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Daily muscle stretching enhances blood flow, endothelial function, capillarity, vascular volume and connectivity in aged skeletal muscle.

Hotta K, Behnke BJ, Arjmandi B, Ghosh P, Chen B, Brooks R, Maraj JJ, Elam ML, Maher P, Kurien D, Churchill A, Sepulveda JL, Kabolowsky MB, Christou DD, Muller-Delp JM.

J Physiol. 2018 Apr 5. doi: 10.1113/JP275459. [Epub ahead of print]


Direct and indirect nigrofugal projections to the nucleus reticularis pontis caudalis mediate in the motor execution of the acoustic startle reflex.

Hormigo S, López DE, Cardoso A, Zapata G, Sepúlveda J, Castellano O.

Brain Struct Funct. 2018 Mar 24. doi: 10.1007/s00429-018-1654-9. [Epub ahead of print]


Analysis of response rate with ANTI PD1/PD-L1 monoclonal antibodies in advanced solid tumors: a meta-analysis of randomized clinical trials.

Carretero-González A, Lora D, Ghanem I, Zugazagoitia J, Castellano D, Sepúlveda JM, López-Martin JA, Paz-Ares L, de Velasco G.

Oncotarget. 2018 Jan 20;9(9):8706-8715. doi: 10.18632/oncotarget.24283. eCollection 2018 Feb 2.


Universal health coverage and intersectoral action for health: key messages from Disease Control Priorities, 3rd edition.

Jamison DT, Alwan A, Mock CN, Nugent R, Watkins D, Adeyi O, Anand S, Atun R, Bertozzi S, Bhutta Z, Binagwaho A, Black R, Blecher M, Bloom BR, Brouwer E, Bundy DAP, Chisholm D, Cieza A, Cullen M, Danforth K, de Silva N, Debas HT, Donkor P, Dua T, Fleming KA, Gallivan M, Garcia PJ, Gawande A, Gaziano T, Gelband H, Glass R, Glassman A, Gray G, Habte D, Holmes KK, Horton S, Hutton G, Jha P, Knaul FM, Kobusingye O, Krakauer EL, Kruk ME, Lachmann P, Laxminarayan R, Levin C, Looi LM, Madhav N, Mahmoud A, Mbanya JC, Measham A, Medina-Mora ME, Medlin C, Mills A, Mills JA, Montoya J, Norheim O, Olson Z, Omokhodion F, Oppenheim B, Ord T, Patel V, Patton GC, Peabody J, Prabhakaran D, Qi J, Reynolds T, Ruacan S, Sankaranarayanan R, Sepúlveda J, Skolnik R, Smith KR, Temmerman M, Tollman S, Verguet S, Walker DG, Walker N, Wu Y, Zhao K.

Lancet. 2018 Mar 17;391(10125):1108-1120. doi: 10.1016/S0140-6736(17)32906-9. Epub 2017 Nov 25. Review.


Urothelial cancer proteomics provides both prognostic and functional information.

de Velasco G, Trilla-Fuertes L, Gamez-Pozo A, Urbanowicz M, Ruiz-Ares G, Sepúlveda JM, Prado-Vazquez G, Arevalillo JM, Zapater-Moros A, Navarro H, Lopez-Vacas R, Manneh R, Otero I, Villacampa F, Paramio JM, Vara JAF, Castellano D.

Sci Rep. 2017 Nov 17;7(1):15819. doi: 10.1038/s41598-017-15920-6.


Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model.

Riquelme G, Sepúlveda JM, Al Ghumgham Z, Del Campo M, Montero C, Lagos N.

Toxicon. 2018 Jan;141:15-17. doi: 10.1016/j.toxicon.2017.11.004. Epub 2017 Nov 13.


Bacteriohopanepolyols along redox gradients in the Humboldt Current System off northern Chile.

Matys ED, Sepúlveda J, Pantoja S, Lange CB, Caniupán M, Lamy F, Summons RE.

Geobiology. 2017 Nov;15(6):844-857. doi: 10.1111/gbi.12250. Epub 2017 Aug 3.


A Prospective Observational Study for Assessment and Outcome Association of Circulating Endothelial Cells in Clear Cell Renal Cell Carcinoma Patients Who Show Initial Benefit from First-line Treatment. The CIRCLES (CIRCuLating Endothelial cellS) Study (SOGUG-CEC-2011-01).

García-Donas J, Leon LA, Esteban E, Vidal-Mendez MJ, Arranz JA, Garcia Del Muro X, Basterretxea L, González Del Alba A, Climent MA, Virizuela JA, Álvarez C, Sepúlveda J, Anido U, López C, Ortiz-Morales MJ, Pérez X, Rodriguez-Antona C, Rodriguez-Moreno JF, Hernando S, Castellano D.

