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In Vivo Toxicity Assessment of Occupational Components of the Carbon Nanotube Life Cycle To Provide Context to Potential Health Effects.

Bishop L, Cena L, Orandle M, Yanamala N, Dahm MM, Birch ME, Evans DE, Kodali VK, Eye T, Battelli L, Zeidler-Erdely PC, Casuccio G, Bunker K, Lupoi JS, Lersch TL, Stefaniak AB, Sager T, Afshari A, Schwegler-Berry D, Friend S, Kang J, Siegrist KJ, Mitchell CA, Lowry DT, Kashon ML, Mercer RR, Geraci CL, Schubauer-Berigan MK, Sargent LM, Erdely A.

ACS Nano. 2017 Sep 26;11(9):8849-8863. doi: 10.1021/acsnano.7b03038. Epub 2017 Aug 4.


Role of engineered metal oxide nanoparticle agglomeration in reactive oxygen species generation and cathepsin B release in NLRP3 inflammasome activation and pulmonary toxicity.

Sager TM, Wolfarth M, Leonard SS, Morris AM, Porter DW, Castranova V, Holian A.

Inhal Toxicol. 2016 Dec;28(14):686-697. Epub 2016 Dec 5.


Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family.

Roberts JR, Mercer RR, Stefaniak AB, Seehra MS, Geddam UK, Chaudhuri IS, Kyrlidis A, Kodali VK, Sager T, Kenyon A, Bilgesu SA, Eye T, Scabilloni JF, Leonard SS, Fix NR, Schwegler-Berry D, Farris BY, Wolfarth MG, Porter DW, Castranova V, Erdely A.

Part Fibre Toxicol. 2016 Jun 21;13(1):34. doi: 10.1186/s12989-016-0145-5.


Factors associated with development of Canine Infectious Respiratory Disease Complex (CIRDC) in dogs in 5 Canadian small animal clinics.

Joffe DJ, Lelewski R, Weese JS, Mcgill-Worsley J, Shankel C, Mendonca S, Sager T, Smith M, Poljak Z.

Can Vet J. 2016 Jan;57(1):46-51.


Effects of nickel-oxide nanoparticle pre-exposure dispersion status on bioactivity in the mouse lung.

Sager T, Wolfarth M, Keane M, Porter D, Castranova V, Holian A.

Nanotoxicology. 2016;10(2):151-61. doi: 10.3109/17435390.2015.1025883. Epub 2015 Apr 28.


Effect of fiber length on carbon nanotube-induced fibrogenesis.

Manke A, Luanpitpong S, Dong C, Wang L, He X, Battelli L, Derk R, Stueckle TA, Porter DW, Sager T, Gou H, Dinu CZ, Wu N, Mercer RR, Rojanasakul Y.

Int J Mol Sci. 2014 Apr 29;15(5):7444-61. doi: 10.3390/ijms15057444.


Investigation of the pulmonary bioactivity of double-walled carbon nanotubes.

Sager TM, Wolfarth MW, Battelli LA, Leonard SS, Andrew M, Steinbach T, Endo M, Tsuruoka S, Porter DW, Castranova V.

J Toxicol Environ Health A. 2013;76(15):922-36. doi: 10.1080/15287394.2013.825571.


Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model.

Sager TM, Wolfarth MW, Andrew M, Hubbs A, Friend S, Chen TH, Porter DW, Wu N, Yang F, Hamilton RF, Holian A.

Nanotoxicology. 2014 May;8(3):317-27. doi: 10.3109/17435390.2013.779757. Epub 2013 Mar 19.


Nanotechnology: toxicologic pathology.

Hubbs AF, Sargent LM, Porter DW, Sager TM, Chen BT, Frazer DG, Castranova V, Sriram K, Nurkiewicz TR, Reynolds SH, Battelli LA, Schwegler-Berry D, McKinney W, Fluharty KL, Mercer RR.

Toxicol Pathol. 2013 Feb;41(2):395-409. doi: 10.1177/0192623312467403. Epub 2013 Feb 6. Review.


Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis.

Bergström AL, Fog K, Sager TN, Bruun AT, Thirstrup K.

ISRN Neurosci. 2013 Dec 5;2013:598587. doi: 10.1155/2013/598587. eCollection 2013.


Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study.

Stapleton PA, Minarchick VC, Cumpston AM, McKinney W, Chen BT, Sager TM, Frazer DG, Mercer RR, Scabilloni J, Andrew ME, Castranova V, Nurkiewicz TR.

Int J Mol Sci. 2012 Oct 24;13(11):13781-803. doi: 10.3390/ijms131113781.


Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles.

McKinney W, Jackson M, Sager TM, Reynolds JS, Chen BT, Afshari A, Krajnak K, Waugh S, Johnson C, Mercer RR, Frazer DG, Thomas TA, Castranova V.

Inhal Toxicol. 2012 Jun;24(7):447-57. doi: 10.3109/08958378.2012.685111.


