Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 154

1.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.

2.

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.

3.

Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.

Cobo I, Martinelli P, Flández M, Bakiri L, Zhang M, Carrillo-de-Santa-Pau E, Jia J, Sánchez-Arévalo Lobo VJ, Megías D, Felipe I, Del Pozo N, Millán I, Thommesen L, Bruland T, Olson SH, Smith J, Schoonjans K, Bamlet WR, Petersen GM, Malats N, Amundadottir LT, Wagner EF, Real FX.

Nature. 2018 Feb 22;554(7693):533-537. doi: 10.1038/nature25751. Epub 2018 Feb 14.

PMID:
29443959
4.

Megatrends in bile acid receptor research.

Adorini L, Schoonjans K, Friedman SL.

Hepatol Commun. 2017 Aug 24;1(8):831-835. doi: 10.1002/hep4.1085. eCollection 2017 Oct. No abstract available.

5.

The Orphan Nuclear Receptor Liver Homolog Receptor-1 (Nr5a2) Regulates Ovarian Granulosa Cell Proliferation.

Meinsohn MC, Morin F, Bertolin K, Duggavathi R, Schoonjans K, Murphy BD.

J Endocr Soc. 2017 Dec 1;2(1):24-41. doi: 10.1210/js.2017-00329. eCollection 2018 Jan 1.

6.

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue.

Velazquez-Villegas LA, Perino A, Lemos V, Zietak M, Nomura M, Pols TWH, Schoonjans K.

Nat Commun. 2018 Jan 16;9(1):245. doi: 10.1038/s41467-017-02068-0.

7.

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.

Li H, Wang X, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J.

Cell Syst. 2018 Jan 24;6(1):90-102.e4. doi: 10.1016/j.cels.2017.10.016. Epub 2017 Nov 30.

8.

A multiscale study of the role of dynamin in the regulation of glucose uptake.

Trouillon R, Letizia MC, Menzies KJ, Mouchiroud L, Auwerx J, Schoonjans K, Gijs MAM.

Integr Biol (Camb). 2017 Oct 16;9(10):810-819. doi: 10.1039/c7ib00015d.

PMID:
28853753
9.

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice.

Akinrotimi O, Riessen R, VanDuyne P, Park JE, Lee YK, Wong LJ, Zavacki AM, Schoonjans K, Anakk S.

Hepatology. 2017 Dec;66(6):1854-1865. doi: 10.1002/hep.29305. Epub 2017 Oct 30.

PMID:
28586124
10.

Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection.

Bertolin K, Meinsohn MC, Suzuki J, Gossen J, Schoonjans K, Duggavathi R, Murphy BD.

Biol Reprod. 2017 Jun 1;96(6):1231-1243. doi: 10.1093/biolre/iox045.

PMID:
28520915
11.

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells.

Lajczak NK, Saint-Criq V, O'Dwyer AM, Perino A, Adorini L, Schoonjans K, Keely SJ.

FASEB J. 2017 Sep;31(9):3848-3857. doi: 10.1096/fj.201601365R. Epub 2017 May 9.

PMID:
28487283
12.

β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.

Somm E, Henry H, Bruce SJ, Aeby S, Rosikiewicz M, Sykiotis GP, Asrih M, Jornayvaz FR, Denechaud PD, Albrecht U, Mohammadi M, Dwyer A, Acierno JS Jr, Schoonjans K, Fajas L, Greub G, Pitteloud N.

JCI Insight. 2017 Apr 20;2(8). pii: 91809. doi: 10.1172/jci.insight.91809. [Epub ahead of print]

13.

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease.

Stein S, Lemos V, Xu P, Demagny H, Wang X, Ryu D, Jimenez V, Bosch F, Lüscher TF, Oosterveer MH, Schoonjans K.

J Clin Invest. 2017 Feb 1;127(2):583-592. doi: 10.1172/JCI85499. Epub 2017 Jan 17.

14.

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.

Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J.

J Hepatol. 2017 Jan;66(1):132-141. doi: 10.1016/j.jhep.2016.08.024. Epub 2016 Sep 20.

15.

Plasma membrane-bound G protein-coupled bile acid receptor attenuates liver ischemia/reperfusion injury via the inhibition of toll-like receptor 4 signaling in mice.

Yang H, Zhou H, Zhuang L, Auwerx J, Schoonjans K, Wang X, Feng C, Lu L.

Liver Transpl. 2017 Jan;23(1):63-74. doi: 10.1002/lt.24628.

16.

