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Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors.

Sanderson JL, Scott JD, Dell'Acqua ML.

J Neurosci. 2018 Feb 13. pii: 2362-17. doi: 10.1523/JNEUROSCI.2362-17.2018. [Epub ahead of print]


Short-Term Preoperative Weight Loss and Postoperative Outcomes in Bariatric Surgery.

Hutcheon DA, Hale AL, Ewing JA, Miller M, Couto F, Bour ES, Cobb WS 4th, Scott JD.

J Am Coll Surg. 2018 Jan 31. pii: S1072-7515(17)32195-6. doi: 10.1016/j.jamcollsurg.2017.12.032. [Epub ahead of print]


Climate vulnerability and resilience in the most valuable North American fishery.

Le Bris A, Mills KE, Wahle RA, Chen Y, Alexander MA, Allyn AJ, Schuetz JG, Scott JD, Pershing AJ.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1831-1836. doi: 10.1073/pnas.1711122115. Epub 2018 Jan 22.


Using an Innovative Telehealth Model to Support Community Providers Who Deliver Perinatal HIV Care.

Ness TE, Annese MF, Martinez-Paz N, Unruh KT, Scott JD, Wood BR.

AIDS Educ Prev. 2017 Dec;29(6):516-526. doi: 10.1521/aeap.2017.29.6.516.


HIV Pre-exposure Prophylaxis (PrEP) Prescribing Through Telehealth.

Stekler JD, Mcmahan V, Ballinger L, Viquez L, Swanson F, Stockton J, Crutsinger-Perry B, Kern D, Scott JD.

J Acquir Immune Defic Syndr. 2017 Dec 26. doi: 10.1097/QAI.0000000000001621. [Epub ahead of print] No abstract available.


Project Extension for Community Healthcare Outcomes (ECHO) in Multiple Sclerosis: Increasing Clinician Capacity.

Johnson KL, Hertz D, Stobbe G, Alschuler K, Kalb R, Alexander KS, Kraft GH, Scott JD.

Int J MS Care. 2017 Nov-Dec;19(6):283-289. doi: 10.7224/1537-2073.2016-099.


Overview of a co-curricular professional development program in a college of pharmacy.

Hoffman J, Chung E, Hess K, Law AV, Samson B, Scott JD.

Curr Pharm Teach Learn. 2017 May;9(3):398-404. doi: 10.1016/j.cptl.2017.01.010. Epub 2017 Apr 13.


Natural killer cells mediate pathophysiology in response to reduced uterine perfusion pressure.

Elfarra J, Amaral LM, McCalmon M, Scott JD, Cunningham MW Jr, Gnam A, Ibrahim T, LaMarca B, Cornelius DC.

Clin Sci (Lond). 2017 Nov 23;131(23):2753-2762. doi: 10.1042/CS20171118. Print 2017 Dec 1.


Investigating the Risk of Date Rape by Auditory Status.

Williams LM, Porter JL, Scott JD, Smith TR, Vogt TV.

Violence Vict. 2017 Dec 1;32(6):1044-1062. doi: 10.1891/0886-6708.VV-D-16-00052. Epub 2017 Oct 10.


Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.

Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD.

Elife. 2017 Oct 2;6. pii: e30872. doi: 10.7554/eLife.30872.


Metallic Surgical Clip Causing Cholangitis after Cholecystectomy.

Erwin PA, Beffa LR, Jones WB, Hale AL, Scott JD.

Am Surg. 2017 Sep 1;83(9):403-405. No abstract available.


First record of locally acquired human babesiosis in Canada caused by Babesia duncani: a case report.

Scott JD.

SAGE Open Med Case Rep. 2017 Aug 29;5:2050313X17725645. doi: 10.1177/2050313X17725645. eCollection 2017.


Barriers to Treatment Access for Chronic Hepatitis C Virus Infection: A Case Series.

Millman AJ, Ntiri-Reid B, Irvin R, Kaufmann MH, Aronsohn A, Duchin JS, Scott JD, Vellozzi C.

Top Antivir Med. 2017 Jul/Aug;25(3):110-113.


