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Items: 1 to 50 of 138

1.

Mouse models of nesprin-related diseases.

Zhou C, Rao L, Warren DT, Shanahan CM, Zhang Q.

Biochem Soc Trans. 2018 May 21. pii: BST20180085. doi: 10.1042/BST20180085. [Epub ahead of print] Review.

PMID:
29784648
2.

Muscle tensions merge to cause a DNA replication crisis.

Brayson D, Ho CY, Shanahan CM.

J Cell Biol. 2018 May 16. pii: jcb.201804041. doi: 10.1083/jcb.201804041. [Epub ahead of print]

PMID:
29769233
3.

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.

Durham AL, Speer MY, Scatena M, Giachelli CM, Shanahan CM.

Cardiovasc Res. 2018 Mar 15;114(4):590-600. doi: 10.1093/cvr/cvy010.

4.

Nesprin-1/2: roles in nuclear envelope organisation, myogenesis and muscle disease.

Zhou C, Rao L, Shanahan CM, Zhang Q.

Biochem Soc Trans. 2018 Apr 17;46(2):311-320. doi: 10.1042/BST20170149. Epub 2018 Feb 27. Review.

PMID:
29487227
5.

Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation.

Ter Braake AD, Tinnemans PT, Shanahan CM, Hoenderop JGJ, de Baaij JHF.

Sci Rep. 2018 Feb 1;8(1):2069. doi: 10.1038/s41598-018-20241-3.

6.

Not all vascular smooth muscle cell exosomes calcify equally in chronic kidney disease.

Dusso A, Colombo MI, Shanahan CM.

Kidney Int. 2018 Feb;93(2):298-301. doi: 10.1016/j.kint.2017.08.036.

PMID:
29389393
7.

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release.

Dautova Y, Kapustin AN, Pappert K, Epple M, Okkenhaug H, Cook SJ, Shanahan CM, Bootman MD, Proudfoot D.

J Mol Cell Cardiol. 2018 Feb;115:82-93. doi: 10.1016/j.yjmcc.2017.12.007. Epub 2017 Dec 20.

8.

In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR.

Li R, Rajan R, Wong WCV, Reid DG, Duer MJ, Somovilla VJ, Martinez-Saez N, Bernardes GJL, Hayward R, Shanahan CM.

Chem Commun (Camb). 2017 Dec 14;53(100):13316-13319. doi: 10.1039/c7cc06624d.

9.

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.

Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P.

Cell. 2017 Nov 30;171(6):1397-1410.e14. doi: 10.1016/j.cell.2017.10.008. Epub 2017 Oct 26.

PMID:
29107331
10.

Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.

Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski KP, Gasior P, Buszman PP, Buszman P, Jahangiri M, Shanahan CM, Hill J, Mayr M.

Circulation. 2018 Jan 9;137(2):166-183. doi: 10.1161/CIRCULATIONAHA.116.023381. Epub 2017 Oct 13.

11.

Magnesium Counteracts Vascular Calcification: Passive Interference or Active Modulation?

Ter Braake AD, Shanahan CM, de Baaij JHF.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1431-1445. doi: 10.1161/ATVBAHA.117.309182. Epub 2017 Jun 29. Review.

PMID:
28663256
12.

Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.

Zhou C, Li C, Zhou B, Sun H, Koullourou V, Holt I, Puckelwartz MJ, Warren DT, Hayward R, Lin Z, Zhang L, Morris GE, McNally EM, Shackleton S, Rao L, Shanahan CM, Zhang Q.

Hum Mol Genet. 2017 Jun 15;26(12):2258-2276. doi: 10.1093/hmg/ddx116.

13.

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.

Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M.

J Clin Invest. 2017 Apr 3;127(4):1546-1560. doi: 10.1172/JCI86924. Epub 2017 Mar 20.

14.

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs.

Brayson D, Shanahan CM.

Nucleus. 2017 Jan 2;8(1):17-33. doi: 10.1080/19491034.2016.1260798. Review.

15.

Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification.

Kapustin AN, Schoppet M, Schurgers LJ, Reynolds JL, McNair R, Heiss A, Jahnen-Dechent W, Hackeng TM, Schlieper G, Harrison P, Shanahan CM.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):e22-e32. doi: 10.1161/ATVBAHA.116.308886. Epub 2017 Jan 19.

16.
17.

Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease.

Furmanik M, Shanahan CM.

Curr Cardiol Rev. 2016 Oct 13. [Epub ahead of print]

PMID:
27758694
18.

Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies.

Rajgor D, Hanley JG, Shanahan CM.

Mol Biol Cell. 2016 Dec 1;27(24):3894-3902. Epub 2016 Oct 12.

19.

Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling.

Cobb AM, Murray TV, Warren DT, Liu Y, Shanahan CM.

Nucleus. 2016 Sep 2;7(5):498-511.

20.

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient.

Cobb AM, Larrieu D, Warren DT, Liu Y, Srivastava S, Smith AJ, Bowater RP, Jackson SP, Shanahan CM.

Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506. [Epub ahead of print]

21.

Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody.

Holt I, Duong NT, Zhang Q, Lam le T, Sewry CA, Mamchaoui K, Shanahan CM, Morris GE.

BMC Cell Biol. 2016 Jun 27;17(1):26. doi: 10.1186/s12860-016-0105-9.

22.

N-terminal nesprin-2 variants regulate β-catenin signalling.

Zhang Q, Minaisah RM, Ferraro E, Li C, Porter LJ, Zhou C, Gao F, Zhang J, Rajgor D, Autore F, Shanahan CM, Warren DT.

Exp Cell Res. 2016 Jul 15;345(2):168-79. doi: 10.1016/j.yexcr.2016.06.008. Epub 2016 Jun 16.

23.

Medial Arterial Calcification: An Overlooked Player in Peripheral Arterial Disease.

Ho CY, Shanahan CM.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1475-82. doi: 10.1161/ATVBAHA.116.306717. Epub 2016 Jun 16. Review.

24.

Identification and Validation of Putative Nesprin Variants.

Autore F, Shanahan CM, Zhang Q.

Methods Mol Biol. 2016;1411:211-20. doi: 10.1007/978-1-4939-3530-7_13.

PMID:
27147044
25.

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation.

Kapustin AN, Shanahan CM.

J Physiol. 2016 Jun 1;594(11):2905-14. doi: 10.1113/JP271340. Epub 2016 Mar 9. Review.

26.

Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.

Santos CX, Hafstad AD, Beretta M, Zhang M, Molenaar C, Kopec J, Fotinou D, Murray TV, Cobb AM, Martin D, Zeh Silva M, Anilkumar N, Schröder K, Shanahan CM, Brewer AC, Brandes RP, Blanc E, Parsons M, Belousov V, Cammack R, Hider RC, Steiner RA, Shah AM.

EMBO J. 2016 Feb 1;35(3):319-34. doi: 10.15252/embj.201592394. Epub 2016 Jan 7.

27.

Phosphodiesterase 1 regulation is a key mechanism in vascular aging.

Bautista Niño PK, Durik M, Danser AH, de Vries R, Musterd-Bhaggoe UM, Meima ME, Kavousi M, Ghanbari M, Hoeijmakers JH, O'Donnell CJ, Franceschini N, Janssen GM, De Mey JG, Liu Y, Shanahan CM, Franco OH, Dehghan A, Roks AJ.

Clin Sci (Lond). 2015 Dec;129(12):1061-75. doi: 10.1042/CS20140753. Epub 2015 Jun 25.

PMID:
26464516
28.

Inhibition of TNF-α Reverses the Pathological Resorption Pit Profile of Osteoclasts from Patients with Acute Charcot Osteoarthropathy.

Petrova NL, Petrov PK, Edmonds ME, Shanahan CM.

J Diabetes Res. 2015;2015:917945. doi: 10.1155/2015/917945. Epub 2015 Jun 2.

29.

Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension.

Soon E, Crosby A, Southwood M, Yang P, Tajsic T, Toshner M, Appleby S, Shanahan CM, Bloch KD, Pepke-Zaba J, Upton P, Morrell NW.

Am J Respir Crit Care Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC.

30.

UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015.

Kapustin AN, Kalinina N, Lopatina T, Davidson SM, Iraci N, Tamkovich S, Smyth L, Ter-Ovanesyan D, Evtushenko EG, Savelieva O, Bertazzo S, Aushev V, Dragovic R, Gracia T, Heck M, Parfyonova YV, Shanahan CM, Tkachuk V.

J Extracell Vesicles. 2015 May 14;4:28094. doi: 10.3402/jev.v4.28094. eCollection 2015. No abstract available.

31.

Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing.

Warren DT, Tajsic T, Porter LJ, Minaisah RM, Cobb A, Jacob A, Rajgor D, Zhang QP, Shanahan CM.

Cell Death Differ. 2015 Sep;22(9):1540-50. doi: 10.1038/cdd.2015.12. Epub 2015 Mar 6.

32.

Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

Kapustin AN, Chatrou ML, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RT, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM.

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.

33.

Neointimal hyperplasia and calcification in medium sized arteries in adult patients with chronic kidney disease.

Chitalia N, Ross L, Krishnamoorthy M, Kapustin A, Shanahan CM, Kaski JC, Roy-Chaudhury P, Chemla E, Banerjee D.

Semin Dial. 2015 May-Jun;28(3):E35-40. doi: 10.1111/sdi.12335. Epub 2014 Dec 9.

PMID:
25488635
34.

BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway.

Zhu D, Mackenzie NC, Shanahan CM, Shroff RC, Farquharson C, MacRae VE.

J Cell Mol Med. 2015 Jan;19(1):165-74. doi: 10.1111/jcmm.12373. Epub 2014 Oct 9.

35.

RNA granules and cytoskeletal links.

Rajgor D, Shanahan CM.