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Xu P, Oosterveer MH, Stein S, Demagny H, Ryu D, Moullan N, Wang X, Can E, Zamboni N, Comment A, Auwerx J, Schoonjans K.

Genes Dev. 2016 Jun 1;30(11):1255-60. doi: 10.1101/gad.277483.116.

17.

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J.

Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28.

18.

Bile acid-FXRα pathways regulate male sexual maturation in mice.

Baptissart M, Martinot E, Vega A, Sédes L, Rouaisnel B, de Haze A, Baron S, Schoonjans K, Caira F, Volle DH.

Oncotarget. 2016 Apr 12;7(15):19468-82. doi: 10.18632/oncotarget.7153.

19.

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology.

Perino A, Schoonjans K.

Trends Pharmacol Sci. 2015 Dec;36(12):847-857. doi: 10.1016/j.tips.2015.08.002. Epub 2015 Nov 2. Review.

PMID:
26541439
20.

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J.

Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16.

21.

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors.

Brighton CA, Rievaj J, Kuhre RE, Glass LL, Schoonjans K, Holst JJ, Gribble FM, Reimann F.

Endocrinology. 2015 Nov;156(11):3961-70. doi: 10.1210/en.2015-1321. Epub 2015 Aug 17.

22.

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.

Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, Spinelli V, Hennuyer N, Caron S, Bantubungi K, Caiazzo R, Reimann F, Marchetti P, Lefebvre P, Bäckhed F, Gribble FM, Schoonjans K, Pattou F, Tailleux A, Staels B, Lestavel S.

Nat Commun. 2015 Jul 2;6:7629. doi: 10.1038/ncomms8629.

23.

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice.

Jo YS, Ryu D, Maida A, Wang X, Evans RM, Schoonjans K, Auwerx J.

Hepatology. 2015 Nov;62(5):1606-18. doi: 10.1002/hep.27907. Epub 2015 Jul 22.

24.

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis.

Lefèvre L, Authier H, Stein S, Majorel C, Couderc B, Dardenne C, Eddine MA, Meunier E, Bernad J, Valentin A, Pipy B, Schoonjans K, Coste A.

Nat Commun. 2015 Apr 15;6:6801. doi: 10.1038/ncomms7801.

25.

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM.

Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5.

26.

Molecular basis for the regulation of the nuclear receptor LRH-1.

Stein S, Schoonjans K.

Curr Opin Cell Biol. 2015 Apr;33:26-34. doi: 10.1016/j.ceb.2014.10.007. Epub 2014 Nov 15. Review.

PMID:
25463843
27.

Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice.

Vega A, Martinot E, Baptissart M, De Haze A, Saru JP, Baron S, Caira F, Schoonjans K, Lobaccaro JM, Volle DH.

Endocrinology. 2015 Feb;156(2):660-9. doi: 10.1210/en.2014-1418. Epub 2014 Nov 26.

PMID:
25426871
28.

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.

Perino A, Pols TW, Nomura M, Stein S, Pellicciari R, Schoonjans K.

J Clin Invest. 2014 Dec;124(12):5424-36. doi: 10.1172/JCI76289. Epub 2014 Nov 3.

29.

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP.

Vega A, Baptissart M, Martinot E, Saru JP, Baron S, Schoonjans K, Volle DH.

Expert Opin Ther Targets. 2014 Dec;18(12):1367-76. doi: 10.1517/14728222.2014.964209. Epub 2014 Sep 29.

PMID:
25263461
30.

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.

Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J.

Cell Metab. 2014 Nov 4;20(5):856-869. doi: 10.1016/j.cmet.2014.08.001. Epub 2014 Sep 4.

31.

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport.

Stein S, Oosterveer MH, Mataki C, Xu P, Lemos V, Havinga R, Dittner C, Ryu D, Menzies KJ, Wang X, Perino A, Houten SM, Melchior F, Schoonjans K.

Cell Metab. 2014 Oct 7;20(4):603-13. doi: 10.1016/j.cmet.2014.07.023. Epub 2014 Aug 28.

32.

Another Shp on the horizon for bile acids.

Perino A, Schoonjans K.

Cell Metab. 2014 Aug 5;20(2):203-5. doi: 10.1016/j.cmet.2014.07.019.

33.

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

Lo Sasso G, Menzies KJ, Mottis A, Piersigilli A, Perino A, Yamamoto H, Schoonjans K, Auwerx J.

PLoS One. 2014 Jul 29;9(7):e103573. doi: 10.1371/journal.pone.0103573. eCollection 2014.

34.