What is the impact of treatment for hepatitis C virus infection?

Wiktor SZ, Scott JD.

Lancet. 2017 Jul 8;390(10090):107-109. doi: 10.1016/S0140-6736(17)31762-2. No abstract available.


Local protein kinase A action proceeds through intact holoenzymes.

Smith FD, Esseltine JL, Nygren PJ, Veesler D, Byrne DP, Vonderach M, Strashnov I, Eyers CE, Eyers PA, Langeberg LK, Scott JD.

Science. 2017 Jun 23;356(6344):1288-1293. doi: 10.1126/science.aaj1669.


Pseudoscaffolds and anchoring proteins: the difference is in the details.

Aggarwal-Howarth S, Scott JD.

Biochem Soc Trans. 2017 Apr 15;45(2):371-379. doi: 10.1042/BST20160329. Review.


Predictors of preoperative weight loss achievement in adult bariatric surgery candidates while following a low-calorie diet for 4 weeks.

Hutcheon DA, Byham-Gray LD, Marcus AF, Scott JD, Miller M.

Surg Obes Relat Dis. 2017 Jun;13(6):1041-1051. doi: 10.1016/j.soard.2016.12.026. Epub 2016 Dec 29.


Detection of Lyme Disease Bacterium, Borrelia burgdorferi sensu lato, in Blacklegged Ticks Collected in the Grand River Valley, Ontario, Canada.

Scott JD, Foley JE, Anderson JF, Clark KL, Durden LA.

Int J Med Sci. 2017 Feb 8;14(2):150-158. doi: 10.7150/ijms.17763. eCollection 2017.


Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.

Scott JD, DeMong DE, Greshock TJ, Basu K, Dai X, Harris J, Hruza A, Li SW, Lin SI, Liu H, Macala MK, Hu Z, Mei H, Zhang H, Walsh P, Poirier M, Shi ZC, Xiao L, Agnihotri G, Baptista MA, Columbus J, Fell MJ, Hyde LA, Kuvelkar R, Lin Y, Mirescu C, Morrow JA, Yin Z, Zhang X, Zhou X, Chang RK, Embrey MW, Sanders JM, Tiscia HE, Drolet RE, Kern JT, Sur SM, Renger JJ, Bilodeau MT, Kennedy ME, Parker EM, Stamford AW, Nargund R, McCauley JA, Miller MW.

J Med Chem. 2017 Apr 13;60(7):2983-2992. doi: 10.1021/acs.jmedchem.7b00045. Epub 2017 Mar 16.


Comment on: Roux-en-Y gastric bypass for the treatment of severe complications after omega-loop gastric bypass.

Scott JD.

Surg Obes Relat Dis. 2017 Jun;13(6):994-996. doi: 10.1016/j.soard.2017.01.033. Epub 2017 Jan 25. No abstract available.


Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF.

Sci Signal. 2017 Jan 24;10(463). pii: eaaf9647. doi: 10.1126/scisignal.aaf9647.


Infectious Diseases Society of America Position Statement on Telehealth and Telemedicine as Applied to the Practice of Infectious Diseases.

Siddiqui J, Herchline T, Kahlon S, Moyer KJ, Scott JD, Wood BR, Young J.

Clin Infect Dis. 2017 Feb 1;64(3):237-242. doi: 10.1093/cid/ciw773.


Evaluation of a Powered Stapler System with Gripping Surface Technology on Surgical Interventions Required During Laparoscopic Sleeve Gastrectomy.

Fegelman E, Knippenberg S, Schwiers M, Stefanidis D, Gersin KS, Scott JD, Fernandez AZ.

J Laparoendosc Adv Surg Tech A. 2017 May;27(5):489-494. doi: 10.1089/lap.2016.0513. Epub 2016 Dec 19.


Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.

Scott JD, Li SW, Brunskill AP, Chen X, Cox K, Cumming JN, Forman M, Gilbert EJ, Hodgson RA, Hyde LA, Jiang Q, Iserloh U, Kazakevich I, Kuvelkar R, Mei H, Meredith J, Misiaszek J, Orth P, Rossiter LM, Slater M, Stone J, Strickland CO, Voigt JH, Wang G, Wang H, Wu Y, Greenlee WJ, Parker EM, Kennedy ME, Stamford AW.

