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Items: 39


Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

Yan Z, Kim E, Datta D, Lewis DA, Soderling SH.

J Neurosci. 2016 Nov 9;36(45):11411-11417. Review.


The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.

Spence EF, Kanak DJ, Carlson BR, Soderling SH.

J Neurosci. 2016 Sep 14;36(37):9696-709. doi: 10.1523/JNEUROSCI.0876-16.2016.


Identification of an elaborate complex mediating postsynaptic inhibition.

Uezu A, Kanak DJ, Bradshaw TW, Soderblom EJ, Catavero CM, Burette AC, Weinberg RJ, Soderling SH.

Science. 2016 Sep 9;353(6304):1123-9. doi: 10.1126/science.aag0821.


A GABAergic nigrotectal pathway for coordination of drinking behavior.

Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, Gaidis E, Barter JW, Kim N, Cai MT, Soderling SH, Yin HH.

Nat Neurosci. 2016 May;19(5):742-748. doi: 10.1038/nn.4285. Epub 2016 Apr 4.


Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.

Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Silver DL, Ji RR, Medina AE, Eroglu C.

Cell. 2016 Jan 14;164(1-2):183-196. doi: 10.1016/j.cell.2015.11.034.


Actin Out: Regulation of the Synaptic Cytoskeleton.

Spence EF, Soderling SH.

J Biol Chem. 2015 Nov 27;290(48):28613-22. doi: 10.1074/jbc.R115.655118. Epub 2015 Oct 9. Review.


CNS myelin wrapping is driven by actin disassembly.

Zuchero JB, Fu MM, Sloan SA, Ibrahim A, Olson A, Zaremba A, Dugas JC, Wienbar S, Caprariello AV, Kantor C, Leonoudakis D, Lariosa-Willingham K, Kronenberg G, Gertz K, Soderling SH, Miller RH, Barres BA.

Dev Cell. 2015 Jul 27;34(2):152-67. doi: 10.1016/j.devcel.2015.06.011. Epub 2015 Jul 9. Erratum in: Dev Cell. 2015 Sep 14;34(5):608. Leonoudakus, Dmitri [corrected to Leonoudakis, Dmitri].


Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.

Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH.

Nat Neurosci. 2015 Jun;18(6):883-91. doi: 10.1038/nn.4015. Epub 2015 May 4.


Astrocytes refine cortical connectivity at dendritic spines.

Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Singh Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu C.

Elife. 2014 Dec 17;3. doi: 10.7554/eLife.04047.


Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall.

Kim IH, Wang H, Soderling SH, Yasuda R.

Elife. 2014 Jul 8;3. doi: 10.7554/eLife.02839.


Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.

Hazai D, Szudoczki R, Ding J, Soderling SH, Weinberg RJ, Sótonyi P, Rácz B.

PLoS One. 2013 Sep 25;8(9):e75248. doi: 10.1371/journal.pone.0075248. eCollection 2013.


Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.

Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-9. doi: 10.1073/pnas.1308419110. Epub 2013 Sep 16.


Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.

Kim IH, Racz B, Wang H, Burianek L, Weinberg R, Yasuda R, Wetsel WC, Soderling SH.

J Neurosci. 2013 Apr 3;33(14):6081-92. doi: 10.1523/JNEUROSCI.0035-13.2013.


Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes.

Burianek LE, Soderling SH.

Semin Cell Dev Biol. 2013 Apr;24(4):258-66. doi: 10.1016/j.semcdb.2012.12.005. Epub 2013 Jan 3. Review.


Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells.

Uezu A, Okada H, Murakoshi H, del Vescovo CD, Yasuda R, Diviani D, Soderling SH.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):E2929-38. doi: 10.1073/pnas.1207358109. Epub 2012 Oct 1.


Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.

Kim IH, Carlson BR, Heindel CC, Kim H, Soderling SH.

J Biol Chem. 2012 Nov 9;287(46):39263-74. doi: 10.1074/jbc.M112.398834. Epub 2012 Sep 24.


