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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.

Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J.

Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.


Neural evidence for the intrinsic value of action as motivation for behavior.

Miura N, Tanabe HC, Sasaki AT, Harada T, Sadato N.

Neuroscience. 2017 Jun 3;352:190-203. doi: 10.1016/j.neuroscience.2017.03.064. Epub 2017 Apr 8.


Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.

Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR.

Cell Rep. 2017 Feb 28;18(9):2088-2095. doi: 10.1016/j.celrep.2017.02.022.


Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.

Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL.

J Clin Invest. 2016 Nov 1;126(11):4088-4102. doi: 10.1172/JCI87148. Epub 2016 Sep 26.


Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome.

Mizuno K, Kawatani J, Tajima K, Sasaki AT, Yoneda T, Komi M, Hirai T, Tomoda A, Joudoi T, Watanabe Y.

Neuroimage Clin. 2016 Sep 26;12:600-606. eCollection 2016.


The role of prosody and context in sarcasm comprehension: Behavioral and fMRI evidence.

Matsui T, Nakamura T, Utsumi A, Sasaki AT, Koike T, Yoshida Y, Harada T, Tanabe HC, Sadato N.

Neuropsychologia. 2016 Jul 1;87:74-84. doi: 10.1016/j.neuropsychologia.2016.04.031. Epub 2016 May 6.


Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells.

Takeuchi K, Senda M, Lo YH, Kofuji S, Ikeda Y, Sasaki AT, Senda T.

FEBS J. 2016 Oct;283(19):3556-3562. doi: 10.1111/febs.13739. Review.


Dynamic Role of the GTP Energy Metabolism in Cancers.

Sasaki AT.

Keio J Med. 2016;65(1):21. doi: 10.2302/kjm.65-001-ABST.


The Brain Mechanisms Underlying the Perception of Pungent Taste of Capsaicin and the Subsequent Autonomic Responses.

Kawakami S, Sato H, Sasaki AT, Tanabe HC, Yoshida Y, Saito M, Toyoda H, Sadato N, Kang Y.

Front Hum Neurosci. 2016 Jan 19;9:720. doi: 10.3389/fnhum.2015.00720. eCollection 2015.


The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT.

Mol Cell. 2016 Jan 21;61(2):187-98. doi: 10.1016/j.molcel.2015.12.011. Epub 2016 Jan 7.


Neural substrates of shared attention as social memory: A hyperscanning functional magnetic resonance imaging study.

Koike T, Tanabe HC, Okazaki S, Nakagawa E, Sasaki AT, Shimada K, Sugawara SK, Takahashi HK, Yoshihara K, Bosch-Bayard J, Sadato N.

Neuroimage. 2016 Jan 15;125:401-412. doi: 10.1016/j.neuroimage.2015.09.076. Epub 2015 Oct 26.


Brain networks of affective mentalizing revealed by the tear effect: The integrative role of the medial prefrontal cortex and precuneus.

Takahashi HK, Kitada R, Sasaki AT, Kawamichi H, Okazaki S, Kochiyama T, Sadato N.

Neurosci Res. 2015 Dec;101:32-43. doi: 10.1016/j.neures.2015.07.005. Epub 2015 Jul 18.


Imaging the passionate stage of romantic love by dopamine dynamics.

Takahashi K, Mizuno K, Sasaki AT, Wada Y, Tanaka M, Ishii A, Tajima K, Tsuyuguchi N, Watanabe K, Zeki S, Watanabe Y.

Front Hum Neurosci. 2015 Apr 9;9:191. doi: 10.3389/fnhum.2015.00191. eCollection 2015.


Effects of terlipressin as early treatment for protection of brain in a model of haemorrhagic shock.

Ida KK, Otsuki DA, Sasaki AT, Borges ES, Castro LU, Sanches TR, Shimizu MH, Andrade LC, Auler JO Jr, Dyson A, Smith KJ, Rocha Filho JA, Malbouisson LM.

