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Items: 1 to 50 of 147

1.

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

PMID:
29429978
2.

Virus-like infection induces human β cell dedifferentiation.

Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R.

JCI Insight. 2018 Feb 8;3(3). pii: 97732. doi: 10.1172/jci.insight.97732. [Epub ahead of print]

3.

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells.

Richards P, Rachdi L, Oshima M, Marchetti P, Bugliani M, Armanet M, Postic C, Guilmeau S, Scharfmann R.

Diabetes. 2018 Mar;67(3):461-472. doi: 10.2337/db17-0595. Epub 2017 Dec 27.

PMID:
29282201
4.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

5.

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.

Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.

Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2.

6.

Mitochondrial Protein UCP2 Controls Pancreas Development.

Broche B, Ben Fradj S, Aguilar E, Sancerni T, Bénard M, Makaci F, Berthault C, Scharfmann R, Alves-Guerra MC, Duvillié B.

Diabetes. 2018 Jan;67(1):78-84. doi: 10.2337/db17-0118. Epub 2017 Oct 27.

PMID:
29079704
7.

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes.

Rouxel O, Da Silva J, Beaudoin L, Nel I, Tard C, Cagninacci L, Kiaf B, Oshima M, Diedisheim M, Salou M, Corbett A, Rossjohn J, McCluskey J, Scharfmann R, Battaglia M, Polak M, Lantz O, Beltrand J, Lehuen A.

Nat Immunol. 2017 Dec;18(12):1321-1331. doi: 10.1038/ni.3854. Epub 2017 Oct 9.

PMID:
28991267
8.

Reconstructing human pancreatic differentiation by mapping specific cell populations during development.

Ramond C, Glaser N, Berthault C, Ameri J, Kirkegaard JS, Hansson M, Honoré C, Semb H, Scharfmann R.

Elife. 2017 Jul 21;6. pii: e27564. doi: 10.7554/eLife.27564.

9.

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.

Ndiaye FK, Ortalli A, Canouil M, Huyvaert M, Salazar-Cardozo C, Lecoeur C, Verbanck M, Pawlowski V, Boutry R, Durand E, Rabearivelo I, Sand O, Marselli L, Kerr-Conte J, Chandra V, Scharfmann R, Poulain-Godefroy O, Marchetti P, Pattou F, Abderrahmani A, Froguel P, Bonnefond A.

Mol Metab. 2017 Apr 8;6(6):459-470. doi: 10.1016/j.molmet.2017.03.011. eCollection 2017 Jun.

10.

Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors.

Ameri J, Borup R, Prawiro C, Ramond C, Schachter KA, Scharfmann R, Semb H.

Cell Rep. 2017 Apr 4;19(1):36-49. doi: 10.1016/j.celrep.2017.03.032.

11.

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M.

Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr.

12.

EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium.

Krizhanovskii C, Kristinsson H, Elksnis A, Wang X, Gavali H, Bergsten P, Scharfmann R, Welsh N.

Islets. 2017 May 4;9(3):e1296995. doi: 10.1080/19382014.2017.1296995. Epub 2017 Feb 28.

PMID:
28277987
13.

Mutations in BOREALIN cause thyroid dysgenesis.

Carré A, Stoupa A, Kariyawasam D, Gueriouz M, Ramond C, Monus T, Léger J, Gaujoux S, Sebag F, Glaser N, Zenaty D, Nitschke P, Bole-Feysot C, Hubert L, Lyonnet S, Scharfmann R, Munnich A, Besmond C, Taylor W, Polak M.

Hum Mol Genet. 2017 Feb 1;26(3):599-610. doi: 10.1093/hmg/ddw419.

PMID:
28025328
14.

Aggregation of Engineered Human β-Cells Into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu.

Lecomte MJ, Pechberty S, Machado C, Da Barroca S, Ravassard P, Scharfmann R, Czernichow P, Duvillié B.

Cell Med. 2016 Aug 12;8(3):99-112. doi: 10.3727/215517916X692843. eCollection 2016 Dec 3.

15.

Mass production of functional human pancreatic β-cells: why and how?

Scharfmann R, Didiesheim M, Richards P, Chandra V, Oshima M, Albagli O.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:128-36. doi: 10.1111/dom.12728. Review. Erratum in: Diabetes Obes Metab. 2016 Dec;18(12 ):1288.

