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Upregulation of RSPO2-GPR48/LGR4 signaling in papillary thyroid carcinoma contributes to tumor progression.

Kang YE, Kim JM, Kim KS, Chang JY, Jung M, Lee J, Yi S, Kim HW, Kim JT, Lee K, Choi MJ, Kang SK, Lee SE, Yi HS, Koo BS, Shong M.

Oncotarget. 2017 Nov 25;8(70):114980-114994. doi: 10.18632/oncotarget.22692. eCollection 2017 Dec 29.


GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.

Chung HK, Kim JT, Kim HW, Kwon M, Kim SY, Shong M, Kim KS, Yi HS.

Sci Rep. 2017 Dec 8;7(1):17238. doi: 10.1038/s41598-017-17574-w.


MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain.

Son DJ, Zheng J, Jung YY, Hwang CJ, Lee HP, Woo JR, Baek SY, Ham YW, Kang MW, Shong M, Kweon GR, Song MJ, Jung JK, Han SB, Kim BY, Yoon DY, Choi BY, Hong JT.

Theranostics. 2017 Oct 16;7(18):4632-4642. doi: 10.7150/thno.18630. eCollection 2017.


The Eosinophil Count Tends to Be Negatively Associated with Levels of Serum Glucose in Patients with Adrenal Cushing Syndrome.

Lee Y, Yi HS, Kim HR, Joung KH, Kang YE, Lee JH, Kim KS, Kim HJ, Ku BJ, Shong M.

Endocrinol Metab (Seoul). 2017 Sep;32(3):353-359. doi: 10.3803/EnM.2017.32.3.353.


Role of Krüppel-Like Factor 4 in the Maintenance of Chemoresistance of Anaplastic Thyroid Cancer.

Lee SI, Kim DK, Seo EJ, Choi EJ, Kwon YW, Jang IH, Lee JC, Kim HY, Shong M, Kim JH, Kim SJ.

Thyroid. 2017 Nov;27(11):1424-1432. doi: 10.1089/thy.2016.0414. Epub 2017 Oct 19.


Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines.

Lee SE, Kang SG, Choi MJ, Jung SB, Ryu MJ, Chung HK, Chang JY, Kim YK, Lee JH, Kim KS, Kim HJ, Lee HK, Yi HS, Shong M.

Diabetes. 2017 Nov;66(11):2774-2788. doi: 10.2337/db17-0333. Epub 2017 Sep 5.


Oncogenes, mitochondrial metabolism, and quality control in differentiated thyroid cancer.

Yi HS, Chang JY, Kim KS, Shong M.

Korean J Intern Med. 2017 Sep;32(5):780-789. doi: 10.3904/kjim.2016.420. Epub 2017 Aug 22. Review.


VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.

Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY.

EMBO Mol Med. 2017 Jun;9(6):750-769. doi: 10.15252/emmm.201607341.


Targeted deletion of Crif1 in mouse epidermis impairs skin homeostasis and hair morphogenesis.

Shin JM, Choi DK, Sohn KC, Kim JY, Im M, Lee Y, Seo YJ, Shong M, Lee JH, Kim CD.

Sci Rep. 2017 Mar 20;7:44828. doi: 10.1038/srep44828.


ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21.

Kang SG, Yi HS, Choi MJ, Ryu MJ, Jung S, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y, Shong M.

J Endocrinol. 2017 Apr;233(1):105-118. doi: 10.1530/JOE-16-0549. Epub 2017 Feb 9.


CR6-Interacting Factor 1 Deficiency Impairs Vascular Function by Inhibiting the Sirt1-Endothelial Nitric Oxide Synthase Pathway.

Nagar H, Jung SB, Ryu MJ, Choi SJ, Piao S, Song HJ, Kang SK, Shin N, Kim DW, Jin SA, Jeong JO, Irani K, Jeon BH, Shong M, Kweon GR, Kim CS.

Antioxid Redox Signal. 2017 Aug 1;27(4):234-249. doi: 10.1089/ars.2016.6719. Epub 2017 May 24.


Regeneration of thyroid follicles from primordial cells in a murine thyroidectomized model.

Lee J, Yi S, Chang JY, Kang YE, Kim HJ, Park KC, Yang KJ, Sul HJ, Kim JO, Yi HS, Zhu X, Cheng SY, Shong M.

Lab Invest. 2017 Apr;97(4):478-489. doi: 10.1038/labinvest.2016.158. Epub 2017 Jan 23.


Dysregulation of mitophagy in carcinogenesis and tumor progression.