Eur Urol Focus. 2017 Oct;3(4-5):430-436. doi: 10.1016/j.euf.2016.09.004. Epub 2016 Oct 4.


Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer.

González-Billalabeitia E, Sepúlveda JM, Maroto P, Aparicio J, Arranz JA, Esteban E, Gironés R, López-Brea M, Mendez-Vidal MJ, Pinto A, Sastre J, de Prado DS, Terrasa J, Vázquez S, Powles T, Beyer J, Castellano D, Del Muro XG; Spanish Germ Cell Cancer Group and the Spanish Oncology Genitourinary Group.

Eur Urol Focus. 2017 Apr;3(2-3):280-286. doi: 10.1016/j.euf.2016.07.002. Epub 2016 Jul 18.


Global health: Towards polio eradication.

Sepúlveda J.

Nature. 2017 Jul 26;547(7664):411-412. doi: 10.1038/547411a. No abstract available.


Testing the Abbreviated Food Technology Neophobia Scale and its relation to satisfaction with food-related life in university students.

Schnettler B, Grunert KG, Miranda-Zapata E, Orellana L, Sepúlveda J, Lobos G, Hueche C, Höger Y.

Food Res Int. 2017 Jun;96:198-205. doi: 10.1016/j.foodres.2017.04.003. Epub 2017 Apr 6.


Food neophobia, life satisfaction and family eating habits in university students.

Schnettler B, Höger Y, Orellana L, Miranda H, Lobos G, Sepúlveda J, Sanchez M, Miranda-Zapata E, Denegri M, Grunert KG, Salinas-Oñate N.

Cad Saude Publica. 2017 Apr 3;33(3):e00165615. doi: 10.1590/0102-311X00165615.


Exercise training reverses age-induced diastolic dysfunction and restores coronary microvascular function.

Hotta K, Chen B, Behnke BJ, Ghosh P, Stabley JN, Bramy JA, Sepulveda JL, Delp MD, Muller-Delp JM.

J Physiol. 2017 Jun 15;595(12):3703-3719. doi: 10.1113/JP274172. Epub 2017 May 23.


Longitudinal multigroup invariance analysis of the satisfaction with food-related life scale in university students.

Schnettler B, Miranda H, Miranda-Zapata E, Salinas-Oñate N, Grunert KG, Lobos G, Sepúlveda J, Orellana L, Hueche C, Bonilla H.

Appetite. 2017 Jun 1;113:91-99. doi: 10.1016/j.appet.2017.02.020. Epub 2017 Feb 17.


Results of a multicenter survey showing interindividual variability among neurosurgeons when deciding on the radicality of surgical resection in glioblastoma highlight the need for more objective guidelines.

Capellades J, Teixidor P, Villalba G, Hostalot C, Plans G, Armengol R, Medrano S, Estival A, Luque R, Gonzalez S, Gil-Gil M, Villa S, Sepulveda J, García-Mosquera JJ, Balana C.

Clin Transl Oncol. 2017 Jun;19(6):727-734. doi: 10.1007/s12094-016-1598-6. Epub 2016 Dec 22.


Isolated Double Chambered Right Ventricle in an Adult Imaged With Magnetic Resonance.

Vaikunth SS, Sepulveda JS, Shinbane JS, Chang PM.

World J Pediatr Congenit Heart Surg. 2016 Nov;7(6):758-760. Epub 2016 Sep 13. No abstract available.


Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region.

Sepulveda JA, Turpin A, McKendrick AM.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4772-8. doi: 10.1167/iovs.16-19288.


The Wide Experience of the Sequential Therapy for Patients with Metastatic Renal Cell Carcinoma.

Lambea J, Anido U, Etxániz O, Flores L, Montesa Á, Sepúlveda JM, Esteban E.

Curr Oncol Rep. 2016 Nov;18(11):66. doi: 10.1007/s11912-016-0553-6. Review.


Mexico's path towards the Sustainable Development Goal for health: an assessment of the feasibility of reducing premature mortality by 40% by 2030.

González-Pier E, Barraza-Lloréns M, Beyeler N, Jamison D, Knaul F, Lozano R, Yamey G, Sepúlveda J.

Lancet Glob Health. 2016 Oct;4(10):e714-25. doi: 10.1016/S2214-109X(16)30181-4. Epub 2016 Aug 30.


Geometrical Measures Obtained from Pretreatment Postcontrast T1 Weighted MRIs Predict Survival Benefits from Bevacizumab in Glioblastoma Patients.

