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Items: 1 to 50 of 95

1.

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.

Bakshi RP, Tatham LM, Savage AC, Tripathi AK, Mlambo G, Ippolito MM, Nenortas E, Rannard SP, Owen A, Shapiro TA.

Nat Commun. 2018 Jan 22;9(1):315. doi: 10.1038/s41467-017-02603-z.

2.

Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology.

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, Doebele RC, Govindan R, Gubens MA, Hennon M, Horn L, Komaki R, Lackner RP, Lanuti M, Leal TA, Leisch LJ, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M.

J Natl Compr Canc Netw. 2017 Apr;15(4):504-535.

PMID:
28404761
3.

Hybrid Coronary Revascularization for the Treatment of Multivessel Coronary Artery Disease: A Multicenter Observational Study.

Puskas JD, Halkos ME, DeRose JJ, Bagiella E, Miller MA, Overbey J, Bonatti J, Srinivas VS, Vesely M, Sutter F, Lynch J, Kirkwood K, Shapiro TA, Boudoulas KD, Crestanello J, Gehrig T, Smith P, Ragosta M, Hoff SJ, Zhao D, Gelijns AC, Szeto WY, Weisz G, Argenziano M, Vassiliades T, Liberman H, Matthai W, Ascheim DD.

J Am Coll Cardiol. 2016 Jul 26;68(4):356-65. doi: 10.1016/j.jacc.2016.05.032.

4.

NCCN Guidelines Insights: Malignant Pleural Mesothelioma, Version 3.2016.

Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Dilling T, Dobelbower M, Govindan R, Hennon M, Horn L, Jahan TM, Komaki R, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Sharma N, Swanson SJ, Stevenson J, Tauer K, Yang SC, Gregory K, Hughes M.

J Natl Compr Canc Netw. 2016 Jul;14(7):825-36.

PMID:
27407123
5.

Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds.

Caton E, Nenortas E, Bakshi RP, Shapiro TA.

Curr Protoc Chem Biol. 2016 Mar 16;8(1):29-58. doi: 10.1002/9780470559277.ch150194.

6.

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 4.2016.

Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower MC, Govindan R, Hennon M, Horn L, Jahan TM, Komaki R, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Sharma N, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M.

J Natl Compr Canc Netw. 2016 Mar;14(3):255-64.

PMID:
26957612
7.

Non-Small Cell Lung Cancer, Version 6.2015.

Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Dilling TJ, Dobelbower MC, Govindan R, Grannis FW Jr, Horn L, Jahan TM, Komaki R, Krug LM, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Rohren E, Schild SE, Shapiro TA, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M; National comprehensive cancer network.

J Natl Compr Canc Netw. 2015 May;13(5):515-24.

PMID:
25964637
8.

Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons.

Tang Girdwood SC, Nenortas E, Shapiro TA.

Biochem Pharmacol. 2015 Jun 15;95(4):227-37. doi: 10.1016/j.bcp.2015.03.018. Epub 2015 Apr 13.

9.

Non-small cell lung cancer, version 1.2015.

Ettinger DS, Wood DE, Akerley W, Bazhenova LA, Borghaei H, Camidge DR, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Dilling TJ, Govindan R, Grannis FW Jr, Horn L, Jahan TM, Komaki R, Kris MG, Krug LM, Lackner RP, Lanuti M, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Patel JD, Pisters KM, Reckamp K, Riely GJ, Rohren E, Schild S, Shapiro TA, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M.

J Natl Compr Canc Netw. 2014 Dec;12(12):1738-61.

PMID:
25505215
10.

All at once: multivessel spontaneous coronary artery dissection with right coronary artery ST-segment elevation myocardial infarction.

Sardar MR, Pieczynski LM, Saeed W, Domsky SM, Shapiro TA, Coady P.

JACC Cardiovasc Interv. 2014 Oct;7(10):e161-2. doi: 10.1016/j.jcin.2014.04.021. No abstract available.

11.

Unanswered questions in patients with concurrent atrial fibrillation and acute coronary syndrome.

Ice DS, Shapiro TA, Gnall EM, Kowey PR.

Am J Cardiol. 2014 Mar 1;113(5):888-96. doi: 10.1016/j.amjcard.2013.11.046. Epub 2013 Dec 12. Review.

PMID:
24528617
12.

Model system to define pharmacokinetic requirements for antimalarial drug efficacy.

Bakshi RP, Nenortas E, Tripathi AK, Sullivan DJ, Shapiro TA.

