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Items: 45

1.

Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers.

Drilon A, Somwar R, Mangatt BP, Edgren H, Desmeules P, Ruusulehto A, Smith RS, Delasos L, Vojnic M, Plodkowski AJ, Sabari J, Ng K, Montecalvo J, Chang J, Tai H, Lockwood WW, Martinez V, Riely GJ, Rudin CM, Kris MG, Arcila ME, Matheny C, Benayed R, Rekhtman N, Ladanyi M, Ganji G.

Cancer Discov. 2018 Apr 2. doi: 10.1158/2159-8290.CD-17-1004. [Epub ahead of print]

PMID:
29610121
2.

Concurrent alterations in EGFR-mutant lung cancers associated with resistance to EGFR kinase inhibitors and characterization of MTOR as a mediator of resistance.

Yu H, Suzawa K, Jordan EJ, Zehir A, Ni A, Kim HR, Kris MG, Hellmann MD, Li BT, Somwar R, Solit DB, Berger MF, Arcila ME, Riely GJ, Ladanyi M.

Clin Cancer Res. 2018 Mar 12. pii: clincanres.2961.2017. doi: 10.1158/1078-0432.CCR-17-2961. [Epub ahead of print]

PMID:
29530932
3.

RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.

Hayashi T, Desmeules P, Smith RS, Drilon A, Somwar R, Ladanyi M.

Clin Cancer Res. 2018 Mar 15;24(6):1436-1447. doi: 10.1158/1078-0432.CCR-17-2343. Epub 2017 Nov 10.

PMID:
29127119
4.

Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations.

Li GG, Somwar R, Joseph J, Smith RS, Hayashi T, Martin L, Franovic A, Schairer A, Martin E, Riely GJ, Harris J, Yan S, Wei G, Oliver JW, Patel R, Multani P, Ladanyi M, Drilon A.

Clin Cancer Res. 2017 Jun 15;23(12):2981-2990. doi: 10.1158/1078-0432.CCR-16-1887. Epub 2016 Dec 23.

PMID:
28011461
5.

Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial.

Drilon A, Rekhtman N, Arcila M, Wang L, Ni A, Albano M, Van Voorthuysen M, Somwar R, Smith RS, Montecalvo J, Plodkowski A, Ginsberg MS, Riely GJ, Rudin CM, Ladanyi M, Kris MG.

Lancet Oncol. 2016 Dec;17(12):1653-1660. doi: 10.1016/S1470-2045(16)30562-9. Epub 2016 Nov 4.

6.

Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma.

Wang D, Narula N, Azzopardi S, Smith RS, Nasar A, Altorki NK, Mittal V, Somwar R, Stiles BM, Du YN.

Oncotarget. 2016 Jun 28;7(26):39957-39969. doi: 10.18632/oncotarget.9554.

7.

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.

Shukla N, Somwar R, Smith RS, Ambati S, Munoz S, Merchant M, D'Arcy P, Wang X, Kobos R, Antczak C, Bhinder B, Shum D, Radu C, Yang G, Taylor BS, Ng CK, Weigelt B, Khodos I, de Stanchina E, Reis-Filho JS, Ouerfelli O, Linder S, Djaballah H, Ladanyi M.

Cancer Res. 2016 Aug 1;76(15):4525-34. doi: 10.1158/0008-5472.CAN-16-1040. Epub 2016 Jun 2.

8.

Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers.

Drilon A, Bergagnini I, Delasos L, Sabari J, Woo KM, Plodkowski A, Wang L, Hellmann MD, Joubert P, Sima CS, Smith R, Somwar R, Rekhtman N, Ladanyi M, Riely GJ, Kris MG.

Ann Oncol. 2016 Jul;27(7):1286-91. doi: 10.1093/annonc/mdw163. Epub 2016 Apr 7.

9.

A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer.

Drilon A, Somwar R, Wagner JP, Vellore NA, Eide CA, Zabriskie MS, Arcila ME, Hechtman JF, Wang L, Smith RS, Kris MG, Riely GJ, Druker BJ, O'Hare T, Ladanyi M, Davare MA.

Clin Cancer Res. 2016 May 15;22(10):2351-8. doi: 10.1158/1078-0432.CCR-15-2013. Epub 2015 Dec 16.

10.

Spatiotemporal dynamics of triglyceride storage in unilocular adipocytes.

Chu M, Sampath H, Cahana DY, Kahl CA, Somwar R, Cornea A, Roberts CT Jr, Varlamov O.

Mol Biol Cell. 2014 Dec 15;25(25):4096-105. doi: 10.1091/mbc.E14-06-1085. Epub 2014 Oct 8.

11.

Protein interaction discovery using parallel analysis of translated ORFs (PLATO).

Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ.

Nat Biotechnol. 2013 Apr;31(4):331-334. doi: 10.1038/nbt.2539. Epub 2013 Mar 17.

12.

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. doi: 10.1073/pnas.1113554108. Epub 2011 Sep 19.

13.

Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.

Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, Wang L, Amato KR, Arcila M, Sos ML, Socci ND, Viale A, de Stanchina E, Ginsberg MS, Thomas RK, Kris MG, Inoue A, Ladanyi M, Miller VA, Michor F, Pao W.