Chang JY, Yi HS, Kim HW, Shong M.

Biochim Biophys Acta. 2017 Aug;1858(8):633-640. doi: 10.1016/j.bbabio.2016.12.008. Epub 2016 Dec 23. Review.


Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M.

J Cell Biol. 2017 Jan 2;216(1):149-165. doi: 10.1083/jcb.201607110. Epub 2016 Dec 16.


An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function.

Lee JH, Kang YE, Chang JY, Park KC, Kim HW, Kim JT, Kim HJ, Yi HS, Shong M, Chung HK, Kim KS.

Am J Transl Res. 2016 Nov 15;8(11):4750-4763. eCollection 2016.


Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.

Lee J, Yi S, Kang YE, Chang JY, Kim JT, Sul HJ, Kim JO, Kim JM, Kim J, Porcelli AM, Kim KS, Shong M.

Oncotarget. 2016 Nov 29;7(48):79117-79130. doi: 10.18632/oncotarget.12997.


Morphological and Functional Changes in the Thyroid Follicles of the Aged Murine and Humans.

Lee J, Yi S, Kang YE, Kim HW, Joung KH, Sul HJ, Kim KS, Shong M.

J Pathol Transl Med. 2016 Nov;50(6):426-435. Epub 2016 Oct 14.


Long-Term Recurrence of Small Papillary Thyroid Cancer and Its Risk Factors in a Korean Multicenter Study.

Hwangbo Y, Kim JM, Park YJ, Lee EK, Lee YJ, Park DJ, Choi YS, Lee KD, Sohn SY, Kim SW, Chung JH, Lim DJ, Kim MH, Kim MJ, Jo YS, Shong MH, Koong SS, Hahm JR, Jung JH, Yi KH.

J Clin Endocrinol Metab. 2017 Feb 1;102(2):625-633. doi: 10.1210/jc.2016-2287.


Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.

Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J.

J Hepatol. 2017 Jan;66(1):132-141. doi: 10.1016/j.jhep.2016.08.024. Epub 2016 Sep 20.


Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.

Nguyen TT, Quan X, Xu S, Das R, Cha SK, Kong ID, Shong M, Wollheim CB, Park KS.

FASEB J. 2016 Dec;30(12):3979-3988. Epub 2016 Aug 26.


Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes Mellitus.

Shin MY, Kim JM, Kang YE, Kim MK, Joung KH, Lee JH, Kim KS, Kim HJ, Ku BJ, Shong M.

J Korean Med Sci. 2016 Sep;31(9):1413-8. doi: 10.3346/jkms.2016.31.9.1413.


NQO1-Knockout Mice Are Highly Sensitive to Clostridium Difficile Toxin A-Induced Enteritis.

Nam ST, Hwang JH, Kim DH, Lu LF, Hong J, Zhang P, Yoon IN, Hwang JS, Chung HK, Shong M, Lee CH, Kim H.

J Microbiol Biotechnol. 2016 Aug 28;26(8):1446-51. doi: 10.4014/jmb.1603.03041.


The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction.

Kang YE, Kim JM, Joung KH, Lee JH, You BR, Choi MJ, Ryu MJ, Ko YB, Lee MA, Lee J, Ku BJ, Shong M, Lee KH, Kim HJ.

PLoS One. 2016 Apr 21;11(4):e0154003. doi: 10.1371/journal.pone.0154003. eCollection 2016.


Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons.

Kim HT, Kim SJ, Sohn YI, Paik SS, Caplette R, Simonutti M, Moon KH, Lee EJ, Min KW, Kim MJ, Lee DG, Simeone A, Lamonerie T, Furukawa T, Choi JS, Kweon HS, Picaud S, Kim IB, Shong M, Kim JW.

Cell Rep. 2015 Nov 3;13(5):990-1002. doi: 10.1016/j.celrep.2015.09.075. Epub 2015 Oct 22.


Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation.

Jang Y, Han J, Kim SJ, Kim J, Lee MJ, Jeong S, Ryu MJ, Seo KS, Choi SY, Shong M, Lim K, Heo JY, Kweon GR.

Oncotarget. 2015 Nov 10;6(35):38127-38. doi: 10.18632/oncotarget.5511.


Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors.

Lee J, Ham S, Lee MH, Kim SJ, Park JH, Lee SE, Chang JY, Joung KH, Kim TY, Kim JM, Sul HJ, Kweon GR, Jo YS, Kim KS, Shong YK, Gasparre G, Chung JK, Porcelli AM, Shong M.