Sci Transl Med. 2013 Oct 2;5(205):205ra135. doi: 10.1126/scitranslmed.3006684.

13.

Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs.

Grab DJ, Nenortas E, Bakshi RP, Nikolskaia OV, Friedman JE, Shapiro TA.

Parasitol Int. 2013 Oct;62(5):461-3. doi: 10.1016/j.parint.2013.06.009. Epub 2013 Jun 28.

14.

Non-small cell lung cancer, version 2.2013.

Ettinger DS, Akerley W, Borghaei H, Chang AC, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Govindan R, Grannis FW Jr, Grant SC, Horn L, Jahan TM, Komaki R, Kong FM, Kris MG, Krug LM, Lackner RP, Lennes IT, Loo BW Jr, Martins R, Otterson GA, Patel JD, Pinder-Schenck MC, Pisters KM, Reckamp K, Riely GJ, Rohren E, Shapiro TA, Swanson SJ, Tauer K, Wood DE, Yang SC, Gregory K, Hughes M; National comprehensive cancer network.

J Natl Compr Canc Netw. 2013 Jun 1;11(6):645-53; quiz 653.

PMID:
23744864
15.

Thymomas and thymic carcinomas: Clinical Practice Guidelines in Oncology.

Ettinger DS, Riely GJ, Akerley W, Borghaei H, Chang AC, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Govindan R, Grannis FW Jr, Grant SC, Horn L, Jahan TM, Komaki R, Kong FM, Kris MG, Krug LM, Lackner RP, Lennes IT, Loo BW Jr, Martins R, Otterson GA, Patel JD, Pinder-Schenck MC, Pisters KM, Reckamp K, Rohren E, Shapiro TA, Swanson SJ, Tauer K, Wood DE, Yang SC, Gregory K, Hughes M; National Comprehensive Cancer Network.

J Natl Compr Canc Netw. 2013 May 1;11(5):562-76.

PMID:
23667206
16.

Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo.

Meyer KJ, Shapiro TA.

J Infect Dis. 2013 Aug 1;208(3):489-99. doi: 10.1093/infdis/jit179. Epub 2013 Apr 22.

17.

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P.

Cancer Prev Res (Phila). 2012 Apr;5(4):603-11. doi: 10.1158/1940-6207.CAPR-11-0538. Epub 2012 Feb 7.

18.

Biomechanical effects of arthroscopic capsulorrhaphy in line with the fibers of the anterior band of the inferior glenohumeral ligament.

Shapiro TA, Gupta A, McGarry MH, Tibone JE, Lee TQ.

Am J Sports Med. 2012 Mar;40(3):672-80. doi: 10.1177/0363546511430307. Epub 2011 Dec 16.

PMID:
22178582
19.

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

Slack RD, Mott BT, Woodard LE, Tripathi A, Sullivan D, Nenortas E, Girdwood SC, Shapiro TA, Posner GH.

J Med Chem. 2012 Jan 12;55(1):291-6. doi: 10.1021/jm201214d. Epub 2011 Dec 15. Erratum in: J Med Chem. 2012 Feb 23;55(4):1788. Triphati, Abhai [corrected to Tripathi, Abhai].

20.

The killing of African trypanosomes by ethidium bromide.

Roy Chowdhury A, Bakshi R, Wang J, Yildirir G, Liu B, Pappas-Brown V, Tolun G, Griffith JD, Shapiro TA, Jensen RE, Englund PT.

PLoS Pathog. 2010 Dec 16;6(12):e1001226. doi: 10.1371/journal.ppat.1001226.

21.

Incredibly late thromboses in first generation drug eluting stents: a case series.

Shaik Z, Mohammed KS, Siddiqi A, Mohammed I, Shapiro TA, Phiambolis TP.

Cases J. 2009 Dec 10;2:9303. doi: 10.1186/1757-1626-2-9303.

22.

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine.

Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH.

Pharmaceuticals (Basel). 2009 Dec 21;2(3):228-235.

23.

Newly identified antibacterial compounds are topoisomerase poisons in African trypanosomes.

Tang SC, Shapiro TA.

Antimicrob Agents Chemother. 2010 Feb;54(2):620-6. doi: 10.1128/AAC.01025-09. Epub 2009 Dec 14.

24.

Unraveling the secrets of regulating mitochondrial DNA replication.

Klingbeil MM, Shapiro TA.

Mol Cell. 2009 Aug 28;35(4):398-400. doi: 10.1016/j.molcel.2009.08.007.

25.

Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

Woodard LE, Chang W, Chen X, Liu JO, Shapiro TA, Posner GH.

