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Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium.

Wang Y, Zhou JS, Xu XC, Li ZY, Chen HP, Ying SM, Li W, Shen HH, Chen ZH.

Int J Chron Obstruct Pulmon Dis. 2018 Feb 9;13:571-581. doi: 10.2147/COPD.S150633. eCollection 2018.


Knockdown of Tfpi-Anchored Endothelial Cells Exacerbates Lipopolysaccharide-Induced Acute Lung Injury via NF-κB Signaling Pathway.

Wang BQ, Shi M, Zhang JP, Wu X, Chang MJ, Chen ZH, Shen HH, Song YL, Zhou J, Bai CX.

Shock. 2018 Feb 12. doi: 10.1097/SHK.0000000000001120. [Epub ahead of print]


Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

Han ML, Velkov T, Zhu Y, Roberts KD, Le Brun AP, Chow SH, Gutu AD, Moskowitz SM, Shen HH, Li J.

ACS Chem Biol. 2018 Jan 19;13(1):121-130. doi: 10.1021/acschembio.7b00836. Epub 2017 Dec 11.


Efficacy and safety of bronchoscopic lung volume reduction therapy in patients with severe emphysema: a meta-analysis of randomized controlled trials.

Wang Y, Lai TW, Xu F, Zhou JS, Li ZY, Xu XC, Chen HP, Ying SM, Li W, Shen HH, Chen ZH.

Oncotarget. 2017 Jul 18;8(44):78031-78043. doi: 10.18632/oncotarget.19352. eCollection 2017 Sep 29.


Core Concept: Circumventing the blood-brain barrier.

Shen HH.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11261-11263. doi: 10.1073/pnas.1716187114. No abstract available.


News Feature: Singing in the brain.

Shen HH.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9490-9493. doi: 10.1073/pnas.1711799114. No abstract available.


Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation.

Xu XC, Wu YF, Zhou JS, Chen HP, Wang Y, Li ZY, Zhao Y, Shen HH, Chen ZH.

Toxicol Lett. 2017 Oct 5;280:206-212. doi: 10.1016/j.toxlet.2017.08.081. Epub 2017 Sep 1.


Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis.

Fang CH, Tsai PI, Huang SW, Sun JS, Chang JZ, Shen HH, Chen SY, Lin FH, Hsu LT, Chen YC.

BMC Infect Dis. 2017 Jul 25;17(1):516. doi: 10.1186/s12879-017-2621-4.


Activation of autophagy is involved in the protective effect of 17β-oestradiol on endotoxaemia-induced multiple organ dysfunction in ovariectomized rats.

Chung MT, Lee YM, Shen HH, Cheng PY, Huang YC, Lin YJ, Huang YY, Lam KK.

J Cell Mol Med. 2017 Dec;21(12):3705-3717. doi: 10.1111/jcmm.13280. Epub 2017 Jul 17.


Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

Han ML, Shen HH, Hansford KA, Schneider EK, Sivanesan S, Roberts KD, Thompson PE, Le Brun AP, Zhu Y, Sani MA, Separovic F, Blaskovich MAT, Baker MA, Moskowitz SM, Cooper MA, Li J, Velkov T.

ACS Infect Dis. 2017 Aug 11;3(8):606-619. doi: 10.1021/acsinfecdis.7b00065. Epub 2017 Jul 11.


Early growth response factor 1 is essential for cigarette smoke-induced MUC5AC expression in human bronchial epithelial cells.

Wang SB, Zhang C, Xu XC, Xu F, Zhou JS, Wu YP, Cao C, Li W, Shen HH, Cao JF, Chen ZH.

Biochem Biophys Res Commun. 2017 Aug 19;490(2):147-154. doi: 10.1016/j.bbrc.2017.06.014. Epub 2017 Jun 8.


Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models.

Huang G, Xu XC, Zhou JS, Li ZY, Chen HP, Wang Y, Li W, Shen HH, Chen ZH.

