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Items: 1 to 50 of 79

1.

Mechanisms of cancer resistance in long-lived mammals.

Seluanov A, Gladyshev VN, Vijg J, Gorbunova V.

Nat Rev Cancer. 2018 Apr 5. doi: 10.1038/s41568-018-0004-9. [Epub ahead of print] Review.

PMID:
29622806
2.

Accurate translation is important for longevity.

Ke Z, Seluanov A, Gorbunova V.

Aging (Albany NY). 2018 Mar 12;10(3):297-298. doi: 10.18632/aging.101398. No abstract available.

3.

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1801-1806. doi: 10.1073/pnas.1721160115. Epub 2018 Feb 5.

PMID:
29432174
4.

Evolution of telomere maintenance and tumour suppressor mechanisms across mammals.

Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160443. doi: 10.1098/rstb.2016.0443.

PMID:
29335367
5.

Cross-species Comparison of Proteome Turnover Kinetics.

Swovick K, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S.

Mol Cell Proteomics. 2018 Apr;17(4):580-591. doi: 10.1074/mcp.RA117.000574. Epub 2018 Jan 10.

6.

Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming.

Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V.

Stem Cell Reports. 2017 Nov 14;9(5):1721-1734. doi: 10.1016/j.stemcr.2017.10.001. Epub 2017 Oct 26.

7.

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.

Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD.

Oncogene. 2018 Jan 25;37(4):427-438. doi: 10.1038/onc.2017.340. Epub 2017 Oct 2.

8.

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species.

Tian X, Seluanov A, Gorbunova V.

Trends Endocrinol Metab. 2017 Oct;28(10):722-734. doi: 10.1016/j.tem.2017.07.004. Epub 2017 Sep 7. Review.

PMID:
28888702
9.

Translation fidelity coevolves with longevity.

Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V.

Aging Cell. 2017 Oct;16(5):988-993. doi: 10.1111/acel.12628. Epub 2017 Jul 13.

10.

Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging.

Tian X, Seluanov A, Gorbunova V.

Cell Metab. 2017 May 2;25(5):991-992. doi: 10.1016/j.cmet.2017.04.022.

PMID:
28467943
11.

Non-canonical aging model systems and why we need them.

Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V.

EMBO J. 2017 Apr 13;36(8):959-963. doi: 10.15252/embj.201796837. Epub 2017 Mar 20. Review. No abstract available.

12.

A review of the biomedical innovations for healthy longevity.

Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A.

Aging (Albany NY). 2017 Jan 29;9(1):7-25. doi: 10.18632/aging.101163. No abstract available.

13.

Lipidome determinants of maximal lifespan in mammals.

Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P.

Sci Rep. 2017 Jan 31;7(1):5. doi: 10.1038/s41598-017-00037-7.

14.

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN.

Elife. 2016 Nov 22;5. pii: e19130. doi: 10.7554/eLife.19130.

15.

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.

Cell Rep. 2016 Sep 6;16(10):2641-2650. doi: 10.1016/j.celrep.2016.08.006. Epub 2016 Aug 25.

16.

Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM.

Dokukin M, Ablaeva Y, Kalaparthi V, Seluanov A, Gorbunova V, Sokolov I.

Biophys J. 2016 Jul 12;111(1):236-46. doi: 10.1016/j.bpj.2016.06.005.

17.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

18.

Dangerous Entrapment for NRF2.

Gorbunova V, Rezazadeh S, Seluanov A.

Cell. 2016 Jun 2;165(6):1312-1313. doi: 10.1016/j.cell.2016.05.061.

19.

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coşkun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V.

Aging (Albany NY). 2016 May;8(5):841-7. doi: 10.18632/aging.100958.

20.

DNA double strand break repair, aging and the chromatin connection.

Gorbunova V, Seluanov A.

Mutat Res. 2016 Jun;788:2-6. doi: 10.1016/j.mrfmmm.2016.02.004. Epub 2016 Feb 15. Review.

21.

DNA repair in species with extreme lifespan differences.

MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J.

Aging (Albany NY). 2015 Dec;7(12):1171-84.

22.

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN.

Cell Rep. 2015 Nov 17;13(7):1319-1326. doi: 10.1016/j.celrep.2015.10.014. Epub 2015 Nov 5.

23.

Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A, Mattheus T, Schmidt H, Seluanov A, Azpurua J, McGowen MR, Ben Jacob E, Li K, Peng S, Zhu X, Liao X, Li S, Krogh A, Zhou X, Brodsky L, Wang J.

Nat Commun. 2015 Aug 12;6:8051. doi: 10.1038/ncomms9051. No abstract available.

PMID:
26264976
24.

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.

MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD.

Aging Cell. 2015 Apr;14(2):288-91. doi: 10.1111/acel.12314. Epub 2015 Jan 28.

25.

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner.

Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z.

Cell Cycle. 2015;14(2):269-76. doi: 10.4161/15384101.2014.980641.

26.

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.

Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1053-8. doi: 10.1073/pnas.1418203112. Epub 2014 Dec 30.

27.

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

Van Meter M, Kashyap M, Rezazadeh S, Geneva AJ, Morello TD, Seluanov A, Gorbunova V.