The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.

Collins LE, Sager TN, Sams AG, Pennarola A, Port RG, Shahriari M, Salamone JD.

Pharmacol Biochem Behav. 2012 Jan;100(3):498-505. doi: 10.1016/j.pbb.2011.10.015. Epub 2011 Oct 20.


Automated gait analysis in bilateral parkinsonian rats and the role of L-DOPA therapy.

Westin JE, Janssen ML, Sager TN, Temel Y.

Behav Brain Res. 2012 Jan 15;226(2):519-28. doi: 10.1016/j.bbr.2011.10.006. Epub 2011 Oct 12.


Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity.

Lauridsen JB, Johansen JL, Rekling JC, Thirstrup K, Moerk A, Sager TN.

Neurosci Res. 2011 Jul;70(3):269-76. doi: 10.1016/j.neures.2011.03.011. Epub 2011 Apr 15.


Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline.

Dencker D, Wörtwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mørk A, Woldbye DP, Wess J, Fink-Jensen A.

J Neurosci. 2011 Apr 20;31(16):5905-8. doi: 10.1523/JNEUROSCI.0370-11.2011.


Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors.

Thirstrup K, Christensen S, Møller HA, Ritzén A, Bergström AL, Sager TN, Jensen HS.

Pharmacol Res. 2011 Sep;64(3):268-73. doi: 10.1016/j.phrs.2011.03.017. Epub 2011 Apr 8.


Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.

Randall PA, Nunes EJ, Janniere SL, Stopper CM, Farrar AM, Sager TN, Baqi Y, Hockemeyer J, Müller CE, Salamone JD.

Psychopharmacology (Berl). 2011 Jul;216(2):173-86. doi: 10.1007/s00213-011-2198-3. Epub 2011 Feb 24.


Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.

Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE.

ACS Nano. 2011 Feb 22;5(2):1223-35. doi: 10.1021/nn1028482. Epub 2011 Jan 20.


Tumor necrosis factor α primes cerebral endothelial cells for erythropoietin-induced angiogenesis.

Wang L, Chopp M, Teng H, Bolz M, Francisco MA, Aluigi DM, Wang XL, Zhang RL, Chrsitensen S, Sager TN, Szalad A, Zhang ZG.

J Cereb Blood Flow Metab. 2011 Feb;31(2):640-7. doi: 10.1038/jcbfm.2010.138. Epub 2010 Aug 11. Erratum in: J Cereb Blood Flow Metab. 2011 May;31(5):1334. Francisco, Moniche Ãlvarez [corrected to Francisco, Moniche-Alvarez].


HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells.

Johansen JL, Sager TN, Lotharius J, Witten L, Mørk A, Egebjerg J, Thirstrup K.

J Neurochem. 2010 Oct;115(1):209-19. doi: 10.1111/j.1471-4159.2010.06917.x. Epub 2010 Aug 19.


Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism.

Nunes EJ, Randall PA, Santerre JL, Given AB, Sager TN, Correa M, Salamone JD.

Neuroscience. 2010 Sep 29;170(1):268-80. doi: 10.1016/j.neuroscience.2010.05.068. Epub 2010 Jun 25.


Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells.

Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH.

J R Soc Interface. 2010 Jun 6;7 Suppl 3:S331-40. doi: 10.1098/rsif.2010.0068.focus. Epub 2010 Mar 31.


A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors.

Jeon J, Dencker D, Wörtwein G, Woldbye DP, Cui Y, Davis AA, Levey AI, Schütz G, Sager TN, Mørk A, Li C, Deng CX, Fink-Jensen A, Wess J.

J Neurosci. 2010 Feb 10;30(6):2396-405. doi: 10.1523/JNEUROSCI.3843-09.2010.


Nest building performance following MPTP toxicity in mice.

Sager TN, Kirchhoff J, Mørk A, Van Beek J, Thirstrup K, Didriksen M, Lauridsen JB.

Behav Brain Res. 2010 Apr 2;208(2):444-9. doi: 10.1016/j.bbr.2009.12.014. Epub 2009 Dec 23.


Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX.

Collins LE, Galtieri DJ, Brennum LT, Sager TN, Hockemeyer J, Müller CE, Hinman JR, Chrobak JJ, Salamone JD.

Pharmacol Biochem Behav. 2010 Feb;94(4):561-9. doi: 10.1016/j.pbb.2009.11.011. Epub 2009 Dec 1.


Effects of the adenosine A 2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide.

Betz AJ, Vontell R, Valenta J, Worden L, Sink KS, Font L, Correa M, Sager TN, Salamone JD.

Neuroscience. 2009 Sep 29;163(1):97-108. doi: 10.1016/j.neuroscience.2009.05.040. Epub 2009 May 23.


Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism.

Salamone JD, Farrar AM, Font L, Patel V, Schlar DE, Nunes EJ, Collins LE, Sager TN.

