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B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells.

Luo W, Weisel F, Shlomchik MJ.

Immunity. 2018 Feb 20;48(2):313-326.e5. doi: 10.1016/j.immuni.2018.01.008.


PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease.

Juchem KW, Sacirbegovic F, Zhang C, Sharpe AH, Russell K, McNiff JM, Demetris AJ, Shlomchik MJ, Shlomchik WD.

J Immunol. 2018 Jan 15;200(2):834-846. doi: 10.4049/jimmunol.1701076. Epub 2017 Dec 6.


Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells.

Roberts AW, Lee BL, Deguine J, John S, Shlomchik MJ, Barton GM.

Immunity. 2017 Nov 21;47(5):913-927.e6. doi: 10.1016/j.immuni.2017.10.006. Epub 2017 Nov 14.


An atlas of B-cell clonal distribution in the human body.

Meng W, Zhang B, Schwartz GW, Rosenfeld AM, Ren D, Thome JJC, Carpenter DJ, Matsuoka N, Lerner H, Friedman AL, Granot T, Farber DL, Shlomchik MJ, Hershberg U, Luning Prak ET.

Nat Biotechnol. 2017 Sep;35(9):879-884. doi: 10.1038/nbt.3942. Epub 2017 Aug 21.


B Cell-Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses.

Sweet RA, Nickerson KM, Cullen JL, Wang Y, Shlomchik MJ.

J Immunol. 2017 Aug 1;199(3):885-893. doi: 10.4049/jimmunol.1600861. Epub 2017 Jun 28.


Lupus and proliferative nephritis are PAD4 independent in murine models.

Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ.

JCI Insight. 2017 May 18;2(10). pii: 92926. doi: 10.1172/jci.insight.92926. [Epub ahead of print]


Do Memory B Cells Form Secondary Germinal Centers? Yes and No.

Shlomchik MJ.

Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1). pii: a029405. doi: 10.1101/cshperspect.a029405. Review.


Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice.

Nickerson KM, Wang Y, Bastacky S, Shlomchik MJ.

PLoS One. 2017 Mar 9;12(3):e0173471. doi: 10.1371/journal.pone.0173471. eCollection 2017.


Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation.

Giles JR, Neves AT, Marshak-Rothstein A, Shlomchik MJ.

JCI Insight. 2017 Feb 23;2(4):e90870. doi: 10.1172/jci.insight.90870.


Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand.

Ols ML, Cullen JL, Turqueti-Neves A, Giles J, Shlomchik MJ.

Immunity. 2016 Nov 15;45(5):1052-1065. doi: 10.1016/j.immuni.2016.10.005. Epub 2016 Oct 25.


A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.

Cui A, Di Niro R, Vander Heiden JA, Briggs AW, Adams K, Gilbert T, O'Connor KC, Vigneault F, Shlomchik MJ, Kleinstein SH.

J Immunol. 2016 Nov 1;197(9):3566-3574. Epub 2016 Oct 5.


ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.

Jash A, Wang Y, Weisel FJ, Scharer CD, Boss JM, Shlomchik MJ, Bhattacharya D.

J Immunol. 2016 Aug 15;197(4):1159-68. doi: 10.4049/jimmunol.1600882. Epub 2016 Jun 29.


Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.

Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC.

J Exp Med. 2016 May 2;213(5):751-69. doi: 10.1084/jem.20150537. Epub 2016 Apr 25.


B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus.

Wen J, Doerner J, Chalmers S, Stock A, Wang H, Gullinello M, Shlomchik MJ, Putterman C.

J Neuroinflammation. 2016 Apr 7;13(1):73. doi: 10.1186/s12974-016-0537-3.


Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9.

Garcia-Martinez I, Santoro N, Chen Y, Hoque R, Ouyang X, Caprio S, Shlomchik MJ, Coffman RL, Candia A, Mehal WZ.

J Clin Invest. 2016 Mar 1;126(3):859-64. doi: 10.1172/JCI83885. Epub 2016 Jan 25.


A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells.

Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ.

Immunity. 2016 Jan 19;44(1):116-130. doi: 10.1016/j.immuni.2015.12.004. Epub 2016 Jan 12.


Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens.

Russell L, John S, Cullen J, Luo W, Shlomchik MJ, Garrett-Sinha LA.

