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First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors.

Hidalgo M, Martinez-Garcia M, Tourneau CL, Massard C, Garralda E, Boni V, Taus A, Albanell J, Sablin MP, Alt M, Bahleda R, Varga A, Boetsch C, Franjkovic I, Heil F, Lahr A, Lechner K, Morel A, Nayak T, Rossomanno S, Smart K, Stubenrauch K, Krieter O.

Clin Cancer Res. 2017 Dec 7. doi: 10.1158/1078-0432.CCR-17-1588. [Epub ahead of print]


The Cys-Arg/N-End Rule Pathway Is a General Sensor of Abiotic Stress in Flowering Plants.

Vicente J, Mendiondo GM, Movahedi M, Peirats-Llobet M, Juan YT, Shen YY, Dambire C, Smart K, Rodriguez PL, Charng YY, Gray JE, Holdsworth MJ.

Curr Biol. 2017 Oct 23;27(20):3183-3190.e4. doi: 10.1016/j.cub.2017.09.006. Epub 2017 Oct 12.


Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction.

Colbeck EJ, Jones E, Hindley JP, Smart K, Schulz R, Browne M, Cutting S, Williams A, Parry L, Godkin A, Ware CF, Ager A, Gallimore A.

Cancer Immunol Res. 2017 Nov;5(11):1005-1015. doi: 10.1158/2326-6066.CIR-17-0131. Epub 2017 Sep 25.


Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial.

Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, Bridgeman H, Adams R, Brewster A, Jones R, Gwynne S, Blount D, Harrop R, Wright M, Hills R, Gallimore A, Godkin A.

JAMA Oncol. 2017 Oct 12;3(10):e172579. doi: 10.1001/jamaoncol.2017.2579. Epub 2017 Oct 12.


Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer.

Scurr M, Pembroke T, Bloom A, Roberts D, Thomson A, Smart K, Bridgeman H, Adams R, Brewster A, Jones R, Gwynne S, Blount D, Harrop R, Hills R, Gallimore A, Godkin A.

Clin Cancer Res. 2017 Nov 15;23(22):6771-6780. doi: 10.1158/1078-0432.CCR-17-0895. Epub 2017 Aug 29.


Perceived bitterness character of beer in relation to hop variety and the impact of hop aroma.

Oladokun O, James S, Cowley T, Dehrmann F, Smart K, Hort J, Cook D.

Food Chem. 2017 Sep 1;230:215-224. doi: 10.1016/j.foodchem.2017.03.031. Epub 2017 Mar 8.


Prevalence of neuropathic pain in knee or hip osteoarthritis: A systematic review and meta-analysis.

French HP, Smart KM, Doyle F.

Semin Arthritis Rheum. 2017 Aug;47(1):1-8. doi: 10.1016/j.semarthrit.2017.02.008. Epub 2017 Feb 20. Review.


Drug updates and approvals: 2016 in review.

Meadowcraft L, Mospan G, Morrisette T, Smart K, Janis M.

Nurse Pract. 2016 Dec 16;41(12):20-27.


Parallel role for the dopamine D1 receptor in gambling and amphetamine reinforcement in healthy volunteers.

Zack MH, Lobo DS, Biback C, Fang T, Smart K, Tatone D, Kalia A, Digiacomo D, Kennedy JL.

J Psychopharmacol. 2017 Jan;31(1):31-42. doi: 10.1177/0269881116665329. Epub 2016 Sep 27.


Nervous System Sensitization as a Predictor of Outcome in the Treatment of Peripheral Musculoskeletal Conditions: A Systematic Review.

O'Leary H, Smart KM, Moloney NA, Doody CM.

Pain Pract. 2017 Feb;17(2):249-266. doi: 10.1111/papr.12484. Epub 2016 Aug 19. Review.


Exercise-induced Hypoalgesia in People With Knee Osteoarthritis With Normal and Abnormal Conditioned Pain Modulation.

Fingleton C, Smart KM, Doody CM.

Clin J Pain. 2017 May;33(5):395-404. doi: 10.1097/AJP.0000000000000418.


Real-time assessment of Streptococcus mutans biofilm metabolism on resin composite.

Esteban Florez FL, Hiers RD, Smart K, Kreth J, Qi F, Merritt J, Khajotia SS.