Behav Brain Res. 2009 Jul 19;201(1):216-22. doi: 10.1016/j.bbr.2009.02.021. Epub 2009 Mar 3.


Striatal extracellular dopamine levels and behavioural reversal in MPTP-lesioned mice.

Kirchhoff J, Mørk A, Brennum LT, Sager TN.

Neuroreport. 2009 Mar 25;20(5):482-6. doi: 10.1097/WNR.0b013e32832984d6.


HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo.

Witten L, Sager T, Thirstrup K, Johansen JL, Larsen DB, Montezinho LP, Mørk A.

J Neurosci Res. 2009 May 15;87(7):1686-94. doi: 10.1002/jnr.21988.


Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area.

Sager TM, Kommineni C, Castranova V.

Part Fibre Toxicol. 2008 Dec 1;5:17. doi: 10.1186/1743-8977-5-17.


Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits.

Lapchak PA, Kirkeby A, Zivin JA, Sager TN.

Brain Res. 2008 Oct 31;1238:208-14. doi: 10.1016/j.brainres.2008.08.017. Epub 2008 Aug 16.


Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats.

Thomsen M, Fink-Jensen A, Woldbye DP, Wörtwein G, Sager TN, Holm R, Pepe LM, Caine SB.

Psychopharmacology (Berl). 2008 Nov;201(1):43-53. doi: 10.1007/s00213-008-1245-1. Epub 2008 Jul 9.


Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism.

Salamone JD, Betz AJ, Ishiwari K, Felsted J, Madson L, Mirante B, Clark K, Font L, Korbey S, Sager TN, Hockemeyer J, Muller CE.

Front Biosci. 2008 May 1;13:3594-605. Review.


Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice.

Sørensen G, Sager TN, Petersen JH, Brennum LT, Thøgersen P, Hee Bengtsen C, Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DP.

Psychopharmacology (Berl). 2008 Jul;199(1):37-46. doi: 10.1007/s00213-008-1069-z. Epub 2008 May 15.


Boronic acid based peptidic receptors for pattern-based saccharide sensing in neutral aqueous media, an application in real-life samples.

Edwards NY, Sager TW, McDevitt JT, Anslyn EV.

J Am Chem Soc. 2007 Nov 7;129(44):13575-83. Epub 2007 Oct 10.


Synthesis and preliminary biological evaluation of 2'-substituted 2-(3'-carboxybicyclo[1.1.1]pentyl)glycine derivatives as group I selective metabotropic glutamate receptor ligands.

Pellicciari R, Filosa R, Fulco MC, Marinozzi M, Macchiarulo A, Novak C, Natalini B, Hermit MB, Nielsen S, Sager TN, Stensbøl TB, Thomsen C.

ChemMedChem. 2006 Mar;1(3):358-65.


Exposure, postexposure, and density-mediated effects of atrazine on amphibians: breaking down net effects into their parts.

Rohr JR, Sager T, Sesterhenn TM, Palmer BD.

Environ Health Perspect. 2006 Jan;114(1):46-50.


KW-6002 protects from MPTP induced dopaminergic toxicity in the mouse.

Pierri M, Vaudano E, Sager T, Englund U.

Neuropharmacology. 2005 Mar;48(4):517-24.


Derivatives of erythropoietin that are tissue protective but not erythropoietic.

Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J, Kallunki P, Larsen AK, Helboe L, Christensen S, Pedersen LO, Nielsen M, Torup L, Sager T, Sfacteria A, Erbayraktar S, Erbayraktar Z, Gokmen N, Yilmaz O, Cerami-Hand C, Xie QW, Coleman T, Cerami A, Brines M.

Science. 2004 Jul 9;305(5681):239-42.


Effects of postnatal anoxia on striatal dopamine metabolism and prepulse inhibition in rats.

Sandager-Nielsen K, Andersen MB, Sager TN, Werge T, Scheel-Krüger J.

Pharmacol Biochem Behav. 2004 Apr;77(4):767-74.


Lethal and sublethal effects of atrazine, carbaryl, endosulfan, and octylphenol on the streamside salamander (Ambystoma barbouri).

Rohr JR, Elskus AA, Shepherd BS, Crowley PH, McCarthy TM, Niedzwiecki JH, Sager T, Sih A, Palmer BD.

Environ Toxicol Chem. 2003 Oct;22(10):2385-92.


Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

Erbayraktar S, Grasso G, Sfacteria A, Xie QW, Coleman T, Kreilgaard M, Torup L, Sager T, Erbayraktar Z, Gokmen N, Yilmaz O, Ghezzi P, Villa P, Fratelli M, Casagrande S, Leist M, Helboe L, Gerwein J, Christensen S, Geist MA, Pedersen LØ, Cerami-Hand C, Wuerth JP, Cerami A, Brines M.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6741-6. Epub 2003 May 13. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102.


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