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Items: 1 to 50 of 126

1.

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing.

Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN.

Sci Adv. 2018 Jan 31;4(1):eaap9004. doi: 10.1126/sciadv.aap9004. eCollection 2018 Jan.

2.

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.

Shimada IS, Hwang SH, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z, Taylor MD, Mukhopadhyay S.

Cell Rep. 2018 Jan 30;22(5):1169-1184. doi: 10.1016/j.celrep.2018.01.018.

3.

The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner.

Hwang SH, White KA, Somatilaka BN, Shelton JM, Richardson JA, Mukhopadhyay S.

Development. 2018 Jan 8;145(1). pii: dev154054. doi: 10.1242/dev.154054.

PMID:
29222391
4.

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

Amoasii L, Long C, Li H, Mireault AA, Shelton JM, Sanchez-Ortiz E, McAnally JR, Bhattacharyya S, Schmidt F, Grimm D, Hauschka SD, Bassel-Duby R, Olson EN.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaan8081. doi: 10.1126/scitranslmed.aan8081. Erratum in: Sci Transl Med. 2018 Jan 24;10 (425):.

5.

Functional correction of dystrophin actin binding domain mutations by genome editing.

Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN.

JCI Insight. 2017 Sep 21;2(18). pii: 95918. doi: 10.1172/jci.insight.95918. [Epub ahead of print]

6.

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model.

Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton JM, Stener-Victorin E, Wernstedt Asterholm I.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7187-E7196. doi: 10.1073/pnas.1708854114. Epub 2017 Aug 8.

7.

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.

Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH.

Cell Rep. 2017 Jun 27;19(13):2756-2770. doi: 10.1016/j.celrep.2017.05.084.

8.

CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice.

Zhang Y, Long C, Li H, McAnally JR, Baskin KK, Shelton JM, Bassel-Duby R, Olson EN.

Sci Adv. 2017 Apr 12;3(4):e1602814. doi: 10.1126/sciadv.1602814. eCollection 2017 Apr.

9.

Tumor physiological changes during hypofractionated stereotactic body radiation therapy assessed using multi-parametric magnetic resonance imaging.

Zhou H, Zhang Z, Denney R, Williams JS, Gerberich J, Stojadinovic S, Saha D, Shelton JM, Mason RP.

Oncotarget. 2017 Jun 6;8(23):37464-37477. doi: 10.18632/oncotarget.16395.

10.

Control of muscle formation by the fusogenic micropeptide myomixer.

Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN.

Science. 2017 Apr 21;356(6335):323-327. doi: 10.1126/science.aam9361. Epub 2017 Apr 6.

11.

Patient compliance following isolated mandibular fracture repair.

Radabaugh JP, Horn AV, Chan SA, Shelton JM, Gal TJ.

Laryngoscope. 2017 Oct;127(10):2230-2235. doi: 10.1002/lary.26556. Epub 2017 Mar 21.

PMID:
28322450
12.

A Twist2-dependent progenitor cell contributes to adult skeletal muscle.

Liu N, Garry GA, Li S, Bezprozvannaya S, Sanchez-Ortiz E, Chen B, Shelton JM, Jaichander P, Bassel-Duby R, Olson EN.

Nat Cell Biol. 2017 Mar;19(3):202-213. doi: 10.1038/ncb3477. Epub 2017 Feb 20.

13.

Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall.

Ripperda CM, Maldonado PA, Acevedo JF, Keller PW, Akgul Y, Shelton JM, Word RA.

Menopause. 2017 Jul;24(7):838-849. doi: 10.1097/GME.0000000000000840.

14.

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.

Anderson DM, Makarewich CA, Anderson KM, Shelton JM, Bezprozvannaya S, Bassel-Duby R, Olson EN.

Sci Signal. 2016 Dec 6;9(457):ra119.

15.

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development.

Anderson KM, Anderson DM, McAnally JR, Shelton JM, Bassel-Duby R, Olson EN.

Nature. 2016 Nov 17;539(7629):433-436. doi: 10.1038/nature20128. Epub 2016 Oct 26.

16.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2016 Apr 1;126(4):1605. doi: 10.1172/JCI86695. Epub 2016 Apr 1. No abstract available.

17.

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN.

Science. 2016 Jan 22;351(6271):400-3. doi: 10.1126/science.aad5725. Epub 2015 Dec 31.

18.

Corrigendum: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.

Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Cheng Zhang C, Sadek HA.

Nature. 2016 Apr 14;532(7598):268. doi: 10.1038/nature16177. Epub 2015 Dec 23. No abstract available.

PMID:
26700813
19.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2015 Dec;125(12):4447-62. doi: 10.1172/JCI82204. Epub 2015 Nov 16. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1605. Livingston, Kenneth [corrected to Livingston, Kenneth A].

20.

Tools and pipelines for BioNano data: molecule assembly pipeline and FASTA super scaffolding tool.

