark of cancer.

El-Naggar AM, Sorensen PH.

J Pathol. 2018 Apr;244(5):650-666. doi: 10.1002/path.5030. Epub 2018 Feb 20. Review.

PMID:
29293271
6.

TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer.

Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N.

Cancer Res. 2018 Jan 15;78(2):489-500. doi: 10.1158/0008-5472.CAN-16-1911. Epub 2017 Nov 28.

PMID:
29183891
7.

hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms.

Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, Chacko S, Lewis SM, Scott IC, Sorensen PHB, Berman JN.

Dev Dyn. 2018 Feb;247(2):289-303. doi: 10.1002/dvdy.24600. Epub 2017 Oct 27.

PMID:
29024245
8.

eEF2K protects MYCN-amplified cells from starvation.

Delaidelli A, Leprivier G, Sorensen PH.

Cell Cycle. 2017 Sep 17;16(18):1633-1634. doi: 10.1080/15384101.2017.1355180. Epub 2017 Aug 2. No abstract available.

PMID:
28767324
9.

Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells.

Thiel U, Schober SJ, Einspieler I, Kirschner A, Thiede M, Schirmer D, Gall K, Blaeschke F, Schmidt O, Jabar S, Ranft A, Alba Rubío R, Dirksen U, Grunewald TGP, Sorensen PH, Richter GHS, von Lüttichau IT, Busch DH, Burdach SEG.

Oncoimmunology. 2017 Apr 12;6(5):e1312239. doi: 10.1080/2162402X.2017.1312239. eCollection 2017.

10.

Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues.

Majzner RG, Simon JS, Grosso JF, Martinez D, Pawel BR, Santi M, Merchant MS, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen PH, Mackall CL, Maris JM.

Cancer. 2017 Oct 1;123(19):3807-3815. doi: 10.1002/cncr.30724. Epub 2017 Jun 13.

PMID:
28608950
11.

MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.

Delaidelli A, Negri GL, Jan A, Jansonius B, El-Naggar A, Lim JKM, Khan D, Zarni Oo H, Carnie CJ, Remke M, Maris JM, Leprivier G, Sorensen PH.

Cell Death Differ. 2017 Sep;24(9):1564-1576. doi: 10.1038/cdd.2017.79. Epub 2017 Jun 2.

PMID:
28574509
12.

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.

von Heyking K, Calzada-Wack J, Göllner S, Neff F, Schmidt O, Hensel T, Schirmer D, Fasan A, Esposito I, Müller-Tidow C, Sorensen PH, Burdach S, Richter GHS.

Mol Oncol. 2017 Sep;11(9):1288-1301. doi: 10.1002/1878-0261.12057. Epub 2017 Aug 21.

13.

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.

Andrio E, Lotte R, Hamaoui D, Cherfils J, Doye A, Daugaard M, Sorensen PH, Bost F, Ruimy R, Mettouchi A, Lemichez E.

Sci Rep. 2017 Mar 20;7:44779. doi: 10.1038/srep44779.

14.

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.

Jan A, Jansonius B, Delaidelli A, Somasekharan SP, Bhanshali F, Vandal M, Negri GL, Moerman D, MacKenzie I, Calon F, Hayden MR, Taubert S, Sorensen PH.

Acta Neuropathol. 2017 Jan;133(1):101-119. doi: 10.1007/s00401-016-1634-1. Epub 2016 Oct 17.

PMID:
27752775
15.

An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity.

Somasekharan SP, El-Naggar A, Sorensen PH, Wang Y, Cheng H.

Evid Based Complement Alternat Med. 2016;2016:9730654. doi: 10.1155/2016/9730654. Epub 2016 Aug 31.

16.

Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility.

Clausen TM, Pereira MA, Al Nakouzi N, Oo HZ, Agerbæk MØ, Lee S, Ørum-Madsen MS, Kristensen AR, El-Naggar A, Grandgenett PM, Grem JL, Hollingsworth MA, Holst PJ, Theander T, Sorensen PH, Daugaard M, Salanti A.

Mol Cancer Res. 2016 Dec;14(12):1288-1299. Epub 2016 Sep 21.

17.

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.

Cell Rep. 2016 Sep 20;16(12):3414. doi: 10.1016/j.celrep.2016.08.072. Epub 2016 Sep 20. No abstract available.

18.

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.

Cetinbas NM, Sudderth J, Harris RC, Cebeci A, Negri GL, Yılmaz ÖH, DeBerardinis RJ, Sorensen PH.

Sci Rep. 2016 Sep 8;6:32606. doi: 10.1038/srep32606.

19.

miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma.

Zhang HF, Alshareef A, Wu C, Jiao JW, Sorensen PH, Lai R, Xu LY, Li EM.

Carcinogenesis. 2016 Sep;37(9):858-869. doi: 10.1093/carcin/bgw079. Epub 2016 Aug 4.

