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Items: 1 to 50 of 76

1.

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells.

Kundu S, Ali MA, Handin N, Padhan N, Larsson J, Karoutsou M, Ban K, Wiśniewski JR, Artursson P, He L, Hellström M, Sjöblom T.

Genome Med. 2018 Jan 4;10(1):2. doi: 10.1186/s13073-017-0511-4.

2.

Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients.

Mezheyeuski A, Bergsland CH, Backman M, Djureinovic D, Sjöblom T, Bruun J, Micke P.

J Pathol. 2018 Apr;244(4):421-431. doi: 10.1002/path.5026. Epub 2018 Feb 5.

PMID:
29282718
3.

Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth.

Pandzic T, Rendo V, Lim J, Larsson C, Larsson J, Stoimenov I, Kundu S, Ali MA, Hellström M, He L, Lindroth AM, Sjöblom T.

Oncotarget. 2017 Oct 9;8(58):98646-98659. doi: 10.18632/oncotarget.21713. eCollection 2017 Nov 17.

4.

A pathology atlas of the human cancer transcriptome.

Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.

Science. 2017 Aug 18;357(6352). pii: eaan2507. doi: 10.1126/science.aan2507.

PMID:
28818916
5.

Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition.

Larsson C, Ali MA, Pandzic T, Lindroth AM, He L, Sjöblom T.

BMC Cancer. 2017 Jul 17;17(1):487. doi: 10.1186/s12885-017-3472-5.

6.

U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, Bill-Axelson A, Birgisson H, Björ O, Edqvist PH, Hansson T, Helleday T, Hellman P, Henriksson K, Hesselager G, Hultdin M, Häggman M, Höglund M, Jonsson H, Larsson C, Lindman H, Ljuslinder I, Mindus S, Nygren P, Pontén F, Riklund K, Rosenquist R, Sandin F, Schwenk JM, Stenling R, Stålberg K, Stålberg P, Sundström C, Thellenberg Karlsson C, Westermark B, Bergh A, Claesson-Welsh L, Palmqvist R, Sjöblom T.

Acta Oncol. 2018 Feb;57(2):187-194. doi: 10.1080/0284186X.2017.1337926. Epub 2017 Jun 20.

PMID:
28631533
7.

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity.

Karlsson H, Fryknäs M, Strese S, Gullbo J, Westman G, Bremberg U, Sjöblom T, Pandzic T, Larsson R, Nygren P.

Oncotarget. 2017 May 2;8(18):30217-30234. doi: 10.18632/oncotarget.16324.

8.

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.

Mathot L, Kundu S, Ljungström V, Svedlund J, Moens L, Adlerteg T, Falk-Sörqvist E, Rendo V, Bellomo C, Mayrhofer M, Cortina C, Sundström M, Micke P, Botling J, Isaksson A, Moustakas A, Batlle E, Birgisson H, Glimelius B, Nilsson M, Sjöblom T.

Cancer Res. 2017 Apr 1;77(7):1730-1740. doi: 10.1158/0008-5472.CAN-16-1921. Epub 2017 Jan 20.

9.

Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy.

Kühnemund M, Wei Q, Darai E, Wang Y, Hernández-Neuta I, Yang Z, Tseng D, Ahlford A, Mathot L, Sjöblom T, Ozcan A, Nilsson M.

Nat Commun. 2017 Jan 17;8:13913. doi: 10.1038/ncomms13913.

10.

Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia.

Pandzic T, Larsson J, He L, Kundu S, Ban K, Akhtar-Ali M, Hellström AR, Schuh A, Clifford R, Blakemore SJ, Strefford JC, Baumann T, Lopez-Guillermo A, Campo E, Ljungström V, Mansouri L, Rosenquist R, Sjöblom T, Hellström M.

Clin Cancer Res. 2016 Dec 15;22(24):6217-6227. Epub 2016 Mar 8.

11.

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.

Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford R, Sutton LA, Blakemore SJ, Stavroyianni N, Agathangelidis A, Rossi D, Höglund M, Kotaskova J, Juliusson G, Belessi C, Chiorazzi N, Panagiotidis P, Langerak AW, Smedby KE, Oscier D, Gaidano G, Schuh A, Davi F, Pott C, Strefford JC, Trentin L, Pospisilova S, Ghia P, Stamatopoulos K, Sjöblom T, Rosenquist R.

Blood. 2016 Feb 25;127(8):1007-16. doi: 10.1182/blood-2015-10-674572. Epub 2015 Dec 16.

12.

Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells.

Akhtar Ali M, Younis S, Wallerman O, Gupta R, Andersson L, Sjöblom T.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7743-8. doi: 10.1073/pnas.1509193112. Epub 2015 Jun 8.

13.

Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers.

Kiflemariam S, Ljungström V, Pontén F, Sjöblom T.