PMID:
27615142
16.

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.

Thomsen SK, Ceroni A, van de Bunt M, Burrows C, Barrett A, Scharfmann R, Ebner D, McCarthy MI, Gloyn AL.

Diabetes. 2016 Dec;65(12):3805-3811. Epub 2016 Aug 23.

17.

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

Chandra V, Karamitri A, Richards P, Cormier F, Ramond C, Jockers R, Armanet M, Albagli-Curiel O, Scharfmann R.

Sci Rep. 2016 May 11;6:25765. doi: 10.1038/srep25765.

18.

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK.

Cell Metab. 2016 May 10;23(5):909-20. doi: 10.1016/j.cmet.2016.04.002. Epub 2016 Apr 28.

19.

A human beta cell line with drug inducible excision of immortalizing transgenes.

Benazra M, Lecomte MJ, Colace C, Müller A, Machado C, Pechberty S, Bricout-Neveu E, Grenier-Godard M, Solimena M, Scharfmann R, Czernichow P, Ravassard P.

Mol Metab. 2015 Oct 20;4(12):916-25. doi: 10.1016/j.molmet.2015.09.008. eCollection 2015 Dec.

20.

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

Kirkegaard JS, Ravassard P, Ingvarsen S, Diedisheim M, Bricout-Neveu E, Grønborg M, Frogne T, Scharfmann R, Madsen OD, Rescan C, Albagli O.

J Clin Invest. 2016 Mar 1;126(3):1109-13. doi: 10.1172/JCI83573. Epub 2016 Feb 22.

21.

Erratum. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033-2041.

Beltrand J, Elie C, Busiah K, Fournier E, Boddaert N, Bahi-Buisson N, Vera M, Bui-Quoc E, Ingster-Moati I, Berdugo M, Simon A, Gozalo C, Djerada Z, Flechtner I, Treluyer JM, Scharfmann R, Cavé H, Vaivre-Douret L, Polak M; GlidKir Study Group.

Diabetes Care. 2016 Jan;39(1):175. doi: 10.2337/dc16-er01. No abstract available.

PMID:
26696658
22.

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.

Pal A, Potjer TP, Thomsen SK, Ng HJ, Barrett A, Scharfmann R, James TJ, Bishop DT, Karpe F, Godsland IF, Vasen HF, Newton-Bishop J, Pijl H, McCarthy MI, Gloyn AL.

Diabetes. 2016 Feb;65(2):527-33. doi: 10.2337/db15-0602. Epub 2015 Nov 5.

23.

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.

van der Torren C, Zaldumbide A, Roelen DL, Duinkerken G, Brand-Schaaf SH, Peakman M, Czernichow P, Ravassard P, Scharfmann R, Roep BO.

Diabetologia. 2016 Jan;59(1):170-5.

24.

Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations.

Beltrand J, Elie C, Busiah K, Fournier E, Boddaert N, Bahi-Buisson N, Vera M, Bui-Quoc E, Ingster-Moati I, Berdugo M, Simon A, Gozalo C, Djerada Z, Flechtner I, Treluyer JM, Scharfmann R, Cavé H, Vaivre-Douret L, Polak M; GlidKir Study Group.

Diabetes Care. 2015 Nov;38(11):2033-41. doi: 10.2337/dc15-0837. Epub 2015 Oct 5. Erratum in: Diabetes Care. 2016 Jan;39(1):175.

PMID:
26438614
25.

Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death.

Fred RG, Kappe C, Ameur A, Cen J, Bergsten P, Ravassard P, Scharfmann R, Welsh N.

Mol Cell Endocrinol. 2015 Oct 15;414:53-63. doi: 10.1016/j.mce.2015.07.015. Epub 2015 Jul 26.

PMID:
26213325
26.

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor.

Bonfanti P, Nobecourt E, Oshima M, Albagli-Curiel O, Laurysens V, Stangé G, Sojoodi M, Heremans Y, Heimberg H, Scharfmann R.

Stem Cells Dev. 2015 Aug 1;24(15):1766-78. doi: 10.1089/scd.2014.0550. Epub 2015 Jun 8.

PMID:
25925840
27.

Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line.

Andersson LE, Valtat B, Bagge A, Sharoyko VV, Nicholls DG, Ravassard P, Scharfmann R, Spégel P, Mulder H.

PLoS One. 2015 Mar 24;10(3):e0120879. doi: 10.1371/journal.pone.0120879. eCollection 2015.

28.

RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.

Chandra V, Albagli-Curiel O, Hastoy B, Piccand J, Randriamampita C, Vaillant E, Cavé H, Busiah K, Froguel P, Vaxillaire M, Rorsman P, Polak M, Scharfmann R.

Cell Rep. 2014 Dec 24;9(6):2206-18. doi: 10.1016/j.celrep.2014.11.010. Epub 2014 Dec 11.

29.

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.

Kariyawasam D, Rachdi L, Carré A, Martin M, Houlier M, Janel N, Delabar JM, Scharfmann R, Polak M.

Endocrinology. 2015 Mar;156(3):1171-80. doi: 10.1210/en.2014-1329. Epub 2014 Dec 9.

PMID:
25490145
30.

Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathway.

Hoarau E, Chandra V, Rustin P, Scharfmann R, Duvillie B.

Cell Death Dis. 2014 Oct 23;5:e1487. doi: 10.1038/cddis.2014.441.

31.

Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation.

Carlier G, Maugein A, Cordier C, Pechberty S, Garfa-Traoré M, Martin P, Scharfmann R, Albagli O.

PLoS One. 2014 Sep 26;9(9):e108202. doi: 10.1371/journal.pone.0108202. eCollection 2014.

32.

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation.

Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B.

Diabetologia. 2014 Nov;57(11):2348-56. doi: 10.1007/s00125-014-3365-y. Epub 2014 Sep 4.

PMID:
25186293
33.

Human pancreas endocrine cell populations and activating ABCC8 mutations.

Busiah K, Verkarre V, Cavé H, Scharfmann R, Polak M.

Horm Res Paediatr. 2014;82(1):59-64. doi: 10.1159/000360004. Epub 2014 Jun 14.

PMID:
24941889
34.

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R.

Cell Cycle. 2014;13(14):2221-9. doi: 10.4161/cc.29250. Epub 2014 May 28.

35.

Development of a conditionally immortalized human pancreatic β cell line.

Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout-Neveu E, Grenier-Godard M, Guez F, Rachdi L, Lohmann M, Czernichow P, Ravassard P.

J Clin Invest. 2014 May;124(5):2087-98. doi: 10.1172/JCI72674. Epub 2014 Mar 25.

36.

Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected].

Busiah K, Drunat S, Vaivre-Douret L, Bonnefond A, Simon A, Flechtner I, Gérard B, Pouvreau N, Elie C, Nimri R, De Vries L, Tubiana-Rufi N, Metz C, Bertrand AM, Nivot-Adamiak S, de Kerdanet M, Stuckens C, Jennane F, Souchon PF, Le Tallec C, Désirée C, Pereira S, Dechaume A, Robert JJ, Phillip M, Scharfmann R, Czernichow P, Froguel P, Vaxillaire M, Polak M, Cavé H; French NDM study group.

Lancet Diabetes Endocrinol. 2013 Nov;1(3):199-207. doi: 10.1016/S2213-8587(13)70059-7. Epub 2013 Sep 6. Erratum in: Lancet Diabetes Endocrinol. 2013 Nov;1(3):e14.

PMID:
24622368
37.

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass.

Rachdi L, Kariyawasam D, Guez F, Aïello V, Arbonés ML, Janel N, Delabar JM, Polak M, Scharfmann R.

Diabetologia. 2014 May;57(5):960-9. doi: 10.1007/s00125-014-3174-3. Epub 2014 Jan 30.

PMID:
24477974
38.

Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic β cell development.

Michau A, Guillemain G, Grosfeld A, Vuillaumier-Barrot S, Grand T, Keck M, L'Hoste S, Chateau D, Serradas P, Teulon J, De Lonlay P, Scharfmann R, Brot-Laroche E, Leturque A, Le Gall M.

J Biol Chem. 2013 Oct 25;288(43):31080-92. doi: 10.1074/jbc.M113.469189. Epub 2013 Aug 28.

39.