J Med Chem. 2009 Dec 10;52(23):7458-62. doi: 10.1021/jm9005934.

26.
27.

Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.

Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO.

Chem Biol. 2009 Feb 27;16(2):193-202. doi: 10.1016/j.chembiol.2009.01.006.

28.

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH.

J Med Chem. 2009 Feb 26;52(4):1198-203. doi: 10.1021/jm801484v.

29.
30.

Activity of indenoisoquinolines against African trypanosomes.

Bakshi RP, Sang D, Morrell A, Cushman M, Shapiro TA.

Antimicrob Agents Chemother. 2009 Jan;53(1):123-8. doi: 10.1128/AAC.00650-07. Epub 2008 Sep 29.

31.

Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, Rottmann M, Wittlin S, Brun R, Shapiro TA.

J Med Chem. 2008 Feb 28;51(4):1035-42. doi: 10.1021/jm701168h. Epub 2008 Jan 31.

PMID:
18232653
32.

A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes.

Scocca JR, Shapiro TA.

Mol Microbiol. 2008 Feb;67(4):820-9. doi: 10.1111/j.1365-2958.2007.06087.x. Epub 2007 Dec 19.

33.

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA.

J Med Chem. 2007 May 17;50(10):2516-9. Epub 2007 Apr 17.

PMID:
17439113
34.

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

Dinkova-Kostova AT, Fahey JW, Wade KL, Jenkins SN, Shapiro TA, Fuchs EJ, Kerns ML, Talalay P.

Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51.

35.

Biomechanical effects of glenoid retroversion in total shoulder arthroplasty.

Shapiro TA, McGarry MH, Gupta R, Lee YS, Lee TQ.

J Shoulder Elbow Surg. 2007 May-Jun;16(3 Suppl):S90-5. Epub 2006 Dec 12.

PMID:
17169588
36.

Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

Shapiro TA, Fahey JW, Dinkova-Kostova AT, Holtzclaw WD, Stephenson KK, Wade KL, Ye L, Talalay P.

Nutr Cancer. 2006;55(1):53-62.

PMID:
16965241
37.

Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.

Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, Posner GH.

J Med Chem. 2006 May 4;49(9):2731-4.

PMID:
16640333
38.

The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice.

Martin JL, Jia G, Martin SS, Shapiro TA, Herrmann HC, Dibattiste PM, Topol EJ, Moliterno DJ.

Catheter Cardiovasc Interv. 2006 Apr;67(4):563-70.

PMID:
16532491
39.
40.

Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge.

Arav-Boger R, Shapiro TA.

Annu Rev Pharmacol Toxicol. 2005;45:565-85. Review.

PMID:
15822189
41.

RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential.

Bakshi RP, Shapiro TA.

Mol Biochem Parasitol. 2004 Aug;136(2):249-55.

PMID:
15478803
42.

Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B.

J Med Chem. 2004 Feb 26;47(5):1299-301.

PMID:
14971910
43.

Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions.

Nenortas E, Kulikowicz T, Burri C, Shapiro TA.

Antimicrob Agents Chemother. 2003 Sep;47(9):3015-7.

44.

DNA topoisomerases as targets for antiprotozoal therapy.

Bakshi RP, Shapiro TA.

Mini Rev Med Chem. 2003 Sep;3(6):597-608. Review.

PMID:
12871162
45.

Isolation of kinetoplast DNA.

Shapiro TA, Klein VA, Englund PT.

Methods Mol Biol. 1999;94:61-7. No abstract available.

PMID:
12844862
46.

An unusual type IB topoisomerase from African trypanosomes.

Bodley AL, Chakraborty AK, Xie S, Burri C, Shapiro TA.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7539-44. Epub 2003 Jun 16.

47.

A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.

Bachi MD, Korshin EE, Hoos R, Szpilman AM, Ploypradith P, Xie S, Shapiro TA, Posner GH.

J Med Chem. 2003 Jun 5;46(12):2516-33.

PMID:
12773055
48.

Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.

Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA.

J Med Chem. 2003 Mar 13;46(6):1060-5.

PMID:
12620083
49.

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

Borstnik K, Paik IH, Shapiro TA, Posner GH.

Int J Parasitol. 2002 Dec 4;32(13):1661-7. Review.

PMID:
12435451
50.

Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents.

Posner GH, Jeon HB, Ploypradith P, Paik IH, Borstnik K, Xie S, Shapiro TA.

J Med Chem. 2002 Aug 29;45(18):3824-8.

PMID:
12190305

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