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Items: 1 to 50 of 192

1.

Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics.

van den Eshof BL, Hoogendijk AJ, Simpson PJ, van Alphen FPJ, Zanivan S, Mertens K, Meijer AB, van den Biggelaar M.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1891-1902. doi: 10.1161/ATVBAHA.117.309926. Epub 2017 Aug 17.

PMID:
28818855
2.

[Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER Statement].

Stevens GA, Alkema L, Black RE, Boerma JT, Collins GS, Ezzati M, Grove JT, Hogan DR, Hogan MC, Horton R, Lawn JE, Marušic A, Mathers CD, Murray CJ, Rudan I, Salomon JA, Simpson PJ, Vos T, Welch V; Grupo de trabalho GATHER.

Epidemiol Serv Saude. 2017 Jan-Mar;26(1):215-222. doi: 10.5123/S1679-49742017000100023. Portuguese.

3.

Correction: Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement.

Stevens GA, Alkema L, Black RE, Boerma JT, Collins GS, Ezzati M, Grove JT, Hogan DR, Hogan MC, Horton R, Lawn JE, Marušić A, Mathers CD, Murray CJ, Rudan I, Salomon JA, Simpson PJ, Vos T, Welch V; GATHER Working Group.

PLoS Med. 2016 Aug 9;13(8):e1002116. doi: 10.1371/journal.pmed.1002116. eCollection 2016 Aug.

4.

Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement.

Stevens GA, Alkema L, Black RE, Boerma JT, Collins GS, Ezzati M, Grove JT, Hogan DR, Hogan MC, Horton R, Lawn JE, Marušić A, Mathers CD, Murray CJ, Rudan I, Salomon JA, Simpson PJ, Vos T, Welch V; (The GATHER Working Group).

Lancet. 2016 Dec 10;388(10062):e19-e23. doi: 10.1016/S0140-6736(16)30388-9. Epub 2016 Jun 28. Review.

5.

Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement.

Stevens GA, Alkema L, Black RE, Boerma JT, Collins GS, Ezzati M, Grove JT, Hogan DR, Hogan MC, Horton R, Lawn JE, Marušić A, Mathers CD, Murray CJ, Rudan I, Salomon JA, Simpson PJ, Vos T, Welch V; GATHER Working Group.

PLoS Med. 2016 Jun 28;13(6):e1002056. doi: 10.1371/journal.pmed.1002056. eCollection 2016 Jun. Erratum in: PLoS Med. 2016 Aug;13(8):e1002116.

6.

Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB.

Marcone S, Haughton K, Simpson PJ, Belton O, Fitzgerald DJ.

J Inflamm (Lond). 2015 Jan 20;12(1):1. doi: 10.1186/s12950-014-0044-1. eCollection 2015.

7.

Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.

Darby JF, Krysztofinska EM, Simpson PJ, Simon AC, Leznicki P, Sriskandarajah N, Bishop DS, Hale LR, Alfano C, Conte MR, Martínez-Lumbreras S, Thapaliya A, High S, Isaacson RL.

PLoS One. 2014 Nov 21;9(11):e113281. doi: 10.1371/journal.pone.0113281. eCollection 2014.

8.

Surgical site infections (SSIs) after stoma reversal (SR): risk factors, implications, and protective strategies.

Chu DI, Schlieve CR, Colibaseanu DT, Simpson PJ, Wagie AE, Cima RR, Habermann EB.

J Gastrointest Surg. 2015 Feb;19(2):327-34. doi: 10.1007/s11605-014-2649-3. Epub 2014 Sep 13.

PMID:
25217092
9.

Aging impairs VEGF-mediated, androgen-dependent regulation of angiogenesis.

Lecce L, Lam YT, Lindsay LA, Yuen SC, Simpson PJ, Handelsman DJ, Ng MK.

Mol Endocrinol. 2014 Sep;28(9):1487-501. doi: 10.1210/me.2013-1405. Epub 2014 Jul 24.

10.

Surgical outcomes in adults with benign and malignant sacrococcygeal teratoma: a single-institution experience of 26 cases.

Simpson PJ, Wise KB, Merchea A, Cheville JC, Moir C, Larson DW, Dozois EJ.

Dis Colon Rectum. 2014 Jul;57(7):851-7. doi: 10.1097/DCR.0000000000000117.

PMID:
24901686
11.

The relationship between endothelial progenitor cell populations and epicardial and microvascular coronary disease-a cellular, angiographic and physiologic study.

