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Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.

Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S.

PLoS One. 2018 Feb 1;13(2):e0192264. doi: 10.1371/journal.pone.0192264. eCollection 2018.


Metformin-induced anticancer activities: recent insights.

Safe S, Nair V, Karki K.

Biol Chem. 2018 Jan 25. pii: /j/bchm.ahead-of-print/hsz-2017-0271/hsz-2017-0271.xml. doi: 10.1515/hsz-2017-0271. [Epub ahead of print] Review.


NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells.

Li Y, Wang F, Lu L, Zhu F, Huang S, Nomie K, Zhang L, Yang DT, Huang W, Kahl BS, Safe S, Wang M, Rui L.

Blood Cancer J. 2017 Nov 23;7(12):632. doi: 10.1038/s41408-017-0005-z. No abstract available.


Carbidopa: a selective Ah receptor modulator (SAhRM).

Safe S.

Biochem J. 2017 Nov 6;474(22):3763-3765. doi: 10.1042/BCJ20170728.


Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT.

Cell Signal. 2017 Dec;40:172-182. doi: 10.1016/j.cellsig.2017.09.006. Epub 2017 Sep 18.


Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells.

Jin UH, Cheng Y, Park H, Davidson LA, Callaway ES, Chapkin RS, Jayaraman A, Asante A, Allred C, Weaver EA, Safe S.

Sci Rep. 2017 Aug 31;7(1):10163. doi: 10.1038/s41598-017-10824-x.


Correction for Hedrick et al., "NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration".

Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S.

Mol Cell Biol. 2017 Aug 28;37(18). pii: e00197-17. doi: 10.1128/MCB.00197-17. Print 2017 Sep 15. No abstract available.


Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells.

Lee HS, Safe S, Lee SO.

Toxicol Appl Pharmacol. 2017 Oct 1;332:32-39. doi: 10.1016/j.taap.2017.07.017. Epub 2017 Jul 25.


Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

Kolluri SK, Jin UH, Safe S.

Arch Toxicol. 2017 Sep;91(9):3209. doi: 10.1007/s00204-017-2026-6. No abstract available.


Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent.

Hedrick E, Safe S.

Mol Cell Biol. 2017 Aug 28;37(18). pii: e00306-17. doi: 10.1128/MCB.00306-17. Print 2017 Sep 15.


Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.

Karki K, Hedrick E, Kasiappan R, Jin UH, Safe S.

Cancer Prev Res (Phila). 2017 Aug;10(8):467-477. doi: 10.1158/1940-6207.CAPR-17-0053. Epub 2017 Jul 3.


Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

Kolluri SK, Jin UH, Safe S.

Arch Toxicol. 2017 Jul;91(7):2497-2513. doi: 10.1007/s00204-017-1981-2. Epub 2017 May 15. Review. Erratum in: Arch Toxicol. 2017 Sep;91(9):3209.


The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy.

Safe S, Cheng Y, Jin UH.

Curr Opin Toxicol. 2017 Feb;2:24-29. doi: 10.1016/j.cotox.2017.01.012. Epub 2017 Feb 1.


The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.

Hedrick E, Lee SO, Safe S.

Mol Carcinog. 2017 Sep;56(9):2066-2075. doi: 10.1002/mc.22662. Epub 2017 May 9.


CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program.

Taoka R, Jinesh GG, Xue W, Safe S, Kamat AM.

Apoptosis. 2017 May;22(5):719-729. doi: 10.1007/s10495-017-1359-1.


Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells.

Jin UH, Cheng Y, Zhou B, Safe S.

Mol Pharmacol. 2017 May;91(5):438-450. doi: 10.1124/mol.116.106245. Epub 2017 Mar 8.


Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer.

Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe S.

J Biol Chem. 2016 Dec 30;291(53):27122-27133. doi: 10.1074/jbc.M116.746339. Epub 2016 Nov 15.


PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1.

