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Items: 1 to 50 of 119

1.

Evaluation of toxicity of glycerol monooleate nanoparticles on PC12 cell line.

Valente F, Bysell H, Simoni E, Boge L, Eriksson M, Martini A, Astolfi L.

Int J Pharm. 2018 Mar 25;539(1-2):23-30. doi: 10.1016/j.ijpharm.2018.01.035. Epub 2018 Jan 31.

PMID:
29366940
2.

Human mesenchymal stromal cell therapy for damaged cochlea repair in nod-scid mice deafened with kanamycin.

Bettini S, Franceschini V, Astolfi L, Simoni E, Mazzanti B, Martini A, Revoltella RP.

Cytotherapy. 2018 Feb;20(2):189-203. doi: 10.1016/j.jcyt.2017.11.003. Epub 2017 Dec 13.

PMID:
29246648
3.

Correction: Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats.

Astolfi L, Simoni E, Valente F, Ghiselli S, Hatzopoulos S, Chicca M, Martini A.

PLoS One. 2017 Sep 21;12(9):e0185525. doi: 10.1371/journal.pone.0185525. eCollection 2017.

4.

Structural Analysis of Uranyl Complexation by the EF-Hand Motif of Calmodulin: Effect of Phosphorylation.

Sauge-Merle S, Brulfert F, Pardoux R, Solari PL, Lemaire D, Safi S, Guilbaud P, Simoni E, Merroun ML, Berthomieu C.

Chemistry. 2017 Nov 2;23(61):15505-15517. doi: 10.1002/chem.201703484. Epub 2017 Oct 10.

PMID:
28869680
5.

Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

Simoni E, Bartolini M, Abu IF, Blockley A, Gotti C, Bottegoni G, Caporaso R, Bergamini C, Andrisano V, Cavalli A, Mellor IR, Minarini A, Rosini M.

Future Med Chem. 2017 Jun;9(10):953-963. doi: 10.4155/fmc-2017-0039. Epub 2017 Jun 20.

PMID:
28632446
6.

Regenerative medicine in hearing recovery.

Simoni E, Orsini G, Chicca M, Bettini S, Franceschini V, Martini A, Astolfi L.

Cytotherapy. 2017 Aug;19(8):909-915. doi: 10.1016/j.jcyt.2017.04.008. Epub 2017 May 19. Review.

PMID:
28532627
7.

Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines.

Maestri V, Tarozzi A, Simoni E, Cilia A, Poggesi E, Naldi M, Nicolini B, Pruccoli L, Rosini M, Minarini A.

Eur J Med Chem. 2017 Aug 18;136:259-269. doi: 10.1016/j.ejmech.2017.05.003. Epub 2017 May 4.

PMID:
28499171
8.

Enzymatic activity of the CaM-PDE1 system upon addition of actinyl ions.

Brulfert F, Safi S, Jeanson A, Foerstendorf H, Weiss S, Berthomieu C, Sauge-Merle S, Simoni É.

J Inorg Biochem. 2017 Jul;172:46-54. doi: 10.1016/j.jinorgbio.2017.04.007. Epub 2017 Apr 8.

PMID:
28427004
9.

Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach.

Simoni E, Serafini MM, Caporaso R, Marchetti C, Racchi M, Minarini A, Bartolini M, Lanni C, Rosini M.

ACS Chem Neurosci. 2017 Jul 19;8(7):1618-1627. doi: 10.1021/acschemneuro.7b00100. Epub 2017 Apr 25.

PMID:
28421738
10.

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease.

Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M.

ACS Med Chem Lett. 2016 Sep 26;7(12):1145-1150. eCollection 2016 Dec 8.

11.

Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats.

Astolfi L, Simoni E, Valente F, Ghiselli S, Hatzopoulos S, Chicca M, Martini A.

PLoS One. 2016 Sep 15;11(9):e0162106. doi: 10.1371/journal.pone.0162106. eCollection 2016. Erratum in: PLoS One. 2017 Sep 21;12 (9):e0185525.

12.

In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer's Disease.

Reggiani AM, Simoni E, Caporaso R, Meunier J, Keller E, Maurice T, Minarini A, Rosini M, Cavalli A.

Sci Rep. 2016 Sep 9;6:33172. doi: 10.1038/srep33172.

13.

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

Tarozzi A, Marchetti C, Nicolini B, D'Amico M, Ticchi N, Pruccoli L, Tumiatti V, Simoni E, Lodola A, Mor M, Milelli A, Minarini A.

Eur J Med Chem. 2016 Jul 19;117:283-91. doi: 10.1016/j.ejmech.2016.04.002. Epub 2016 Apr 4.