J Immunol Res. 2017;2017:7915975. doi: 10.1155/2017/7915975. Epub 2017 Apr 23. Review.


Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation.

Ochkur SI, Doyle AD, Jacobsen EA, LeSuer WE, Li W, Protheroe CA, Zellner KR, Colbert D, Shen HH, Irvin CG, Lee JJ, Lee NA.

J Leukoc Biol. 2017 Sep;102(3):589-599. doi: 10.1189/jlb.3HI1116-488RR. Epub 2017 May 17.


Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective.

Li ZY, Wu YF, Xu XC, Zhou JS, Wang Y, Shen HH, Chen ZH.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L207-L217. doi: 10.1152/ajplung.00562.2016. Epub 2017 May 4. Review.


Sophocarpine Protects Mice from ConA-Induced Hepatitis via Inhibition of the IFN-Gamma/STAT1 Pathway.

Sang XX, Wang RL, Zhang CE, Liu SJ, Shen HH, Guo YM, Zhang YM, Niu M, Wang JB, Bai ZF, Xiao XH.

Front Pharmacol. 2017 Mar 21;8:140. doi: 10.3389/fphar.2017.00140. eCollection 2017.


Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats.

Shen HH, Huang SY, Cheng PY, Chu YJ, Chen SY, Lam KK, Lee YM.

Menopause. 2017 Aug;24(8):959-969. doi: 10.1097/GME.0000000000000864.


Inner Workings: How do mosquitoes smell us? The answers could help eradicate disease.

Shen HH.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2096-2098. doi: 10.1073/pnas.1701738114. No abstract available.


Neural Representation and Causal Models in Motor Cortex.

Chaisanguanthum KS, Shen HH, Sabes PN.

J Neurosci. 2017 Mar 22;37(12):3413-3424. doi: 10.1523/JNEUROSCI.1000-16.2017. Epub 2017 Feb 20.


Activating transcription factor 3 represses cigarette smoke-induced IL6 and IL8 expression via suppressing NF-κB activation.

Wu YP, Cao C, Wu YF, Li M, Lai TW, Zhu C, Wang Y, Ying SM, Chen ZH, Shen HH, Li W.

Toxicol Lett. 2017 Mar 15;270:17-24. doi: 10.1016/j.toxlet.2017.02.002. Epub 2017 Feb 6.


miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling.

Wang B, Yao K, Wise AF, Lau R, Shen HH, Tesch GH, Ricardo SD.

Clin Sci (Lond). 2017 Mar 1;131(5):411-423. doi: 10.1042/CS20160571. Epub 2017 Jan 4.


Bcl-2 inhibitors reduce steroid-insensitive airway inflammation.

Tian BP, Xia LX, Bao ZQ, Zhang H, Xu ZW, Mao YY, Cao C, Che LQ, Liu JK, Li W, Chen ZH, Ying S, Shen HH.

J Allergy Clin Immunol. 2017 Aug;140(2):418-430. doi: 10.1016/j.jaci.2016.11.027. Epub 2016 Dec 31.


Modulations of SIR-nucleosome interactions of reconstructed yeast silent pre-heterochromatin by O-acetyl-ADP-ribose and magnesium.

Tung SY, Wang SH, Lee SP, Tsai SP, Shen HH, Chen FJ, Wu YY, Hsiao SP, Liou GG.

Mol Biol Cell. 2017 Feb 1;28(3):381-386. doi: 10.1091/mbc.E16-06-0359. Epub 2016 Dec 8.


Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.

Jacobsen EA, Ochkur SI, Doyle AD, LeSuer WE, Li W, Protheroe CA, Colbert D, Zellner KR, Shen HH, Irvin CG, Lee JJ, Lee NA.

Am J Respir Crit Care Med. 2017 May 15;195(10):1321-1332. doi: 10.1164/rccm.201606-1129OC.


Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1.