Carcinogenesis. 2015 Nov;36(11):1407-18. doi: 10.1093/carcin/bgv122. Epub 2015 Sep 8.


Mitochondrial Energy Metabolism and Thyroid Cancers.

Lee J, Chang JY, Kang YE, Yi S, Lee MH, Joung KH, Kim KS, Shong M.

Endocrinol Metab (Seoul). 2015 Jun;30(2):117-23. doi: 10.3803/EnM.2015.30.2.117. Review.


Differences in physicians' and patients' perception of acute hypothyroid symptoms induced by thyroid hormone withdrawal in thyroid cancer patients: a multicenter survey in Korea.

Lim DJ, Kim WB, Kim BH, Kim TY, Jo YS, Kang HC, Park YJ, Yi KH, Shong M, Kim IJ, Park DJ, Kim SW, Chung JH, Lee J, Koong SS, Shong YK.

Eur Thyroid J. 2015 Mar;4(1):48-54. doi: 10.1159/000371512. Epub 2015 Feb 19.


Regulation of systemic energy homeostasis by serotonin in adipose tissues.

Oh CM, Namkung J, Go Y, Shong KE, Kim K, Kim H, Park BY, Lee HW, Jeon YH, Song J, Shong M, Yadav VK, Karsenty G, Kajimura S, Lee IK, Park S, Kim H.

Nat Commun. 2015 Apr 13;6:6794. doi: 10.1038/ncomms7794.


Response: GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J 2014;38:472-9).

Hong JH, Ku BJ, Shong M.

Diabetes Metab J. 2015 Feb;39(1):84-6. doi: 10.4093/dmj.2015.39.1.84. No abstract available.


Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.

Kim YK, Joung KH, Ryu MJ, Kim SJ, Kim H, Chung HK, Lee MH, Lee SE, Choi MJ, Chang JY, Hong HJ, Kim KS, Lee SH, Kweon GR, Kim H, Lee CH, Kim HJ, Shong M.

Diabetologia. 2015 Apr;58(4):771-80. doi: 10.1007/s00125-015-3506-y. Epub 2015 Feb 8.


Thyroid dysfunction associated with follicular cell steatosis in obese male mice and humans.

Lee MH, Lee JU, Joung KH, Kim YK, Ryu MJ, Lee SE, Kim SJ, Chung HK, Choi MJ, Chang JY, Lee SH, Kweon GR, Kim HJ, Kim KS, Kim SM, Jo YS, Park J, Cheng SY, Shong M.

Endocrinology. 2015 Mar;156(3):1181-93. doi: 10.1210/en.2014-1670. Epub 2015 Jan 2.


GDF15 Is a Novel Biomarker for Impaired Fasting Glucose.

Hong JH, Chung HK, Park HY, Joung KH, Lee JH, Jung JG, Kim KS, Kim HJ, Ku BJ, Shong M.

Diabetes Metab J. 2014 Dec;38(6):472-9. doi: 10.4093/dmj.2014.38.6.472. Epub 2014 Dec 15.


Efficacy of a Once-Monthly Pill Containing Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis.

Cho IJ, Chung HY, Kim SW, Lee JW, Lee TW, Kim HS, Kim SG, Choi HS, Choi SH, Shin CS, Oh KW, Min YK, Koh JM, Rhee Y, Byun DW, Chung YS, Park JH, Chung DJ, Shong M, Hong EG, Lee CB, Baek KH, Kang MI.

Endocrinol Metab (Seoul). 2015 Sep;30(3):272-9. doi: 10.3803/EnM.2015.30.3.272. Epub 2014 Dec 9.


The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation.

Chung HK, Kim YK, Park JH, Ryu MJ, Chang JY, Hwang JH, Lee CH, Kim SH, Kim HJ, Kweon GR, Kim KS, Shong M.

Liver Int. 2015 Apr;35(4):1341-53. doi: 10.1111/liv.12741. Epub 2015 Jan 10.


CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.

Byun J, Son SM, Cha MY, Shong M, Hwang YJ, Kim Y, Ryu H, Moon M, Kim KS, Mook-Jung I.

Cell Death Differ. 2015 Jun;22(6):959-73. doi: 10.1038/cdd.2014.184. Epub 2014 Nov 7.


The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction.

Hwang JH, Kim YH, Noh JR, Gang GT, Kim KS, Chung HK, Tadi S, Yim YH, Shong M, Lee CH.

Arch Toxicol. 2015 Nov;89(11):2159-66. doi: 10.1007/s00204-014-1340-5. Epub 2014 Sep 17.


CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS.

