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Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.

Moon H, Donahue LR, Choi E, Scumpia PO, Lowry WE, Grenier JK, Zhu J, White AC.

Cell Stem Cell. 2017 Nov 2;21(5):665-678.e6. doi: 10.1016/j.stem.2017.09.001. Epub 2017 Oct 12.


Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.

Purbey PK, Scumpia PO, Kim PJ, Tong AJ, Iwamoto KS, McBride WH, Smale ST.

Immunity. 2017 Sep 19;47(3):421-434.e3. doi: 10.1016/j.immuni.2017.08.017.


Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation.

Song C, Piva M, Sun L, Hong A, Moriceau G, Kong X, Zhang H, Lomeli S, Qian J, Yu CC, Damoiseaux R, Kelley MC, Dahlman KB, Scumpia PO, Sosman JA, Johnson DB, Ribas A, Hugo W, Lo RS.

Cancer Discov. 2017 Nov;7(11):1248-1265. doi: 10.1158/2159-8290.CD-17-0401. Epub 2017 Sep 1.


A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L.

Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030.


Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.

Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST.

PLoS Pathog. 2017 Jul 13;13(7):e1006496. doi: 10.1371/journal.ppat.1006496. eCollection 2017 Jul.


Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2627-35. doi: 10.1073/pnas.1515793113. Epub 2016 Apr 25.


Systematic evaluation of natural scaffolds in cutaneous wound healing.

Cam C, Zhu S, Truong NF, Scumpia PO, Segura T.

J Mater Chem B. 2015 Oct 28;3(40):7986-7992. Epub 2015 Aug 21.


Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality.

Wynn JL, Scumpia PO, Stocks BT, Romano-Keeler J, Alrifai MW, Liu JH, Kim AS, Alford CE, Matta P, Weitkamp JH, Moore DJ.

J Immunol. 2015 Aug 1;195(3):1064-70. doi: 10.4049/jimmunol.1500771. Epub 2015 Jun 22.


Papules on the face and body.

Anastasiou C, Scumpia PO, Smart C, Young LC.

Cutis. 2015 May;95(5):E22-4. No abstract available.


Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks.

Griffin DR, Weaver WM, Scumpia PO, Di Carlo D, Segura T.

Nat Mater. 2015 Jul;14(7):737-44. doi: 10.1038/nmat4294. Epub 2015 Jun 1.


TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.

Cuenca AG, Joiner DN, Gentile LF, Cuenca AL, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Behrns KE, Efron PA, Nacionales D, Lui C, Wallet SM, Reeves WH, Mathews CE, Moldawer LL.

J Immunol. 2015 Feb 1;194(3):1169-77. doi: 10.4049/jimmunol.1302676. Epub 2014 Dec 29.


Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis.

Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M.

J Invest Dermatol. 2015 Jan;135(1):151-159. doi: 10.1038/jid.2014.352. Epub 2014 Aug 11.


Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.

Cuenca AG, Cuenca AL, Winfield RD, Joiner DN, Gentile L, Delano MJ, Kelly-Scumpia KM, Scumpia PO, Matheny MK, Scarpace PJ, Vila L, Efron PA, LaFace DM, Moldawer LL.

J Immunol. 2014 Jun 15;192(12):6111-9. doi: 10.4049/jimmunol.1302895. Epub 2014 May 14.


Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling.

Scumpia PO, Kelly-Scumpia K, Stevens BR.

Neurochem Int. 2014 Jan;64:55-63. doi: 10.1016/j.neuint.2013.11.006. Epub 2013 Nov 20.


Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.

Weinstein JS, Delano MJ, Xu Y, Kelly-Scumpia KM, Nacionales DC, Li Y, Lee PY, Scumpia PO, Yang L, Sobel E, Moldawer LL, Reeves WH.

J Immunol. 2013 Apr 15;190(8):3916-27. doi: 10.4049/jimmunol.1201880. Epub 2013 Mar 18.


B cells enhance early innate immune responses during bacterial sepsis.

Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL.

J Exp Med. 2011 Aug 1;208(8):1673-82. doi: 10.1084/jem.20101715. Epub 2011 Jul 11.


Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.

Delano MJ, Kelly-Scumpia KM, Thayer TC, Winfield RD, Scumpia PO, Cuenca AG, Harrington PB, O'Malley KA, Warner E, Gabrilovich S, Mathews CE, Laface D, Heyworth PG, Ramphal R, Strieter RM, Moldawer LL, Efron PA.

J Immunol. 2011 Jul 15;187(2):911-8. doi: 10.4049/jimmunol.1100588. Epub 2011 Jun 20.


Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.

Cuenca AG, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Vila L, Delano MJ, Mathews CE, Wallet SM, Reeves WH, Behrns KE, Nacionales DC, Efron PA, Kunkel SL, Moldawer LL.

Infect Immun. 2011 Jul;79(7):2746-54. doi: 10.1128/IAI.01291-10. Epub 2011 Apr 25.


Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.

Delano MJ, Thayer T, Gabrilovich S, Kelly-Scumpia KM, Winfield RD, Scumpia PO, Cuenca AG, Warner E, Wallet SM, Wallet MA, O'Malley KA, Ramphal R, Clare-Salzer M, Efron PA, Mathews CE, Moldawer LL.

J Immunol. 2011 Jan 1;186(1):195-202. doi: 10.4049/jimmunol.1002104. Epub 2010 Nov 24.


A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma.

Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moreno C, Scumpia PO, Laface DM, Heyworth PG, Efron PA, Moldawer LL.

Mol Med. 2011 Mar-Apr;17(3-4):281-92. doi: 10.2119/molmed.2010.00178. Epub 2010 Nov 12. Review.


Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling.

Scumpia PO, Kelly-Scumpia KM, Delano MJ, Weinstein JS, Cuenca AG, Al-Quran S, Bovio I, Akira S, Kumagai Y, Moldawer LL.

J Immunol. 2010 Mar 1;184(5):2247-51. doi: 10.4049/jimmunol.0903652. Epub 2010 Feb 3.


Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.

Kelly-Scumpia KM, Scumpia PO, Delano MJ, Weinstein JS, Cuenca AG, Wynn JL, Moldawer LL.

J Exp Med. 2010 Feb 15;207(2):319-26. doi: 10.1084/jem.20091959. Epub 2010 Jan 13.


Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem.

Winfield RD, Delano MJ, Pande K, Scumpia PO, Laface D, Moldawer LL.

JPEN J Parenter Enteral Nutr. 2008 Nov-Dec;32(6):651-5. doi: 10.1177/0148607108325075. Review.


Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.

Weinstein JS, Nacionales DC, Lee PY, Kelly-Scumpia KM, Yan XJ, Scumpia PO, Vale-Cruz DS, Sobel E, Satoh M, Chiorazzi N, Reeves WH.

J Immunol. 2008 Sep 1;181(5):3259-67.


Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.

Wynn JL, Scumpia PO, Winfield RD, Delano MJ, Kelly-Scumpia K, Barker T, Ungaro R, Levy O, Moldawer LL.

Blood. 2008 Sep 1;112(5):1750-8. doi: 10.1182/blood-2008-01-130500. Epub 2008 Jun 30.


A novel type I IFN-producing cell subset in murine lupus.

Lee PY, Weinstein JS, Nacionales DC, Scumpia PO, Li Y, Butfiloski E, van Rooijen N, Moldawer L, Satoh M, Reeves WH.

J Immunol. 2008 Apr 1;180(7):5101-8.


Role of Toll-like receptors in the development of sepsis.

Tsujimoto H, Ono S, Efron PA, Scumpia PO, Moldawer LL, Mochizuki H.

Shock. 2008 Mar;29(3):315-21. doi: 10.1097/SHK.0b013e318157ee55. Review.


Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes.