PMID:
27135370
14.

Cochlear implant and inflammation reaction: Safety study of a new steroid-eluting electrode.

Astolfi L, Simoni E, Giarbini N, Giordano P, Pannella M, Hatzopoulos S, Martini A.

Hear Res. 2016 Jun;336:44-52. doi: 10.1016/j.heares.2016.04.005. Epub 2016 Apr 21.

PMID:
27109196
15.

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.

Rosini M, Simoni E, Caporaso R, Minarini A.

Future Med Chem. 2016 Apr;8(6):697-711. doi: 10.4155/fmc-2016-0003. Epub 2016 Apr 15. Review.

PMID:
27079260
16.

Electrical stimulation of the frontal cortex enhances slow-frequency EEG activity and sleepiness.

D'Atri A, De Simoni E, Gorgoni M, Ferrara M, Ferlazzo F, Rossini PM, De Gennaro L.

Neuroscience. 2016 Jun 2;324:119-30. doi: 10.1016/j.neuroscience.2016.03.007. Epub 2016 Mar 8.

PMID:
26964682
17.

Structural Environment and Stability of the Complexes Formed Between Calmodulin and Actinyl Ions.

Brulfert F, Safi S, Jeanson A, Martinez-Baez E, Roques J, Berthomieu C, Solari PL, Sauge-Merle S, Simoni É.

Inorg Chem. 2016 Mar 21;55(6):2728-36. doi: 10.1021/acs.inorgchem.5b02440. Epub 2016 Mar 8.

PMID:
26954703
18.

Frequency-dependent effects of oscillatory-tDCS on EEG oscillations: a study with Better OSCillation detection method (BOSC).

D'Atri A, De Simoni E, Gorgoni M, Ferrara M, Ferlazzo F, Rossini PM, De Gennaro L.

Arch Ital Biol. 2015 Jun-Sep;153(2-3):124-34. doi: 10.12871/000398292015237.

PMID:
26742666
19.

Thermodynamic and Structural Investigation of Synthetic Actinide-Peptide Scaffolds.

Safi S, Jeanson A, Roques J, Solari PL, Charnay-Pouget F, Den Auwer C, Creff G, Aitken DJ, Simoni E.

Inorg Chem. 2016 Jan 19;55(2):877-86. doi: 10.1021/acs.inorgchem.5b02379. Epub 2016 Jan 4.

PMID:
26727631
20.

Actinide(IV) Deposits on Bone: Potential Role of the Osteopontin-Thorium Complex.

Creff G, Safi S, Roques J, Michel H, Jeanson A, Solari PL, Basset C, Simoni E, Vidaud C, Den Auwer C.

Inorg Chem. 2016 Jan 4;55(1):29-36. doi: 10.1021/acs.inorgchem.5b02349. Epub 2015 Dec 18.

PMID:
26684435
21.

Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease.

Simoni E, Serafini MM, Bartolini M, Caporaso R, Pinto A, Necchi D, Fiori J, Andrisano V, Minarini A, Lanni C, Rosini M.

ChemMedChem. 2016 Jun 20;11(12):1309-17. doi: 10.1002/cmdc.201500422. Epub 2015 Oct 26.

PMID:
26497622
22.

An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.

Palermo G, Minniti E, Greco ML, Riccardi L, Simoni E, Convertino M, Marchetti C, Rosini M, Sissi C, Minarini A, De Vivo M.

Chem Commun (Camb). 2015 Oct 1;51(76):14310-3. doi: 10.1039/c5cc05065k. Epub 2015 Aug 3.

PMID:
26234198
23.

Rheolytic Pharmacomechanical Thrombectomy for the Management of Acute Limb Ischemia: Results From the PEARL Registry.

Leung DA, Blitz LR, Nelson T, Amin A, Soukas PA, Nanjundappa A, Garcia MJ, Lookstein R, Simoni EJ.

J Endovasc Ther. 2015 Aug;22(4):546-57. doi: 10.1177/1526602815592849. Epub 2015 Jun 24.

PMID:
26109628
24.

Sensorineural hearing loss and ischemic injury: Development of animal models to assess vascular and oxidative effects.

Olivetto E, Simoni E, Guaran V, Astolfi L, Martini A.

Hear Res. 2015 Sep;327:58-68. doi: 10.1016/j.heares.2015.05.004. Epub 2015 May 15.

PMID:
25987500
25.

Endovascular Management of Deep Vein Thrombosis with Rheolytic Thrombectomy: Final Report of the Prospective Multicenter PEARL (Peripheral Use of AngioJet Rheolytic Thrombectomy with a Variety of Catheter Lengths) Registry.