Am J Pathol. 2015 Jun;185(6):1600-9. doi: 10.1016/j.ajpath.2015.02.019. Epub 2015 Apr 10.

PMID:
25864925
14.

Computational and molecular tools for scalable rAAV-mediated genome editing.

Stoimenov I, Ali MA, Pandzic T, Sjöblom T.

Nucleic Acids Res. 2015 Mar 11;43(5):e30. doi: 10.1093/nar/gku1286. Epub 2014 Dec 8.

15.

1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer.

Mayrhofer M, Kultima HG, Birgisson H, Sundström M, Mathot L, Edlund K, Viklund B, Sjöblom T, Botling J, Micke P, Påhlman L, Glimelius B, Isaksson A.

BMC Cancer. 2014 Nov 24;14:872. doi: 10.1186/1471-2407-14-872.

16.

In situ sequencing identifies TMPRSS2-ERG fusion transcripts, somatic point mutations and gene expression levels in prostate cancers.

Kiflemariam S, Mignardi M, Ali MA, Bergh A, Nilsson M, Sjöblom T.

J Pathol. 2014 Oct;234(2):253-61. doi: 10.1002/path.4392. Epub 2014 Aug 4.

PMID:
24931216
17.

Local and systemic protumorigenic effects of cancer-associated fibroblast-derived GDF15.

Bruzzese F, Hägglöf C, Leone A, Sjöberg E, Roca MS, Kiflemariam S, Sjöblom T, Hammarsten P, Egevad L, Bergh A, Ostman A, Budillon A, Augsten M.

Cancer Res. 2014 Jul 1;74(13):3408-17. doi: 10.1158/0008-5472.CAN-13-2259. Epub 2014 Apr 29.

18.

A pragmatic definition of therapeutic synergy suitable for clinically relevant in vitro multicompound analyses.

Kashif M, Andersson C, Åberg M, Nygren P, Sjöblom T, Hammerling U, Larsson R, Gustafsson MG.

Mol Cancer Ther. 2014 Jul;13(7):1964-76. doi: 10.1158/1535-7163.MCT-13-0430. Epub 2014 Apr 22.

19.

In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics.

Grundberg I, Kiflemariam S, Mignardi M, Imgenberg-Kreuz J, Edlund K, Micke P, Sundström M, Sjöblom T, Botling J, Nilsson M.

Oncotarget. 2013 Dec;4(12):2407-18.

20.

Automated serial extraction of DNA and RNA from biobanked tissue specimens.

Mathot L, Wallin M, Sjöblom T.

BMC Biotechnol. 2013 Aug 19;13:66. doi: 10.1186/1472-6750-13-66.

21.

Validation of a yeast functional assay for p53 mutations using clonal sequencing.

Iggo R, Rudewicz J, Monceau E, Sevenet N, Bergh J, Sjoblom T, Bonnefoi H.

J Pathol. 2013 Dec;231(4):441-8. doi: 10.1002/path.4243.

22.

Gene rearrangements in hormone receptor negative breast cancers revealed by mate pair sequencing.

Jiao X, Hooper SD, Djureinovic T, Larsson C, Wärnberg F, Tellgren-Roth C, Botling J, Sjöblom T.

BMC Genomics. 2013 Mar 12;14:165. doi: 10.1186/1471-2164-14-165.

23.

Automated genotyping of biobank samples by multiplex amplification of insertion/deletion polymorphisms.

Mathot L, Falk-Sörqvist E, Moens L, Allen M, Sjöblom T, Nilsson M.

PLoS One. 2012;7(12):e52750. doi: 10.1371/journal.pone.0052750. Epub 2012 Dec 27.

24.

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.

Peña C, Céspedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hägglöf C, Birgisson H, Bojmar L, Jirström K, Sandström P, Olsson E, Veerla S, Gallardo A, Sjöblom T, Chang AC, Reddel RR, Mangues R, Augsten M, Ostman A.

Cancer Res. 2013 Feb 15;73(4):1287-97. doi: 10.1158/0008-5472.CAN-12-1875. Epub 2012 Dec 14.

25.

Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements.

Hooper SD, Jiao X, Sundström E, Rehman FL, Tellgren-Roth C, Sjöblom T, Cavelier L.

BMC Res Notes. 2012 Nov 22;5:648. doi: 10.1186/1756-0500-5-648.

26.

Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes.

Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE, Sjöblom T, Markowitz SD, Powell SM, Vogelstein B, Barber TD.

Mol Cancer Res. 2012 Jun;10(6):739-49. doi: 10.1158/1541-7786.MCR-11-0483. Epub 2012 Apr 19.

27.

Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers.

Kiflemariam S, Andersson S, Asplund A, Pontén F, Sjöblom T.

PLoS One. 2012;7(3):e32927. doi: 10.1371/journal.pone.0032927. Epub 2012 Mar 8.

28.

Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.