Molina D, Pérez-Beteta J, Martínez-González A, Sepúlveda JM, Peralta S, Gil-Gil MJ, Reynes G, Herrero A, De Las Peñas R, Luque R, Capellades J, Balaña C, Pérez-García VM.

PLoS One. 2016 Aug 24;11(8):e0161484. doi: 10.1371/journal.pone.0161484. eCollection 2016.


Biochemical indices of oxidative stress and inflammation in the evaluation of peripheral artery disease.

Fort-Gallifa I, García-Heredia A, Hernández-Aguilera A, Simó JM, Sepúlveda J, Martín-Paredero V, Camps J, Joven J.

Free Radic Biol Med. 2016 Aug;97:568-576. doi: 10.1016/j.freeradbiomed.2016.07.011. Epub 2016 Jul 19.


Gonyautoxins: First evidence in pain management in total knee arthroplasty.

Hinzpeter J, Barrientos C, Zamorano Á, Martinez Á, Palet M, Wulf R, Barahona M, Sepúlveda JM, Guerra M, Bustamante T, Del Campo M, Tapia E, Lagos N.

Toxicon. 2016 Sep 1;119:180-5. doi: 10.1016/j.toxicon.2016.06.010. Epub 2016 Jun 15.


Temozolomide induces radiologic pseudoprogression and tumor cell vanishing in oligodendroglioma.

Hernandez-Lain A, Hilario A, Sepulveda JM, Cantero D, Ramos A, Perez-Nuñez A.

Neurology. 2016 Jul 5;87(1):114-5. doi: 10.1212/WNL.0000000000002810. Epub 2016 Jun 1. No abstract available.


Well-Differentiated Grade 2, Type 3 Gastrointestinal Neuroendocrine Tumour with Bilateral Metastatic Ovarian Involvement: Report of an Unusual Case.

Manneh R, Castellano D, Caso O, Loinaz C, Jiménez J, Estenoz J, Calatayud M, Sepúlveda JM, García-Carbonero R.

Case Rep Oncol. 2016 Apr 27;9(1):255-61. doi: 10.1159/000445940. eCollection 2016 Jan-Apr.


Hábitos de alimentación familiar, apoyo familiar y bienestar subjetivo en estudiantes universitarios en Chile.

Schnettler B, Höger Y, Orellana L, Sepúlveda J, Salinas-Oñate N, Lobos G, Grunert KG.

Nutr Hosp. 2016 Mar 25;33(2):131. doi: 10.20960/nh.131. Spanish.


Characterisation of the triple negative breast cancer phenotype associated with the development of central nervous system metastases.

Laimito KR, Gámez-Pozo A, Sepúlveda J, Manso L, López-Vacas R, Pascual T, Fresno Vara JA, Ciruelos E.

Ecancermedicalscience. 2016 Apr 11;10:632. doi: 10.3332/ecancer.2016.632. eCollection 2016. Review.


Leakage decrease detected by dynamic susceptibility-weighted contrast-enhanced perfusion MRI predicts survival in recurrent glioblastoma treated with bevacizumab.

Hilario A, Sepulveda JM, Hernandez-Lain A, Salvador E, Koren L, Manneh R, Ruano Y, Perez-Nuñez A, Lagares A, Ramos A.

Clin Transl Oncol. 2017 Jan;19(1):51-57. doi: 10.1007/s12094-016-1502-4. Epub 2016 Mar 30.


Bevacizumab and temozolomide versus temozolomide alone as neoadjuvant treatment in unresected glioblastoma: the GENOM 009 randomized phase II trial.

Balana C, De Las Penas R, Sepúlveda JM, Gil-Gil MJ, Luque R, Gallego O, Carrato C, Sanz C, Reynes G, Herrero A, Ramirez JL, Pérez-Segura P, Berrocal A, Vieitez JM, Garcia A, Vazquez-Estevez S, Peralta S, Fernandez I, Henriquez I, Martinez-Garcia M, De la Cruz JJ, Capellades J, Giner P, Villà S.

J Neurooncol. 2016 May;127(3):569-79. doi: 10.1007/s11060-016-2065-5. Epub 2016 Feb 3.


Dietary restraint and self-discrepancy in male university students.

Orellana L, Grunert KG, Sepúlveda J, Lobos G, Denegri M, Miranda H, Adasme-Berríos C, Mora M, Etchebarne S, Salinas-Oñate N, Schnettler B.

Eat Behav. 2016 Apr;21:123-8. doi: 10.1016/j.eatbeh.2016.01.005. Epub 2016 Jan 26.


High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.

