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Epigenome-wide SRC-1 mediated gene silencing represses cellular differentiation in advanced breast cancer.

Ward E, Vareslija D, Charmsaz S, Fagan A, Browne AL, Cosgrove NS, Cocchiglia S, Purcell SP, Hudson L, Das S, O'Connor D, O'Halloran PJ, Sims AH, Hill AD, Young LS.

Clin Cancer Res. 2018 Mar 22. pii: clincanres.2615.2017. doi: 10.1158/1078-0432.CCR-17-2615. [Epub ahead of print]


Outcome of bowel function following anterior resection for rectal cancer-an analysis using the low anterior resection syndrome (LARS) score.

Kupsch J, Jackisch T, Matzel KE, Zimmer J, Schreiber A, Sims A, Witzigmann H, Stelzner S.

Int J Colorectal Dis. 2018 Mar 15. doi: 10.1007/s00384-018-3006-x. [Epub ahead of print]


Using a Community Bus Tour to Increase Knowledge of Health Disparities among Pediatric Residents.

Lichtenstein C, de la Torre D, Falusi O, Sims A, Smiley Y, Baiyewu M.

Acad Pediatr. 2018 Mar 9. pii: S1876-2859(18)30124-4. doi: 10.1016/j.acap.2018.03.004. [Epub ahead of print] No abstract available.


Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.


MCL-1 is a prognostic indicator and drug target in breast cancer.

Campbell KJ, Dhayade S, Ferrari N, Sims AH, Johnson E, Mason SM, Dickson A, Ryan KM, Kalna G, Edwards J, Tait SWG, Blyth K.

Cell Death Dis. 2018 Jan 16;9(2):19. doi: 10.1038/s41419-017-0035-2.


MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape.

Menachery VD, Schäfer A, Burnum-Johnson KE, Mitchell HD, Eisfeld AJ, Walters KB, Nicora CD, Purvine SO, Casey CP, Monroe ME, Weitz KK, Stratton KG, Webb-Robertson BM, Gralinski LE, Metz TO, Smith RD, Waters KM, Sims AC, Kawaoka Y, Baric RS.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1012-E1021. doi: 10.1073/pnas.1706928115. Epub 2018 Jan 16.


Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis.

Sarvi S, Patel H, Li J, Dodd GL, Creedon H, Muir M, Ward J, Dawson JC, Lee M, Culley J, Salter DM, Sims AH, Byron A, Brunton VG.

Cancer Res. 2018 Mar 15;78(6):1484-1496. doi: 10.1158/0008-5472.CAN-17-1518. Epub 2018 Jan 12.


Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

Hollis RL, Meynert AM, Churchman M, Rye T, Mackean M, Nussey F, Arends MJ, Sims AH, Semple CA, Herrington CS, Gourley C.

BMC Cancer. 2018 Jan 3;18(1):16. doi: 10.1186/s12885-017-3981-2.


GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

De Francesco EM, Sims AH, Maggiolini M, Sotgia F, Lisanti MP, Clarke RB.

Breast Cancer Res. 2017 Dec 6;19(1):129. doi: 10.1186/s13058-017-0923-5.


Predicting the risk of cucurbit downy mildew in the eastern United States using an integrated aerobiological model.

Neufeld KN, Keinath AP, Gugino BK, McGrath MT, Sikora EJ, Miller SA, Ivey ML, Langston DB, Dutta B, Keever T, Sims A, Ojiambo PS.

Int J Biometeorol. 2017 Nov 25. doi: 10.1007/s00484-017-1474-2. [Epub ahead of print]


Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS.

mSphere. 2017 Nov 15;2(6). pii: e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec.


Complications following vaginal mesh procedures for stress urinary incontinence: an 8 year study of 92,246 women.

Keltie K, Elneil S, Monga A, Patrick H, Powell J, Campbell B, Sims AJ.

Sci Rep. 2017 Sep 20;7(1):12015. doi: 10.1038/s41598-017-11821-w.


Thompson hemiarthroplasty versus modular unipolar implants for patients requiring hemiarthroplasty of the hip: A systematic review of the evidence.

Sims AL, Farrier AJ, Reed MR, Sheldon TA.

Bone Joint Res. 2017 Aug;6(8):506-513. doi: 10.1302/2046-3758.68.BJR-2016-0256.R1.


Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Canel M, Byron A, Sims AH, Cartier J, Patel H, Frame MC, Brunton VG, Serrels B, Serrels A.

Cancer Res. 2017 Oct 1;77(19):5301-5312. doi: 10.1158/0008-5472.CAN-17-0418. Epub 2017 Aug 14.


Impacts of temperature and selected chemical digestion methods on microplastic particles.

Munno K, Helm PA, Jackson DA, Rochman C, Sims A.

Environ Toxicol Chem. 2018 Jan;37(1):91-98. doi: 10.1002/etc.3935. Epub 2017 Oct 12.


Student Perceptions and Acceptance of Mobile Technology in an Undergraduate Nursing Program.

George TP, DeCristofaro C, Murphy PF, Sims A.

Healthcare (Basel). 2017 Jul 21;5(3). pii: E35. doi: 10.3390/healthcare5030035.