Chan KH, Simpson PJ, Yong AS, Dunn LL, Chawantanpipat C, Hsu C, Yu Y, Keech AC, Celermajer DS, Ng MK.

PLoS One. 2014 Apr 15;9(4):e93980. doi: 10.1371/journal.pone.0093980. eCollection 2014.

12.

Augmentation of clozapine with amisulpride: an effective therapeutic strategy for violent treatment-resistant schizophrenia patients in a UK high-security hospital.

Hotham JE, Simpson PJ, Brooman-White RS, Basu A, Ross CC, Humphreys SA, Larkin F, Gupta N, Das M.

CNS Spectr. 2014 Oct;19(5):403-10. doi: 10.1017/S1092852913000874. Epub 2013 Nov 28.

PMID:
24284256
13.

A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis.

Dunn LL, Simpson PJ, Prosser HC, Lecce L, Yuen GS, Buckle A, Sieveking DP, Vanags LZ, Lim PR, Chow RW, Lam YT, Clayton Z, Bao S, Davies MJ, Stadler N, Celermajer DS, Stocker R, Bursill CA, Cooke JP, Ng MK.

Diabetes. 2014 Feb;63(2):675-87. doi: 10.2337/db13-0417. Epub 2013 Nov 5.

14.

Heterogenous malignant presacral teratoma with a locally destructive benign intrasacral component.

Simpson PJ, Kehl J, Rose PS, Dozois EJ.

Tech Coloproctol. 2014 Jun;18(6):605-6. doi: 10.1007/s10151-013-1087-7. Epub 2013 Nov 1. No abstract available.

PMID:
24178949
15.

The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase.

Tabib-Salazar A, Liu B, Doughty P, Lewis RA, Ghosh S, Parsy ML, Simpson PJ, O'Dwyer K, Matthews SJ, Paget MS.

Nucleic Acids Res. 2013 Jun;41(11):5679-91. doi: 10.1093/nar/gkt277. Epub 2013 Apr 19.

16.

Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins.

Leen EN, Kwok KY, Birtley JR, Simpson PJ, Subba-Reddy CV, Chaudhry Y, Sosnovtsev SV, Green KY, Prater SN, Tong M, Young JC, Chung LM, Marchant J, Roberts LO, Kao CC, Matthews S, Goodfellow IG, Curry S.

J Virol. 2013 May;87(10):5318-30. doi: 10.1128/JVI.03151-12. Epub 2013 Mar 13.

17.

Effects of continuous positive airway pressure on endothelial function and circulating progenitor cells in obstructive sleep apnoea: a randomised sham-controlled study.

Simpson PJ, Hoyos CM, Celermajer D, Liu PY, Ng MK.

Int J Cardiol. 2013 Oct 3;168(3):2042-8. doi: 10.1016/j.ijcard.2013.01.166. Epub 2013 Feb 27.

PMID:
23453448
18.

Specific DNA recognition mediated by a type IV pilin.

Cehovin A, Simpson PJ, McDowell MA, Brown DR, Noschese R, Pallett M, Brady J, Baldwin GS, Lea SM, Matthews SJ, Pelicic V.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3065-70. doi: 10.1073/pnas.1218832110. Epub 2013 Feb 5.

19.

Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins.

Simon AC, Simpson PJ, Goldstone RM, Krysztofinska EM, Murray JW, High S, Isaacson RL.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1327-32. doi: 10.1073/pnas.1207518110. Epub 2013 Jan 7.

20.

Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia.

Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ, Jin L, Packman LC, Shlien A, Campbell P, Kirwan M, Dokal I, Warren AJ.

Blood. 2013 Feb 7;121(6):1028-38. doi: 10.1182/blood-2012-10-461491. Epub 2012 Nov 27.

21.

1H, 13C and 15N assignments of Sgt2 N-terminal dimerisation domain and its binding partner, Get5 Ubiquitin-like domain.

Simon AC, Simpson PJ, Hawthorne W, Hale LR, Goldstone RM, Isaacson RL.

Biomol NMR Assign. 2013 Oct;7(2):271-4. doi: 10.1007/s12104-012-9425-7. Epub 2012 Sep 22.

PMID:
23001946
22.

Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA.

Douse CH, Green JL, Salgado PS, Simpson PJ, Thomas JC, Langsley G, Holder AA, Tate EW, Cota E.

J Biol Chem. 2012 Oct 26;287(44):36968-77. doi: 10.1074/jbc.M112.379842. Epub 2012 Aug 29.

