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Items: 47

1.

Preclinical Efficacy of an Antibody-Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET.

Terwisscha van Scheltinga AG, Ogasawara A, Pacheco G, Vanderbilt AN, Tinianow JN, Gupta N, Li D, Firestein R, Marik J, Scales SJ, Williams SP.

Mol Cancer Ther. 2017 Jan;16(1):134-142. doi: 10.1158/1535-7163.MCT-16-0449. Epub 2016 Oct 19.

2.

Phase I Study of DMOT4039A, an Antibody-Drug Conjugate Targeting Mesothelin, in Patients with Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer.

Weekes CD, Lamberts LE, Borad MJ, Voortman J, McWilliams RR, Diamond JR, de Vries EG, Verheul HM, Lieu CH, Kim GP, Wang Y, Scales SJ, Samineni D, Brunstein F, Choi Y, Maslyar DJ, Colon-Otero G.

Mol Cancer Ther. 2016 Mar;15(3):439-47. doi: 10.1158/1535-7163.MCT-15-0693. Epub 2016 Jan 28.

3.

The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.

Singh J, Wen X, Scales SJ.

J Biol Chem. 2015 Dec 4;290(49):29663-75. doi: 10.1074/jbc.M115.665810. Epub 2015 Oct 8.

4.

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates.

Cuellar TL, Barnes D, Nelson C, Tanguay J, Yu SF, Wen X, Scales SJ, Gesch J, Davis D, van Brabant Smith A, Leake D, Vandlen R, Siebel CW.

Nucleic Acids Res. 2015 Jan;43(2):1189-203. doi: 10.1093/nar/gku1362. Epub 2014 Dec 30.

5.

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R.

Dev Cell. 2014 Nov 10;31(3):345-357. doi: 10.1016/j.devcel.2014.09.018. Epub 2014 Nov 10.

6.

An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models.

Scales SJ, Gupta N, Pacheco G, Firestein R, French DM, Koeppen H, Rangell L, Barry-Hamilton V, Luis E, Chuh J, Zhang Y, Ingle GS, Fourie-O'Donohue A, Kozak KR, Ross S, Dennis MS, Spencer SD.

Mol Cancer Ther. 2014 Nov;13(11):2630-40. doi: 10.1158/1535-7163.MCT-14-0487-T. Epub 2014 Sep 23.

7.

DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles.

Ingle GS, Scales SJ.

Traffic. 2014 Mar;15(3):255-72. doi: 10.1111/tra.12144. Epub 2014 Jan 14.

8.

Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.

Jurisch-Yaksi N, Rose AJ, Lu H, Raemaekers T, Munck S, Baatsen P, Baert V, Vermeire W, Scales SJ, Verleyen D, Vandepoel R, Tylzanowski P, Yaksi E, de Ravel T, Yost HJ, Froyen G, Arrington CB, Annaert W.

J Cell Biol. 2013 Mar 18;200(6):709-20. doi: 10.1083/jcb.201208175. Epub 2013 Mar 11.

9.

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK.

Cell. 2013 Jan 17;152(1-2):210-23. doi: 10.1016/j.cell.2012.12.026.

10.

FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma.

Elkins K, Zheng B, Go M, Slaga D, Du C, Scales SJ, Yu SF, McBride J, de Tute R, Rawstron A, Jack AS, Ebens A, Polson AG.

Mol Cancer Ther. 2012 Oct;11(10):2222-32. doi: 10.1158/1535-7163.MCT-12-0087. Epub 2012 Jul 17.

11.

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

Shen BQ, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, Parsons-Reponte KL, Tien J, Yu SF, Mai E, Li D, Tibbitts J, Baudys J, Saad OM, Scales SJ, McDonald PJ, Hass PE, Eigenbrot C, Nguyen T, Solis WA, Fuji RN, Flagella KM, Patel D, Spencer SD, Khawli LA, Ebens A, Wong WL, Vandlen R, Kaur S, Sliwkowski MX, Scheller RH, Polakis P, Junutula JR.