Shelton JM, Coleman MC, Herndon N, Lu N, Lam ET, Anantharaman T, Sheth P, Brown SJ.

BMC Genomics. 2015 Sep 29;16:734. doi: 10.1186/s12864-015-1911-8.

21.

Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.

Shelton JM, Corran P, Risley P, Silva N, Hubbart C, Jeffreys A, Rowlands K, Craik R, Cornelius V, Hensmann M, Molloy S, Sepulveda N, Clark TG, Band G, Clarke GM, Spencer CC, Kerasidou A, Campino S, Auburn S, Tall A, Ly AB, Mercereau-Puijalon O, Sakuntabhai A, Djimdé A, Maiga B, Touré O, Doumbo OK, Dolo A, Troye-Blomberg M, Mangano VD, Verra F, Modiano D, Bougouma E, Sirima SB, Ibrahim M, Hussain A, Eid N, Elzein A, Mohammed H, Elhassan A, Elhassan I, Williams TN, Ndila C, Macharia A, Marsh K, Manjurano A, Reyburn H, Lemnge M, Ishengoma D, Carter R, Karunaweera N, Fernando D, Dewasurendra R, Drakeley CJ, Riley EM, Kwiatkowski DP, Rockett KA; MalariaGEN Consortium.

Malar J. 2015 Aug 28;14:333. doi: 10.1186/s12936-015-0833-x.

22.

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.

Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Zhang CC, Sadek HA.

Nature. 2015 Jul 9;523(7559):226-30. doi: 10.1038/nature14582. Epub 2015 Jun 22. Erratum in: Nature. 2016 Apr 14;532(7598):268.

PMID:
26098368
23.

Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.

Cenik BK, Garg A, McAnally JR, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN, Liu N.

J Clin Invest. 2015 Apr;125(4):1569-78. doi: 10.1172/JCI80115. Epub 2015 Mar 16.

24.

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.

Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN.

Cell. 2015 Feb 12;160(4):595-606. doi: 10.1016/j.cell.2015.01.009. Epub 2015 Jan 29.

25.

Characterizing cardiac donation after circulatory death: implications for perfusion preservation.

Brant SM, Cobert ML, West LM, Shelton JM, Jessen ME, Peltz M.

Ann Thorac Surg. 2014 Dec;98(6):2107-13; discussion 2113-4. doi: 10.1016/j.athoracsur.2014.05.091. Epub 2014 Oct 17.

PMID:
25443014
26.

Trans-cranial opening of the blood-brain barrier in targeted regions using a stereotaxic brain atlas and focused ultrasound energy.

Bing C, Ladouceur-Wodzak M, Wanner CR, Shelton JM, Richardson JA, Chopra R.

J Ther Ultrasound. 2014 Aug 4;2:13. doi: 10.1186/2050-5736-2-13. eCollection 2014.

27.

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA.

Long C, McAnally JR, Shelton JM, Mireault AA, Bassel-Duby R, Olson EN.

Science. 2014 Sep 5;345(6201):1184-1188. doi: 10.1126/science.1254445. Epub 2014 Aug 14.

28.

Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor.

Long C, Grueter CE, Song K, Qin S, Qi X, Kong YM, Shelton JM, Richardson JA, Zhang CL, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11521-6. doi: 10.1073/pnas.1411251111. Epub 2014 Jul 21.

29.

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling.

Chen Z, Holland W, Shelton JM, Ali A, Zhan X, Won S, Tomisato W, Liu C, Li X, Moresco EM, Beutler B.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7367-72. doi: 10.1073/pnas.1406511111. Epub 2014 May 5.

30.

Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation.

Abedin MJ, Nguyen A, Jiang N, Perry CE, Shelton JM, Watson DK, Ferdous A.

Circ Res. 2014 May 23;114(11):1690-9. doi: 10.1161/CIRCRESAHA.1134303145. Epub 2014 Apr 11.

31.

Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.

Luo Y, Kumar P, Chen CC, Latham J, Wang L, Tudela C, Alexander JM, Shelton JM, McKown L, Mendelson CR.

Mol Endocrinol. 2014 Jun;28(6):965-75. doi: 10.1210/me.2014-1003. Epub 2014 Apr 11.

32.

Requirement of MEF2A, C, and D for skeletal muscle regeneration.

Liu N, Nelson BR, Bezprozvannaya S, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4109-14. doi: 10.1073/pnas.1401732111. Epub 2014 Mar 3.

33.

A reevaluation of CD22 expression in human lung cancer.

Pop LM, Barman S, Shao C, Poe JC, Venturi GM, Shelton JM, Pop IV, Gerber DE, Girard L, Liu XY, Behrens C, Rodriguez-Canales J, Liu H, Wistuba II, Richardson JA, Minna JD, Tedder TF, Vitetta ES.

Cancer Res. 2014 Jan 1;74(1):263-71. doi: 10.1158/0008-5472.CAN-13-1436.

34.