Jiao X, Wood LD, Lindman M, Jones S, Buckhaults P, Polyak K, Sukumar S, Carter H, Kim D, Karchin R, Sjöblom T.

Genes Chromosomes Cancer. 2012 May;51(5):480-9. doi: 10.1002/gcc.21935. Epub 2012 Feb 3.

29.

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S.

Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7.

PMID:
22154651
30.

Structural alterations from multiple displacement amplification of a human genome revealed by mate-pair sequencing.

Jiao X, Rosenlund M, Hooper SD, Tellgren-Roth C, He L, Fu Y, Mangion J, Sjöblom T.

PLoS One. 2011;6(7):e22250. doi: 10.1371/journal.pone.0022250. Epub 2011 Jul 22.

31.

Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors.

Cunningham JL, Díaz de Ståhl T, Sjöblom T, Westin G, Dumanski JP, Janson ET.

Genes Chromosomes Cancer. 2011 Feb;50(2):82-94. doi: 10.1002/gcc.20834.

PMID:
21104784
32.

Efficient and scalable serial extraction of DNA and RNA from frozen tissue samples.

Mathot L, Lindman M, Sjöblom T.

Chem Commun (Camb). 2011 Jan 7;47(1):547-9. doi: 10.1039/c0cc02248a. Epub 2010 Nov 23.

PMID:
21103565
33.

Targeted resequencing of candidate genes using selector probes.

Johansson H, Isaksson M, Sörqvist EF, Roos F, Stenberg J, Sjöblom T, Botling J, Micke P, Edlund K, Fredriksson S, Kultima HG, Ericsson O, Nilsson M.

Nucleic Acids Res. 2011 Jan;39(2):e8. doi: 10.1093/nar/gkq1005. Epub 2010 Nov 8.

34.

Molecular pathways in tumor progression: from discovery to functional understanding.

Ali MA, Sjöblom T.

Mol Biosyst. 2009 Sep;5(9):902-8. doi: 10.1039/b903502h. Epub 2009 Jul 14. Review.

PMID:
19668850
35.

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.

Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K, Ostman A.

Am J Pathol. 2009 Jul;175(1):334-41. doi: 10.2353/ajpath.2009.081030. Epub 2009 Jun 4.

36.

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.

Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjöblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16224-9. doi: 10.1073/pnas.0808041105. Epub 2008 Oct 13.

37.
38.

The genomic landscapes of human breast and colorectal cancers.

Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B.

Science. 2007 Nov 16;318(5853):1108-13. Epub 2007 Oct 11.

39.

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.

Gal A, Sjöblom T, Fedorova L, Imreh S, Beug H, Moustakas A.

Oncogene. 2008 Feb 21;27(9):1218-30. Epub 2007 Aug 27.

PMID:
17724470
40.

A multidimensional analysis of genes mutated in breast and colorectal cancers.

Lin J, Gan CM, Zhang X, Jones S, Sjöblom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE.

Genome Res. 2007 Sep;17(9):1304-18. Epub 2007 Aug 10.

41.

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.

Jarvius M, Paulsson J, Weibrecht I, Leuchowius KJ, Andersson AC, Wählby C, Gullberg M, Botling J, Sjöblom T, Markova B, Ostman A, Landegren U, Söderberg O.

Mol Cell Proteomics. 2007 Sep;6(9):1500-9. Epub 2007 Jun 12.

42.

Genome-wide mutational analyses of breast and colorectal cancers.

Lin J, Sjöblom T.

Discov Med. 2007 Feb;7(37):13-9.

43.

Large-scale identification of novel transcripts in the human genome.

Peters BA, St Croix B, Sjöblom T, Cummins JM, Silliman N, Ptak J, Saha S, Kinzler KW, Hatzis C, Velculescu VE.

Genome Res. 2007 Mar;17(3):287-92. Epub 2007 Jan 31.

44.

The consensus coding sequences of human breast and colorectal cancers.

Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.

Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.

45.

The colorectal microRNAome.

Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92. Epub 2006 Feb 27.

46.

An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases.

Persson C, Kappert K, Engström U, Ostman A, Sjöblom T.

Methods. 2005 Jan;35(1):37-43.

PMID:
15588984
47.

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.

Furuhashi M, Sjöblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin CH, Ostman A.

Cancer Res. 2004 Apr 15;64(8):2725-33.

48.

Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.

Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin CH, Ostman A, Ylä-Herttuala S.

Circulation. 2004 Mar 9;109(9):1140-6. Epub 2004 Feb 9.

49.

Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases.

Persson C, Sjöblom T, Groen A, Kappert K, Engström U, Hellman U, Heldin CH, den Hertog J, Ostman A.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1886-91. Epub 2004 Feb 4.

50.

Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice.

Sjöblom T, Yakymovych I, Heldin CH, Ostman A, Souchelnytskyi S.

Eur J Cancer. 2004 Jan;40(2):267-74.

PMID:
14728942

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