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Items: 1 to 50 of 57

1.

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.

Laiho P, Kokko A, Vanharanta S, Salovaara R, Sammalkorpi H, Järvinen H, Mecklin JP, Karttunen TJ, Tuppurainen K, Davalos V, Schwartz S Jr, Arango D, Mäkinen MJ, Aaltonen LA.

Oncogene. 2007 Jan 11;26(2):312-20. Epub 2006 Jul 3.

PMID:
16819509
2.

Increased risk of cancer in patients with fumarate hydratase germline mutation.

Lehtonen HJ, Kiuru M, Ylisaukko-Oja SK, Salovaara R, Herva R, Koivisto PA, Vierimaa O, Aittomäki K, Pukkala E, Launonen V, Aaltonen LA.

J Med Genet. 2006 Jun;43(6):523-6. Epub 2005 Sep 9.

3.

SMAD4 levels and response to 5-fluorouracil in colorectal cancer.

Alhopuro P, Alazzouzi H, Sammalkorpi H, Dávalos V, Salovaara R, Hemminki A, Järvinen H, Mecklin JP, Schwartz S Jr, Aaltonen LA, Arango D.

Clin Cancer Res. 2005 Sep 1;11(17):6311-6.

4.

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.

Arango D, Laiho P, Kokko A, Alhopuro P, Sammalkorpi H, Salovaara R, Nicorici D, Hautaniemi S, Alazzouzi H, Mecklin JP, Järvinen H, Hemminki A, Astola J, Schwartz S Jr, Aaltonen LA.

Gastroenterology. 2005 Sep;129(3):874-84.

PMID:
16143127
5.

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.

Hienonen T, Salovaara R, Mecklin JP, Järvinen H, Karhu A, Aaltonen LA.

Int J Cancer. 2006 Jan 15;118(2):505-8.

6.

Gene expression signatures for colorectal cancer microsatellite status and HNPCC.

Kruhøffer M, Jensen JL, Laiho P, Dyrskjøt L, Salovaara R, Arango D, Birkenkamp-Demtroder K, Sørensen FB, Christensen LL, Buhl L, Mecklin JP, Järvinen H, Thykjaer T, Wikman FP, Bech-Knudsen F, Juhola M, Nupponen NN, Laurberg S, Andersen CL, Aaltonen LA, Ørntoft TF.

Br J Cancer. 2005 Jun 20;92(12):2240-8.

7.

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.

Hienonen T, Sammalkorpi H, Enholm S, Alhopuro P, Barber TD, Lehtonen R, Nupponen NN, Lehtonen H, Salovaara R, Mecklin JP, Järvinen H, Koistinen R, Arango D, Launonen V, Vogelstein B, Karhu A, Aaltonen LA.

Cancer Res. 2005 Jun 1;65(11):4607-13.

8.

SMAD4 as a prognostic marker in colorectal cancer.

Alazzouzi H, Alhopuro P, Salovaara R, Sammalkorpi H, Järvinen H, Mecklin JP, Hemminki A, Schwartz S Jr, Aaltonen LA, Arango D.

Clin Cancer Res. 2005 Apr 1;11(7):2606-11.

9.

Colorectal pretumor progression before and after loss of DNA mismatch repair.

Calabrese P, Tsao JL, Yatabe Y, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Tavaré S, Shibata D.

Am J Pathol. 2004 Apr;164(4):1447-53.

10.

Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancer.

Kettunen E, Anttila S, Seppänen JK, Karjalainen A, Edgren H, Lindström I, Salovaara R, Nissén AM, Salo J, Mattson K, Hollmén J, Knuutila S, Wikman H.

Cancer Genet Cytogenet. 2004 Mar;149(2):98-106.

PMID:
15036884
11.

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.

