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Items: 1 to 50 of 187

1.

PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.

Werder RB, Lynch JP, Simpson JC, Zhang V, Hodge NH, Poh M, Forbes-Blom E, Kulis C, Smythe ML, Upham JW, Spann K, Everard ML, Phipps S.

Sci Transl Med. 2018 May 9;10(440). pii: eaao0052. doi: 10.1126/scitranslmed.aao0052.

PMID:
29743346
2.

Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells.

Walsh DP, Murphy RD, Panarella A, Raftery RM, Cavanagh B, Simpson JC, O'Brien FJ, Heise A, Cryan SA.

Mol Pharm. 2018 May 7;15(5):1878-1891. doi: 10.1021/acs.molpharmaceut.8b00044. Epub 2018 Apr 6.

PMID:
29590755
3.
4.

Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.

Byrne DJ, Harmon MJ, Simpson JC, Blackstone C, O'Sullivan NC.

J Genet Genomics. 2017 Oct 20;44(10):493-501. doi: 10.1016/j.jgg.2017.06.003. Epub 2017 Sep 21.

5.

Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans.

Lyden A, Lombardi L, Sire W, Li P, Simpson JC, Butler G, Lee GU.

Nanoscale. 2017 Oct 26;9(41):15911-15922. doi: 10.1039/c7nr04724j.

PMID:
29019498
6.

Functional characterisation of the YIPF protein family in mammalian cells.

Kranjc T, Dempsey E, Cagney G, Nakamura N, Shields DC, Simpson JC.

Histochem Cell Biol. 2017 Apr;147(4):439-451. doi: 10.1007/s00418-016-1527-3. Epub 2016 Dec 20.

PMID:
27999994
7.

Systematic functional analysis of the Ras GTPase family unveils a conserved network required for anterograde protein trafficking.

Caruso ME, Jenna S, Baillie DL, Bossé R, Simpson JC, Chevet E, Taouji S.

Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600302.

8.

Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.

Long M, Simpson JC.

Tissue Cell. 2017 Apr;49(2 Pt A):163-169. doi: 10.1016/j.tice.2016.09.007. Epub 2016 Sep 28. Review.

PMID:
27720426
9.

Genome-Wide siRNA Screening Using Forward Transfection: Identification of Modulators of Membrane Trafficking in Mammalian Cells.

Bexiga MG, Simpson JC.

Methods Mol Biol. 2016;1470:39-48. doi: 10.1007/978-1-4939-6337-9_4.

PMID:
27581283
10.

A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells.

Panarella A, Bexiga MG, Galea G, O' Neill ED, Salvati A, Dawson KA, Simpson JC.

Sci Rep. 2016 Jul 4;6:28865. doi: 10.1038/srep28865.

11.

Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time.

Grossi M, Morgunova M, Cheung S, Scholz D, Conroy E, Terrile M, Panarella A, Simpson JC, Gallagher WM, O'Shea DF.

Nat Commun. 2016 Mar 1;7:10855. doi: 10.1038/ncomms10855.

12.

Implementation of the Rank-Weighted Co-localization (RWC) algorithm in multiple image analysis platforms for quantitative analysis of microscopy images.

Singan VR, Simpson JC.

Source Code Biol Med. 2016 Feb 16;11:2. doi: 10.1186/s13029-016-0048-8. eCollection 2016.

13.

Accurate and semi-automated analysis of bacterial association with mammalian cells.

Murphy CM, Paré S, Galea G, Simpson JC, Smith SG.

J Microbiol Methods. 2016 Mar;122:8-12. doi: 10.1016/j.mimet.2015.12.016. Epub 2016 Jan 6.

PMID:
26769557
14.

High-content analysis of Rab protein function at the ER-Golgi interface.

Galea G, Simpson JC.

Bioarchitecture. 2015;5(3-4):44-53. doi: 10.1080/19490992.2015.1102826. Epub 2015 Dec 22.

15.

A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking.

Galea G, Bexiga MG, Panarella A, O'Neill ED, Simpson JC.

J Cell Sci. 2015 Jul 1;128(13):2339-49. doi: 10.1242/jcs.167973. Epub 2015 May 21.

16.

Enhanced recovery from surgery in the UK: an audit of the enhanced recovery partnership programme 2009-2012.

Simpson JC, Moonesinghe SR, Grocott MP, Kuper M, McMeeking A, Oliver CM, Galsworthy MJ, Mythen MG; National Enhanced Recovery Partnership Advisory Board.

Br J Anaesth. 2015 Oct;115(4):560-8. doi: 10.1093/bja/aev105. Epub 2015 Apr 29.

17.

High-content analysis for drug delivery and nanoparticle applications.

Brayden DJ, Cryan SA, Dawson KA, O'Brien PJ, Simpson JC.