Nat Commun. 2014 Sep 23;5:5011. doi: 10.1038/ncomms6011.

28.

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.

Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM, de Magalhães JP.

Bioinformatics. 2014 Dec 15;30(24):3558-60. doi: 10.1093/bioinformatics/btu579. Epub 2014 Aug 28.

29.

Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age.

Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V.

PLoS Genet. 2014 Jul 17;10(7):e1004511. doi: 10.1371/journal.pgen.1004511. eCollection 2014 Jul.

30.

SIRT6: a promising target for cancer prevention and therapy.

Van Meter M, Gorbunova V, Seluanov A.

Adv Exp Med Biol. 2014;818:181-96. doi: 10.1007/978-1-4471-6458-6_9. Review.

PMID:
25001537
31.

Comparative genetics of longevity and cancer: insights from long-lived rodents.

Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J.

Nat Rev Genet. 2014 Aug;15(8):531-40. doi: 10.1038/nrg3728. Epub 2014 Jul 1. Review.

32.

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A, Mattheus T, Schmidt H, Seluanov A, Azpurua J, McGowen MR, Ben Jacob E, Li K, Peng S, Zhu X, Liao X, Li S, Krogh A, Zhou X, Brodsky L, Wang J.

Nat Commun. 2014 Jun 3;5:3966. doi: 10.1038/ncomms4966. Erratum in: Nat Commun. 2015;6:8051.

PMID:
24892994
33.

Regulation of Rad51 promoter.

Hine CM, Li H, Xie L, Mao Z, Seluanov A, Gorbunova V.

Cell Cycle. 2014;13(13):2038-45. doi: 10.4161/cc.29016. Epub 2014 Apr 29.

34.

Utilization of Rad51C promoter for transcriptional targeting of cancer cells.

Cao Y, Xu Y, Zhang L, Li Z, Jiang Y, Tian X, Seluanov A, Gorbunova V, Mao Z.

Oncotarget. 2014 Apr 15;5(7):1805-11.

35.

Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups.

Ke Z, Vaidya A, Ascher J, Seluanov A, Gorbunova V.

J Am Assoc Lab Anim Sci. 2014 Jan;53(1):89-91.

36.

Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.

Azpurua J, Ke Z, Chen IX, Zhang Q, Ermolenko DN, Zhang ZD, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17350-5. doi: 10.1073/pnas.1313473110. Epub 2013 Sep 30.

37.

Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging.

Yang JN, Seluanov A, Gorbunova V.

PLoS One. 2013 Sep 17;8(9):e73318. doi: 10.1371/journal.pone.0073318. eCollection 2013.

38.

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.

Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A.

Nature. 2013 Jul 18;499(7458):346-9. doi: 10.1038/nature12234. Epub 2013 Jun 19.

39.

IGF1R levels in the brain negatively correlate with longevity in 16 rodent species.

Azpurua J, Yang JN, Van Meter M, Liu Z, Kim J, Lobo Ladd AA, Coppi AA, Gorbunova V, Seluanov A.

Aging (Albany NY). 2013 Apr;5(4):304-14.

40.

Long-lived cancer-resistant rodents as new model species for cancer research.

Azpurua J, Seluanov A.

Front Genet. 2013 Jan 9;3:319. doi: 10.3389/fgene.2012.00319. eCollection 2012.

41.

 Forever young?  Exploring the link between rapamycin, longevity and cancer.

Van Meter M, Seluanov A, Gorbunova V.

Cell Cycle. 2012 Dec 1;11(23):4296-7. doi: 10.4161/cc.22868. Epub 2012 Nov 14. No abstract available.

42.

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism.

Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19392-6. doi: 10.1073/pnas.1217211109. Epub 2012 Nov 5.

43.

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11800-5. doi: 10.1073/pnas.1200583109. Epub 2012 Jul 2.

44.

Replicatively senescent cells are arrested in G1 and G2 phases.

Mao Z, Ke Z, Gorbunova V, Seluanov A.

Aging (Albany NY). 2012 Jun;4(6):431-5.

45.

The second international conference "genetics of aging and longevity".

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P.

Aging (Albany NY). 2012 May;4(5):305-17. No abstract available.

46.

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S.

PLoS One. 2011;6(12):e28714. doi: 10.1371/journal.pone.0028714. Epub 2011 Dec 9.

47.

Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.

Hine CM, Seluanov A, Gorbunova V.

Mol Ther. 2012 Feb;20(2):347-55. doi: 10.1038/mt.2011.215. Epub 2011 Oct 18.

48.

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.

Van Meter M, Mao Z, Gorbunova V, Seluanov A.

Aging (Albany NY). 2011 Sep;3(9):829-35. Review.

49.

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.

Van Meter M, Mao Z, Gorbunova V, Seluanov A.

Cell Cycle. 2011 Sep 15;10(18):3153-8. Epub 2011 Sep 15.

50.

SIRT6 promotes DNA repair under stress by activating PARP1.

Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V.

Science. 2011 Jun 17;332(6036):1443-6. doi: 10.1126/science.1202723.

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