Lacey A, Rodrigues-Hoffman A, Safe S.

Cancer Res. 2017 Feb 1;77(3):732-741. doi: 10.1158/0008-5472.CAN-16-1546. Epub 2016 Nov 18.


Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.

Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S.

Toxicol Sci. 2017 Feb;155(2):458-473. doi: 10.1093/toxsci/kfw230. Epub 2016 Nov 11.


Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner.

Bridi MS, Hawk JD, Chatterjee S, Safe S, Abel T.

Neuropsychopharmacology. 2017 May;42(6):1243-1253. doi: 10.1038/npp.2016.253. Epub 2016 Nov 11.


Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors.

Hedrick E, Li X, Safe S.

Mol Cancer Ther. 2017 Jan;16(1):205-216. doi: 10.1158/1535-7163.MCT-16-0451. Epub 2016 Nov 3.


Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets.

Safe S, Kasiappan R.

Phytother Res. 2016 Nov;30(11):1723-1732. doi: 10.1002/ptr.5669. Epub 2016 Jul 7. Review.


Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer.

Godugu C, Doddapaneni R, Safe SH, Singh M.

Eur J Pharm Biopharm. 2016 Nov;108:168-179. doi: 10.1016/j.ejpb.2016.08.006. Epub 2016 Aug 30.


Lipid-based oral delivery systems for skin deposition of a potential chemopreventive DIM derivative: characterization and evaluation.

Boakye CH, Patel K, Patel AR, Faria HA, Zucolotto V, Safe S, Singh M.

Drug Deliv Transl Res. 2016 Oct;6(5):526-39. doi: 10.1007/s13346-016-0302-2.


2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice.

Moore RW, Fritz WA, Schneider AJ, Lin TM, Branam AM, Safe S, Peterson RE.

Toxicol Appl Pharmacol. 2016 Aug 15;305:242-249. doi: 10.1016/j.taap.2016.04.018. Epub 2016 May 3.


Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS).

Lacey A, Hedrick E, Li X, Patel K, Doddapaneni R, Singh M, Safe S.

Oncotarget. 2016 May 24;7(21):31257-69. doi: 10.18632/oncotarget.9112.


CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species.

Takeuchi H, Taoka R, Mmeje CO, Jinesh GG, Safe S, Kamat AM.

Urol Oncol. 2016 Aug;34(8):337.e11-8. doi: 10.1016/j.urolonc.2016.02.025. Epub 2016 Mar 30.


Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention.

Boakye CHA, Patel K, Doddapaneni R, Bagde A, Behl G, Chowdhury N, Safe S, Singh M.

Colloids Surf B Biointerfaces. 2016 Jul 1;143:156-167. doi: 10.1016/j.colsurfb.2016.03.036. Epub 2016 Mar 15.


Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

Hedrick E, Cheng Y, Jin UH, Kim K, Safe S.

Oncotarget. 2016 Apr 19;7(16):22245-56. doi: 10.18632/oncotarget.7925.


High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome.

Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S.

Gynecol Oncol. 2016 May;141(2):348-356. doi: 10.1016/j.ygyno.2016.02.030. Epub 2016 Mar 11.


NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration.

Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S.

Mol Cell Biol. 2016 Apr 15;36(9):1383-94. doi: 10.1128/MCB.00912-15. Print 2016 May. Erratum in: Mol Cell Biol. 2017 Aug 28;37(18):.


miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.

Ying W, Tseng A, Chang RC, Wang H, Lin YL, Kanameni S, Brehm T, Morin A, Jones B, Splawn T, Criscitiello M, Golding MC, Bazer FW, Safe S, Zhou B.

Sci Rep. 2016 Feb 1;6:20176. doi: 10.1038/srep20176.


Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors.

Li X, Pathi SS, Safe S.

BMC Cancer. 2015 Dec 16;15:974. doi: 10.1186/s12885-015-1956-8.


MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

Ying W, Tseng A, Chang RC, Morin A, Brehm T, Triff K, Nair V, Zhuang G, Song H, Kanameni S, Wang H, Golding MC, Bazer FW, Chapkin RS, Safe S, Zhou B.

J Clin Invest. 2015 Nov 2;125(11):4149-59. doi: 10.1172/JCI81656. Epub 2015 Oct 5.


A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro.

Hammond SL, Safe S, Tjalkens RB.

Neurosci Lett. 2015 Oct 21;607:83-89. doi: 10.1016/j.neulet.2015.09.015. Epub 2015 Sep 14.


Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.

Gandhy SU, Imanirad P, Jin UH, Nair V, Hedrick E, Cheng Y, Corton JC, Kim K, Safe S.

Oncotarget. 2015 Sep 22;6(28):26359-72. doi: 10.18632/oncotarget.4560.


Enhanced Percutaneous Delivery of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane for Skin Cancer Chemoprevention.

Boakye CH, Shah PP, Doddapaneni R, Patel AR, Safe S, Singh M.

J Biomed Nanotechnol. 2015 Jul;11(7):1269-81.


Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy.

Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S.

Endocr Relat Cancer. 2015 Oct;22(5):831-40. doi: 10.1530/ERC-15-0063. Epub 2015 Jul 30.


Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles.

Riddell N, Jin UH, Safe S, Cheng Y, Chittim B, Konstantinov A, Parette R, Pena-Abaurrea M, Reiner EJ, Poirier D, Stefanac T, McAlees AJ, McCrindle R.

Environ Sci Technol. 2015 Sep 1;49(17):10658-66. doi: 10.1021/acs.est.5b02751. Epub 2015 Aug 13.


Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors.

Hedrick E, Crose L, Linardic CM, Safe S.

Mol Cancer Ther. 2015 Sep;14(9):2143-53. doi: 10.1158/1535-7163.MCT-15-0148. Epub 2015 Jul 10.


Dietary γ-Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPARγ.

Das Gupta S, Sae-tan S, Wahler J, So JY, Bak MJ, Cheng LC, Lee MJ, Lin Y, Shih WJ, Shull JD, Safe S, Yang CS, Suh N.

Cancer Prev Res (Phila). 2015 Sep;8(9):807-16. doi: 10.1158/1940-6207.CAPR-15-0154. Epub 2015 Jun 30.


Evaluation of self-emulsified DIM-14 in dogs for oral bioavailability and in Nu/nu mice bearing stem cell lung tumor models for anticancer activity.

Patel AR, Doddapaneni R, Andey T, Wilson H, Safe S, Singh M.

J Control Release. 2015 Sep 10;213:18-26. doi: 10.1016/j.jconrel.2015.06.014. Epub 2015 Jun 14.


Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma.

Hedrick E, Lee SO, Kim G, Abdelrahim M, Jin UH, Safe S, Abudayyeh A.

PLoS One. 2015 Jun 2;10(6):e0128308. doi: 10.1371/journal.pone.0128308. eCollection 2015.


A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells.

Fan YY, Davidson LA, Callaway ES, Wright GA, Safe S, Chapkin RS.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 1;309(1):G1-9. doi: 10.1152/ajpgi.00052.2015. Epub 2015 May 14.


Nuclear receptor 4A (NR4A) family - orphans no more.

Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB.

J Steroid Biochem Mol Biol. 2016 Mar;157:48-60. doi: 10.1016/j.jsbmb.2015.04.016. Epub 2015 Apr 23.


The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration.

Cheng Y, Jutooru I, Chadalapaka G, Corton JC, Safe S.

Oncotarget. 2015 May 10;6(13):10840-52.


Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.

Cheng Y, Jin UH, Allred CD, Jayaraman A, Chapkin RS, Safe S.

Drug Metab Dispos. 2015 Oct;43(10):1536-43. doi: 10.1124/dmd.115.063677. Epub 2015 Apr 14.

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