The XprESS Multi-Sinus Dilation System for the Treatment of Chronic Sinusitis: A NICE Medical Technology Guidance.

Jenks M, Willits I, Turner EE, Hewitt N, Arber M, Cole H, Craig J, Sims A.

Appl Health Econ Health Policy. 2017 Oct;15(5):567-582. doi: 10.1007/s40258-017-0337-7. Review.


Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.


Current treatment trends and the need for better predictive tools in the management of ductal carcinoma in situ of the breast.

Martínez-Pérez C, Turnbull AK, Ekatah GE, Arthur LM, Sims AH, Thomas JS, Dixon JM.

Cancer Treat Rev. 2017 Apr;55:163-172. doi: 10.1016/j.ctrv.2017.03.009. Epub 2017 Mar 31. Review.


WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel.

Artibani M, Sims AH, Slight J, Aitken S, Thornburn A, Muir M, Brunton VG, Del-Pozo J, Morrison LR, Katz E, Hastie ND, Hohenstein P.

Sci Rep. 2017 Mar 27;7:45255. doi: 10.1038/srep45255.


Balancing selection maintains polymorphisms at neurogenetic loci in field experiments.

Lonn E, Koskela E, Mappes T, Mokkonen M, Sims AM, Watts PC.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3690-3695. doi: 10.1073/pnas.1621228114. Epub 2017 Mar 21.


Erratum to: Spectra Optia® for Automated Red Blood Cell Exchange in Patients with Sickle Cell Disease: A NICE Medical Technology Guidance.

Willits I, Cole H, Jones R, Carter K, Arber M, Jenks M, Craig J, Sims A.

Appl Health Econ Health Policy. 2017 Aug;15(4):539. doi: 10.1007/s40258-017-0322-1. No abstract available.


Spectra Optia® for Automated Red Blood Cell Exchange in Patients with Sickle Cell Disease: A NICE Medical Technology Guidance.

Willits I, Cole H, Jones R, Carter K, Arber M, Jenks M, Craig J, Sims A.

Appl Health Econ Health Policy. 2017 Aug;15(4):455-468. doi: 10.1007/s40258-016-0302-x. Review. Erratum in: Appl Health Econ Health Policy. 2017 Aug;15(4):539.


MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling.

Burnum-Johnson KE, Kyle JE, Eisfeld AJ, Casey CP, Stratton KG, Gonzalez JF, Habyarimana F, Negretti NM, Sims AC, Chauhan S, Thackray LB, Halfmann PJ, Walters KB, Kim YM, Zink EM, Nicora CD, Weitz KK, Webb-Robertson BM, Nakayasu ES, Ahmer B, Konkel ME, Motin V, Baric RS, Diamond MS, Kawaoka Y, Waters KM, Smith RD, Metz TO.

Analyst. 2017 Jan 26;142(3):442-448. doi: 10.1039/c6an02486f.


Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and Hospital Episode Statistics.

Burn J, Sims AJ, Keltie K, Patrick H, Welham SA, Heaney LG, Niven RM.

J Asthma. 2017 Oct;54(8):872-879. doi: 10.1080/02770903.2016.1263652. Epub 2016 Dec 1.


Facial deformations during nasal continuous positive airway pressure therapy.

Sims A, Simmons A, Hoffman M, Schindhelm K.

J Biomech. 2016 Dec 8;49(16):3848-3854. doi: 10.1016/j.jbiomech.2016.10.027. Epub 2016 Oct 22.


Accuracy of pulse interval timing in ambulatory blood pressure measurement.

Kane SA, Blake JR, McArdle FJ, Langley P, Sims AJ.

Sci Rep. 2016 Nov 23;6:37472. doi: 10.1038/srep37472.


MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses.

Nakayasu ES, Nicora CD, Sims AC, Burnum-Johnson KE, Kim YM, Kyle JE, Matzke MM, Shukla AK, Chu RK, Schepmoes AA, Jacobs JM, Baric RS, Webb-Robertson BJ, Smith RD, Metz TO.

mSystems. 2016 May 10;1(3). pii: e00043-16. eCollection 2016 May-Jun.


"Feature Detection" vs. "Predictive Coding" Models of Plant Behavior.

Calvo P, Baluška F, Sims A.

Front Psychol. 2016 Oct 4;7:1505. eCollection 2016.


Making collaboration work.

Sims A.

Nurs Child Young People. 2016 Oct 7;28(8):16.


Long-term outcome of extralevator abdominoperineal excision (ELAPE) for low rectal cancer.

Stelzner S, Hellmich G, Sims A, Kittner T, Puffer E, Zimmer J, Bleyl D, Witzigmann H.

Int J Colorectal Dis. 2016 Oct;31(10):1729-37. doi: 10.1007/s00384-016-2637-z. Epub 2016 Sep 9.


Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.


Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing.

Selli C, Pearce DA, Sims AH, Tosun M.

Mol Cell Biochem. 2016 Sep;420(1-2):129-40. doi: 10.1007/s11010-016-2776-0. Epub 2016 Jul 22.


Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies.