Cytoglobin modulates myogenic progenitor cell viability and muscle regeneration.

Singh S, Canseco DC, Manda SM, Shelton JM, Chirumamilla RR, Goetsch SC, Ye Q, Gerard RD, Schneider JW, Richardson JA, Rothermel BA, Mammen PP.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E129-38. doi: 10.1073/pnas.1314962111. Epub 2013 Dec 23.

35.

Posttraumatic Chondrocyte Apoptosis in the Murine Xiphoid.

Davis CG, Eisner E, McGlynn M, Shelton JM, Richardson J, Borrelli J Jr, Chen CC.

Cartilage. 2013 Oct;4(4):345-53. doi: 10.1177/1947603513489830.

36.

Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.

Chapman KM, Powell HM, Chaudhary J, Shelton JM, Richardson JA, Richardson TE, Hamra FK.

Mol Cell Proteomics. 2013 Nov;12(11):3221-36. doi: 10.1074/mcp.M113.030585. Epub 2013 Aug 12.

37.

Hippo pathway effector Yap promotes cardiac regeneration.

Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44. doi: 10.1073/pnas.1313192110. Epub 2013 Aug 5.

38.

Myomaker is a membrane activator of myoblast fusion and muscle formation.

Millay DP, O'Rourke JR, Sutherland LB, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN.

Nature. 2013 Jul 18;499(7458):301-5. doi: 10.1038/nature12343.

39.

Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI.

Winterberg PD, Wang Y, Lin KM, Hartono JR, Nagami GT, Zhou XJ, Shelton JM, Richardson JA, Lu CY.

Am J Physiol Renal Physiol. 2013 Jul 15;305(2):F164-72. doi: 10.1152/ajprenal.00487.2012. Epub 2013 May 8.

40.

Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy.

Cao DJ, Jiang N, Blagg A, Johnstone JL, Gondalia R, Oh M, Luo X, Yang KC, Shelton JM, Rothermel BA, Gillette TG, Dorn GW, Hill JA.

J Am Heart Assoc. 2013 Apr 8;2(2):e000016. doi: 10.1161/JAHA.113.000016.

41.

Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance.

Quintens R, Singh S, Lemaire K, De Bock K, Granvik M, Schraenen A, Vroegrijk IO, Costa V, Van Noten P, Lambrechts D, Lehnert S, Van Lommel L, Thorrez L, De Faudeur G, Romijn JA, Shelton JM, Scorrano L, Lijnen HR, Voshol PJ, Carmeliet P, Mammen PP, Schuit F.

PLoS One. 2013;8(2):e56719. doi: 10.1371/journal.pone.0056719. Epub 2013 Feb 27.

42.

Laryngeal aging and acoustic changes in male rat ultrasonic vocalizations.

Peterson JR, Watts CR, Morris JA, Shelton JM, Cooper BG.

Dev Psychobiol. 2013 Dec;55(8):818-28. doi: 10.1002/dev.21072. Epub 2012 Jul 20.

PMID:
22821353
43.

microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.

Liu N, Williams AH, Maxeiner JM, Bezprozvannaya S, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN.

J Clin Invest. 2012 Jun;122(6):2054-65. doi: 10.1172/JCI62656. Epub 2012 May 1.

44.

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.

Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC.

J Lipid Res. 2012 Jun;53(6):1080-92. doi: 10.1194/jlr.M023382. Epub 2012 Apr 9.

45.

Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats.

Taurog JD, Rival C, van Duivenvoorde LM, Satumtira N, Dorris ML, Sun M, Shelton JM, Richardson JA, Hamra FK, Hammer RE, Tung KS.

Arthritis Rheum. 2012 Aug;64(8):2518-28. doi: 10.1002/art.34480.

46.

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.

Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA.

J Clin Invest. 2012 Mar;122(3):1109-18. doi: 10.1172/JCI60329. Epub 2012 Feb 13.

47.

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice.

Moresi V, Carrer M, Grueter CE, Rifki OF, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1649-54. doi: 10.1073/pnas.1121159109. Epub 2012 Jan 17.

48.

Assessing the severity of rainfall-derived infiltration and inflow and sewer deterioration based on the flux stability of sewage markers.

Shelton JM, Kim L, Fang J, Ray C, Yan T.

Environ Sci Technol. 2011 Oct 15;45(20):8683-90. doi: 10.1021/es2019115. Epub 2011 Sep 26.

PMID:
21902223
49.

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.

Xie X, Brown MS, Shelton JM, Richardson JA, Goldstein JL, Liang G.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15330-5. doi: 10.1073/pnas.1112751108. Epub 2011 Sep 6.

50.

Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy.

Liu N, Bezprozvannaya S, Shelton JM, Frisard MI, Hulver MW, McMillan RP, Wu Y, Voelker KA, Grange RW, Richardson JA, Bassel-Duby R, Olson EN.

J Clin Invest. 2011 Aug;121(8):3258-68. doi: 10.1172/JCI46267.

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