J Med Chem. 2016 Dec 8;59(23):10435-10450. Epub 2016 Nov 18.


Regulation of the phosphatase PP2B by protein-protein interactions.

Nygren PJ, Scott JD.

Biochem Soc Trans. 2016 Oct 15;44(5):1313-1319. Review.


Established Population of Blacklegged Ticks with High Infection Prevalence for the Lyme Disease Bacterium, Borrelia burgdorferi Sensu Lato, on Corkscrew Island, Kenora District, Ontario.

Scott JD, Foley JE, Clark KL, Anderson JF, Durden LA, Manord JM, Smith ML.

Int J Med Sci. 2016 Oct 27;13(11):881-891. eCollection 2016.


Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.

Li L, Li J, Drum BM, Chen Y, Yin H, Guo X, Luckey SW, Gilbert ML, McKnight GS, Scott JD, Santana LF, Liu Q.

Cardiovasc Res. 2017 Feb;113(2):147-159. doi: 10.1093/cvr/cvw221. Epub 2016 Nov 17.


Detection of Borrelia Genomospecies 2 in Ixodes spinipalpis Ticks Collected from a Rabbit in Canada.

Scott JD, Clark KL, Foley JE, Anderson JF, Durden LA, Manord JM, Smith ML.

J Parasitol. 2017 Feb;103(1):38-46. doi: 10.1645/16-127. Epub 2016 Nov 11.


The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.

Kennedy ME, Stamford AW, Chen X, Cox K, Cumming JN, Dockendorf MF, Egan M, Ereshefsky L, Hodgson RA, Hyde LA, Jhee S, Kleijn HJ, Kuvelkar R, Li W, Mattson BA, Mei H, Palcza J, Scott JD, Tanen M, Troyer MD, Tseng JL, Stone JA, Parker EM, Forman MS.

Sci Transl Med. 2016 Nov 2;8(363):363ra150.


Impact of a Telehealth Program That Delivers Remote Consultation and Longitudinal Mentorship to Community HIV Providers.

Wood BR, Unruh KT, Martinez-Paz N, Annese M, Ramers CB, Harrington RD, Dhanireddy S, Kimmerly L, Scott JD, Spach DH.

Open Forum Infect Dis. 2016 Jun 20;3(3):ofw123. eCollection 2016 Sep.


Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state.

Bjerregaard-Andersen K, Østensen E, Scott JD, Taskén K, Morth JP.

Acta Crystallogr F Struct Biol Commun. 2016 Aug;72(Pt 8):591-7. doi: 10.1107/S2053230X16010189. Epub 2016 Jul 13.


Second Messengers.

Newton AC, Bootman MD, Scott JD.

Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8). pii: a005926. doi: 10.1101/cshperspect.a005926. Review.


Meeting the Demands of the Affordable Care Act: Improving Access to Primary Care.

McGough PM, Norris TE, Scott JD, Burner TG.

Popul Health Manag. 2017 Apr;20(2):87-89. doi: 10.1089/pop.2016.0030. Epub 2016 Jul 25. No abstract available.


AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption.

Whiting JL, Ogier L, Forbush KA, Bucko P, Gopalan J, Seternes OM, Langeberg LK, Scott JD.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4328-37. doi: 10.1073/pnas.1607745113. Epub 2016 Jul 11.


Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.

Kountz TS, Lee KS, Aggarwal-Howarth S, Curran E, Park JM, Harris DA, Stewart A, Hendrickson J, Camp ND, Wolf-Yadlin A, Wang EH, Scott JD, Hague C.

J Biol Chem. 2016 Aug 26;291(35):18210-21. doi: 10.1074/jbc.M116.729517. Epub 2016 Jul 5.


ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme.

Cherry AE, Haas BR, Naydenov AV, Fung S, Xu C, Swinney K, Wagenbach M, Freeling J, Canton DA, Coy J, Horne EA, Rickman B, Vicente JJ, Scott JD, Ho RJ, Liggitt D, Wordeman L, Stella N.