Sepulveda JL, Gutierrez-Pajares JL, Luna A, Yao Y, Tobias JW, Thomas S, Woo Y, Giorgi F, Komissarova EV, Califano A, Wang TC, Sepulveda AR.

Mod Pathol. 2016 Feb;29(2):182-93. doi: 10.1038/modpathol.2015.144. Epub 2016 Jan 15.


[Global health 2035: implications for Mexico (commentary)].

Beyeler N, González-Pier E, Alleyne G, Barraza-Lloréns M, Frenk J, Pablos-Mendez A, Pérez-Cuevas R, Regalia F, Sepúlveda J, Jamison D, Yamey G.

Salud Publica Mex. 2015 Sep-Oct;57(5):441-3. Spanish. No abstract available.


GEINOFOTE: efficacy and safety of fotemustine in patients with high-grade recurrent gliomas and poor performance status.

Pérez-Segura P, Manneh R, Ceballos I, García A, Benavides M, Fuster J, Vaz MA, Cano JM, Berros JP, Covela M, Moreno V, Quintanar T, García Bueno JM, Fernández I, Sepúlveda J.

Clin Transl Oncol. 2016 Aug;18(8):805-12. doi: 10.1007/s12094-015-1444-2. Epub 2015 Nov 5.


Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil: data from the Brazilian Type 1 Diabetes Study Group.

Felício JS, de Souza AC, Koury CC, Neto JF, Miléo KB, Santos FM, Motta AR, Silva DD, Arbage TP, Carvalho CT, de Rider Brito HA, Yamada ES, Cobas RA, Matheus A, Tannus L, Palma CC, Japiassu L, Carneiro JR, Rodacki M, Zajdenverg L, de Araújo NB, de Menezes Cordeiro M, Luescher JL, Berardo RS, Nery M, Cani C, do Carmo Arruda Marques M, Calliari LE, de Noronha RM, Manna TD, Savoldelli R, Penha FG, Foss MC, Foss-Freitas MC, Pires AC, Robles FC, Negrato CA, de Fatima Guedes M, Dib SA, Dualib P, da Silva SC, Sepúlveda J, Sampaio E, Rea RR, de Almeida Faria AC, Tschiedel B, Lavigne S, Cardozo GA, Azevedo M, Canani LH, Zucatti AT, Coral MH, Pereira DA, de Araujo LA, Pedrosa HC, Tolentino M, Prado FA, Rassi N, de Araujo LB, Fonseca RM, Guedes AD, de Mattos OS, Faria M, Azulay R, E Forti AC, Façanha CF, Junior RM, Montenegro AP, Melo NH, Rezende KF, Ramos A, Jezini DL, Gomes MB; Brazilian Type 1 Diabetes Study Group (BrazDiab1SG).

Diabetol Metab Syndr. 2015 Oct 6;7:87. doi: 10.1186/s13098-015-0081-9. eCollection 2015.


CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration.

Tristão FS, Lazzarini M, Martin S, Amar M, Stühmer W, Kirchhoff F, Gomes LA, Lanfumey L, Prediger RD, Sepulveda JE, Del-Bel EA, Raisman-Vozari R.

Neurotox Res. 2016 Apr;29(3):364-80. doi: 10.1007/s12640-015-9557-5. Epub 2015 Sep 24.


Customizing Structure-Function Displacements in the Macula for Individual Differences.

Turpin A, Chen S, Sepulveda JA, McKendrick AM.

Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5984-9. doi: 10.1167/iovs.15-17384.


Mutational analysis by next generation sequencing of gastric type dysplasia occurring in hyperplastic polyps of the stomach: Mutations in gastric hyperplastic polyps.

Salomao M, Luna AM, Sepulveda JL, Sepulveda AR.

Exp Mol Pathol. 2015 Dec;99(3):468-73. doi: 10.1016/j.yexmp.2015.08.014. Epub 2015 Aug 29.


[Hyper-immunoglobulin E syndrome: report of one case].

Aguilera G, Cárcamo G, Sepúlveda J, Vinet AM, Martínez C.

Rev Med Chil. 2015 Jun;143(6):801-4. doi: 10.4067/S0034-98872015000600014. Spanish.


[Epidermic growth factor receptor (EGFR) in glioblastomas: the mechanism of tumorigenesis and its role as a therapeutic target].

Zahonero C, Sepúlveda JM, Sánchez-Gómez P.

Rev Neurol. 2015 Jul 16;61(2):85-93. Review. Spanish.


Nature and nurture in atherosclerosis: The roles of acylcarnitine and cell membrane-fatty acid intermediates.

Blair HC, Sepulveda J, Papachristou DJ.