J Immunol. 2015 Oct 15;195(8):3574-83. doi: 10.4049/jimmunol.1500776. Epub 2015 Sep 9.


B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.

Giles JR, Kashgarian M, Koni PA, Shlomchik MJ.

J Immunol. 2015 Sep 15;195(6):2571-9. doi: 10.4049/jimmunol.1500792. Epub 2015 Aug 12.


Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

Di Niro R, Lee SJ, Vander Heiden JA, Elsner RA, Trivedi N, Bannock JM, Gupta NT, Kleinstein SH, Vigneault F, Gilbert TJ, Meffre E, McSorley SJ, Shlomchik MJ.

Immunity. 2015 Jul 21;43(1):120-31. doi: 10.1016/j.immuni.2015.06.013. Epub 2015 Jul 14.


Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease.

Di Niro R, Snir O, Kaukinen K, Yaari G, Lundin KE, Gupta NT, Kleinstein SH, Cols M, Cerutti A, Mäki M, Shlomchik MJ, Sollid LM.

Mucosal Immunol. 2016 Jan;9(1):254-64. doi: 10.1038/mi.2015.57. Epub 2015 Jul 8.


Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus.

Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ.

Immunity. 2015 Mar 17;42(3):552-65. doi: 10.1016/j.immuni.2015.02.015.


Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection.

Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RD, Choudhury BP, Stowell SR, Lee J, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R.

Immunity. 2015 Feb 17;42(2):367-378. doi: 10.1016/j.immuni.2015.01.009. Epub 2015 Feb 10.


Suppression of systemic autoimmunity by the innate immune adaptor STING.

Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E710-7. doi: 10.1073/pnas.1420217112. Epub 2015 Feb 2.


Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.

Sang A, Niu H, Cullen J, Choi SC, Zheng YY, Wang H, Shlomchik MJ, Morel L.

J Immunol. 2014 Aug 15;193(4):1609-21. doi: 10.4049/jimmunol.1303000. Epub 2014 Jul 11.


CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.

Zuccarino-Catania GV, Sadanand S, Weisel FJ, Tomayko MM, Meng H, Kleinstein SH, Good-Jacobson KL, Shlomchik MJ.

Nat Immunol. 2014 Jul;15(7):631-7. doi: 10.1038/ni.2914. Epub 2014 Jun 1.


Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance.

Chappell CP, Giltiay NV, Draves KE, Chen C, Hayden-Ledbetter MS, Shlomchik MJ, Kaplan DH, Clark EA.

J Immunol. 2014 Jun 15;192(12):5789-5801. doi: 10.4049/jimmunol.1303259. Epub 2014 May 14.


CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence.

Conter LJ, Song E, Shlomchik MJ, Tomayko MM.

PLoS One. 2014 Mar 24;9(3):e92009. doi: 10.1371/journal.pone.0092009. eCollection 2014.


Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences.

Uduman M, Shlomchik MJ, Vigneault F, Church GM, Kleinstein SH.

J Immunol. 2014 Feb 1;192(3):867-74. doi: 10.4049/jimmunol.1301551. Epub 2013 Dec 27.


IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.

Simonetti G, Carette A, Silva K, Wang H, De Silva NS, Heise N, Siebel CW, Shlomchik MJ, Klein U.

J Exp Med. 2013 Dec 16;210(13):2887-902. doi: 10.1084/jem.20131026. Epub 2013 Dec 9.


MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.

Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS.

J Exp Med. 2013 Dec 16;210(13):2921-37. doi: 10.1084/jem.20130699. Epub 2013 Dec 9.


Context-specific BAFF-R signaling by the NF-κB and PI3K pathways.

Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC.

Cell Rep. 2013 Nov 27;5(4):1022-35. doi: 10.1016/j.celrep.2013.10.022. Epub 2013 Nov 14.


Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice.

Giltiay NV, Lu Y, Cullen JL, Jørgensen TN, Shlomchik MJ, Li X.

J Immunol. 2013 Sep 1;191(5):2155-63. doi: 10.4049/jimmunol.1300152. Epub 2013 Jul 31.


Multiple transcription factor binding sites predict AID targeting in non-Ig genes.

Duke JL, Liu M, Yaari G, Khalil AM, Tomayko MM, Shlomchik MJ, Schatz DG, Kleinstein SH.