PLoS One. 2014 Jun 6;9(6):e98670. doi: 10.1371/journal.pone.0098670. eCollection 2014.


Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data.

Kim WG, Kim TY, Kim TH, Jang HW, Jo YS, Park YJ, Kim SW, Kim WB, Shong M, Park DJ, Chung JH, Shong YK, Cho BY.

Korean J Intern Med. 2014 May;29(3):325-33. doi: 10.3904/kjim.2014.29.3.325. Epub 2014 Apr 29.


SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation.

Seo KS, Park JH, Heo JY, Jing K, Han J, Min KN, Kim C, Koh GY, Lim K, Kang GY, Uee Lee J, Yim YH, Shong M, Kwak TH, Kweon GR.

Oncogene. 2015 Mar 12;34(11):1354-62. doi: 10.1038/onc.2014.76. Epub 2014 Mar 31.


The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy.

Yang CS, Kim JJ, Lee HM, Jin HS, Lee SH, Park JH, Kim SJ, Kim JM, Han YM, Lee MS, Kweon GR, Shong M, Jo EK.

Autophagy. 2014 May;10(5):785-802. doi: 10.4161/auto.28072. Epub 2014 Feb 25.


Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells.

Nam ST, Hwang JH, Kim DH, Park MJ, Lee IH, Nam HJ, Kang JK, Kim SK, Hwang JS, Chung HK, Shong M, Lee CH, Kim H.

BMB Rep. 2014 Sep;47(9):494-9.


β-Lapachone alleviates alcoholic fatty liver disease in rats.

Shin S, Park J, Li Y, Min KN, Kong G, Hur GM, Kim JM, Shong M, Jung MS, Park JK, Jeong KH, Park MG, Kwak TH, Brazil DP, Park J.

Cell Signal. 2014 Feb;26(2):295-305. doi: 10.1016/j.cellsig.2013.11.020. Epub 2013 Nov 22.


Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice.

Gang GT, Hwang JH, Kim YH, Noh JR, Kim KS, Jeong JY, Choi DE, Lee KW, Jung JY, Shong M, Lee CH.

Free Radic Biol Med. 2014 Feb;67:139-49. doi: 10.1016/j.freeradbiomed.2013.10.817. Epub 2013 Nov 1.


IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter.

Ock S, Ahn J, Lee SH, Kang H, Offermanns S, Ahn HY, Jo YS, Shong M, Cho BY, Jo D, Abel ED, Lee TJ, Park WJ, Lee IK, Kim J.

FASEB J. 2013 Dec;27(12):4899-908. doi: 10.1096/fj.13-231381. Epub 2013 Aug 27.


RAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer.

Lee SE, Lee JU, Lee MH, Ryu MJ, Kim SJ, Kim YK, Choi MJ, Kim KS, Kim JM, Kim JW, Koh YW, Lim DS, Jo YS, Shong M.

Oncogenesis. 2013 Jul 15;2:e55. doi: 10.1038/oncsis.2013.12.


Protective role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in cisplatin-induced nephrotoxicity.

Gang GT, Kim YH, Noh JR, Kim KS, Jung JY, Shong M, Hwang JH, Lee CH.

Toxicol Lett. 2013 Aug 29;221(3):165-75. doi: 10.1016/j.toxlet.2013.06.239. Epub 2013 Jul 4.


NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats.

Kim YH, Hwang JH, Kim KS, Noh JR, Gang GT, Kim SW, Jang SP, Lee SJ, Her SH, Jeong KH, Kwak TH, Park WJ, Balyasnikova IV, Shong M, Lee CH.

Cardiovasc Res. 2013 Sep 1;99(4):743-50. doi: 10.1093/cvr/cvt147. Epub 2013 Jun 6.


The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice.

Noh JR, Hwang JH, Kim YH, Kim KS, Gang GT, Kim SW, Kim DK, Shong M, Lee IK, Choi HS, Lee CH.

Int J Biochem Cell Biol. 2013 Aug;45(8):1538-45. doi: 10.1016/j.biocel.2013.05.004. Epub 2013 May 13.


Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice.

Ryu MJ, Kim SJ, Kim YK, Choi MJ, Tadi S, Lee MH, Lee SE, Chung HK, Jung SB, Kim HJ, Jo YS, Kim KS, Lee SH, Kim JM, Kweon GR, Park KC, Lee JU, Kong YY, Lee CH, Chung J, Shong M.

PLoS Genet. 2013;9(3):e1003356. doi: 10.1371/journal.pgen.1003356. Epub 2013 Mar 14.

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