Dent Mater. 2016 Oct;32(10):1263-9. doi: 10.1016/ Epub 2016 Aug 8.


A potential case of remission of Parkinson's disease.

Smart K, Durso R, Morgan J, McNamara P.

J Complement Integr Med. 2016 Sep 1;13(3):311-315. doi: 10.1515/jcim-2016-0019.


Modulation of retinal image vasculature analysis to extend utility and provide secondary value from optical coherence tomography imaging.

Cameron JR, Ballerini L, Langan C, Warren C, Denholm N, Smart K, MacGillivray TJ.

J Med Imaging (Bellingham). 2016 Apr;3(2):020501. doi: 10.1117/1.JMI.3.2.020501. Epub 2016 May 2.


A Practical and Portable Solids-State Electronic Terahertz Imaging System.

Smart K, Du J, Li L, Wang D, Leslie K, Ji F, Li XD, Zeng da Z.

Sensors (Basel). 2016 Apr 22;16(4). pii: E579. doi: 10.3390/s16040579.


The impact of hop bitter acid and polyphenol profiles on the perceived bitterness of beer.

Oladokun O, Tarrega A, James S, Smart K, Hort J, Cook D.

Food Chem. 2016 Aug 15;205:212-20. doi: 10.1016/j.foodchem.2016.03.023. Epub 2016 Mar 8.


Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.

Smart KM, Wand BM, O'Connell NE.

Cochrane Database Syst Rev. 2016 Feb 24;2:CD010853. doi: 10.1002/14651858.CD010853.pub2. Review.


A Bayesian approach to analyzing phenotype microarray data enables estimation of microbial growth parameters.

Gerstgrasser M, Nicholls S, Stout M, Smart K, Powell C, Kypraios T, Stekel D.

J Bioinform Comput Biol. 2016 Jun;14(3):1650007. doi: 10.1142/S0219720016500074. Epub 2015 Nov 23.


"I'm Coming Home, Tell the World I'm Coming Home". The Long Homecoming and Mental Health Treatment of Iraq and Afghanistan War Veterans.

Rozanova J, Noulas P, Smart K, Roy A, Southwick SM, Davidson L, Harpaz-Rotem I.

Psychiatr Q. 2016 Sep;87(3):427-43. doi: 10.1007/s11126-015-9398-7.


Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

Colbeck EJ, Hindley JP, Smart K, Jones E, Bloom A, Bridgeman H, McPherson RC, Turner DG, Ladell K, Price DA, O'Connor RA, Anderton SM, Godkin AJ, Gallimore AM.

Oncotarget. 2015 Sep 22;6(28):24649-59. doi: 10.18632/oncotarget.5584.


Screening of Non- Saccharomyces cerevisiae Strains for Tolerance to Formic Acid in Bioethanol Fermentation.

Oshoma CE, Greetham D, Louis EJ, Smart KA, Phister TG, Powell C, Du C.

PLoS One. 2015 Aug 18;10(8):e0135626. doi: 10.1371/journal.pone.0135626. eCollection 2015.


The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects.

Miller BE, Mistry S, Smart K, Connolly P, Carpenter DC, Cooray H, Bloomer JC, Tal-Singer R, Lazaar AL.

BMC Pharmacol Toxicol. 2015 Jun 20;16:18. doi: 10.1186/s40360-015-0017-x.


Pain sensitisation and the risk of poor outcome following physiotherapy for patients with moderate to severe knee osteoarthritis: protocol for a prospective cohort study.

O'Leary H, Smart KM, Moloney NA, Blake C, Doody CM.

BMJ Open. 2015 Jun 9;5(6):e007430. doi: 10.1136/bmjopen-2014-007430.


Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis.

Fingleton C, Smart K, Moloney N, Fullen BM, Doody C.

Osteoarthritis Cartilage. 2015 Jul;23(7):1043-56. doi: 10.1016/j.joca.2015.02.163. Epub 2015 Mar 5. Review.


Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6.

Mendiondo GM, Gibbs DJ, Szurman-Zubrzycka M, Korn A, Marquez J, Szarejko I, Maluszynski M, King J, Axcell B, Smart K, Corbineau F, Holdsworth MJ.

Plant Biotechnol J. 2016 Jan;14(1):40-50. doi: 10.1111/pbi.12334. Epub 2015 Feb 6.