Sci Transl Med. 2011 Jul 6;3(90):90ra59. doi: 10.1126/scitranslmed.3002356.

14.

Live-cell imaging demonstrates rapid cargo exchange between lipid droplets in adipocytes.

Somwar R, Roberts CT Jr, Varlamov O.

FEBS Lett. 2011 Jun 23;585(12):1946-50. doi: 10.1016/j.febslet.2011.05.016. Epub 2011 May 12.

15.

Dosimetry of 18F-labeled tyrosine kinase inhibitor SKI-249380, a dasatinib-tracer for PET imaging.

Dunphy MP, Zanzonico P, Veach D, Somwar R, Pillarsetty N, Lewis J, Larson S.

Mol Imaging Biol. 2012 Feb;14(1):25-31. doi: 10.1007/s11307-010-0462-2.

16.

Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes.

Varlamov O, Somwar R, Cornea A, Kievit P, Grove KL, Roberts CT Jr.

Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E486-96. doi: 10.1152/ajpendo.00330.2010. Epub 2010 Jun 22.

17.

Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells.

Somwar R, Shum D, Djaballah H, Varmus H.

J Biomol Screen. 2009 Dec;14(10):1176-84. doi: 10.1177/1087057109350919.

18.

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M.

Oncogene. 2009 Aug 6;28(31):2773-83. doi: 10.1038/onc.2009.135. Epub 2009 Jun 15.

19.

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W.

PLoS Med. 2007 Oct 9;4(10):e294.

20.

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.

Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, Chiang A, Yang G, Ouerfelli O, Kris MG, Ladanyi M, Miller VA, Pao W.

Clin Cancer Res. 2006 Nov 1;12(21):6494-501.

21.

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H.

PLoS Med. 2005 Mar;2(3):e73. Epub 2005 Feb 22.

22.

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells.

Ceddia RB, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G.

Diabetologia. 2005 Jan;48(1):132-9. Epub 2004 Dec 24.

PMID:
15619075
23.

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake.

Sweeney G, Garg RR, Ceddia RB, Li D, Ishiki M, Somwar R, Foster LJ, Neilsen PO, Prestwich GD, Rudich A, Klip A.

J Biol Chem. 2004 Jul 30;279(31):32233-42. Epub 2004 May 27.

24.

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.

Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A.

J Biol Chem. 2003 May 16;278(20):17953-62. Epub 2003 Mar 11.

25.

Activation of the glucose transporter GLUT4 by insulin.

Furtado LM, Somwar R, Sweeney G, Niu W, Klip A.

Biochem Cell Biol. 2002;80(5):569-78. Review.

PMID:
12440698
26.

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.

Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, Trevillyan J, Scherer PE, Rondinone CM, Klip A.

J Biol Chem. 2002 Dec 27;277(52):50386-95. Epub 2002 Oct 21.

27.
28.
29.
30.

Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport.

Somwar R, Niu W, Kim DY, Sweeney G, Randhawa VK, Huang C, Ramlal T, Klip A.

J Biol Chem. 2001 Dec 7;276(49):46079-87. Epub 2001 Oct 11.

32.

Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.

Somwar R, Perreault M, Kapur S, Taha C, Sweeney G, Ramlal T, Kim DY, Keen J, Côte CH, Klip A, Marette A.

Diabetes. 2000 Nov;49(11):1794-800.

PMID:
11078445
33.

Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.

Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A.

Diabetologia. 2000 Mar;43(3):294-303.

PMID:
10768090
34.

Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor.

Yusta B, Somwar R, Wang F, Munroe D, Grinstein S, Klip A, Drucker DJ.

J Biol Chem. 1999 Oct 22;274(43):30459-67.

35.

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts.

Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, Klip A.

Mol Cell Biol. 1999 Jun;19(6):4008-18.

36.
37.

Rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic Ca2+ and cPKC.

Khayat ZA, Tsakiridis T, Ueyama A, Somwar R, Ebina Y, Klip A.

Am J Physiol. 1998 Dec;275(6 Pt 1):C1487-97.

PMID:
9843710
38.

Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves phosphatidylinositol 3-kinase and protein kinase C-zeta.

Sweeney G, Somwar R, Ramlal T, Martin-Vasallo P, Klip A.

Diabetologia. 1998 Oct;41(10):1199-204.

PMID:
9794108
39.

Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expression.

Tsakiridis T, Bergman A, Somwar R, Taha C, Aktories K, Cruz TF, Klip A, Downey GP.

J Biol Chem. 1998 Oct 23;273(43):28322-31.

40.

Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms.

Somwar R, Sumitani S, Taha C, Sweeney G, Klip A.

Am J Physiol. 1998 Oct;275(4 Pt 1):E618-25.

PMID:
9755080
42.
43.
44.

Insulin regulation and selective segregation with glucose transporter-4 of the membrane aminopeptidase vp165 in rat skeletal muscle cells.

Sumitani S, Ramlal T, Somwar R, Keller SR, Klip A.

Endocrinology. 1997 Mar;138(3):1029-34.

PMID:
9048605
45.

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