20.

ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors.

Alassiri AH, Ali RH, Shen Y, Lum A, Strahlendorf C, Deyell R, Rassekh R, Sorensen PH, Laskin J, Marra M, Yip S, Lee CH, Ng TL.

Am J Surg Pathol. 2016 Aug;40(8):1051-61. doi: 10.1097/PAS.0000000000000677.

PMID:
27259007
21.

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.

Cell Rep. 2016 May 17;15(7):1481-1492. doi: 10.1016/j.celrep.2016.04.032. Epub 2016 May 5. Erratum in: Cell Rep. 2016 Sep 20;16(12 ):3414.

22.

Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.

Hingorani P, Janeway K, Crompton BD, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, Mody R, DuBois SG, Parsons DW, Khanna C, Lau C, Hawkins DS, Randall RL, Smith M, Sorensen PH, Plon SE, Skapek SX, Lessnick S, Gorlick R, Reed DR.

Cancer Genet. 2016 May;209(5):182-94. doi: 10.1016/j.cancergen.2016.03.004. Epub 2016 Apr 5. Review.

23.

Erratum: Unsafe abortion in rural Tanzania - the use of traditional medicine from a patient and a provider perspective.

Rasch V, Sørensen PH, Wang AR, Tibazarwa F, Jäger AK.

BMC Pregnancy Childbirth. 2015 Dec 29;15:355. doi: 10.1186/s12884-015-0794-7. No abstract available.

24.

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.

Salanti A, Clausen TM, Agerbæk MØ, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M.

Cancer Cell. 2015 Oct 12;28(4):500-514. doi: 10.1016/j.ccell.2015.09.003.

25.

Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?

Lawlor ER, Sorensen PH.

Crit Rev Oncog. 2015;20(3-4):155-71. Review.

26.

Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.

Qin H, Cho M, Haso W, Zhang L, Tasian SK, Oo HZ, Negri GL, Lin Y, Zou J, Mallon BS, Maude S, Teachey DT, Barrett DM, Orentas RJ, Daugaard M, Sorensen PH, Grupp SA, Fry TJ.

Blood. 2015 Jul 30;126(5):629-39. doi: 10.1182/blood-2014-11-612903. Epub 2015 Jun 3.

27.

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.

El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH.

Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003.

28.

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected].

Jan A, Karasinska JM, Kang MH, de Haan W, Ruddle P, Kaur A, Connolly C, Leavitt BR, Sorensen PH, Hayden MR.

Neurosci Lett. 2015 Jun 26;598:66-72. doi: 10.1016/j.neulet.2015.05.007. Epub 2015 May 6. Erratum in: Neurosci Lett. 2015 Aug 18;602():172.

PMID:
25957561
29.

Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line.

Moore JB 4th, Loeb DM, Hong KU, Sorensen PH, Triche TJ, Lee DW, Barbato MI, Arceci RJ.

Front Cell Dev Biol. 2015 Mar 9;3:15. doi: 10.3389/fcell.2015.00015. eCollection 2015.

30.

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.

Somasekharan SP, El-Naggar A, Leprivier G, Cheng H, Hajee S, Grunewald TG, Zhang F, Ng T, Delattre O, Evdokimova V, Wang Y, Gleave M, Sorensen PH.

J Cell Biol. 2015 Mar 30;208(7):913-29. doi: 10.1083/jcb.201411047. Epub 2015 Mar 23.

31.

Unsafe abortion in rural Tanzania - the use of traditional medicine from a patient and a provider perspective.

Rasch V, Sørensen PH, Wang AR, Tibazarwa F, Jäger AK.

BMC Pregnancy Childbirth. 2014 Dec 19;14:419. doi: 10.1186/s12884-014-0419-6. Erratum in: BMC Pregnancy Childbirth. 2015;15:355.

32.

Stress-mediated translational control in cancer cells.

Leprivier G, Rotblat B, Khan D, Jan E, Sorensen PH.

Biochim Biophys Acta. 2015 Jul;1849(7):845-60. doi: 10.1016/j.bbagrm.2014.11.002. Epub 2014 Nov 10. Review.

PMID:
25464034
33.

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction.

Cetinbas N, Daugaard M, Mullen AR, Hajee S, Rotblat B, Lopez A, Li A, DeBerardinis RJ, Sorensen PH.

Oncogene. 2015 Jul 23;34(30):4005-10. doi: 10.1038/onc.2014.316. Epub 2014 Oct 6.

34.

How does oncogene transformation render tumor cells hypersensitive to nutrient deprivation?

Leprivier G, Sorensen PH.

Bioessays. 2014 Nov;36(11):1082-90. doi: 10.1002/bies.201400085. Epub 2014 Sep 22.

PMID:
25244326
35.

Toward a drug development path that targets metastatic progression in osteosarcoma.

Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton PJ, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Meltzer P, Kirsch DG, Janeway KA, Weigel B, Randall L, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Smith M, Uren A, Patel SR, Trent J, Savage SA, Mirabello L, Reinke D, Barkaukas DA, Krailo M, Bernstein M.

Clin Cancer Res. 2014 Aug 15;20(16):4200-9. doi: 10.1158/1078-0432.CCR-13-2574. Epub 2014 May 6.

36.

DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development.

Shah ED, Fisch BM, Arceci RJ, Buckley JD, Reaman GH, Sorensen PH, Triche TJ, Reynolds CP.

Cancer Chemother Pharmacol. 2014 May;73(5):1089-93. doi: 10.1007/s00280-014-2433-9. Epub 2014 Mar 25.

PMID:
24663501
37.

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.

Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP.

Nat Commun. 2014 Mar 11;5:3430. doi: 10.1038/ncomms4430.

38.

ChildSeq-RNA: A next-generation sequencing-based diagnostic assay to identify known fusion transcripts in childhood sarcomas.

Qadir MA, Zhan SH, Kwok B, Bruestle J, Drees B, Popescu OE, Sorensen PH.

J Mol Diagn. 2014 May;16(3):361-70. doi: 10.1016/j.jmoldx.2014.01.002. Epub 2014 Feb 8.

PMID:
24517889
39.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10.

40.

Attitudes of parents toward the return of targeted and incidental genomic research findings in children.

Fernandez CV, Bouffet E, Malkin D, Jabado N, O'Connell C, Avard D, Knoppers BM, Ferguson M, Boycott KM, Sorensen PH, Orr AC, Robitaille JM, McMaster CR.

Genet Med. 2014 Aug;16(8):633-40. doi: 10.1038/gim.2013.201. Epub 2014 Jan 16.

PMID:
24434691
41.

Hospitalisation patterns change over time in patients with atrial fibrillation.

Qvist JF, Sørensen PH, Dixen U.

Dan Med J. 2014 Jan;61(1):A4765.

PMID:
24393590
42.

Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation.

Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, Wang J, Li Z, Addya S, Sorensen PH, Lisanti MP, Quong A, Ertel A, Pestell RG.

Cancer Res. 2014 Feb 1;74(3):829-39. doi: 10.1158/0008-5472.CAN-13-2466. Epub 2013 Dec 12.

43.

[Surviving nutrient deprivation by restraining translation elongation: biological function of the eEF2 kinase].

Leprivier G, Rotblat B, Delattre O, Sorensen PH.

Med Sci (Paris). 2013 Nov;29(11):951-3. doi: 10.1051/medsci/20132911007. Epub 2013 Nov 20. French. No abstract available.

44.

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.

Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH.

Nat Commun. 2013;4:2180. doi: 10.1038/ncomms3180.

45.

Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.

Cetinbas N, Huang-Hobbs H, Tognon C, Leprivier G, An J, McKinney S, Bowden M, Chow C, Gleave M, McIntosh LP, Sorensen PH.

J Biol Chem. 2013 Sep 27;288(39):27940-50. doi: 10.1074/jbc.M113.475301. Epub 2013 Jun 24.

46.

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.

Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo AR, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Kwok B, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins VP, Jones RG, Pollak M, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD, Sorensen PH.

Cell. 2013 May 23;153(5):1064-79. doi: 10.1016/j.cell.2013.04.055.

47.

ERBB4 confers metastatic capacity in Ewing sarcoma.

Mendoza-Naranjo A, El-Naggar A, Wai DH, Mistry P, Lazic N, Ayala FR, da Cunha IW, Rodriguez-Viciana P, Cheng H, Tavares Guerreiro Fregnani JH, Reynolds P, Arceci RJ, Nicholson A, Triche TJ, Soares FA, Flanagan AM, Wang YZ, Strauss SJ, Sorensen PH.

EMBO Mol Med. 2013 Jul;5(7):1087-102. doi: 10.1002/emmm.201202343. Epub 2013 May 16.

48.

Attitudes of Canadian researchers toward the return to participants of incidental and targeted genomic findings obtained in a pediatric research setting.

Fernandez CV, Strahlendorf C, Avard D, Knoppers BM, O'Connell C, Bouffet E, Malkin D, Jabado N, Boycott K, Sorensen PH.

Genet Med. 2013 Jul;15(7):558-64. doi: 10.1038/gim.2012.183. Epub 2013 Jan 31.

49.

IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors.

Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M, Sorensen PH, Seth A.

Sci Signal. 2012 Dec 18;5(255):ra92. doi: 10.1126/scisignal.2003184.

PMID:
23250396
50.

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis.

Somasekharan SP, Koc M, Morizot A, Micheau O, Sorensen PH, Gaide O, Andera L, Martinou JC.

Apoptosis. 2013 Mar;18(3):324-36. doi: 10.1007/s10495-012-0782-6.

PMID:
23179179

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