Crit Care. 2015 Mar 13;19:107. doi: 10.1186/s13054-015-0825-9.


Frequency-specific network topologies in the resting human brain.

Sasai S, Homae F, Watanabe H, Sasaki AT, Tanabe HC, Sadato N, Taga G.

Front Hum Neurosci. 2014 Dec 22;8:1022. doi: 10.3389/fnhum.2014.01022. eCollection 2014.


Role of the precuneus in the detection of incongruency between tactile and visual texture information: A functional MRI study.

Kitada R, Sasaki AT, Okamoto Y, Kochiyama T, Sadato N.

Neuropsychologia. 2014 Nov;64:252-62. doi: 10.1016/j.neuropsychologia.2014.09.028. Epub 2014 Oct 2.


Perceiving active listening activates the reward system and improves the impression of relevant experiences.

Kawamichi H, Yoshihara K, Sasaki AT, Sugawara SK, Tanabe HC, Shinohara R, Sugisawa Y, Tokutake K, Mochizuki Y, Anme T, Sadato N.

Soc Neurosci. 2015;10(1):16-26. doi: 10.1080/17470919.2014.954732. Epub 2014 Sep 4.


Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder.

Okamoto Y, Kitada R, Tanabe HC, Hayashi MJ, Kochiyama T, Munesue T, Ishitobi M, Saito DN, Yanaka HT, Omori M, Wada Y, Okazawa H, Sasaki AT, Morita T, Itakura S, Kosaka H, Sadato N.

Neurosci Res. 2014 Oct;87:66-76. doi: 10.1016/j.neures.2014.06.012. Epub 2014 Jul 24.


The brain network underlying the recognition of hand gestures in the blind: the supramodal role of the extrastriate body area.

Kitada R, Yoshihara K, Sasaki AT, Hashiguchi M, Kochiyama T, Sadato N.

J Neurosci. 2014 Jul 23;34(30):10096-108. doi: 10.1523/JNEUROSCI.0500-14.2014.


Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.

Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT.

J Biol Chem. 2014 Feb 14;289(7):3950-9. doi: 10.1074/jbc.M113.531178. Epub 2013 Dec 13.


Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.

Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL.

J Biol Chem. 2013 Dec 27;288(52):36856-62. doi: 10.1074/jbc.C113.525691. Epub 2013 Nov 18.


Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC.

Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057.


Medial prefrontal cortex activation is commonly invoked by reputation of self and romantic partners.

Kawamichi H, Sasaki AT, Matsunaga M, Yoshihara K, Takahashi HK, Tanabe HC, Sadato N.

PLoS One. 2013 Sep 23;8(9):e74958. doi: 10.1371/journal.pone.0074958. eCollection 2013.


The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.

Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki AT, Aronow B, Warnick RE, Lawler S, Driscoll JJ.

Sci Rep. 2013;3:2392. doi: 10.1038/srep02392.


The anterior insular and anterior cingulate cortices in emotional processing for self-face recognition.

Morita T, Tanabe HC, Sasaki AT, Shimada K, Kakigi R, Sadato N.

Soc Cogn Affect Neurosci. 2014 May;9(5):570-9. doi: 10.1093/scan/nst011. Epub 2013 Jan 31.


Early visual experience and the recognition of basic facial expressions: involvement of the middle temporal and inferior frontal gyri during haptic identification by the early blind.

Kitada R, Okamoto Y, Sasaki AT, Kochiyama T, Miyahara M, Lederman SJ, Sadato N.

Front Hum Neurosci. 2013 Jan 28;7:7. doi: 10.3389/fnhum.2013.00007. eCollection 2013.


From gestures to words: spontaneous verbal labeling of complex sequential hand movements reduces fMRI activation of the imitation-related regions.

Miyahara M, Kitada R, Sasaki AT, Okamoto Y, Tanabe HC, Sadato N.

Neurosci Res. 2013 Mar;75(3):228-38. doi: 10.1016/j.neures.2012.12.007. Epub 2013 Jan 23.


