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Items: 28

1.

PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.

Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S.

Sci Transl Med. 2018 May 9;10(440). pii: eaao0052. doi: 10.1126/scitranslmed.aao0052.

PMID:
29743346
2.

Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23.

Barkan DT, Cheng XL, Celino H, Tran TT, Bhandari A, Craik CS, Sali A, Smythe ML.

BMC Bioinformatics. 2016 Nov 23;17(1):481.

3.

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.

Ranganath S, Bhandari A, Avitahl-Curtis N, McMahon J, Wachtel D, Zhang J, Leitheiser C, Bernier SG, Liu G, Tran TT, Celino H, Tobin J, Jung J, Zhao H, Glen KE, Graul C, Griffin A, Schairer WC, Higgins C, Reza TL, Mowe E, Rivers S, Scott S, Monreal A, Shea C, Bourne G, Coons C, Smith A, Tang K, Mandyam RA, Masferrer J, Liu D, Patel DV, Fretzen A, Murphy CA, Milne GT, Smythe ML, Carlson KE.

PLoS One. 2015 Nov 10;10(11):e0141330. doi: 10.1371/journal.pone.0141330. eCollection 2015.

4.

Sigma-class glutathione transferases.

Flanagan JU, Smythe ML.

Drug Metab Rev. 2011 May;43(2):194-214. doi: 10.3109/03602532.2011.560157. Epub 2011 Mar 22. Review.

PMID:
21425928
5.

Conformational searching using a population-based incremental learning algorithm.

Long SM, Tran TT, Adams P, Darwen P, Smythe ML.

J Comput Chem. 2011 Jun;32(8):1541-9. doi: 10.1002/jcc.21732. Epub 2011 Feb 1.

PMID:
21284005
6.

Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.

Tran TT, Kulis C, Long SM, Bryant D, Adams P, Smythe ML.

J Comput Aided Mol Des. 2010 Nov;24(11):917-34. doi: 10.1007/s10822-010-9384-y. Epub 2010 Sep 23.

PMID:
20862601
7.

Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases.

Christ AN, Labzin L, Bourne GT, Fukunishi H, Weber JE, Sweet MJ, Smythe ML, Flanagan JU.

J Med Chem. 2010 Aug 12;53(15):5536-48. doi: 10.1021/jm100194a.

PMID:
20684598
8.

Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.

Weber JE, Oakley AJ, Christ AN, Clark AG, Hayes JD, Hall R, Hume DA, Board PG, Smythe ML, Flanagan JU.

Eur J Med Chem. 2010 Feb;45(2):447-54. doi: 10.1016/j.ejmech.2009.10.025. Epub 2009 Oct 23.

PMID:
19939518
9.

Library of biphenyl privileged substructures using a safety-catch linker approach.

Severinsen R, Bourne GT, Tran TT, Ankersen M, Begtrup M, Smythe ML.

J Comb Chem. 2008 Jul-Aug;10(4):557-66. doi: 10.1021/cc800006g. Epub 2008 May 8.

PMID:
18462009
10.

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.

Horton DA, Bourne GT, Coughlan J, Kaiser SM, Jacobs CM, Jones A, Rühmann A, Turner JY, Smythe ML.

Org Biomol Chem. 2008 Apr 21;6(8):1386-95. doi: 10.1039/b800464a. Epub 2008 Feb 28.

PMID:
18385845
11.

A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide libraries.

Darwen PJ, Tran TT, Bourne GT, Nielson JL, Smythe ML.

Comb Chem High Throughput Screen. 2006 Aug;9(7):559-63.

PMID:
16925515
12.

Topological side-chain classification of beta-turns: ideal motifs for peptidomimetic development.

Tran TT, McKie J, Meutermans WD, Bourne GT, Andrews PR, Smythe ML.

J Comput Aided Mol Des. 2005 Aug;19(8):551-66. Epub 2005 Nov 23.

PMID:
16328857
13.

A convenient method for synthesis of cyclic peptide libraries.

Bourne GT, Nielson JL, Coughlan JF, Darwen P, Campitelli MR, Horton DA, Rhümann A, Love SG, Tran TT, Smythe ML.