A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas.

Ondondo B, Colbeck E, Jones E, Smart K, Lauder SN, Hindley J, Godkin A, Moser B, Ager A, Gallimore A.

Immunology. 2015 May;145(1):94-104. doi: 10.1111/imm.12430. Erratum in: Immunology. 2015 Oct;146(2):347.


The genetic basis of variation in clean lineages of Saccharomyces cerevisiae in response to stresses encountered during bioethanol fermentations.

Greetham D, Wimalasena TT, Leung K, Marvin ME, Chandelia Y, Hart AJ, Phister TG, Tucker GA, Louis EJ, Smart KA.

PLoS One. 2014 Aug 12;9(8):e103233. doi: 10.1371/journal.pone.0103233. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119343.


Phenotypic characterisation of Saccharomyces spp. yeast for tolerance to stresses encountered during fermentation of lignocellulosic residues to produce bioethanol.

Wimalasena TT, Greetham D, Marvin ME, Liti G, Chandelia Y, Hart A, Louis EJ, Phister TG, Tucker GA, Smart KA.

Microb Cell Fact. 2014 Mar 27;13(1):47. doi: 10.1186/1475-2859-13-47.


Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial.

Khalid S, Murdoch R, Newlands A, Smart K, Kelsall A, Holt K, Dockry R, Woodcock A, Smith JA.

J Allergy Clin Immunol. 2014 Jul;134(1):56-62. doi: 10.1016/j.jaci.2014.01.038. Epub 2014 Mar 22.


Development of a phenotypic assay for characterisation of ethanologenic yeast strain sensitivity to inhibitors released from lignocellulosic feedstocks.

Greetham D, Wimalasena T, Kerruish DW, Brindley S, Ibbett RN, Linforth RL, Tucker G, Phister TG, Smart KA.

J Ind Microbiol Biotechnol. 2014 Jun;41(6):931-45. doi: 10.1007/s10295-014-1431-6. Epub 2014 Mar 25.


Global metabolic response of Enterococcus faecalis to oxygen.

Portela CA, Smart KF, Tumanov S, Cook GM, Villas-Bôas SG.

J Bacteriol. 2014 Jun;196(11):2012-22. doi: 10.1128/JB.01354-13. Epub 2014 Mar 21.


Tolerance of pentose utilising yeast to hydrogen peroxide-induced oxidative stress.

Spencer J, Phister TG, Smart KA, Greetham D.

BMC Res Notes. 2014 Mar 17;7:151. doi: 10.1186/1756-0500-7-151.


Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.

Rogers SL, Hughes BA, Jones CA, Freedman L, Smart K, Taylor N, Stewart PM, Shackleton CH, Krone NP, Blissett J, Tomlinson JW.

J Clin Endocrinol Metab. 2014 May;99(5):E821-31. doi: 10.1210/jc.2013-3254. Epub 2014 Feb 11.


The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers.

Miller BE, Smart K, Mistry S, Ambery CL, Bloomer JC, Connolly P, Sanderson D, Shreeves T, Smith R, Lazaar AL.

Eur J Drug Metab Pharmacokinet. 2014 Sep;39(3):173-81. doi: 10.1007/s13318-014-0179-8. Epub 2014 Feb 7.


TRPV1 inhibition does not prevent cold dry air-elicited symptoms in non-allergic rhinitis.

Murdoch RD, Bareille P, Denyer J, Newlands A, Bentley J, Smart K, Yarnall K, Patel D.

Int J Clin Pharmacol Ther. 2014 Apr;52(4):267-76. doi: 10.5414/CP202013.


Escalating regulation of 5T4-specific IFN-γ+ CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy.

Scurr M, Bloom A, Pembroke T, Srinivasan R, Brown C, Smart K, Bridgeman H, Davies M, Hargest R, Phillips S, Christian A, Hockey T, Gallimore A, Godkin A.

Cancer Immunol Res. 2013 Dec;1(6). doi: 10.1158/2326-6066.CIR-13-0035.


Nature of Si-H interactions in a series of ruthenium silazane complexes using multinuclear solid-state NMR and neutron diffraction.

Smart KA, Grellier M, Coppel Y, Vendier L, Mason SA, Capelli SC, Albinati A, Montiel-Palma V, Muñoz-Hernández MA, Sabo-Etienne S.

