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Items: 1 to 50 of 74

1.

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.

Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H.

Cell Mol Life Sci. 2017 Dec 30. doi: 10.1007/s00018-017-2728-1. [Epub ahead of print]

PMID:
29290039
2.

Targeting G Protein-Coupled Receptors by Capture Compound Mass Spectrometry: A Case Study with Sertindole.

Blex C, Michaelis S, Schrey AK, Furkert J, Eichhorst J, Bartho K, Gyapon Quast F, Marais A, Hakelberg M, Gruber U, Niquet S, Popp O, Kroll F, Sefkow M, Schülein R, Dreger M, Köster H.

Chembiochem. 2017 Aug 17;18(16):1639-1649. doi: 10.1002/cbic.201700152. Epub 2017 Jul 7.

PMID:
28557180
3.

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schülein R, Bader M, Santos RA, Unger T, Steckelings UM.

Hypertension. 2017 Jun;69(6):1128-1135. doi: 10.1161/HYPERTENSIONAHA.116.08814. Epub 2017 May 1.

PMID:
28461604
4.

Functional Significance of the Signal Peptides of Corticotropin-Releasing Factor Receptors.

Schulein R, Gibert A, Rutz C.

Curr Mol Pharmacol. 2017;10(4):311-317. doi: 10.2174/1874467210666170224094915.

PMID:
28240192
5.

Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids.

Hinz KM, Neef D, Rutz C, Furkert J, Köhrle J, Schülein R, Krause G.

Mol Cell Endocrinol. 2017 Mar 5;443:163-174. doi: 10.1016/j.mce.2017.01.024. Epub 2017 Jan 18.

PMID:
28108384
6.

Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3'-Diiodothyronine across the Plasma Membrane.

Kinne A, Wittner M, Wirth EK, Hinz KM, Schülein R, Köhrle J, Krause G.

Eur Thyroid J. 2015 Sep;4(Suppl 1):42-50. doi: 10.1159/000381542. Epub 2015 May 28.

7.

A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia.

Vezzoli V, Duminuco P, Vottero A, Kleinau G, Schülein R, Minari R, Bassi I, Bernasconi S, Persani L, Bonomi M.

Hum Mol Genet. 2015 Nov 1;24(21):6003-12. doi: 10.1093/hmg/ddv313. Epub 2015 Aug 5.

PMID:
26246498
8.

N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking, and Signal Transduction.

Rutz C, Klein W, Schülein R.

Prog Mol Biol Transl Sci. 2015;132:267-87. doi: 10.1016/bs.pmbts.2015.03.003. Epub 2015 Apr 11. Review.

PMID:
26055063
9.

Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.

Hinz KM, Meyer K, Kinne A, Schülein R, Köhrle J, Krause G.

Mol Endocrinol. 2015 Jun;29(6):933-42. doi: 10.1210/me.2015-1044. Epub 2015 May 6.

10.

Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study.

Klein W, Westendorf C, Schmidt A, Conill-Cortés M, Rutz C, Blohs M, Beyermann M, Protze J, Krause G, Krause E, Schülein R.

PLoS One. 2015 Mar 25;10(3):e0120886. doi: 10.1371/journal.pone.0120886. eCollection 2015.

11.

The specific monomer/dimer equilibrium of the corticotropin-releasing factor receptor type 1 is established in the endoplasmic reticulum.

Teichmann A, Gibert A, Lampe A, Grzesik P, Rutz C, Furkert J, Schmoranzer J, Krause G, Wiesner B, Schülein R.

J Biol Chem. 2014 Aug 29;289(35):24250-62. doi: 10.1074/jbc.M114.553644. Epub 2014 Jun 25.

12.

Use of Kaede and Kikume green-red fusions for live cell imaging of G protein-coupled receptors.

Schmidt A, Wiesner B, Schülein R, Teichmann A.

Methods Mol Biol. 2014;1174:139-56. doi: 10.1007/978-1-4939-0944-5_9. Review.

PMID:
24947379
13.

Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation.

Grzesik P, Teichmann A, Furkert J, Rutz C, Wiesner B, Kleinau G, Schülein R, Gromoll J, Krause G.

FEBS J. 2014 Mar;281(5):1479-92. doi: 10.1111/febs.12718. Epub 2014 Feb 10.

14.

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.