Garcia MJ, Lookstein R, Malhotra R, Amin A, Blitz LR, Leung DA, Simoni EJ, Soukas PA.

J Vasc Interv Radiol. 2015 Jun;26(6):777-85; quiz 786. doi: 10.1016/j.jvir.2015.01.036. Epub 2015 Mar 29.

PMID:
25824314
26.

Microbeam x-ray absorption spectroscopy study of chromium in large-grain uranium dioxide fuel.

Mieszczynski C, Kuri G, Bertsch J, Martin M, Borca CN, Delafoy Ch, Simoni E.

J Phys Condens Matter. 2014 Sep 3;26(35):355009. doi: 10.1088/0953-8984/26/35/355009. Epub 2014 Aug 11.

PMID:
25109302
27.

A soft-surgery approach to minimize hearing damage caused by the insertion of a cochlear implant electrode: a guinea pig animal model.

Giordano P, Hatzopoulos S, Giarbini N, Prosser S, Petruccelli J, Simoni E, Faccioli C, Astolfi L, Martini A.

Otol Neurotol. 2014 Sep;35(8):1440-5. doi: 10.1097/MAO.0000000000000440.

PMID:
24853240
28.

Correlation of articular involvement, skin disfigurement and unemployment with depressive symptoms in patients with systemic sclerosis: a hospital sample.

Tedeschini E, Pingani L, Simoni E, Ferrari D, Giubbarelli C, Giuggioli D, Lumetti F, Rigatelli M, Ferri C, Ferrari S.

Int J Rheum Dis. 2014 Feb;17(2):186-94. doi: 10.1111/1756-185X.12100. Epub 2013 May 29.

PMID:
24576274
29.

Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces.

Rosini M, Simoni E, Minarini A, Melchiorre C.

Neurochem Res. 2014 Oct;39(10):1914-23. doi: 10.1007/s11064-014-1250-1. Epub 2014 Feb 4. Review.

PMID:
24493627
30.

Deep Vein Thrombosis: Final Report of the Prospective Multicenter Pearl Registry on Endovascular Treatment.

Amin A, Blitz L, Garcia M, Lookstein R, Simoni E, Soukas P.

J Vasc Surg Venous Lymphat Disord. 2014 Jan;2(1):108. doi: 10.1016/j.jvsv.2013.10.015. Epub 2013 Dec 12. No abstract available.

PMID:
26992993
31.

Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.

Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6254-8. doi: 10.1016/j.bmcl.2013.09.091. Epub 2013 Oct 5.

PMID:
24140444
32.

Oxidative stress in Alzheimer's disease: are we connecting the dots?

Rosini M, Simoni E, Milelli A, Minarini A, Melchiorre C.

J Med Chem. 2014 Apr 10;57(7):2821-31. doi: 10.1021/jm400970m. Epub 2013 Nov 5.

PMID:
24131448
33.

Exploring the effects of isothiocyanates on chemotherapeutic drugs.

Minarini A, Milelli A, Fimognari C, Simoni E, Turrini E, Tumiatti V.

Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):25-38. doi: 10.1517/17425255.2013.843668. Epub 2013 Oct 3. Review.

PMID:
24087843
34.

Cochlear implants and drug delivery: In vitro evaluation of dexamethasone release.

Astolfi L, Guaran V, Marchetti N, Olivetto E, Simoni E, Cavazzini A, Jolly C, Martini A.

J Biomed Mater Res B Appl Biomater. 2014 Feb;102(2):267-73. doi: 10.1002/jbm.b.33004. Epub 2013 Aug 30.

PMID:
23997036
35.

Association between idiopathic hearing loss and mitochondrial DNA mutations: a study on 169 hearing-impaired subjects.

Guaran V, Astolfi L, Castiglione A, Simoni E, Olivetto E, Galasso M, Trevisi P, Busi M, Volinia S, Martini A.

Int J Mol Med. 2013 Oct;32(4):785-94. doi: 10.3892/ijmm.2013.1470. Epub 2013 Aug 16.

36.

Multifunctional tacrine derivatives in Alzheimer's disease.

Minarini A, Milelli A, Simoni E, Rosini M, Bolognesi ML, Marchetti C, Tumiatti V.

Curr Top Med Chem. 2013;13(15):1771-86. Review.

PMID:
23931443
37.

The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.

Rosini M, Simoni E, Bartolini M, Soriano E, Marco-Contelles J, Andrisano V, Monti B, Windisch M, Hutter-Paier B, McClymont DW, Mellor IR, Bolognesi ML.