23.

Changes in protein dynamics of the DNA repair dioxygenase AlkB upon binding of Fe(2+) and 2-oxoglutarate.

Bleijlevens B, Shivarattan T, van den Boom KS, de Haan A, van der Zwan G, Simpson PJ, Matthews SJ.

Biochemistry. 2012 Apr 24;51(16):3334-41. doi: 10.1021/bi201699e. Epub 2012 Apr 9.

PMID:
22443471
24.

Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus.

Garnett JA, Martínez-Santos VI, Saldaña Z, Pape T, Hawthorne W, Chan J, Simpson PJ, Cota E, Puente JL, Girón JA, Matthews S.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3950-5. doi: 10.1073/pnas.1106733109. Epub 2012 Feb 21.

25.

What are the issues in organ donation in 2012?

Simpson PJ.

Br J Anaesth. 2012 Jan;108 Suppl 1:i3-6. doi: 10.1093/bja/aer352. No abstract available.

26.

¹H, ¹³C and ¹⁵N resonance assignments of the kinetochore localisation domain of BUBR1, a central component of the spindle assembly checkpoint.

Simpson PJ, Cota E, Bolanos-Garcia VM.

Biomol NMR Assign. 2012 Apr;6(1):115-8. doi: 10.1007/s12104-011-9355-9. Epub 2011 Dec 27.

PMID:
22201036
27.

Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation.

Garnett JA, Simpson PJ, Taylor J, Benjamin SV, Tagliaferri C, Cota E, Chen YY, Wu H, Matthews S.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):421-6. doi: 10.1016/j.bbrc.2011.11.131. Epub 2011 Dec 7.

28.

Crystallographic analysis of polypyrimidine tract-binding protein-Raver1 interactions involved in regulation of alternative splicing.

Joshi A, Coelho MB, Kotik-Kogan O, Simpson PJ, Matthews SJ, Smith CW, Curry S.

Structure. 2011 Dec 7;19(12):1816-25. doi: 10.1016/j.str.2011.09.020.

29.

Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina.

Simpson PJ, Codd R.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):783-8. doi: 10.1016/j.bbrc.2011.10.003. Epub 2011 Oct 7.

PMID:
22005463
30.

Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.

Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL.

Structure. 2011 Nov 9;19(11):1691-700. doi: 10.1016/j.str.2011.09.017. Epub 2011 Oct 13. Erratum in: Structure. 2011 Dec 7;19(12):1895.

31.

Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans.

Salgado PS, Yan R, Taylor JD, Burchell L, Jones R, Hoyer LL, Matthews SJ, Simpson PJ, Cota E.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15775-9. doi: 10.1073/pnas.1103496108. Epub 2011 Sep 6.

32.

Atomic resolution insights into curli fiber biogenesis.

Taylor JD, Zhou Y, Salgado PS, Patwardhan A, McGuffie M, Pape T, Grabe G, Ashman E, Constable SC, Simpson PJ, Lee WC, Cota E, Chapman MR, Matthews SJ.

Structure. 2011 Sep 7;19(9):1307-16. doi: 10.1016/j.str.2011.05.015.

33.

Epilepsy: increased mortality risk linked with childhood-onset epilepsy.

Simpson PJ.

Nat Rev Neurol. 2011 Mar;7(3):124. No abstract available.

PMID:
21509996
34.

Experimental arthritis: Oral aggrecanase inhibitor may slow postinjury cartilage breakdown.

Simpson PJ.

Nat Rev Rheumatol. 2011 Mar;7(3):131. No abstract available.

PMID:
21491648
35.

Cardiac resuscitation: assisted CPR improves outcomes.

Simpson PJ.

Nat Rev Cardiol. 2011 Mar;8(3):121. doi: 10.1038/nrcardio.2011.13. No abstract available.

PMID:
21475319
36.

Device therapy: LVADs as a bridge to recovery.

Simpson PJ.

Nat Rev Cardiol. 2011 Mar;8(3):120. doi: 10.1038/nrcardio.2011.14. No abstract available.

PMID:
21475317
37.

Enzymatic activities and functional interdependencies of Bacillus subtilis lipoteichoic acid synthesis enzymes.

Wörmann ME, Corrigan RM, Simpson PJ, Matthews SJ, Gründling A.

Mol Microbiol. 2011 Feb;79(3):566-83. doi: 10.1111/j.1365-2958.2010.07472.x. Epub 2010 Dec 7.