Nat Biotechnol. 2012 Jan 22;30(2):184-9. doi: 10.1038/nbt.2108.

PMID:
22267010
12.

Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation.

Mao Y, Shang Y, Pham VC, Ernst JA, Lill JR, Scales SJ, Zha J.

J Biol Chem. 2011 Dec 2;286(48):41852-61. doi: 10.1074/jbc.M111.288514. Epub 2011 Oct 12.

13.

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes.

Gao X, Arenas-Ramirez N, Scales SJ, Hannoush RN.

FEBS Lett. 2011 Aug 4;585(15):2501-6. doi: 10.1016/j.febslet.2011.06.033. Epub 2011 Jul 2.

14.

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK.

Cell. 2011 May 13;145(4):513-28. doi: 10.1016/j.cell.2011.04.019.

15.

Functional characterization of putative cilia genes by high-content analysis.

Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ.

Mol Biol Cell. 2011 Apr;22(7):1104-19. doi: 10.1091/mbc.E10-07-0596. Epub 2011 Feb 2.

16.

Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.

Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A.

Dev Cell. 2011 Jan 18;20(1):33-46. doi: 10.1016/j.devcel.2010.12.001.

17.

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.

Dijkgraaf GJ, Alicke B, Weinmann L, Januario T, West K, Modrusan Z, Burdick D, Goldsmith R, Robarge K, Sutherlin D, Scales SJ, Gould SE, Yauch RL, de Sauvage FJ.

Cancer Res. 2011 Jan 15;71(2):435-44. doi: 10.1158/0008-5472.CAN-10-2876. Epub 2010 Dec 1.

18.

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK.

Genes Dev. 2010 Oct 1;24(19):2180-93. doi: 10.1101/gad.1966210.

19.

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.

Maun HR, Wen X, Lingel A, de Sauvage FJ, Lazarus RA, Scales SJ, Hymowitz SG.

J Biol Chem. 2010 Aug 20;285(34):26570-80. doi: 10.1074/jbc.M110.112284. Epub 2010 May 26.

20.

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.

Wen X, Lai CK, Evangelista M, Hongo JA, de Sauvage FJ, Scales SJ.

Mol Cell Biol. 2010 Apr;30(8):1910-22. doi: 10.1128/MCB.01089-09. Epub 2010 Feb 12.

21.

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS.

Curr Biol. 2009 Aug 11;19(15):1320-6. doi: 10.1016/j.cub.2009.06.046. Epub 2009 Jul 9.

22.

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA.

Nat Struct Mol Biol. 2009 Jul;16(7):691-7. doi: 10.1038/nsmb.1632. Epub 2009 Jun 28.

PMID:
19561609
23.

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Scales SJ, de Sauvage FJ.

Trends Pharmacol Sci. 2009 Jun;30(6):303-12. doi: 10.1016/j.tips.2009.03.007. Epub 2009 May 13. Review.

PMID:
19443052
24.

Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.

Polson AG, Calemine-Fenaux J, Chan P, Chang W, Christensen E, Clark S, de Sauvage FJ, Eaton D, Elkins K, Elliott JM, Frantz G, Fuji RN, Gray A, Harden K, Ingle GS, Kljavin NM, Koeppen H, Nelson C, Prabhu S, Raab H, Ross S, Slaga DS, Stephan JP, Scales SJ, Spencer SD, Vandlen R, Wranik B, Yu SF, Zheng B, Ebens A.

Cancer Res. 2009 Mar 15;69(6):2358-64. doi: 10.1158/0008-5472.CAN-08-2250. Epub 2009 Mar 3. Erratum in: Cancer Res. 2010 Feb 1;70(3):1275. Slaga, Dion S [added].

25.

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.

Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4254-9. doi: 10.1073/pnas.0813203106. Epub 2009 Feb 25.

26.

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake.