Pearce DA, Arthur LM, Turnbull AK, Renshaw L, Sabine VS, Thomas JS, Bartlett JM, Dixon JM, Sims AH.

Sci Rep. 2016 Jul 7;6:29434. doi: 10.1038/srep29434.


Intermittent energy restriction induces changes in breast gene expression and systemic metabolism.

Harvie MN, Sims AH, Pegington M, Spence K, Mitchell A, Vaughan AA, Allwood JW, Xu Y, Rattray NJ, Goodacre R, Evans DG, Mitchell E, McMullen D, Clarke RB, Howell A.

Breast Cancer Res. 2016 May 28;18(1):57. doi: 10.1186/s13058-016-0714-4.


Prevalence and management of recurrent respiratory papillomatosis (RRP) in the UK: cross-sectional study.

Donne AJ, Keltie K, Cole H, Sims AJ, Patrick H, Powell S.

Clin Otolaryngol. 2017 Feb;42(1):86-91. doi: 10.1111/coa.12683. Epub 2016 Jun 19.


Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review.

Kane SA, Blake JR, McArdle FJ, Langley P, Sims AJ.

Open Heart. 2016 Apr 12;3(1):e000362. doi: 10.1136/openhrt-2015-000362. eCollection 2016. Erratum in: Open Heart. 2016;3(1):e000362corr1.


Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.

Thornbrough JM, Jha BK, Yount B, Goldstein SA, Li Y, Elliott R, Sims AC, Baric RS, Silverman RH, Weiss SR.

MBio. 2016 Mar 29;7(2):e00258. doi: 10.1128/mBio.00258-16.


SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.


Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.

Creedon H, Gómez-Cuadrado L, Tarnauskaitė Ž, Balla J, Canel M, MacLeod KG, Serrels B, Fraser C, Unciti-Broceta A, Tracey N, Le Bihan T, Klinowska T, Sims AH, Byron A, Brunton VG.

Oncotarget. 2016 Mar 8;7(10):11539-52. doi: 10.18632/oncotarget.7317.


The World Hip Trauma Evaluation Study 3: Hemiarthroplasty Evaluation by Multicentre Investigation - WHITE 3: HEMI - An Abridged Protocol.

Sims AL, Parsons N, Achten J, Griffin XL, Costa ML, Reed MR.

Bone Joint Res. 2016 Jan;5(1):18-25. doi: 10.1302/2046-3758.51.2000473.


Computerized clinical decision support for the early recognition and management of acute kidney injury: a qualitative evaluation of end-user experience.

Kanagasundaram NS, Bevan MT, Sims AJ, Heed A, Price DA, Sheerin NS.

Clin Kidney J. 2016 Feb;9(1):57-62. doi: 10.1093/ckj/sfv130. Epub 2015 Dec 18.


Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors.

Varešlija D, McBryan J, Fagan A, Redmond AM, Hao Y, Sims AH, Turnbull A, Dixon JM, Ó Gaora P, Hudson L, Purcell S, Hill AD, Young LS.

Clin Cancer Res. 2016 Jun 1;22(11):2765-77. doi: 10.1158/1078-0432.CCR-15-1583. Epub 2016 Jan 13.


US radiation oncology practice patterns for posttreatment survivor care.

Koontz BF, Benda R, De Los Santos J, Hoffman KE, Huq MS, Morrell R, Sims A, Stevens S, Yu JB, Chen RC.

Pract Radiat Oncol. 2016 Jan-Feb;6(1):50-6. doi: 10.1016/j.prro.2015.10.002. Epub 2015 Oct 9.


Tegaderm CHG IV Securement Dressing for Central Venous and Arterial Catheter Insertion Sites: A NICE Medical Technology Guidance.

Jenks M, Craig J, Green W, Hewitt N, Arber M, Sims A.

Appl Health Econ Health Policy. 2016 Apr;14(2):135-49. doi: 10.1007/s40258-015-0202-5. Review.


Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.

Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC.

Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001.


Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

Simões BM, O'Brien CS, Eyre R, Silva A, Yu L, Sarmiento-Castro A, Alférez DG, Spence K, Santiago-Gómez A, Chemi F, Acar A, Gandhi A, Howell A, Brennan K, Rydén L, Catalano S, Andó S, Gee J, Ucar A, Sims AH, Marangoni E, Farnie G, Landberg G, Howell SJ, Clarke RB.

Cell Rep. 2015 Sep 29;12(12):1968-77. doi: 10.1016/j.celrep.2015.08.050. Epub 2015 Sep 17.


MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.

Mondal T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James AR, Hoberg E, Moustakas A, Gyllensten U, Jones SJ, Gustafsson CM, Sims AH, Westerlund F, Gorab E, Kanduri C.

Nat Commun. 2015 Jul 24;6:7743. doi: 10.1038/ncomms8743.


ViibraTip for Testing Vibration Perception to Detect Diabetic Peripheral Neuropathy: A NICE Medical Technology Guidance.

Willits I, Cole H, Jones R, Dimmock P, Arber M, Craig J, Sims A.

Appl Health Econ Health Policy. 2015 Aug;13(4):315-24. doi: 10.1007/s40258-015-0181-6. Review.

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