Methods Mol Biol. 2005;298:151-65.

PMID:
16044546
14.

A versatile synthetic approach to peptidyl privileged structures using a "safety-catch" linker.

Horton DA, Severinsen R, Kofod-Hansen M, Bourne GT, Smythe ML.

J Comb Chem. 2005 May-Jun;7(3):421-35.

PMID:
15877471
15.

A safety catch linker for Fmoc-based assembly of constrained cyclic peptides.

Ravn J, Bourne GT, Smythe ML.

J Pept Sci. 2005 Sep;11(9):572-8.

PMID:
15742335
16.

Intramolecular disulphide bond arrangements in nonhomologous proteins.

Hartig GR, Tran TT, Smythe ML.

Protein Sci. 2005 Feb;14(2):474-82.

17.

Increased site 1 affinity improves biopotency of porcine growth hormone. Evidence against diffusion dependent receptor dimerization.

Wan Y, McDevitt A, Shen B, Smythe ML, Waters MJ.

J Biol Chem. 2004 Oct 22;279(43):44775-84. Epub 2004 Aug 5.

18.
19.

Difficult macrocyclizations: new strategies for synthesizing highly strained cyclic tetrapeptides.

Meutermans WD, Bourne GT, Golding SW, Horton DA, Campitelli MR, Craik D, Scanlon M, Smythe ML.

Org Lett. 2003 Jul 24;5(15):2711-4.

PMID:
12868896
20.

The combinatorial synthesis of bicyclic privileged structures or privileged substructures.

Horton DA, Bourne GT, Smythe ML.

Chem Rev. 2003 Mar;103(3):893-930. Review. No abstract available.

PMID:
12630855
21.

Exploring privileged structures: the combinatorial synthesis of cyclic peptides.

Horton DA, Bourne GT, Smythe ML.

Mol Divers. 2002;5(4):289-304. Review.

PMID:
12549678
22.

Exploring privileged structures: the combinatorial synthesis of cyclic peptides.

Horton DA, Bourne GT, Smythe ML.

J Comput Aided Mol Des. 2002 May-Jun;16(5-6):415-30. Review.

PMID:
12489688
23.

The development and application of a novel safety-catch linker for BOC-based assembly of libraries of cyclic peptides.

Bourne GT, Golding SW, McGeary RP, Meutermans WD, Jones A, Marshall GR, Alewood PF, Smythe ML.

J Org Chem. 2001 Nov 16;66(23):7706-13.

PMID:
11701025
24.

A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1(,).

Bourne GT, Meutermans WD, Alewood PF, McGeary RP, Scanlon M, Watson AA, Smythe ML.

J Org Chem. 1999 Apr 30;64(9):3095-3101.

PMID:
11674407
25.

Proteolysis of human hemoglobin by schistosome cathepsin D.

Brindley PJ, Kalinna BH, Wong JY, Bogitsh BJ, King LT, Smyth DJ, Verity CK, Abbenante G, Brinkworth RI, Fairlie DP, Smythe ML, Milburn PJ, Bielefeldt-Ohmann H, Zheng Y, McManus DP.

Mol Biochem Parasitol. 2001 Jan 15;112(1):103-12.

PMID:
11166391
26.

An activated O --> N acyl transfer auxiliary: efficient amide-backbone substitution of hindered "difficult" peptides.

Miranda LP, Meutermans WD, Smythe ML, Alewood PF.

J Org Chem. 2000 Sep 8;65(18):5460-8.

PMID:
10970282
27.

Proteolytic degradation of host hemoglobin by schistosomes.

Brindley PJ, Kalinna BH, Dalton JP, Day SR, Wong JY, Smythe ML, McManus DP.

Mol Biochem Parasitol. 1997 Oct;89(1):1-9. Review.

PMID:
9297696
28.

Rational design of potent sialidase-based inhibitors of influenza virus replication.

von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, Oliver SW, et al.

Nature. 1993 Jun 3;363(6428):418-23.

PMID:
8502295

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