A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.

Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A.

PLoS One. 2013;8(1):e54127. doi: 10.1371/journal.pone.0054127. Epub 2013 Jan 10.


Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL.

Nat Struct Mol Biol. 2013 Jan;20(1):46-52. doi: 10.1038/nsmb.2430. Epub 2012 Nov 25.


Neural networks for action representation: a functional magnetic-resonance imaging and dynamic causal modeling study.

Sasaki AT, Kochiyama T, Sugiura M, Tanabe HC, Sadato N.

Front Hum Neurosci. 2012 Aug 14;6:236. doi: 10.3389/fnhum.2012.00236. eCollection 2012.


Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules.

Fujimura K, Sasaki AT, Anderson P.

Nucleic Acids Res. 2012 Sep;40(16):8099-110. doi: 10.1093/nar/gks566. Epub 2012 Jun 20.


A NIRS-fMRI study of resting state network.

Sasai S, Homae F, Watanabe H, Sasaki AT, Tanabe HC, Sadato N, Taga G.

Neuroimage. 2012 Oct 15;63(1):179-93. doi: 10.1016/j.neuroimage.2012.06.011. Epub 2012 Jun 17.


Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.

Cell. 2012 Mar 30;149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6.


Characterization of KRAS rearrangements in metastatic prostate cancer.

Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM.

Cancer Discov. 2011 Jun;1(1):35-43. doi: 10.1158/2159-8274.CD-10-0022. Epub 2011 Jun 1.


Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.

Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC.

Science. 2011 Dec 2;334(6060):1278-83. doi: 10.1126/science.1211485. Epub 2011 Nov 3.


Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG.

Nat Genet. 2011 Jul 31;43(9):869-74. doi: 10.1038/ng.890.


A fluorescent reporter of AMPK activity and cellular energy stress.

Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC.

Cell Metab. 2011 Apr 6;13(4):476-486. doi: 10.1016/j.cmet.2011.03.006.


Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC.

Sci Signal. 2011 Mar 8;4(163):ra13. doi: 10.1126/scisignal.2001518.


A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.

Charest PG, Shen Z, Lakoduk A, Sasaki AT, Briggs SP, Firtel RA.

Dev Cell. 2010 May 18;18(5):737-49. doi: 10.1016/j.devcel.2010.03.017.


Spatiotemporal regulation of Ras-GTPases during chemotaxis.

Sasaki AT, Firtel RA.

Methods Mol Biol. 2009;571:333-48. doi: 10.1007/978-1-60761-198-1_23.


Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP.

J Clin Invest. 2008 Sep;118(9):3065-74. doi: 10.1172/JCI34739.


G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility.

Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K, Sundheimer LW, Meili R, Devreotes PN, Firtel RA.

J Cell Biol. 2007 Jul 16;178(2):185-91.


Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.

Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA.

J Biol Chem. 2007 Apr 20;282(16):11874-84. Epub 2007 Mar 1.


Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.

Sasaki AT, Firtel RA.

Eur J Cell Biol. 2006 Sep;85(9-10):873-95. Epub 2006 Jun 5. Review.


Finding the way: directional sensing and cell polarization through Ras signalling.

Sasaki AT, Firtel RA.

Novartis Found Symp. 2005;269:73-87; discussion 87-91, 223-30.


Rho Rocks PTEN.

Meili R, Sasaki AT, Firtel RA.

Nat Cell Biol. 2005 Apr;7(4):334-5. No abstract available.


Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.

Sasaki AT, Chun C, Takeda K, Firtel RA.

J Cell Biol. 2004 Nov 8;167(3):505-18.


Hemagglutination test for the diagnosis of human neurocysticercosis: development of a stable reagent using homologous and heterologous antigens.

Ferreira AP, Vaz AJ, Nakamura PM, Sasaki AT, Ferreira AW, Livramento JA.

Rev Inst Med Trop Sao Paulo. 1997 Jan-Feb;39(1):29-33.


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