Peptide array X-linking (PAX): a new peptide-protein identification approach.

Okada H, Uezu A, Soderblom EJ, Moseley MA 3rd, Gertler FB, Soderling SH.

PLoS One. 2012;7(5):e37035. doi: 10.1371/journal.pone.0037035. Epub 2012 May 14.


SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes.

Okada H, Uezu A, Mason FM, Soderblom EJ, Moseley MA 3rd, Soderling SH.

Sci Signal. 2011 Nov 29;4(201):rs13. doi: 10.1126/scisignal.2002189.


WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.

Carlson BR, Lloyd KE, Kruszewski A, Kim IH, Rodriguiz RM, Heindel C, Faytell M, Dudek SM, Wetsel WC, Soderling SH.

J Neurosci. 2011 Feb 16;31(7):2447-60. doi: 10.1523/JNEUROSCI.4433-10.2011.


Bi-modal regulation of a formin by srGAP2.

Mason FM, Heimsath EG, Higgs HN, Soderling SH.

J Biol Chem. 2011 Feb 25;286(8):6577-86. doi: 10.1074/jbc.M110.190397. Epub 2010 Dec 9.


Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders.

Svitkina T, Lin WH, Webb DJ, Yasuda R, Wayman GA, Van Aelst L, Soderling SH.

J Neurosci. 2010 Nov 10;30(45):14937-42. doi: 10.1523/JNEUROSCI.4276-10.2010. Review.


Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.

Kim IH, Park SK, Hong ST, Jo YS, Kim EJ, Park EH, Han SB, Shin HS, Sun W, Kim HT, Soderling SH, Kim H.

J Neurosci. 2009 Nov 4;29(44):14039-49. doi: 10.1523/JNEUROSCI.2483-09.2009.


Mechanisms of cellular protrusions branch out.

Carlson B, Soderling SH.

Dev Cell. 2009 Sep;17(3):307-9. doi: 10.1016/j.devcel.2009.08.015.


Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling.

Soderling SH.

Sci Signal. 2009 Jan 27;2(55):pe5. doi: 10.1126/scisignal.255pe5. Review.


A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.

Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K, Langeberg LK, Banker G, Raber J, Scott JD.

J Neurosci. 2007 Jan 10;27(2):355-65.


WAVE signalling: from biochemistry to biology.

Soderling SH, Scott JD.

Biochem Soc Trans. 2006 Feb;34(Pt 1):73-6. Review.


Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm.

Vasta V, Sonnenburg WK, Yan C, Soderling SH, Shimizu-Albergine M, Beavo JA.

Biol Reprod. 2005 Oct;73(4):598-609. Epub 2005 May 18.


Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.

Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4445-50. Epub 2003 Apr 2.


Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723-8. Epub 2003 Feb 10.


The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.

Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T, Scott JD.

Nat Cell Biol. 2002 Dec;4(12):970-5.


Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.

Rascón A, Soderling SH, Schaefer JB, Beavo JA.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4714-9.


Cloning and characterization of two splice variants of human phosphodiesterase 11A.

Hetman JM, Robas N, Baxendale R, Fidock M, Phillips SC, Soderling SH, Beavo JA.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12891-5.


Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.

Westphal RS, Soderling SH, Alto NM, Langeberg LK, Scott JD.

EMBO J. 2000 Sep 1;19(17):4589-600.


Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.

Soderling SH, Beavo JA.

Curr Opin Cell Biol. 2000 Apr;12(2):174-9. Review.


Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.

Hetman JM, Soderling SH, Glavas NA, Beavo JA.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):472-6.


Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.

Soderling SH, Bayuga SJ, Beavo JA.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7071-6.


Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.

Soderling SH, Bayuga SJ, Beavo JA.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8991-6.


Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.

Soderling SH, Bayuga SJ, Beavo JA.

J Biol Chem. 1998 Jun 19;273(25):15553-8.


Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.

Enslen H, Sun P, Brickey D, Soderling SH, Klamo E, Soderling TR.

J Biol Chem. 1994 Jun 3;269(22):15520-7.

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