Lehtonen R, Kiuru M, Vanharanta S, Sjöberg J, Aaltonen LM, Aittomäki K, Arola J, Butzow R, Eng C, Husgafvel-Pursiainen K, Isola J, Järvinen H, Koivisto P, Mecklin JP, Peltomäki P, Salovaara R, Wasenius VM, Karhu A, Launonen V, Nupponen NN, Aaltonen LA.

Am J Pathol. 2004 Jan;164(1):17-22.

12.

The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study.

Müller W, Burgart LJ, Krause-Paulus R, Thibodeau SN, Almeida M, Edmonston TB, Boland CR, Sutter C, Jass JR, Lindblom A, Lubinski J, MacDermot K, Sanders DS, Morreau H, Müller A, Oliani C, Orntoft T, Ponz De Leon M, Rosty C, Rodriguez-Bigas M, Rüschoff J, Ruszkiewicz A, Sabourin J, Salovaara R, Möslein G; ICG-HNPCC (International Collaborative Group).

Fam Cancer. 2001;1(2):87-92.

PMID:
14574003
13.

Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer.

Renkonen E, Zhang Y, Lohi H, Salovaara R, Abdel-Rahman WM, Nilbert M, Aittomaki K, Jarvinen HJ, Mecklin JP, Lindblom A, Peltomaki P.

J Clin Oncol. 2003 Oct 1;21(19):3629-37.

PMID:
14512394
14.

Little evidence for involvement of MLH3 in colorectal cancer predisposition.

Hienonen T, Laiho P, Salovaara R, Mecklin JP, Järvinen H, Sistonen P, Peltomäki P, Lehtonen R, Nupponen NN, Launonen V, Karhu A, Aaltonen LA.

Int J Cancer. 2003 Aug 20;106(2):292-6.

15.

Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.

Laiho P, Hienonen T, Karhu A, Lipton L, Aalto Y, Thomas HJ, Birkenkamp-Demtroder K, Hodgson S, Salovaara R, Mecklin JP, Järvinen H, Knuutila S, Halford S, Ørntoft TF, Tomlinson I, Launonen V, Houlston R, Aaltonen LA.

Oncogene. 2003 Apr 10;22(14):2206-14.

PMID:
12687022
16.

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.

Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12327-32. Epub 2002 Sep 6.

17.

Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.

Kiuru M, Lehtonen R, Arola J, Salovaara R, Järvinen H, Aittomäki K, Sjöberg J, Visakorpi T, Knuutila S, Isola J, Delahunt B, Herva R, Launonen V, Karhu A, Aaltonen LA.

Cancer Res. 2002 Aug 15;62(16):4554-7.

18.

PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.

Zhou XP, Loukola A, Salovaara R, Nystrom-Lahti M, Peltomäki P, de la Chapelle A, Aaltonen LA, Eng C.

Am J Pathol. 2002 Aug;161(2):439-47.

19.

Frequent loss of SMAD4/DPC4 protein in colorectal cancers.

Salovaara R, Roth S, Loukola A, Launonen V, Sistonen P, Avizienyte E, Kristo P, Järvinen H, Souchelnytskyi S, Sarlomo-Rikala M, Aaltonen LA.

Gut. 2002 Jul;51(1):56-9.

20.

Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.

Kuismanen SA, Moisio AL, Schweizer P, Truninger K, Salovaara R, Arola J, Butzow R, Jiricny J, Nyström-Lahti M, Peltomäki P.

Am J Pathol. 2002 Jun;160(6):1953-8.

21.

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.

Kim KM, Salovaara R, Mecklin JP, Järvinen HJ, Aaltonen LA, Shibata D.

Am J Pathol. 2002 Apr;160(4):1503-6.

22.

Sudden death due to rupture of the arteria pancreatica magna: a complication of an immature pseudocyst in chronic pancreatitis.

Lunetta P, Penttilä A, Salovaara R, Sajantila A.

Int J Legal Med. 2002 Feb;116(1):43-6.

PMID:
11924708
23.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomäki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen LA; Multiple Leiomyoma Consortium.