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

Lo Sasso G, Ryu D, Mouchiroud L, Fernando SC, Anderson CL, Katsyuba E, Piersigilli A, Hottiger MO, Schoonjans K, Auwerx J.

PLoS One. 2014 Jul 11;9(7):e102495. doi: 10.1371/journal.pone.0102495. eCollection 2014.

35.

Probing the Binding Site of Bile Acids in TGR5.

Macchiarulo A, Gioiello A, Thomas C, Pols TW, Nuti R, Ferrari C, Giacchè N, De Franco F, Pruzanski M, Auwerx J, Schoonjans K, Pellicciari R.

ACS Med Chem Lett. 2013 Oct 15;4(12):1158-62. doi: 10.1021/ml400247k. eCollection 2013 Dec 12.

36.

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.

Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J.

Cell Metab. 2014 Jun 3;19(6):1034-41. doi: 10.1016/j.cmet.2014.04.002. Epub 2014 May 8.

37.

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.

Baptissart M, Vega A, Martinot E, Pommier AJ, Houten SM, Marceau G, de Haze A, Baron S, Schoonjans K, Lobaccaro JM, Volle DH.

Hepatology. 2014 Sep;60(3):1054-65. doi: 10.1002/hep.27204.

PMID:
24798773
38.

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.

Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM.

Eur Heart J. 2015 Jan 1;36(1):51-9. doi: 10.1093/eurheartj/ehu095. Epub 2014 Mar 6.

39.

The orphan nuclear receptor Nr5a2 is essential for luteinization in the female mouse ovary.

Bertolin K, Gossen J, Schoonjans K, Murphy BD.

Endocrinology. 2014 May;155(5):1931-43. doi: 10.1210/en.2013-1765. Epub 2014 Feb 19.

PMID:
24552399
40.

Vitamin D and energy homeostasis: of mice and men.

Bouillon R, Carmeliet G, Lieben L, Watanabe M, Perino A, Auwerx J, Schoonjans K, Verstuyf A.

Nat Rev Endocrinol. 2014 Feb;10(2):79-87. doi: 10.1038/nrendo.2013.226. Epub 2013 Nov 19. Review.

PMID:
24247221
41.

Hepatic glucose sensing and integrative pathways in the liver.

Oosterveer MH, Schoonjans K.

Cell Mol Life Sci. 2014 Apr;71(8):1453-67. doi: 10.1007/s00018-013-1505-z. Epub 2013 Nov 7. Review.

PMID:
24196749
42.

Metabolic characterization of a Sirt5 deficient mouse model.

Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J.

Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806.

43.

Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network.

Mrosek N, Meissburger B, Mataki C, Roeder E, Ukropec J, Klimes I, Gasperikova D, Nawroth PP, Rudofsky G, Auwerx J, Schoonjans K, Wolfrum C.

Mol Metab. 2013 Mar 16;2(3):314-23. doi: 10.1016/j.molmet.2013.03.003. eCollection 2013.

44.

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J.

Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016.

45.

Liver receptor homolog-1 is essential for pregnancy.

Zhang C, Large MJ, Duggavathi R, DeMayo FJ, Lydon JP, Schoonjans K, Kovanci E, Murphy BD.

Nat Med. 2013 Aug;19(8):1061-6. doi: 10.1038/nm.3192. Epub 2013 Jun 30.

46.

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.

Péan N, Doignon I, Garcin I, Besnard A, Julien B, Liu B, Branchereau S, Spraul A, Guettier C, Humbert L, Schoonjans K, Rainteau D, Tordjmann T.

Hepatology. 2013 Oct;58(4):1451-60. doi: 10.1002/hep.26463. Epub 2013 Aug 19.

PMID:
23686672
47.

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Flandez M, Cendrowski J, Cañamero M, Salas A, del Pozo N, Schoonjans K, Real FX.

Gut. 2014 Apr;63(4):647-55. doi: 10.1136/gutjnl-2012-304381. Epub 2013 Apr 18.

PMID:
23598351
48.

NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.

Fortin J, Kumar V, Zhou X, Wang Y, Auwerx J, Schoonjans K, Boehm U, Boerboom D, Bernard DJ.

PLoS One. 2013;8(3):e59058. doi: 10.1371/journal.pone.0059058. Epub 2013 Mar 11.

49.

The TGR5 receptor mediates bile acid-induced itch and analgesia.

Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU.

J Clin Invest. 2013 Apr;123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25.

50.

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.

Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU.

Gastroenterology. 2013 Jan;144(1):145-54. doi: 10.1053/j.gastro.2012.09.055. Epub 2012 Oct 3.

PMID:
23041323

Supplemental Content

Loading ...
Support Center