Caicedo RA, Li N, Des Robert C, Scumpia PO, Hubsher CP, Wasserfall CH, Schatz DA, Atkinson MA, Neu J.

Pediatr Res. 2008 Mar;63(3):303-7.


In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.

Kelly-Scumpia KM, Nacionales DC, Scumpia PO, Weinstein JS, Narain S, Moldawer LL, Satoh M, Reeves WH.

Arthritis Rheum. 2007 Oct;56(10):3379-86.


Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis.

Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL.

Blood. 2007 Nov 15;110(10):3673-81. Epub 2007 Aug 9.


Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis.

Wynn JL, Scumpia PO, Delano MJ, O'Malley KA, Ungaro R, Abouhamze A, Moldawer LL.

Shock. 2007 Dec;28(6):675-683.


MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.

Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL.

J Exp Med. 2007 Jun 11;204(6):1463-74. Epub 2007 Jun 4.


Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists.

Uchida T, Scumpia PO, Murasko DM, Seki S, Woulfe S, Clare-Salzler MJ, Moldawer LL.

J Immunol. 2007 Mar 15;178(6):3886-92.


Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL.

J Immunol. 2006 Dec 1;177(11):7943-9.


Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.

Matsumoto T, O'Malley K, Efron PA, Burger C, McAuliffe PF, Scumpia PO, Uchida T, Tschoeke SK, Fujita S, Moldawer LL, Hemming AW, Foley DP.

Surgery. 2006 Nov;140(5):793-802. Epub 2006 Aug 23.


Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.

Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Brownstein BH, Tompkins RG, Toner M.

Anal Chem. 2006 Aug 1;78(15):5453-61.


"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.

Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH.

Arthritis Rheum. 2006 May;54(5):1557-67.


Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.

Lee PY, Scumpia PO, Byars JA, Kelly KM, Zhuang H, Shuster JS, Theriaque DW, Segal MS, Reeves WH, Brantly ML.

Vaccine. 2006 May 8;24(19):4035-40. Epub 2006 Jan 9.


Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.

McAuliffe PF, Efron PA, Scumpia PO, Uchida T, Mutschlecner SC, Rout WR, Moldawer LL, Cendan JC.

Obes Surg. 2005 Nov-Dec;15(10):1424-31.


Biology of interleukin-10 and its regulatory roles in sepsis syndromes.

Scumpia PO, Moldawer LL.

Crit Care Med. 2005 Dec;33(12 Suppl):S468-71. Review. No abstract available.


Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.

McAuliffe PF, Murday ME, Efron PA, Scumpia PO, Ungaro R, Abouhamze A, Tannahill CL, Hutchins B, LaFace D, Moldawer LL.

Gene Ther. 2006 Feb;13(3):276-82.


CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis.

Scumpia PO, McAuliffe PF, O'Malley KA, Ungaro R, Uchida T, Matsumoto T, Remick DG, Clare-Salzler MJ, Moldawer LL, Efron PA.

J Immunol. 2005 Sep 1;175(5):3282-6.


Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions.

Tsujimoto H, Uchida T, Efron PA, Scumpia PO, Verma A, Matsumoto T, Tschoeke SK, Ungaro RF, Ono S, Seki S, Clare-Salzler MJ, Baker HV, Mochizuki H, Ramphal R, Moldawer LL.

J Leukoc Biol. 2005 Oct;78(4):888-97. Epub 2005 Jul 20.


Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.

Oberholzer A, Oberholzer C, Efron PA, Scumpia PO, Uchida T, Bahjat K, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Tsai V, Hutchins B, Moldawer LL, Laface D, Clare-Salzler MJ.

Shock. 2005 Jun;23(6):507-15.


Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats.

Sarcia PJ, Scumpia PO, Moldawer LL, DeMarco VG, Skimming JW.

Shock. 2003 Jul;20(1):41-5.


Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and impairs blood oxygenation in rats.

Haque IU, Huang CJ, Scumpia PO, Nasiroglu O, Skimming JW.

Crit Care Med. 2003 May;31(5):1454-60.


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