Shang Y, Mao Y, Batson J, Scales SJ, Phillips G, Lackner MR, Totpal K, Williams S, Yang J, Tang Z, Modrusan Z, Tan C, Liang WC, Tsai SP, Vanderbilt A, Kozuka K, Hoeflich K, Tien J, Ross S, Li C, Lee SH, Song A, Wu Y, Stephan JP, Ashkenazi A, Zha J.

Mol Cancer Ther. 2008 Sep;7(9):2599-608. doi: 10.1158/1535-7163.MCT-07-2401.

27.

A paracrine requirement for hedgehog signalling in cancer.

Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ.

Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.

PMID:
18754008
28.

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate.

Ingle GS, Chan P, Elliott JM, Chang WS, Koeppen H, Stephan JP, Scales SJ.

Br J Haematol. 2008 Jan;140(1):46-58. Epub 2007 Nov 7.

29.
30.

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma.

Polson AG, Yu SF, Elkins K, Zheng B, Clark S, Ingle GS, Slaga DS, Giere L, Du C, Tan C, Hongo JA, Gogineni A, Cole MJ, Vandlen R, Stephan JP, Young J, Chang W, Scales SJ, Ross S, Eaton D, Ebens A.

Blood. 2007 Jul 15;110(2):616-23. Epub 2007 Mar 20.

31.

CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.

Helmy KY, Katschke KJ Jr, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M.

Cell. 2006 Mar 10;124(5):915-27.

32.

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates.

Austin CD, Wen X, Gazzard L, Nelson C, Scheller RH, Scales SJ.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17987-92. Epub 2005 Dec 1.

33.

Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.

Scales SJ, Hesser BA, Masuda ES, Scheller RH.

J Biol Chem. 2002 Aug 2;277(31):28271-9. Epub 2002 May 24.

34.

The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF.

Scales SJ, Yoo BY, Scheller RH.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14262-7.

35.

Cell biology. Fusion without SNAREs?

Scales SJ, Finley MF, Scheller RH.

Science. 2001 Nov 2;294(5544):1015-6.

PMID:
11691976
36.

A discontinuous SNAP-25 C-terminal coil supports exocytosis.

Chen YA, Scales SJ, Jagath JR, Scheller RH.

J Biol Chem. 2001 Jul 27;276(30):28503-8. Epub 2001 May 23.

37.

Calcium regulation of exocytosis in PC12 cells.

Chen YA, Scales SJ, Duvvuri V, Murthy M, Patel SM, Schulman H, Scheller RH.

J Biol Chem. 2001 Jul 13;276(28):26680-7. Epub 2001 May 18.

38.

Sequential SNARE assembly underlies priming and triggering of exocytosis.

Chen YA, Scales SJ, Scheller RH.

Neuron. 2001 Apr;30(1):161-70.

39.

The specifics of membrane fusion.

Scales SJ, Bock JB, Scheller RH.

Nature. 2000 Sep 14;407(6801):144-6. No abstract available.

40.

Membrane recruitment of coatomer and binding to dilysine signals are separate events.

Gomez M, Scales SJ, Kreis TE, Perez F.

J Biol Chem. 2000 Sep 15;275(37):29162-9.

41.

SNAREs contribute to the specificity of membrane fusion.

Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH.

Neuron. 2000 May;26(2):457-64.

42.

Coat proteins regulating membrane traffic.

Scales SJ, Gomez M, Kreis TE.

Int Rev Cytol. 2000;195:67-144. Review.

PMID:
10603575
43.

Lipid membranes shape up.

Scales SJ, Scheller RH.

Nature. 1999 Sep 9;401(6749):123-4. No abstract available.

PMID:
10490016
44.

Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes.

Shima DT, Scales SJ, Kreis TE, Pepperkok R.

Curr Biol. 1999 Jul 29-Aug 12;9(15):821-4.

45.

SNARE complex formation is triggered by Ca2+ and drives membrane fusion.

Chen YA, Scales SJ, Patel SM, Doung YC, Scheller RH.

Cell. 1999 Apr 16;97(2):165-74.

46.
47.

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