Wu YP, Wu YF, Zhang C, Zhou HB, Cao C, Li M, Zhu C, Ying SM, Chen ZH, Shen HH, Li W.

Am J Pathol. 2017 Feb;187(2):280-291. doi: 10.1016/j.ajpath.2016.10.012. Epub 2016 Nov 29.


News Feature: To master memory, researchers pursue its roots.

Shen HH.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11376-11379. No abstract available.


Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy.

Shen HH, Liu GS, Chow SH, Wang JH, He Z, Nguyen C, Lin TW, Bui BV.

PLoS One. 2016 Oct 6;11(10):e0164035. doi: 10.1371/journal.pone.0164035. eCollection 2016.


Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury.

Hu Y, Lou J, Mao YY, Lai TW, Liu LY, Zhu C, Zhang C, Liu J, Li YY, Zhang F, Li W, Ying SM, Chen ZH, Shen HH.

Autophagy. 2016 Dec;12(12):2286-2299. Epub 2016 Sep 22.


Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine.

Stubenrauch C, Belousoff MJ, Hay ID, Shen HH, Lillington J, Tuck KL, Peters KM, Phan MD, Lo AW, Schembri MA, Strugnell RA, Waksman G, Lithgow T.

Nat Microbiol. 2016 May 16;1(7):16064. doi: 10.1038/nmicrobiol.2016.64.


New Approach for High-Voltage Electrical Double-Layer Capacitors Using Vertical Graphene Nanowalls with and without Nitrogen Doping.

Chi YW, Hu CC, Shen HH, Huang KP.

Nano Lett. 2016 Sep 14;16(9):5719-27. doi: 10.1021/acs.nanolett.6b02401. Epub 2016 Aug 31.


Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications.

Liu F, Xuan NX, Ying SM, Li W, Chen ZH, Shen HH.

Mediators Inflamm. 2016;2016:6943135. doi: 10.1155/2016/6943135. Epub 2016 Jul 20. Review.


17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats.

Wang YL, Shen HH, Cheng PY, Chu YJ, Hwang HR, Lam KK, Lee YM.

PLoS One. 2016 May 25;11(5):e0155583. doi: 10.1371/journal.pone.0155583. eCollection 2016.


Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis.

Wang B, Yao K, Huuskes BM, Shen HH, Zhuang J, Godson C, Brennan EP, Wilkinson-Berka JL, Wise AF, Ricardo SD.

Mol Ther. 2016 Aug;24(7):1290-301. doi: 10.1038/mt.2016.90. Epub 2016 May 18.


News Feature: Better models for brain disease.

Shen HH.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5461-4. doi: 10.1073/pnas.1605358113. No abstract available.


Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.

Xia LX, Hua W, Jin Y, Tian BP, Qiu ZW, Zhang C, Che LQ, Zhou HB, Wu YF, Huang HQ, Lan F, Ke YH, Lee JJ, Li W, Ying SM, Chen ZH, Shen HH.

Cell Death Dis. 2016 Apr 7;7:e2175. doi: 10.1038/cddis.2016.74.


Autophagy plays an essential role in cigarette smoke-induced expression of MUC5AC in airway epithelium.

Zhou JS, Zhao Y, Zhou HB, Wang Y, Wu YF, Li ZY, Xuan NX, Zhang C, Hua W, Ying SM, Li W, Shen HH, Chen ZH.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1042-52. doi: 10.1152/ajplung.00418.2015. Epub 2016 Apr 1.


[Thymopolypeptides combined with matrine type alkaloids suppress HBV replication].

Liu XQ, Shen HH, Chen JX, Bai ZF, Wang JB, Xiao XH.

Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1275-1281. doi: 10.4268/cjcmm20160719. Chinese.


Inner Workings: Sitting still, for science.

Shen HH.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):1960-2. doi: 10.1073/pnas.1600165113. No abstract available.


Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma.

Zhang C, Zhang LH, Wu YF, Lai TW, Wang HS, Xiao H, Che LQ, Ying SM, Li W, Chen ZH, Shen HH.