Biochem Soc Trans. 2014 Aug;42(4):1206-10. doi: 10.1042/BST20140067. Review.

PMID:
25110026
36.

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

King SJ, Nowak K, Suryavanshi N, Holt I, Shanahan CM, Ridley AJ.

Cytoskeleton (Hoboken). 2014 Jul;71(7):423-34. doi: 10.1002/cm.21182. Epub 2014 Jun 25.

PMID:
24931616
37.

Mammalian microtubule P-body dynamics are mediated by nesprin-1.

Rajgor D, Mellad JA, Soong D, Rattner JB, Fritzler MJ, Shanahan CM.

J Cell Biol. 2014 May 26;205(4):457-75. doi: 10.1083/jcb.201306076.

38.

HDL in children with CKD promotes endothelial dysfunction and an abnormal vascular phenotype.

Shroff R, Speer T, Colin S, Charakida M, Zewinger S, Staels B, Chinetti-Gbaguidi G, Hettrich I, Rohrer L, O'Neill F, McLoughlin E, Long D, Shanahan CM, Landmesser U, Fliser D, Deanfield JE.

J Am Soc Nephrol. 2014 Nov;25(11):2658-68. doi: 10.1681/ASN.2013111212. Epub 2014 May 22.

39.

NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization.

Chow WY, Rajan R, Muller KH, Reid DG, Skepper JN, Wong WC, Brooks RA, Green M, Bihan D, Farndale RW, Slatter DA, Shanahan CM, Duer MJ.

Science. 2014 May 16;344(6185):742-6. doi: 10.1126/science.1248167.

40.

Nesprins: tissue-specific expression of epsilon and other short isoforms.

Duong NT, Morris GE, Lam le T, Zhang Q, Sewry CA, Shanahan CM, Holt I.

PLoS One. 2014 Apr 9;9(4):e94380. doi: 10.1371/journal.pone.0094380. eCollection 2014.

41.

Novel use of a Dektak 150 surface profiler unmasks differences in resorption pit profiles between control and Charcot patient osteoclasts.

Petrova NL, Petrov PK, Edmonds ME, Shanahan CM.

Calcif Tissue Int. 2014 Apr;94(4):403-11. doi: 10.1007/s00223-013-9820-9. Epub 2013 Dec 10. Erratum in: Calcif Tissue Int. 2014 Apr;94(4):412-3.

PMID:
24322885
42.

The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages.

Müller KH, Motskin M, Philpott AJ, Routh AF, Shanahan CM, Duer MJ, Skepper JN.

Biomaterials. 2014 Jan;35(3):1074-88. doi: 10.1016/j.biomaterials.2013.10.041. Epub 2013 Oct 30.

43.

Neuropathy and the vascular-bone axis in diabetes: lessons from Charcot osteoarthropathy.

Petrova NL, Shanahan CM.

Osteoporos Int. 2014 Apr;25(4):1197-207. doi: 10.1007/s00198-013-2511-6. Epub 2013 Oct 3. Review.

PMID:
24091593
44.

Mechanisms of vascular calcification in CKD-evidence for premature ageing?

Shanahan CM.

Nat Rev Nephrol. 2013 Nov;9(11):661-70. doi: 10.1038/nrneph.2013.176. Epub 2013 Sep 10. Review.

PMID:
24018414
45.

Nesprins: from the nuclear envelope and beyond.

Rajgor D, Shanahan CM.

Expert Rev Mol Med. 2013 Jul 5;15:e5. doi: 10.1017/erm.2013.6. Review.

46.

Citrate occurs widely in healthy and pathological apatitic biomineral: mineralized articular cartilage, and intimal atherosclerotic plaque and apatitic kidney stones.

Reid DG, Duer MJ, Jackson GE, Murray RC, Rodgers AL, Shanahan CM.

Calcif Tissue Int. 2013 Sep;93(3):253-60. doi: 10.1007/s00223-013-9751-5. Epub 2013 Jun 19.

PMID:
23780351
47.

Autophagy and matrix vesicles: new partners in vascular calcification.

Shanahan CM.

Kidney Int. 2013 Jun;83(6):984-6. doi: 10.1038/ki.2013.75.

48.

Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins.

Autore F, Pfuhl M, Quan X, Williams A, Roberts RG, Shanahan CM, Fraternali F.

PLoS One. 2013 May 6;8(5):e63633. doi: 10.1371/journal.pone.0063633. Print 2013.

49.

Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.

New SE, Goettsch C, Aikawa M, Marchini JF, Shibasaki M, Yabusaki K, Libby P, Shanahan CM, Croce K, Aikawa E.

Circ Res. 2013 Jun 21;113(1):72-7. doi: 10.1161/CIRCRESAHA.113.301036. Epub 2013 Apr 24.

50.

Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.

Liu Y, Drozdov I, Shroff R, Beltran LE, Shanahan CM.

Circ Res. 2013 May 10;112(10):e99-109. doi: 10.1161/CIRCRESAHA.111.300543. Epub 2013 Apr 5.

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