Mouse muscle as an ectopic permissive site for human pancreatic development.

Capito C, Simon MT, Aiello V, Clark A, Aigrain Y, Ravassard P, Scharfmann R.

Diabetes. 2013 Oct;62(10):3479-87. doi: 10.2337/db13-0554. Epub 2013 Jul 8.

40.

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family.

Bonnefond A, Vaillant E, Philippe J, Skrobek B, Lobbens S, Yengo L, Huyvaert M, Cavé H, Busiah K, Scharfmann R, Polak M, Abdul-Rasoul M, Froguel P, Vaxillaire M.

Diabetes Metab. 2013 May;39(3):276-80. doi: 10.1016/j.diabet.2013.02.007. Epub 2013 Apr 4.

PMID:
23562494
41.

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl.

Mokhtari D, Al-Amin A, Turpaev K, Li T, Idevall-Hagren O, Li J, Wuttke A, Fred RG, Ravassard P, Scharfmann R, Tengholm A, Welsh N.

Diabetologia. 2013 Jun;56(6):1327-38. doi: 10.1007/s00125-013-2868-2. Epub 2013 Mar 5.

PMID:
23462796
42.

mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1.

Denis JA, Gauthier M, Rachdi L, Aubert S, Giraud-Triboult K, Poydenot P, Benchoua A, Champon B, Maury Y, Baldeschi C, Scharfmann R, Piétu G, Peschanski M, Martinat C.

J Cell Sci. 2013 Apr 15;126(Pt 8):1763-72. doi: 10.1242/jcs.116285. Epub 2013 Feb 26.

43.

Fetal pancreas transplants are dependent on prolactin for their development and prevent type 1 diabetes in syngeneic but not allogeneic mice.

Fourcade G, Colombo BM, Grégoire S, Baeyens A, Rachdi L, Guez F, Goffin V, Scharfmann R, Salomon BL.

Diabetes. 2013 May;62(5):1646-55. doi: 10.2337/db12-0448. Epub 2013 Feb 19.

44.

Concise review: in search of unlimited sources of functional human pancreatic beta cells.

Scharfmann R, Rachdi L, Ravassard P.

Stem Cells Transl Med. 2013 Jan;2(1):61-7. doi: 10.5966/sctm.2012-0120. Epub 2012 Dec 19. Review.

45.

Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse.

Zertal-Zidani S, Busiah K, Edelman A, Polak M, Scharfmann R.

Diabetologia. 2013 Feb;56(2):330-9. doi: 10.1007/s00125-012-2778-8. Epub 2012 Nov 24.

46.

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.

Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakić N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J.

Cell Metab. 2012 Oct 3;16(4):435-48. doi: 10.1016/j.cmet.2012.08.010.

47.

GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes.

Bonnefond A, Sand O, Guerin B, Durand E, De Graeve F, Huyvaert M, Rachdi L, Kerr-Conte J, Pattou F, Vaxillaire M, Polak M, Scharfmann R, Czernichow P, Froguel P.

Diabetologia. 2012 Oct;55(10):2845-2847. doi: 10.1007/s00125-012-2645-7. Epub 2012 Jul 18. No abstract available.

PMID:
22806356
48.

Activation of the transcription factor carbohydrate-responsive element-binding protein by glucose leads to increased pancreatic beta cell differentiation in rats.

Soggia A, Flosseau K, Ravassard P, Szinnai G, Scharfmann R, Guillemain G.

Diabetologia. 2012 Oct;55(10):2713-2722. doi: 10.1007/s00125-012-2623-0. Epub 2012 Jul 5.

49.

HIF1α and pancreatic β-cell development.

Heinis M, Soggia A, Bechetoille C, Simon MT, Peyssonnaux C, Rustin P, Scharfmann R, Duvillié B.

FASEB J. 2012 Jul;26(7):2734-42. doi: 10.1096/fj.11-199224. Epub 2012 Mar 16.

50.

[First immortalised cell lines phenotypically and functionally equivalent to human insulin-secreting pancreatic beta cells].

Ravassard P, Czernichow P, Scharfmann R.

Med Sci (Paris). 2012 Feb;28(2):149-51. doi: 10.1051/medsci/2012282011. Epub 2012 Feb 27. French. No abstract available.

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