Inorg Chem. 2014 Jan 21;53(2):1156-65. doi: 10.1021/ic4027199. Epub 2014 Jan 6.


Intraexaminer and interexaminer reliability of manual palpation and pressure algometry of the lower limb nerves in asymptomatic subjects.

Fingleton CP, Dempsey L, Smart K, Doody CM.

J Manipulative Physiol Ther. 2014 Feb;37(2):97-104. doi: 10.1016/j.jmpt.2013.12.006. Epub 2014 Jan 3.


Concurrent quantification of cellular and extracellular components of biofilms.

Khajotia SS, Smart KH, Pilula M, Thompson DM.

J Vis Exp. 2013 Dec 10;(82):e50639. doi: 10.3791/50639.


Orthopaedic triage at a physiotherapist-led 'Musculoskeletal Assessment Clinic': a seven-month service evaluation of outcomes.

O'Farrell S, Smart KM, Caffrey A, Daly O, Doody C.

Ir J Med Sci. 2014 Dec;183(4):565-71. doi: 10.1007/s11845-013-1052-5. Epub 2013 Dec 12.


Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics.

Ondondo B, Jones E, Hindley J, Cutting S, Smart K, Bridgeman H, Matthews KK, Ladell K, Price DA, Jackson DG, Godkin A, Ager A, Gallimore A.

Int J Cancer. 2014 May 1;134(9):2156-67. doi: 10.1002/ijc.28556. Epub 2013 Nov 8.


Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells.

Scurr M, Ladell K, Besneux M, Christian A, Hockey T, Smart K, Bridgeman H, Hargest R, Phillips S, Davies M, Price D, Gallimore A, Godkin A.

Mucosal Immunol. 2014 Mar;7(2):428-39. doi: 10.1038/mi.2013.62. Epub 2013 Sep 25.


Bioengineering silicon quantum dot theranostics using a network analysis of metabolomic and proteomic data in cardiac ischemia.

Erogbogbo F, May J, Swihart M, Prasad PN, Smart K, Jack SE, Korcyk D, Webster M, Stewart R, Zeng I, Jullig M, Bakeev K, Jamieson M, Kasabov N, Gopalan B, Liang L, Hu R, Schliebs S, Villas-Boas S, Gladding P.

Theranostics. 2013 Sep 4;3(9):719-28. doi: 10.7150/thno.5010. eCollection 2013.


Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist.

Holland C, van Drunen C, Denyer J, Smart K, Segboer C, Terreehorst I, Newlands A, Beerahee M, Fokkens W, Tsitoura DC.

Br J Clin Pharmacol. 2014 May;77(5):777-88. doi: 10.1111/bcp.12219.


Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology.

Lauder SN, Jones E, Smart K, Bloom A, Williams AS, Hindley JP, Ondondo B, Taylor PR, Clement M, Fielding C, Godkin AJ, Jones SA, Gallimore AM.

Eur J Immunol. 2013 Oct;43(10):2613-25. doi: 10.1002/eji.201243018. Epub 2013 Aug 12.


The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis.

Bareille P, Murdoch RD, Denyer J, Bentley J, Smart K, Yarnall K, Zieglmayer P, Zieglmayer R, Lemell P, Horak F.

Int J Clin Pharmacol Ther. 2013 Jul;51(7):576-84. doi: 10.5414/CP201890.


Modafinil increases reward salience in a slot machine game in low and high impulsivity pathological gamblers.

Smart K, Desmond RC, Poulos CX, Zack M.

Neuropharmacology. 2013 Oct;73:66-74. doi: 10.1016/j.neuropharm.2013.05.015. Epub 2013 May 24.


Surfactant protein (SP)-A suppresses preterm delivery and inflammation via TLR2.

Agrawal V, Smart K, Jilling T, Hirsch E.

PLoS One. 2013 May 20;8(5):e63990. doi: 10.1371/journal.pone.0063990. Print 2013.


Step-by-step introduction of silazane moieties at ruthenium: different extents of Ru-H-Si bond activation.

Smart KA, Grellier M, Vendier L, Mason SA, Capelli SC, Albinati A, Sabo-Etienne S.

Inorg Chem. 2013 Mar 4;52(5):2654-61. doi: 10.1021/ic302682f. Epub 2013 Feb 19.


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