Drug Discov Today. 2015 Aug;20(8):942-57. doi: 10.1016/j.drudis.2015.04.001. Epub 2015 Apr 20. Review.

PMID:
25908578
18.

A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways.

Lecat S, Matthes HW, Pepperkok R, Simpson JC, Galzi JL.

Mol Cell Proteomics. 2015 May;14(5):1385-99. doi: 10.1074/mcp.M114.046698. Epub 2015 Mar 10.

19.

Hydroxyapatite and fluorapatite coatings on dental screws: effects of blast coating process and biological response.

Dunne CF, Twomey B, Kelly C, Simpson JC, Stanton KT.

J Mater Sci Mater Med. 2015 Jan;26(1):5347. doi: 10.1007/s10856-014-5347-5. Epub 2015 Jan 13.

PMID:
25578701
20.

Biocompatibility of ferroelectric lithium niobate and the influence of polarization charge on osteoblast proliferation and function.

Carville NC, Collins L, Manzo M, Gallo K, Lukasz BI, McKayed KK, Simpson JC, Rodriguez BJ.

J Biomed Mater Res A. 2015 Aug;103(8):2540-8. doi: 10.1002/jbm.a.35390. Epub 2014 Dec 25.

PMID:
25504748
21.

Trajectory-based co-localization measures for nanoparticle-cell interaction studies.

Varela JA, Åberg C, Simpson JC, Dawson KA.

Small. 2015 May 6;11(17):2026-31. doi: 10.1002/smll.201401849. Epub 2014 Dec 15.

PMID:
25504742
22.

Development and validation of the Surgical Outcome Risk Tool (SORT).

Protopapa KL, Simpson JC, Smith NC, Moonesinghe SR.

Br J Surg. 2014 Dec;101(13):1774-83. doi: 10.1002/bjs.9638.

23.

The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport.

Heffernan LF, Simpson JC.

Biochem Soc Trans. 2014 Oct;42(5):1453-9. doi: 10.1042/BST20140178. Review.

PMID:
25233431
24.

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

Farrell J, Kelly C, Rauch J, Kida K, García-Muñoz A, Monsefi N, Turriziani B, Doherty C, Mehta JP, Matallanas D, Simpson JC, Kolch W, von Kriegsheim A.

J Proteome Res. 2014 Jun 6;13(6):2874-86. doi: 10.1021/pr5000285. Epub 2014 May 5.

PMID:
24766643
25.

Motorcyclists' perceptions and experiences of riding and risk and their advice for safety.

Simpson JC, Wilson S, Currey N.

Traffic Inj Prev. 2015;16(2):159-67. doi: 10.1080/15389588.2014.911852. Epub 2014 Oct 9.

PMID:
24761932
26.

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.

Higa A, Taouji S, Lhomond S, Jensen D, Fernandez-Zapico ME, Simpson JC, Pasquet JM, Schekman R, Chevet E.

Mol Cell Biol. 2014 May;34(10):1839-49. doi: 10.1128/MCB.01484-13. Epub 2014 Mar 17.

27.

Introduction to the postanaesthetic care unit.

Simpson JC, Moonesinghe SR.

Perioper Med (Lond). 2013 Mar 22;2(1):5. doi: 10.1186/2047-0525-2-5.

28.

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

Sauvageau E, Rochdi MD, Oueslati M, Hamdan FF, Percherancier Y, Simpson JC, Pepperkok R, Bouvier M.

Traffic. 2014 Apr;15(4):383-400. doi: 10.1111/tra.12148. Epub 2014 Feb 6.

29.

RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells.

Bexiga MG, Kelly C, Dawson KA, Simpson JC.

Nanomedicine (Lond). 2014 Aug;9(11):1651-64. doi: 10.2217/nnm.13.151. Epub 2013 Dec 20.

30.

Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation.

Michel G, Matthes HW, Hachet-Haas M, El Baghdadi K, de Mey J, Pepperkok R, Simpson JC, Galzi JL, Lecat S.

J Cell Sci. 2014 Feb 15;127(Pt 4):773-87. doi: 10.1242/jcs.136432. Epub 2013 Dec 11.

31.

High-content screening and analysis of the Golgi complex.

Galea G, Simpson JC.

Methods Cell Biol. 2013;118:281-95. doi: 10.1016/B978-0-12-417164-0.00017-3.

PMID:
24295313
32.

Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles.

Wang F, Bexiga MG, Anguissola S, Boya P, Simpson JC, Salvati A, Dawson KA.

Nanoscale. 2013 Nov 21;5(22):10868-76. doi: 10.1039/c3nr03249c. Epub 2013 Oct 9.

PMID:
24108393
33.

Human diseases associated with form and function of the Golgi complex.

Bexiga MG, Simpson JC.