Nat Genet. 2002 Apr;30(4):406-10. Epub 2002 Feb 25.

PMID:
11865300
24.

Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development.

Nakagawa H, Nuovo GJ, Zervos EE, Martin EW Jr, Salovaara R, Aaltonen LA, de la Chapelle A.

Cancer Res. 2001 Oct 1;61(19):6991-5.

25.

Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers.

Woodford-Richens KL, Rowan AJ, Poulsom R, Bevan S, Salovaara R, Aaltonen LA, Houlston RS, Wright NA, Tomlinson IP.

Am J Pathol. 2001 Oct;159(4):1293-300.

26.

Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology.

Kiuru M, Launonen V, Hietala M, Aittomäki K, Vierimaa O, Salovaara R, Arola J, Pukkala E, Sistonen P, Herva R, Aaltonen LA.

Am J Pathol. 2001 Sep;159(3):825-9.

27.

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.

Zhou XP, Woodford-Richens K, Lehtonen R, Kurose K, Aldred M, Hampel H, Launonen V, Virta S, Pilarski R, Salovaara R, Bodmer WF, Conrad BA, Dunlop M, Hodgson SV, Iwama T, Järvinen H, Kellokumpu I, Kim JC, Leggett B, Markie D, Mecklin JP, Neale K, Phillips R, Piris J, Rozen P, Houlston RS, Aaltonen LA, Tomlinson IP, Eng C.

Am J Hum Genet. 2001 Oct;69(4):704-11. Epub 2001 Aug 30.

28.
29.

Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC).

Loukola A, Eklin K, Laiho P, Salovaara R, Kristo P, Järvinen H, Mecklin JP, Launonen V, Aaltonen LA.

Cancer Res. 2001 Jun 1;61(11):4545-9.

30.

E-cadherin is not frequently mutated in hereditary gastric cancer.

Avizienyte E, Launonen V, Salovaara R, Kiviluoto T, Aaltonen LA.

J Med Genet. 2001 Jan;38(1):49-52. No abstract available.

31.

Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer.

Schweizer P, Moisio AL, Kuismanen SA, Truninger K, Vierumäki R, Salovaara R, Arola J, Butzow R, Jiricny J, Peltomäki P, Nyström-Lahti M.

Cancer Res. 2001 Apr 1;61(7):2813-5.

32.

No SMAD4 hypermethylation in colorectal cancer.

Roth S, Laiho P, Salovaara R, Launonen V, Aaltonen LA.

Br J Cancer. 2000 Oct;83(8):1015-9.

33.

Population-based molecular detection of hereditary nonpolyposis colorectal cancer.

Salovaara R, Loukola A, Kristo P, Kääriäinen H, Ahtola H, Eskelinen M, Härkönen N, Julkunen R, Kangas E, Ojala S, Tulikoura J, Valkamo E, Järvinen H, Mecklin JP, Aaltonen LA, de la Chapelle A.

J Clin Oncol. 2000 Jun;18(11):2193-200. Erratum in: J Clin Oncol 2000 Oct 1;18(19):3456.

PMID:
10829038
34.

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.

Kuismanen SA, Holmberg MT, Salovaara R, de la Chapelle A, Peltomäki P.

Am J Pathol. 2000 May;156(5):1773-9.

35.

No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.

Launonen V, Avizienyte E, Loukola A, Laiho P, Salovaara R, Järvinen H, Mecklin JP, Oku A, Shimane M, Kim HC, Kim JC, Nezu J, Aaltonen LA.

Cancer Res. 2000 Feb 1;60(3):546-8.

36.

Genetic reconstruction of individual colorectal tumor histories.

Tsao JL, Yatabe Y, Salovaara R, Järvinen HJ, Mecklin JP, Aaltonen LA, Tavaré S, Shibata D.

Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1236-41.

37.

Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.