Sci Rep. 2016 Feb 10;6:21515. doi: 10.1038/srep21515.


Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6.

Chen JX, Shen HH, Niu M, Guo YM, Liu XQ, Han YZ, Zhang YM, Zhao YL, Bai BK, Zhou WJ, Xiao XH.

Virus Res. 2016 Apr 2;215:104-13. doi: 10.1016/j.virusres.2015.12.005. Epub 2015 Dec 9.


Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium.

Chen ZH, Wu YF, Wang PL, Wu YP, Li ZY, Zhao Y, Zhou JS, Zhu C, Cao C, Mao YY, Xu F, Wang BB, Cormier SA, Ying SM, Li W, Shen HH.

Autophagy. 2016;12(2):297-311. doi: 10.1080/15548627.2015.1124224.


Core Concept: Resting-state connectivity.

Shen HH.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14115-6. doi: 10.1073/pnas.1518785112. Review. No abstract available.


Fertilization of Mouse Gametes in Vitro Using a Digital Microfluidic System.

Huang HY, Shen HH, Chung LY, Chung YH, Chen CC, Hsu CH, Fan SK, Yao DJ.

IEEE Trans Nanobioscience. 2015 Dec;14(8):857-63. doi: 10.1109/TNB.2015.2485303. Epub 2015 Oct 27.


Efficacy of Compound Kushen Injection in Relieving Cancer-Related Pain: A Systematic Review and Meta-Analysis.

Guo YM, Huang YX, Shen HH, Sang XX, Ma X, Zhao YL, Xiao XH.

Evid Based Complement Alternat Med. 2015;2015:840742. doi: 10.1155/2015/840742. Epub 2015 Oct 4. Review.


Deconvoluting the Effect of the Hydrophobic and Hydrophilic Domains of an Amphiphilic Integral Membrane Protein in Lipid Bicontinuous Cubic Mesophases.

van 't Hag L, Shen HH, Lu J, Hawley AM, Gras SL, Drummond CJ, Conn CE.

Langmuir. 2015 Nov 10;31(44):12025-34. doi: 10.1021/acs.langmuir.5b03256. Epub 2015 Oct 29.


Molecular architecture of the active mitochondrial protein gate.

Shiota T, Imai K, Qiu J, Hewitt VL, Tan K, Shen HH, Sakiyama N, Fukasawa Y, Hayat S, Kamiya M, Elofsson A, Tomii K, Horton P, Wiedemann N, Pfanner N, Lithgow T, Endo T.

Science. 2015 Sep 25;349(6255):1544-8. doi: 10.1126/science.aac6428.


Surfactin at the Water/Air Interface and in Solution.

Iglesias-Fernández J, Darré L, Kohlmeyer A, Thomas RK, Shen HH, Domene C.

Langmuir. 2015 Oct 13;31(40):11097-104. doi: 10.1021/acs.langmuir.5b02305. Epub 2015 Oct 1.


Infectious disease surveillance in China.

Bai BK, Xu Z, Shen HH.

J Infect. 2015 Dec;71(6):698-700. doi: 10.1016/j.jinf.2015.08.010. Epub 2015 Sep 9. No abstract available.


Defining the structural characteristics of annexin V binding to a mimetic apoptotic membrane.

Lu J, Le Brun AP, Chow SH, Shiota T, Wang B, Lin TW, Liu GS, Shen HH.

Eur Biophys J. 2015 Dec;44(8):697-708. doi: 10.1007/s00249-015-1068-z. Epub 2015 Aug 14.


Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module.

Selkrig J, Belousoff MJ, Headey SJ, Heinz E, Shiota T, Shen HH, Beckham SA, Bamert RS, Phan MD, Schembri MA, Wilce MC, Scanlon MJ, Strugnell RA, Lithgow T.

Sci Rep. 2015 Aug 5;5:12905. doi: 10.1038/srep12905.

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