ChemMedChem. 2013 Aug;8(8):1276-81. doi: 10.1002/cmdc.201300263. Epub 2013 Jul 3. No abstract available.

PMID:
23824986
38.

Osteopontin: a uranium phosphorylated binding-site characterization.

Safi S, Creff G, Jeanson A, Qi L, Basset C, Roques J, Solari PL, Simoni E, Vidaud C, Den Auwer C.

Chemistry. 2013 Aug 19;19(34):11261-9. doi: 10.1002/chem.201300989. Epub 2013 Jul 3.

PMID:
23824755
39.

Vertigo "in the pink": The impact of female gender on psychiatric-psychosomatic comorbidity in benign paroxysmal positional vertigo patients.

Ferrari S, Monzani D, Baraldi S, Simoni E, Prati G, Forghieri M, Rigatelli M, Genovese E, Pingani L.

Psychosomatics. 2014 May-Jun;55(3):280-8. doi: 10.1016/j.psym.2013.02.005. Epub 2013 Jun 4.

PMID:
23756120
40.

Correlation of adverse effects of cisplatin administration in patients affected by solid tumours: a retrospective evaluation.

Astolfi L, Ghiselli S, Guaran V, Chicca M, Simoni E, Olivetto E, Lelli G, Martini A.

Oncol Rep. 2013 Apr;29(4):1285-92. doi: 10.3892/or.2013.2279. Epub 2013 Feb 6.

41.

Uranyl ion interaction at the water/NiO(100) interface: a predictive investigation by first-principles molecular dynamic simulations.

Sebbari K, Roques J, Domain C, Simoni E.

J Chem Phys. 2012 Oct 28;137(16):164701. doi: 10.1063/1.4759506.

PMID:
23126731
42.

Car-Parrinello molecular dynamics study of the uranyl behaviour at the gibbsite/water interface.

Lectez S, Roques J, Salanne M, Simoni E.

J Chem Phys. 2012 Oct 21;137(15):154705. doi: 10.1063/1.4758935.

PMID:
23083182
43.

Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.

Simoni E, Daniele S, Bottegoni G, Pizzirani D, Trincavelli ML, Goldoni L, Tarozzo G, Reggiani A, Martini C, Piomelli D, Melchiorre C, Rosini M, Cavalli A.

J Med Chem. 2012 Nov 26;55(22):9708-21. doi: 10.1021/jm3009458. Epub 2012 Oct 17.

44.

Outcomes of AngioJet® thrombectomy in hemodialysis vascular access grafts and fistulas: PEARL I Registry.

Simoni E, Blitz L, Lookstein R.

J Vasc Access. 2013 Jan-Mar;14(1):72-6. doi: 10.5301/jva.5000102. Epub 2012 Aug 3.

PMID:
22865534
45.

A new oral otoprotective agent. Part 1: Electrophysiology data from protection against noise-induced hearing loss.

Cascella V, Giordano P, Hatzopoulos S, Petruccelli J, Prosser S, Simoni E, Astolfi L, Fetoni AR, Skarżyński H, Martini A.

Med Sci Monit. 2012 Jan;18(1):BR1-8.

46.

Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.

Bolognesi ML, Simoni E, Rosini M, Minarini A, Tumiatti V, Melchiorre C.

Curr Top Med Chem. 2011 Nov;11(22):2797-806. Review.

PMID:
22039879
47.

Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.

Minarini A, Milelli A, Tumiatti V, Rosini M, Simoni E, Bolognesi ML, Andrisano V, Bartolini M, Motori E, Angeloni C, Hrelia S.

Neuropharmacology. 2012 Feb;62(2):997-1003. doi: 10.1016/j.neuropharm.2011.10.007. Epub 2011 Oct 21.

PMID:
22032870
48.

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.

Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C.

Eur J Med Chem. 2011 Nov;46(11):5435-42. doi: 10.1016/j.ejmech.2011.09.001. Epub 2011 Sep 8.

PMID:
21924801
49.

Ions in solutions: Determining their polarizabilities from first-principles.

Molina JJ, Lectez S, Tazi S, Salanne M, Dufrêche JF, Roques J, Simoni E, Madden PA, Turq P.

J Chem Phys. 2011 Jan 7;134(1):014511. doi: 10.1063/1.3518101.

PMID:
21219011
50.

Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents.

Simoni E, Bergamini C, Fato R, Tarozzi A, Bains S, Motterlini R, Cavalli A, Bolognesi ML, Minarini A, Hrelia P, Lenaz G, Rosini M, Melchiorre C.

J Med Chem. 2010 Oct 14;53(19):7264-8. doi: 10.1021/jm100637k.

PMID:
20831222

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