Int J Mol Sci. 2013 Sep 10;14(9):18670-81. doi: 10.3390/ijms140918670. Review.

34.

Positive persistent visual symptoms (visual snow) presenting as a migraine variant in a 12-year-old girl.

Simpson JC, Goadsby PJ, Prabhakar P.

Pediatr Neurol. 2013 Nov;49(5):361-3. doi: 10.1016/j.pediatrneurol.2013.07.005. Epub 2013 Aug 19.

PMID:
23968568
35.

A real-time impedance based method to assess Rhodococcus equi virulence.

Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Lieggi NT, Luo H, Simpson JC, Meijer WG.

PLoS One. 2013;8(3):e60612. doi: 10.1371/journal.pone.0060612. Epub 2013 Mar 28.

36.

Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.

Stadler C, Rexhepaj E, Singan VR, Murphy RF, Pepperkok R, Uhlén M, Simpson JC, Lundberg E.

Nat Methods. 2013 Apr;10(4):315-23. doi: 10.1038/nmeth.2377. Epub 2013 Feb 24.

PMID:
23435261
37.

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc).

McCarthy JM, Franke M, Resenberger UK, Waldron S, Simpson JC, Tatzelt J, Appelhans D, Rogers MS.

PLoS One. 2013;8(1):e55282. doi: 10.1371/journal.pone.0055282. Epub 2013 Jan 28.

38.

Actin in action: imaging approaches to study cytoskeleton structure and function.

McKayed KK, Simpson JC.

Cells. 2013 Nov 14;2(4):715-31. doi: 10.3390/cells2040715.

39.

Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells.

Singan VR, Handzic K, Simpson JC.

Biochem Soc Trans. 2012 Dec 1;40(6):1389-93. doi: 10.1042/BST20120145. Review.

PMID:
23176486
40.

Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.

Yi P, Higa A, Taouji S, Bexiga MG, Marza E, Arma D, Castain C, Le Bail B, Simpson JC, Rosenbaum J, Balabaud C, Bioulac-Sage P, Blanc JF, Chevet E.

Mol Cancer Ther. 2012 Dec;11(12):2610-20. doi: 10.1158/1535-7163.MCT-12-0516. Epub 2012 Oct 5.

41.

Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells.

Varela JA, Bexiga MG, Åberg C, Simpson JC, Dawson KA.

J Nanobiotechnology. 2012 Sep 24;10:39. doi: 10.1186/1477-3155-10-39.

42.

Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A.

Roth SD, Schüttrumpf J, Milanov P, Abriss D, Ungerer C, Quade-Lyssy P, Simpson JC, Pepperkok R, Seifried E, Tonn T.

PLoS One. 2012;7(9):e44505. doi: 10.1371/journal.pone.0044505. Epub 2012 Sep 4.

43.

A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients.

Singan VR, Handzic K, Curran KM, Simpson JC.

BMC Res Notes. 2012 Jun 8;5:281. doi: 10.1186/1756-0500-5-281.

44.

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.

Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, Hériché JK, Neumann B, Mateos A, Blake J, Bechtel S, Benes V, Wiemann S, Ellenberg J, Pepperkok R.

Nat Cell Biol. 2012 Jun 3;14(7):764-74. doi: 10.1038/ncb2510.

PMID:
22660414
45.

High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells.

Sandin P, Fitzpatrick LW, Simpson JC, Dawson KA.

ACS Nano. 2012 Feb 28;6(2):1513-21. doi: 10.1021/nn204448x. Epub 2012 Feb 1.

PMID:
22276691
46.

Preventing unintentional childhood injury at home: injury circumstances and interventions.

Simpson JC, Nicholls J.

Int J Inj Contr Saf Promot. 2012;19(2):141-51. doi: 10.1080/17457300.2011.635208. Epub 2011 Dec 2.

PMID:
22136531
47.

Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images.

Singan VR, Jones TR, Curran KM, Simpson JC.

BMC Bioinformatics. 2011 Oct 21;12:407. doi: 10.1186/1471-2105-12-407.

48.

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.

Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M.

Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. doi: 10.1074/mcp.M111.009241. Epub 2011 Jul 21.

49.

A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells.

Tängemo C, Ronchi P, Colombelli J, Haselmann U, Simpson JC, Antony C, Stelzer EH, Pepperkok R, Reynaud EG.

J Cell Sci. 2011 Mar 15;124(Pt 6):978-87. doi: 10.1242/jcs.079640.

50.

Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line.

Bexiga MG, Varela JA, Wang F, Fenaroli F, Salvati A, Lynch I, Simpson JC, Dawson KA.

Nanotoxicology. 2011 Dec;5(4):557-67. doi: 10.3109/17435390.2010.539713. Epub 2010 Dec 15.

PMID:
21142842

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