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Items: 17

1.

An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor.

Titze MI, Schaaf O, Hofmann MH, Sanderson MP, Zahn SK, Quant J, Lehr T.

Cancer Chemother Pharmacol. 2017 Mar;79(3):545-558. doi: 10.1007/s00280-017-3252-6. Epub 2017 Feb 27.

PMID:
28243682
2.

A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques.

Titze MI, Schaaf O, Hofmann MH, Sanderson MP, Zahn SK, Quant J, Lehr T.

Cancer Chemother Pharmacol. 2016 Jun;77(6):1303-14. doi: 10.1007/s00280-016-3049-z. Epub 2016 May 9.

PMID:
27160688
3.

A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.

Waizenegger IC, Baum A, Steurer S, Stadtmüller H, Bader G, Schaaf O, Garin-Chesa P, Schlattl A, Schweifer N, Haslinger C, Colbatzky F, Mousa S, Kalkuhl A, Kraut N, Adolf GR.

Mol Cancer Ther. 2016 Mar;15(3):354-65. doi: 10.1158/1535-7163.MCT-15-0617. Epub 2016 Feb 25.

4.

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.

Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Müller S, Nar H, Rogers C, Rumpel K, Schaaf O, Steurer S, Tallant C, Vakoc CR, Zeeb M, Zoephel A, Pearson M, Boehmelt G, McConnell D.

J Med Chem. 2016 May 26;59(10):4462-75. doi: 10.1021/acs.jmedchem.5b01865. Epub 2016 Mar 10.

5.

Ozonated water is inferior to propanol-based hand rubs for disinfecting hands.

Appelgrein C, Hosgood G, Dunn AL, Schaaf O.

J Hosp Infect. 2016 Apr;92(4):340-3. doi: 10.1016/j.jhin.2015.08.029. Epub 2015 Dec 15.

PMID:
26832646
6.

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.

Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N.

Mol Cancer Ther. 2015 Dec;14(12):2762-72. doi: 10.1158/1535-7163.MCT-15-0539. Epub 2015 Oct 5.

7.

In vitro comparison of secure Aberdeen and square knots with plasma- and fat-coated polydioxanone.

Schaaf O, Glyde M, Day RE.

Vet Surg. 2010 Jul;39(5):553-60. doi: 10.1111/j.1532-950X.2009.00640.x. Epub 2010 Mar 10.

PMID:
20230594
8.

Sand impaction of the small intestine in eight dogs.

Moles AD, McGhite A, Schaaf OR, Read R.

J Small Anim Pract. 2010 Jan;51(1):29-33. doi: 10.1111/j.1748-5827.2009.00847.x.

PMID:
20137006
9.

Biceps brachii and brachialis tendon of insertion injuries in eleven racing greyhounds.

Schaaf OR, Eaton-Wells R, Mitchell RA.

Vet Surg. 2009 Oct;38(7):825-33. doi: 10.1111/j.1532-950X.2009.00593.x.

PMID:
19781025
10.

A secure Aberdeen knot: in vitro assessment of knot security in plasma and fat.

Schaaf O, Glyde M, Day RE.

J Small Anim Pract. 2009 Aug;50(8):415-21. doi: 10.1111/j.1748-5827.2009.00771.x.

PMID:
19689669
11.

Ketones as building blocks for dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selection pressure of the biological target.

Hochgürtel M, Biesinger R, Kroth H, Piecha D, Hofmann MW, Krause S, Schaaf O, Nicolau C, Eliseev AV.

J Med Chem. 2003 Jan 30;46(3):356-8.

PMID:
12540234
12.

Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries.

Hochgürtel M, Kroth H, Piecha D, Hofmann MW, Nicolau C, Krause S, Schaaf O, Sonnenmoser G, Eliseev AV.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3382-7. Epub 2002 Mar 12.

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