J Immunol. 2013 Apr 15;190(8):3878-88. doi: 10.4049/jimmunol.1202547. Epub 2013 Mar 20.


Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus.

Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ.

Immunity. 2013 Mar 21;38(3):528-40. doi: 10.1016/j.immuni.2012.11.017. Epub 2013 Mar 14.


Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1.

Nickerson KM, Cullen JL, Kashgarian M, Shlomchik MJ.

J Immunol. 2013 Apr 15;190(8):3889-94. doi: 10.4049/jimmunol.1203525. Epub 2013 Mar 6.


Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses.

Sweet RA, Cullen JL, Shlomchik MJ.

J Immunol. 2013 Mar 1;190(5):1974-81. doi: 10.4049/jimmunol.1202816. Epub 2013 Jan 30.


TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.

Nickerson KM, Christensen SR, Cullen JL, Meng W, Luning Prak ET, Shlomchik MJ.

J Immunol. 2013 Feb 15;190(4):1447-56. doi: 10.4049/jimmunol.1202115. Epub 2013 Jan 7.


Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.

Nanton MR, Way SS, Shlomchik MJ, McSorley SJ.

J Immunol. 2012 Dec 15;189(12):5503-7. doi: 10.4049/jimmunol.1201413. Epub 2012 Nov 12.


NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.

Campbell AM, Kashgarian M, Shlomchik MJ.

Sci Transl Med. 2012 Oct 24;4(157):157ra141. doi: 10.1126/scitranslmed.3004801.


B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity.

Khalil AM, Cambier JC, Shlomchik MJ.

Science. 2012 Jun 1;336(6085):1178-81. doi: 10.1126/science.1213368. Epub 2012 May 3.


Germinal center selection and the development of memory B and plasma cells.

Shlomchik MJ, Weisel F.

Immunol Rev. 2012 May;247(1):52-63. doi: 10.1111/j.1600-065X.2012.01124.x. Review.


Germinal centers.

Shlomchik MJ, Weisel F.

Immunol Rev. 2012 May;247(1):5-10. doi: 10.1111/j.1600-065X.2012.01125.x. No abstract available.


CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation.

Good-Jacobson KL, Song E, Anderson S, Sharpe AH, Shlomchik MJ.

J Immunol. 2012 May 1;188(9):4217-25. doi: 10.4049/jimmunol.1102885. Epub 2012 Mar 26.


B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.

Teichmann LL, Kashgarian M, Weaver CT, Roers A, Müller W, Shlomchik MJ.

J Immunol. 2012 Jan 15;188(2):678-85. doi: 10.4049/jimmunol.1102456. Epub 2011 Dec 9.


Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.

Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A, Blazar BR.

Blood. 2012 Feb 9;119(6):1570-80. doi: 10.1182/blood-2011-07-364414. Epub 2011 Nov 9.


An acquired defect in IgG-dependent phagocytosis explains the impairment in antibody-mediated cellular depletion in Lupus.

Ahuja A, Teichmann LL, Wang H, Dunn R, Kehry MR, Shlomchik MJ.

J Immunol. 2011 Oct 1;187(7):3888-94. doi: 10.4049/jimmunol.1101629. Epub 2011 Aug 26.


A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.

Juchem KW, Anderson BE, Zhang C, McNiff JM, Demetris AJ, Farber DL, Caton AJ, Shlomchik WD, Shlomchik MJ.

Blood. 2011 Dec 1;118(23):6209-19. doi: 10.1182/blood-2011-01-330035. Epub 2011 Jul 18.


Detecting selection in immunoglobulin sequences.

Uduman M, Yaari G, Hershberg U, Stern JA, Shlomchik MJ, Kleinstein SH.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W499-504. doi: 10.1093/nar/gkr413. Epub 2011 Jun 10.


Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⁺ effector memory T cells.

Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Jain D, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ.

Eur J Immunol. 2011 Sep;41(9):2782-92. doi: 10.1002/eji.201141678. Epub 2011 Aug 18.


Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.

Sweet RA, Ols ML, Cullen JL, Milam AV, Yagita H, Shlomchik MJ.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7932-7. doi: 10.1073/pnas.1018571108. Epub 2011 Apr 25.

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