Loukola A, Salovaara R, Kristo P, Moisio AL, Kääriäinen H, Ahtola H, Eskelinen M, Härkönen N, Julkunen R, Kangas E, Ojala S, Tulikoura J, Valkamo E, Järvinen H, Mecklin JP, de la Chapelle A, Aaltonen LA.

Am J Pathol. 1999 Dec;155(6):1849-53.

38.

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability.

Riccio A, Aaltonen LA, Godwin AK, Loukola A, Percesepe A, Salovaara R, Masciullo V, Genuardi M, Paravatou-Petsotas M, Bassi DE, Ruggeri BA, Klein-Szanto AJ, Testa JR, Neri G, Bellacosa A.

Nat Genet. 1999 Nov;23(3):266-8. No abstract available.

PMID:
10545939
39.

Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.

Kuismanen SA, Holmberg MT, Salovaara R, Schweizer P, Aaltonen LA, de La Chapelle A, Nyström-Lahti M, Peltomäki P.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12661-6.

40.

Missense and nonsense mutations in codon 659 of MLH1 cause aberrant splicing of messenger RNA in HNPCC kindreds.

Nyström-Lahti M, Holmberg M, Fidalgo P, Salovaara R, de la Chapelle A, Jiricny J, Peltomäki P.

Genes Chromosomes Cancer. 1999 Dec;26(4):372-5.

PMID:
10534773
41.

SMAD genes in juvenile polyposis.

Roth S, Sistonen P, Salovaara R, Hemminki A, Loukola A, Johansson M, Avizienyte E, Cleary KA, Lynch P, Amos CI, Kristo P, Mecklin JP, Kellokumpu I, Järvinen H, Aaltonen LA.

Genes Chromosomes Cancer. 1999 Sep;26(1):54-61.

PMID:
10441006
42.

Colorectal adenoma and cancer divergence. Evidence of multilineage progression.

Tsao JL, Tavaré S, Salovaara R, Jass JR, Aaltonen LA, Shibata D.

Am J Pathol. 1999 Jun;154(6):1815-24.

43.

Cancer risk in mutation carriers of DNA-mismatch-repair genes.

Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, de la Chapelle A, Peltomäki P, Mecklin JP, Järvinen HJ.

Int J Cancer. 1999 Apr 12;81(2):214-8.

44.

LKB1 somatic mutations in sporadic tumors.

Avizienyte E, Loukola A, Roth S, Hemminki A, Tarkkanen M, Salovaara R, Arola J, Bützow R, Husgafvel-Pursiainen K, Kokkola A, Järvinen H, Aaltonen LA.

Am J Pathol. 1999 Mar;154(3):677-81.

45.

Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.

Tsao JL, Zhang J, Salovaara R, Li ZH, Järvinen HJ, Mecklin JP, Aaltonen LA, Shibata D.

Am J Pathol. 1998 Oct;153(4):1189-200.

46.

Comparative genomic hybridization reveals differences in DNA copy number changes between sporadic gastric carcinomas and gastric carcinomas from patients with hereditary nonpolyposis colorectal cancer.

Larramendy ML, el-Rifai W, Kokkola A, Puolakkainen P, Monni O, Salovaara R, Aarnio M, Knuutila S.

Cancer Genet Cytogenet. 1998 Oct 1;106(1):62-5.

PMID:
9772911
47.

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.

Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE, Fosså SD, Salovaara R, Aaltonen LA.

Cancer Res. 1998 May 15;58(10):2087-90.

48.

Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.

Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A.

N Engl J Med. 1998 May 21;338(21):1481-7.

49.

Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene.

Hemminki A, Höglund P, Pukkala E, Salovaara R, Järvinen H, Norio R, Aaltonen LA.

Oncogene. 1998 Feb 5;16(5):681-4.

50.

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Höglund P, Järvinen H, Kristo P, Pelin K, Ridanpää M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA.

Nature. 1998 Jan 8;391(6663):184-7.

PMID:
9428765

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