38.

Comparison of equipment management and cleaning protocols for rigid sigmoidoscopy.

Simpson PJ, McMurrick PJ, Polglase AL, Koh CE.

ANZ J Surg. 2010 Oct;80(10):728-31. doi: 10.1111/j.1445-2197.2010.05279.x. Epub 2010 Aug 16.

PMID:
21040334
39.

Complete 1H, 13C and 15N NMR assignments for donor-strand complemented AafA, the major pilin of aggregative adherence fimbriae (AAF/II) from enteroaggregative E. coli.

Yang Y, Berry AA, Lee WC, Garnett JA, Marchant J, Levine JA, Simpson PJ, Fogel SA, Varney KM, Matthews SJ, Nataro JP, Inman KG.

Biomol NMR Assign. 2011 Apr;5(1):1-5. doi: 10.1007/s12104-010-9252-7. Epub 2010 Aug 17.

PMID:
20814767
40.

Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting.

Simpson PJ, Schwappach B, Dohlman HG, Isaacson RL.

Structure. 2010 Aug 11;18(8):897-902. doi: 10.1016/j.str.2010.07.003. Review.

41.

Backbone 1H, 15N, 13C and Ile, Leu, Val methyl chemical shift assignments for the 33.5 kDa N-terminal domain of Candida albicans ALS1.

Yan R, Simpson PJ, Matthews SJ, Cota E.

Biomol NMR Assign. 2010 Oct;4(2):187-90. doi: 10.1007/s12104-010-9243-8. Epub 2010 Jun 17.

PMID:
20556550
42.

Resolution of two native monomeric 90kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes.

Simpson PJ, McKinzie AA, Codd R.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):13-8. doi: 10.1016/j.bbrc.2010.06.002. Epub 2010 Jun 12.

PMID:
20547139
43.

The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.

Bergeron JR, Huthoff H, Veselkov DA, Beavil RL, Simpson PJ, Matthews SJ, Malim MH, Sanderson MR.

PLoS Pathog. 2010 Jun 3;6(6):e1000925. doi: 10.1371/journal.ppat.1000925.

44.

The periplasmic nitrate reductase in Shewanella: the resolution, distribution and functional implications of two NAP isoforms, NapEDABC and NapDAGHB.

Simpson PJ, Richardson DJ, Codd R.

Microbiology. 2010 Feb;156(Pt 2):302-12. doi: 10.1099/mic.0.034421-0. Epub 2009 Dec 3. Review.

PMID:
19959582
45.

Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress.

Simpson PJ, Tantitadapitak C, Reed AM, Mather OC, Bunce CM, White SA, Ride JP.

J Mol Biol. 2009 Sep 18;392(2):465-80. doi: 10.1016/j.jmb.2009.07.023. Epub 2009 Jul 15.

PMID:
19616008
46.

Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells.

Zhou W, Tu Y, Simpson PJ, Kuhajda FP.

Oncogene. 2009 Aug 20;28(33):2979-87. doi: 10.1038/onc.2009.160. Epub 2009 Jun 22.

PMID:
19543323
47.

Automated assignment in selectively methyl-labeled proteins.

Xu Y, Liu M, Simpson PJ, Isaacson R, Cota E, Marchant J, Yang D, Zhang X, Freemont P, Matthews S.

J Am Chem Soc. 2009 Jul 15;131(27):9480-1. doi: 10.1021/ja9020233.

48.

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

Davies NJ, Hayden RE, Simpson PJ, Birtwistle J, Mayer K, Ride JP, Bunce CM.

Cancer Res. 2009 Jun 1;69(11):4769-75. doi: 10.1158/0008-5472.CAN-08-4533.

49.

Does the use of nizatidine, as a pro-kinetic agent, improve gastric emptying in patients post-oesophagectomy?

Simpson PJ, Ooi C, Chong J, Smith A, Baldey A, Staples M, Woods S.

J Gastrointest Surg. 2009 Mar;13(3):432-7. doi: 10.1007/s11605-008-0736-z. Epub 2008 Nov 1.

PMID:
18979143
50.

Dynamic states of the DNA repair enzyme AlkB regulate product release.

Bleijlevens B, Shivarattan T, Flashman E, Yang Y, Simpson PJ, Koivisto P, Sedgwick B, Schofield CJ, Matthews SJ.

EMBO Rep. 2008 Sep;9(9):872-7. doi: 10.1038/embor.2008.120. Epub 2008 Jul 11.

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