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New blood: Creative funding of disease-specific research.

Seaman WE, Locksley RM, Welsh MJ.

Sci Transl Med. 2015 May 20;7(288):288ed5. doi: 10.1126/scitranslmed.aaa9513. No abstract available.


Traumatic brain injury induces macrophage subsets in the brain.

Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE.

Eur J Immunol. 2013 Aug;43(8):2010-22. doi: 10.1002/eji.201243084. Epub 2013 Jun 5.


Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.

Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV.

PLoS One. 2011;6(8):e23800. doi: 10.1371/journal.pone.0023800. Epub 2011 Aug 19.


Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.

Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE.

J Biol Chem. 2011 Jan 14;286(2):942-51. doi: 10.1074/jbc.M110.198200. Epub 2010 Oct 29.


Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2.

Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE.

J Leukoc Biol. 2010 Jun;87(6):1041-57. doi: 10.1189/jlb.1108708. Epub 2010 Mar 3.


Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3505-10. doi: 10.1073/pnas.0913192107. Epub 2010 Feb 4.


A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.

Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE.

J Neurochem. 2009 May;109(4):1144-56. doi: 10.1111/j.1471-4159.2009.06042.x. Epub 2009 Mar 19.


TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.

N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE.

J Cell Biol. 2009 Jan 26;184(2):215-23. doi: 10.1083/jcb.200808080.


Tim-2 is the receptor for H-ferritin on oligodendrocytes.

Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR.

J Neurochem. 2008 Dec;107(6):1495-505. doi: 10.1111/j.1471-4159.2008.05678.x. Epub 2008 Nov 5.


Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.

Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE.

J Biol Chem. 2008 Jun 20;283(25):17351-61. doi: 10.1074/jbc.M800907200. Epub 2008 Apr 14.


The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.

Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD.

Infect Immun. 2008 Jun;76(6):2439-47. doi: 10.1128/IAI.00115-08. Epub 2008 Apr 7.


Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL.

J Immunol. 2006 Aug 15;177(4):2051-5.


TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.

Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC.

J Bone Miner Res. 2006 Feb;21(2):237-45. Epub 2005 Oct 20.


Clinical academic rheumatology: comment on the article by Wickersham et al.

Seaman WE.

Arthritis Rheum. 2005 Oct 15;53(5):800; author reply 800-1. No abstract available.


TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.

Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR.

J Exp Med. 2005 Oct 3;202(7):955-65.


Expression and activation of signal regulatory protein alpha on astrocytomas.

Chen TT, Brown EJ, Huang EJ, Seaman WE.

Cancer Res. 2004 Jan 1;64(1):117-27.


CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation.

Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR.

J Immunol. 2003 Dec 15;171(12):6541-8.


Pattern recognition by TREM-2: binding of anionic ligands.

Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE.

J Immunol. 2003 Jul 15;171(2):594-9.


Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.


Ligand interactions by activating and inhibitory Ly-49 receptors.

Nakamura MC, Seaman WE.

Immunol Rev. 2001 Jun;181:138-48. Review.


Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.

Daws MR, Lanier LL, Seaman WE, Ryan JC.

Eur J Immunol. 2001 Mar;31(3):783-91.


Natural killer cells and natural killer T cells.

Seaman WE.

Arthritis Rheum. 2000 Jun;43(6):1204-17. Review.


Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor.

Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC.

J Immunol. 1999 Nov 1;163(9):4694-700.


Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity.

Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE.

J Exp Med. 1999 Feb 1;189(3):493-500.


DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.

McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH.

J Biol Chem. 1998 Dec 4;273(49):32934-42.


The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.

Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K.

J Immunol. 1998 Jun 15;160(12):5971-8.


Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology.

Rolstad B, Seaman WE.

Scand J Immunol. 1998 May;47(5):412-25. Review. No abstract available.


Divergent functions of lectin-like receptors on NK cells.

Ryan JC, Seaman WE.

Immunol Rev. 1997 Feb;155:79-89. Review.


Recognition and signaling by mouse Ly-49 receptors.

Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E.

Chem Immunol. 1996;64:19-27. Review. No abstract available.


NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity.

Ryan JC, Niemi EC, Nakamura MC, Seaman WE.

J Exp Med. 1995 May 1;181(5):1911-5.


A family of murine NK cell receptors specific for target cell MHC class I molecules.

Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR.

Semin Immunol. 1995 Apr;7(2):89-101. Review.


Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain.

Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE.

Immunity. 1994 Dec;1(9):785-92.


A natural killer cell receptor specific for a major histocompatibility complex class I molecule.

Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM.

J Exp Med. 1994 Aug 1;180(2):687-92.


Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules.

Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE.

J Immunol. 1992 Sep 1;149(5):1631-5.


NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium.

Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE.

J Immunol. 1991 Nov 1;147(9):3244-50.


cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.

Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE.

J Immunol. 1991 Nov 1;147(9):3229-36.


Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line.

Goldfien RD, Seaman WE, Hempel WM, Imboden JB.

J Immunol. 1991 Jun 1;146(11):3703-8.


Characterization of signal-transducing molecules on natural killer cells.

Imboden JB, Bell G, Seaman WE.

Biochem Soc Trans. 1991 Apr;19(2):265-8. No abstract available.


Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells.

Imboden JB, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE.

J Immunol. 1989 Nov 1;143(9):3100-3.


Selective manipulation of the immune response in vivo by monoclonal antibodies.

Seaman WE, Wofsy D.

Annu Rev Med. 1988;39:231-41. Review.


Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes.

Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH.

Ann N Y Acad Sci. 1988;524:345-55. Review. No abstract available.


Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder.

Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE.

Arthritis Rheum. 1987 Sep;30(9):1040-5.


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