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Items: 21


Human mesenchymal stem cells preferentially migrate toward highly oncogenic human hepatocellular carcinoma cells with activated EpCAM signaling.

Endaya B, Guan SP, Newman JP, Huynh H, Sia KC, Chong ST, Kok CYL, Chung AYF, Liu BB, Hui KM, Lam PYP.

Oncotarget. 2017 May 5;8(33):54629-54639. doi: 10.18632/oncotarget.17633. eCollection 2017 Aug 15.


AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells.

Chen HM, Yang CM, Chang JF, Wu CS, Sia KC, Lin WN.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L255-69. doi: 10.1152/ajplung.00218.2015. Epub 2016 Jun 10.


Xenograft-directed personalized therapy for a patient with post-transplant relapse of ALL.

Trahair TN, Lock RB, Sutton R, Sia KC, Evans K, Richmond J, Law T, Venn NC, Irving JA, Moore S, Nievergall E, Dang P, Heatley SL, White DL, Revesz T.

Bone Marrow Transplant. 2016 Sep;51(9):1279-82. doi: 10.1038/bmt.2016.122. Epub 2016 May 16. No abstract available.


Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia.

Dolai S, Sia KC, Robbins AK, Zhong L, Heatley SL, Vincent TL, Hochgräfe F, Sutton R, Kurmasheva RT, Revesz T, White DL, Houghton PJ, Smith MA, Teachey DT, Daly RJ, Raftery MJ, Lock RB.

Cancer Res. 2016 Mar 9. pii: canres.2786.2015. [Epub ahead of print]


Correction of Murine Diabetic Hyperglycaemia With A Single Systemic Administration of An AAV2/8 Vector Containing A Novel Codon Optimized Human Insulin Gene.

Gan SU, Notaridou M, Fu ZY, Lee KO, Sia KC, Nathwani AC, Della Peruta M, Calne RY.

Curr Gene Ther. 2016;16(1):65-72.


Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.

Yulyana Y, Tovmasyan A, Ho IA, Sia KC, Newman JP, Ng WH, Guo CM, Hui KM, Batinic-Haberle I, Lam PY.

Stem Cell Rev. 2016 Feb;12(1):140-55. doi: 10.1007/s12015-015-9628-2.


Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status.

Chong DQ, Toh XY, Ho IA, Sia KC, Newman JP, Yulyana Y, Ng WH, Lai SH, Ho MM, Dinesh N, Tham CK, Lam PY.

BMC Cancer. 2015 Apr 11;15:255. doi: 10.1186/s12885-015-1191-3.


Transient knockdown-mediated deficiency in plectin alters hepatocellular motility in association with activated FAK and Rac1-GTPase.

Cheng CC, Lai YC, Lai YS, Hsu YH, Chao WT, Sia KC, Tseng YH, Liu YH.

Cancer Cell Int. 2015 Mar 7;15:29. doi: 10.1186/s12935-015-0177-1. eCollection 2015.


Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling.

Yulyana Y, Ho IA, Sia KC, Newman JP, Toh XY, Endaya BB, Chan JK, Gnecchi M, Huynh H, Chung AY, Lim KH, Leong HS, Iyer NG, Hui KM, Lam PY.

Mol Ther. 2015 Apr;23(4):746-56. doi: 10.1038/mt.2015.13. Epub 2015 Jan 26.


Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia.

Suryani S, Bracken LS, Harvey RC, Sia KC, Carol H, Chen IM, Evans K, Dietrich PA, Roberts KG, Kurmasheva RT, Billups CA, Mullighan CG, Willman CL, Loh ML, Hunger SP, Houghton PJ, Smith MA, Lock RB.

Mol Cancer Ther. 2015 Feb;14(2):364-74. doi: 10.1158/1535-7163.MCT-14-0647. Epub 2014 Dec 10.


Matrix metalloproteinase-1-mediated mesenchymal stem cell tumor tropism is dependent on crosstalk with stromal derived growth factor 1/C-X-C chemokine receptor 4 axis.

Ho IA, Yulyana Y, Sia KC, Newman JP, Guo CM, Hui KM, Lam PY.

FASEB J. 2014 Oct;28(10):4359-68. doi: 10.1096/fj.14-252551. Epub 2014 Jun 30.


Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.

Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW.

Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21.


The potential application of a transcriptionally regulated oncolytic herpes simplex virus for human cancer therapy.

Miao L, Fraefel C, Sia KC, Newman JP, Mohamed-Bashir SA, Ng WH, Lam PY.

Br J Cancer. 2014 Jan 7;110(1):94-106. doi: 10.1038/bjc.2013.692. Epub 2013 Nov 5.


Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model.

Sia KC, Huynh H, Chung AY, Ooi LL, Lim KH, Hui KM, Lam PY.

Mol Cancer Ther. 2013 Aug;12(8):1651-64. doi: 10.1158/1535-7163.MCT-13-0056. Epub 2013 May 29.


Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging.

Sia KC, Huynh H, Chinnasamy N, Hui KM, Lam PY.

Gene Ther. 2012 May;19(5):532-42. doi: 10.1038/gt.2011.131. Epub 2011 Sep 15. Erratum in: Gene Ther. 2012 Sep;19(9):956.


Hybrid herpes simplex virus/Epstein-Barr virus amplicon viral vectors confer enhanced transgene expression in primary human tumors and human bone marrow-derived mesenchymal stem cells.

Sia KC, Chong WK, Ho IA, Yulyana Y, Endaya B, Huynh H, Lam PY.

J Gene Med. 2010 Oct;12(10):848-58. doi: 10.1002/jgm.1506.


Targeting human glioma cells using HSV-1 amplicon peptide display vector.

Ho IA, Miao L, Sia KC, Wang GY, Hui KM, Lam PY.

Gene Ther. 2010 Feb;17(2):250-60. doi: 10.1038/gt.2009.128. Epub 2009 Oct 8.


An Efficient and Safe Herpes Simplex Virus Type 1 Amplicon Vector for Transcriptionally Targeted Therapy of Human Hepatocellular Carcinomas.

Lam PY, Sia KC, Khong JH, Geest B, Lim KS, Ho IA, Wang GY, Miao L, Huynh H, Hui KM.

Mol Ther. 2007 Jun;15(6):1129-1136. doi: 10.1038/ Epub 2016 Dec 7.


An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas.

Lam PY, Sia KC, Khong JH, De Geest B, Lim KS, Ho IA, Wang GY, Miao LV, Huynh H, Hui KM.

Mol Ther. 2007 Jun;15(6):1129-36. Epub 2007 Apr 10.


Optimal purification method for Herpes-based viral vectors that confers minimal cytotoxicity for systemic route of vector administration.

Sia KC, Wang GY, Ho IA, Khor HY, Miao L, Hui KM, Lam PY.

J Virol Methods. 2007 Feb;139(2):166-74. Epub 2006 Oct 30.


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