Vascul Pharmacol. 2016 Mar;78:17-23. doi: 10.1016/j.vph.2015.06.012. Epub 2015 Jun 30. Review.


Sequential treatments in hereditary leiomyomatosis and renal cell carcinoma (HLRCC): Case report and review of the literature.

de Velasco G, Munoz C, Sepulveda JM, Castellano D.

Can Urol Assoc J. 2015 Mar-Apr;9(3-4):E243-6. doi: 10.5489/cuaj.2264.


Analyzing Food-Related Life Satisfaction and other Predictors of Life Satisfaction in Central Chile.

Schnettler B, Lobos G, Orellana L, Grunert K, Sepúlveda J, Mora M, Denegri M, Miranda H.

Span J Psychol. 2015 Jun 17;18:E38. doi: 10.1017/sjp.2015.32.


Evaluation of Mutational Testing of Preneoplastic Barrett's Mucosa by Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus.

Del Portillo A, Lagana SM, Yao Y, Uehara T, Jhala N, Ganguly T, Nagy P, Gutierrez J, Luna A, Abrams J, Liu Y, Brand R, Sepulveda JL, Falk GW, Sepulveda AR.

J Mol Diagn. 2015 Jul;17(4):412-9. doi: 10.1016/j.jmoldx.2015.02.006. Epub 2015 Jun 8.


Relationship between the domains of the Multidimensional Students' Life Satisfaction Scale, satisfaction with food-related life and happiness in university students.

Schnettler B, Orellana L, Lobos G, Miranda H, Sepúlveda J, Etchebarne S, Mora M, Adasme-Berríos C, Grunert KG.

Nutr Hosp. 2015 Jun 1;31(6):2752-63. doi: 10.3305/nh.2015.31.6.8593.


A phase II study of feasibility and toxicity of bevacizumab in combination with temozolomide in patients with recurrent glioblastoma.

Sepúlveda JM, Belda-Iniesta C, Gil-Gil M, Pérez-Segura P, Berrocal A, Reynés G, Gallego O, Capellades J, Ordoñez JM, La Orden B, Balañá C.

Clin Transl Oncol. 2015 Sep;17(9):743-50. doi: 10.1007/s12094-015-1304-0. Epub 2015 Jun 2.


Molecular and histologic considerations in the assessment of serrated polyps.

Yang HM, Mitchell JM, Sepulveda JL, Sepulveda AR.

Arch Pathol Lab Med. 2015 Jun;139(6):730-41. doi: 10.5858/arpa.2014-0424-RA. Review.


Immunohistochemical analysis of paraoxonases and chemokines in arteries of patients with peripheral artery disease.

Hernández-Aguilera A, Sepúlveda J, Rodríguez-Gallego E, Guirro M, García-Heredia A, Cabré N, Luciano-Mateo F, Fort-Gallifa I, Martín-Paredero V, Joven J, Camps J.

Int J Mol Sci. 2015 May 18;16(5):11323-38. doi: 10.3390/ijms160511323.


Capreomycin oleate microparticles for intramuscular administration: Preparation, in vitro release and preliminary in vivo evaluation.

Cambronero-Rojas A, Torres-Vergara P, Godoy R, von Plessing C, Sepúlveda J, Gómez-Gaete C.

J Control Release. 2015 Jul 10;209:229-37. doi: 10.1016/j.jconrel.2015.05.001. Epub 2015 May 5.


Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma.

Zahonero C, Aguilera P, Ramírez-Castillejo C, Pajares M, Bolós MV, Cantero D, Perez-Nuñez A, Hernández-Laín A, Sánchez-Gómez P, Sepúlveda JM.

Mol Cancer Ther. 2015 Jul;14(7):1548-58. doi: 10.1158/1535-7163.MCT-14-0736. Epub 2015 May 4.


Long-term survival in a patient with progressive multifocal leukoencephalopathy after therapy with rituximab, fludarabine and cyclophosphamide for chronic lymphocytic leukemia.

Garrote H, de la Fuente A, Oña R, Rodríguez I, Echevarría JE, Sepúlveda JM, García JF.

Exp Hematol Oncol. 2015 Mar 1;4:8. doi: 10.1186/s40164-015-0003-4. eCollection 2015.


Eating habits and subjective well-being. A typology of students in Chilean state universities.

Schnettler B, Miranda H, Lobos G, Orellana L, Sepúlveda J, Denegri M, Etchebarne S, Mora M, Grunert KG.

Appetite. 2015 Jun;89:203-14. doi: 10.1016/j.appet.2015.02.008. Epub 2015 Feb 9.


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