Mol Cancer Ther. 2016 Sep;15(9):2018-29. doi: 10.1158/1535-7163.MCT-15-0800. Epub 2016 Jun 20.


Borrelia mayonii: prying open Pandora's box of spirochetes.

Scott JD.

Lancet Infect Dis. 2016 Jun;16(6):637. doi: 10.1016/S1473-3099(16)30053-6. No abstract available.


Bacterial spore coat protein kinases: A new twist to an old story.

Scott JD, Newton AC.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6811-2. doi: 10.1073/pnas.1607004113. Epub 2016 Jun 10. No abstract available.


Prevalence of the Lyme Disease Spirochete, Borrelia burgdorferi, in Blacklegged Ticks, Ixodes scapularis at Hamilton-Wentworth, Ontario.

Scott JD, Anderson JF, Durden LA, Smith ML, Manord JM, Clark KL.

Int J Med Sci. 2016 Apr 10;13(5):316-24. doi: 10.7150/ijms.14552. eCollection 2016.


Response to Comments on "Slow adaptation in the face of rapid warming leads to collapse of the Gulf of Maine cod fishery".

Pershing AJ, Alexander MA, Hernandez CM, Kerr LA, Le Bris A, Mills KE, Nye JA, Record NR, Scannell HA, Scott JD, Sherwood GD, Thomas AC.

Science. 2016 Apr 22;352(6284):423. doi: 10.1126/science.aae0463.


Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.

Riggle KM, Riehle KJ, Kenerson HL, Turnham R, Homma MK, Kazami M, Samelson B, Bauer R, McKnight GS, Scott JD, Yeung RS.

Pediatr Res. 2016 Jul;80(1):110-8. doi: 10.1038/pr.2016.36. Epub 2016 Mar 8.


Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma.

Riggle KM, Turnham R, Scott JD, Yeung RS, Riehle KJ.

Pediatr Blood Cancer. 2016 Jul;63(7):1163-7. doi: 10.1002/pbc.25970. Epub 2016 Mar 14. Review.


Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.

Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF.

J Biol Chem. 2016 Mar 4;291(10):4912. doi: 10.1074/jbc.A114.622811. No abstract available.


A Vulnerability Assessment of Fish and Invertebrates to Climate Change on the Northeast U.S. Continental Shelf.

Hare JA, Morrison WE, Nelson MW, Stachura MM, Teeters EJ, Griffis RB, Alexander MA, Scott JD, Alade L, Bell RJ, Chute AS, Curti KL, Curtis TH, Kircheis D, Kocik JF, Lucey SM, McCandless CT, Milke LM, Richardson DE, Robillard E, Walsh HJ, McManus MC, Marancik KE, Griswold CA.

PLoS One. 2016 Feb 3;11(2):e0146756. doi: 10.1371/journal.pone.0146756. eCollection 2016.


Studies abound on how far north Ixodes scapularis ticks are transported by birds.

Scott JD.

Ticks Tick Borne Dis. 2016 Mar;7(2):327-8. doi: 10.1016/j.ttbdis.2015.12.001. Epub 2015 Dec 17.


AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.

Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD.

Cell Signal. 2016 Jul;28(7):733-40. doi: 10.1016/j.cellsig.2015.12.015. Epub 2015 Dec 24.


Confronting Ethical and Regulatory Challenges of Emergency Care Research With Conscious Patients.

Dickert NW, Brown J, Cairns CB, Eaves-Leanos A, Goldkind SF, Kim SY, Nichol G, O'Conor KJ, Scott JD, Sinert R, Wendler D, Wright DW, Silbergleit R.

Ann Emerg Med. 2016 Apr;67(4):538-45. doi: 10.1016/j.annemergmed.2015.10.026. Epub 2015 Dec 18.


Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology.

Turnham RE, Scott JD.

Gene. 2016 Feb 15;577(2):101-8. doi: 10.1016/j.gene.2015.11.052. Epub 2015 Dec 12. Review.

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