Hoyer I, Haas AK, Kreuchwig A, Schülein R, Krause G.

Biochem Soc Trans. 2013 Feb 1;41(1):213-7. doi: 10.1042/BST20120319. Review.

15.

The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization.

Teichmann A, Rutz C, Kreuchwig A, Krause G, Wiesner B, Schülein R.

J Biol Chem. 2012 Aug 3;287(32):27265-74. doi: 10.1074/jbc.M112.360594. Epub 2012 Jun 11.

16.

Live cell imaging of G protein-coupled receptors.

Teichmann A, Schmidt A, Wiesner B, Oksche A, Schülein R.

Methods Mol Biol. 2012;897:139-69. doi: 10.1007/978-1-61779-909-9_7.

PMID:
22674164
17.

The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.

Zampatis DE, Rutz C, Furkert J, Schmidt A, Wüstenhagen D, Kubick S, Tsopanoglou NE, Schülein R.

FEBS Lett. 2012 Jul 30;586(16):2351-9. doi: 10.1016/j.febslet.2012.05.042. Epub 2012 May 31.

18.

Use of Kikume green-red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors.

Ridelis I, Schmidt A, Teichmann A, Furkert J, Wiesner B, Schülein R.

FEBS Lett. 2012 Mar 23;586(6):784-91. doi: 10.1016/j.febslet.2012.01.043. Epub 2012 Jan 28.

19.

The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling.

Liu Y, Echtermeyer F, Thilo F, Theilmeier G, Schmidt A, Schülein R, Jensen BL, Loddenkemper C, Jankowski V, Marcussen N, Gollasch M, Arendshorst WJ, Tepel M.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):378-85. doi: 10.1161/ATVBAHA.111.241018. Epub 2011 Dec 8. Erratum in: Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):e24.

20.

Primary and secondary thyroid hormone transporters.

Kinne A, Schülein R, Krause G.

Thyroid Res. 2011 Aug 3;4 Suppl 1:S7. doi: 10.1186/1756-6614-4-S1-S7.

21.

Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin.

Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R.

J Biol Chem. 2011 Oct 14;286(41):35588-600. doi: 10.1074/jbc.M111.239244. Epub 2011 Jul 30.

22.

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).

Kleinau G, Hoyer I, Kreuchwig A, Haas AK, Rutz C, Furkert J, Worth CL, Krause G, Schülein R.

J Biol Chem. 2011 Jul 22;286(29):25859-71. doi: 10.1074/jbc.M110.196980. Epub 2011 May 17.

23.

Functional significance of cleavable signal peptides of G protein-coupled receptors.

Schülein R, Westendorf C, Krause G, Rosenthal W.

Eur J Cell Biol. 2012 Apr;91(4):294-9. doi: 10.1016/j.ejcb.2011.02.006. Epub 2011 May 4. Review.

PMID:
21543132
24.

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.

Schulz K, Rutz C, Westendorf C, Ridelis I, Vogelbein S, Furkert J, Schmidt A, Wiesner B, Schülein R.

J Biol Chem. 2010 Oct 22;285(43):32878-87. doi: 10.1074/jbc.M110.129627. Epub 2010 Aug 3.

25.

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.

Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G.

Cell Mol Life Sci. 2011 Jan;68(1):159-67. doi: 10.1007/s00018-010-0451-2. Epub 2010 Jul 22.

26.

Distortion-tolerant 3D recognition of underwater objects using neural networks.

Schulein R, Do CM, Javidi B.

J Opt Soc Am A Opt Image Sci Vis. 2010 Mar 1;27(3):461-8. doi: 10.1364/JOSAA.27.000461.

PMID:
20208936
27.

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G.

FASEB J. 2010 Jul;24(7):2347-54. doi: 10.1096/fj.09-149146. Epub 2010 Feb 23.

28.

3D imaging with axially distributed sensing.

Schulein R, DaneshPanah M, Javidi B.

Opt Lett. 2009 Jul 1;34(13):2012-4.

PMID:
19571983
29.

The sequence after the signal peptide of the G protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane.

Alken M, Schmidt A, Rutz C, Furkert J, Kleinau G, Rosenthal W, Schülein R.

Mol Pharmacol. 2009 Apr;75(4):801-11. doi: 10.1124/mol.108.051581. Epub 2009 Jan 9.

30.

Use of Kaede fusions to visualize recycling of G protein-coupled receptors.

