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Items: 19


TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.

Thornton P, Sevalle J, Deery MJ, Fraser G, Zhou Y, Ståhl S, Franssen EH, Dodd RB, Qamar S, Gomez Perez-Nievas B, Nicol LS, Eketjäll S, Revell J, Jones C, Billinton A, St George-Hyslop PH, Chessell I, Crowther DC.

EMBO Mol Med. 2017 Oct;9(10):1366-1378. doi: 10.15252/emmm.201707673.


A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.

Brethour D, Mehrabian M, Williams D, Wang X, Ghodrati F, Ehsani S, Rubie EA, Woodgett JR, Sevalle J, Xi Z, Rogaeva E, Schmitt-Ulms G.

Sci Rep. 2017 Jan 18;7:40313. doi: 10.1038/srep40313.


Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways.

Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH.

Mol Cell Neurosci. 2015 May;66(Pt A):3-11. doi: 10.1016/j.mcn.2015.02.016. Epub 2015 Mar 4. Review.


ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

Duplan E, Giaime E, Viotti J, Sévalle J, Corti O, Brice A, Ariga H, Qi L, Checler F, Alves da Costa C.

J Cell Sci. 2013 May 1;126(Pt 9):2124-33. doi: 10.1242/jcs.127340. Epub 2013 Feb 27.


Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.

Duplan E, Sevalle J, Viotti J, Goiran T, Bauer C, Renbaum P, Levy-Lahad E, Gautier CA, Corti O, Leroudier N, Checler F, da Costa CA.

J Mol Cell Biol. 2013 Apr;5(2):132-42. doi: 10.1093/jmcb/mjt003. Epub 2013 Jan 28.


Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein.

Peuchmaur M, Lacour MA, Sévalle J, Lisowski V, Touati-Jallabe Y, Rodier F, Martinez J, Checler F, Hernandez JF.

Bioorg Med Chem. 2013 Feb 15;21(4):1018-29. doi: 10.1016/j.bmc.2012.11.045. Epub 2012 Dec 5.


Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.

Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M.

J Neurosci. 2012 Aug 22;32(34):11820-34.


Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.

Flammang B, Pardossi-Piquard R, Sevalle J, Debayle D, Dabert-Gay AS, Thévenet A, Lauritzen I, Checler F.

J Alzheimers Dis. 2012;30(1):145-53. doi: 10.3233/JAD-2012-112186.


Galantamine-based hybrid molecules with acetylcholinesterase, butyrylcholinesterase and γ-secretase inhibition activities.

Vezenkov L, Sevalle J, Danalev D, Ivanov T, Bakalova A, Georgieva M, Checler F.

Curr Alzheimer Res. 2012 Jun;9(5):600-5.


p53-dependent control of transactivation of the Pen2 promoter by presenilins.

Dunys J, Sevalle J, Giaime E, Pardossi-Piquard R, Vitek MP, Renbaum P, Levy-Lahad E, Zhang YW, Xu H, Checler F, da Costa CA.

J Cell Sci. 2009 Nov 1;122(Pt 21):4003-8. doi: 10.1242/jcs.051169.


Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.

J Neurochem. 2009 Jul;110(1):275-83. doi: 10.1111/j.1471-4159.2009.06131.x. Epub 2009 Apr 29.


APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.

Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE.

J Biol Chem. 2009 Jun 12;284(24):16298-307. doi: 10.1074/jbc.M109.000067. Epub 2009 Apr 15.


Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide.

Sevalle J, Amoyel A, Robert P, Fournié-Zaluski MC, Roques B, Checler F.

J Neurochem. 2009 Apr;109(1):248-56. doi: 10.1111/j.1471-4159.2009.05950.x. Epub 2009 Feb 23.


TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.

Dolcini V, Dunys J, Sevalle J, Chen F, Guillot-Sestier MV, St George-Hyslop P, Fraser PE, Checler F.

Biochem Biophys Res Commun. 2008 Jun 20;371(1):69-74. doi: 10.1016/j.bbrc.2008.03.151. Epub 2008 Apr 9.


NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.


The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

Checler F, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Kawarai T, Girardot N, St George-Hyslop P, da Costa CA.

Curr Alzheimer Res. 2007 Sep;4(4):423-6. Review.


Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betAAPP and APLP." Neuron 46, 541-554.

Pardossi-Piquard R, Dunys J, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Sévalle J, Pimplikar S, St George-Hyslop P, Checler F.

Neuron. 2007 Feb 15;53(4):483-6. No abstract available.


p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.

Dunys J, Kawarai T, Sevalle J, Dolcini V, George-Hyslop PS, Da Costa CA, Checler F.

J Biol Chem. 2007 Apr 6;282(14):10516-25. Epub 2007 Feb 2.


Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Boyer N, Kawarai T, Girardot N, St George-Hyslop P, Checler F.

J Neurosci. 2006 Jun 7;26(23):6377-85.

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