Schmidt A, Wiesner B, Weisshart K, Schulz K, Furkert J, Lamprecht B, Rosenthal W, Schülein R.

Traffic. 2009 Jan;10(1):2-15. doi: 10.1111/j.1600-0854.2008.00843.x. Epub 2008 Oct 14.

31.

Effect of carrier lifetime on forward-biased silicon Mach-Zehnder modulators.

Zhou GR, Geis MW, Spector SJ, Gan F, Grein ME, Schulein RT, Orcutt JS, Yoon JU, Lennon DM, Lyszczarz TM, Ippen EP, Käertner FX.

Opt Express. 2008 Apr 14;16(8):5218-26.

PMID:
18542624
32.

All silicon infrared photodiodes: photo response and effects of processing temperature.

Geis MW, Spector SJ, Grein ME, Schulein RJ, Yoon JU, Lennon DM, Wynn CM, Palmacci ST, Gan F, Käertner FX, Lyszczarz TM.

Opt Express. 2007 Dec 10;15(25):16886-95.

PMID:
19550979
33.

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides.

Oueslati M, Hermosilla R, Schönenberger E, Oorschot V, Beyermann M, Wiesner B, Schmidt A, Klumperman J, Rosenthal W, Schülein R.

J Biol Chem. 2007 Jul 13;282(28):20676-85. Epub 2007 May 8.

34.

A translocated bacterial protein protects vascular endothelial cells from apoptosis.

Schmid MC, Scheidegger F, Dehio M, Balmelle-Devaux N, Schulein R, Guye P, Chennakesava CS, Biedermann B, Dehio C.

PLoS Pathog. 2006 Nov;2(11):e115.

35.

TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.

Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.

J Immunol. 2006 Nov 15;177(10):6833-41.

36.

The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide.

Rutz C, Renner A, Alken M, Schulz K, Beyermann M, Wiesner B, Rosenthal W, Schülein R.

J Biol Chem. 2006 Aug 25;281(34):24910-21. Epub 2006 Jun 8.

37.

The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding.

Thielen A, Oueslati M, Hermosilla R, Krause G, Oksche A, Rosenthal W, Schülein R.

FEBS Lett. 2005 Sep 26;579(23):5227-35.

38.

A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization.

Neuschäfer-Rube F, Hermosilla R, Kuna M, Pathe-Neuschäfer-Rube A, Schülein R, Püschel GP.

Br J Pharmacol. 2005 Aug;145(8):1132-42.

39.

The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor.

Alken M, Rutz C, Köchl R, Donalies U, Oueslati M, Furkert J, Wietfeld D, Hermosilla R, Scholz A, Beyermann M, Rosenthal W, Schülein R.

Biochem J. 2005 Sep 1;390(Pt 2):455-64.

40.
41.

A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells.

Schulein R, Guye P, Rhomberg TA, Schmid MC, Schröder G, Vergunst AC, Carena I, Dehio C.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):856-61. Epub 2005 Jan 10.

42.

Disease-causing V(2) vasopressin receptors are retained in different compartments of the early secretory pathway.

Hermosilla R, Oueslati M, Donalies U, Schönenberger E, Krause E, Oksche A, Rosenthal W, Schülein R.

Traffic. 2004 Dec;5(12):993-1005.

43.

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.

Wüller S, Wiesner B, Löffler A, Furkert J, Krause G, Hermosilla R, Schaefer M, Schülein R, Rosenthal W, Oksche A.

J Biol Chem. 2004 Nov 5;279(45):47254-63. Epub 2004 Aug 19.

44.

HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.

Droese J, Mokros T, Hermosilla R, Schülein R, Lipp M, Höpken UE, Rehm A.

Biochem Biophys Res Commun. 2004 Sep 10;322(1):42-9.

PMID:
15313171
45.

The early stages of the intracellular transport of membrane proteins: clinical and pharmacological implications.

Schülein R.

Rev Physiol Biochem Pharmacol. 2004;151:45-91. Epub 2004 Apr 23. Review.

PMID:
15103508
46.
47.
48.

The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens.

Engelsberg A, Hermosilla R, Karsten U, Schülein R, Dörken B, Rehm A.

J Biol Chem. 2003 Jun 20;278(25):22998-3007. Epub 2003 Apr 2.

49.
50.

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