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Items: 31

1.

The target landscape of clinical kinase drugs.

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.

Science. 2017 Dec 1;358(6367). pii: eaan4368. doi: 10.1126/science.aan4368.

PMID:
29191878
2.

Pharmacoproteomic characterisation of human colon and rectal cancer.

Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B.

Mol Syst Biol. 2017 Nov 3;13(11):951. doi: 10.15252/msb.20177701.

3.

Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation.

Werfel S, Leierseder S, Ruprecht B, Kuster B, Engelhardt S.

Nucleic Acids Res. 2017 Sep 29;45(17):10218-10228. doi: 10.1093/nar/gkx640.

4.

Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment.

Hinz L, Ahles A, Ruprecht B, Küster B, Engelhardt S.

PLoS One. 2017 May 4;12(5):e0176450. doi: 10.1371/journal.pone.0176450. eCollection 2017.

5.

Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis.

Ruprecht B, Zaal EA, Zecha J, Wu W, Berkers CR, Kuster B, Lemeer S.

Cancer Res. 2017 Apr 15;77(8):1842-1853. doi: 10.1158/0008-5472.CAN-16-2976. Epub 2017 Feb 16.

6.

High pH Reversed-Phase Micro-Columns for Simple, Sensitive, and Efficient Fractionation of Proteome and (TMT labeled) Phosphoproteome Digests.

Ruprecht B, Zecha J, Zolg DP, Kuster B.

Methods Mol Biol. 2017;1550:83-98. doi: 10.1007/978-1-4939-6747-6_8.

PMID:
28188525
7.

Hydrophilic Strong Anion Exchange (hSAX) Chromatography Enables Deep Fractionation of Tissue Proteomes.

Ruprecht B, Wang D, Chiozzi RZ, Li LH, Hahne H, Kuster B.

Methods Mol Biol. 2017;1550:69-82. doi: 10.1007/978-1-4939-6747-6_7.

PMID:
28188524
8.

Optimized Enrichment of Phosphoproteomes by Fe-IMAC Column Chromatography.

Ruprecht B, Koch H, Domasinska P, Frejno M, Kuster B, Lemeer S.

Methods Mol Biol. 2017;1550:47-60. doi: 10.1007/978-1-4939-6747-6_5.

PMID:
28188522
9.

Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells.

Koch H, Wilhelm M, Ruprecht B, Beck S, Frejno M, Klaeger S, Kuster B.

J Proteome Res. 2016 Dec 2;15(12):4490-4504. Epub 2016 Nov 16.

PMID:
27794612
10.

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.

Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Médard G, Schwalbe H, Kuster B.

ACS Chem Biol. 2016 Dec 16;11(12):3400-3411. Epub 2016 Nov 7.

PMID:
27768280
11.

A bead-based western for high-throughput cellular signal transduction analyses.

Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, Joos TO, Kling S, Poetz O, Fehm T, Neubauer H, Kuster B, Templin MF.

Nat Commun. 2016 Sep 23;7:12852. doi: 10.1038/ncomms12852.

12.

MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome.

Ruprecht B, Roesli C, Lemeer S, Kuster B.

Proteomics. 2016 May;16(10):1447-56. doi: 10.1002/pmic.201500523. Epub 2016 May 2.

PMID:
26990019
13.

Evaluation of Kinase Activity Profiling Using Chemical Proteomics.

Ruprecht B, Zecha J, Heinzlmeir S, Médard G, Lemeer S, Kuster B.

ACS Chem Biol. 2015 Dec 18;10(12):2743-52. doi: 10.1021/acschembio.5b00616. Epub 2015 Oct 5.

PMID:
26378887
14.

Optimized chemical proteomics assay for kinase inhibitor profiling.

Médard G, Pachl F, Ruprecht B, Klaeger S, Heinzlmeir S, Helm D, Qiao H, Ku X, Wilhelm M, Kuehne T, Wu Z, Dittmann A, Hopf C, Kramer K, Kuster B.

J Proteome Res. 2015 Mar 6;14(3):1574-86. doi: 10.1021/pr5012608. Epub 2015 Feb 20.

PMID:
25660469
15.

Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns.

Ruprecht B, Koch H, Medard G, Mundt M, Kuster B, Lemeer S.

Mol Cell Proteomics. 2015 Jan;14(1):205-15. doi: 10.1074/mcp.M114.043109. Epub 2014 Nov 13.

16.

Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics.

Helm D, Vissers JP, Hughes CJ, Hahne H, Ruprecht B, Pachl F, Grzyb A, Richardson K, Wildgoose J, Maier SK, Marx H, Wilhelm M, Becher I, Lemeer S, Bantscheff M, Langridge JI, Kuster B.

Mol Cell Proteomics. 2014 Dec;13(12):3709-15. doi: 10.1074/mcp.M114.041038. Epub 2014 Aug 8.

17.

Proteomic analysis of phosphorylation in cancer.

Ruprecht B, Lemeer S.

Expert Rev Proteomics. 2014 Jun;11(3):259-67. doi: 10.1586/14789450.2014.901156. Epub 2014 Mar 26. Review.

PMID:
24666026
18.

DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.

Hahne H, Pachl F, Ruprecht B, Maier SK, Klaeger S, Helm D, Médard G, Wilm M, Lemeer S, Kuster B.

Nat Methods. 2013 Oct;10(10):989-91. doi: 10.1038/nmeth.2610. Epub 2013 Aug 25.

PMID:
23975139
19.

Characterization of a high field Orbitrap mass spectrometer for proteome analysis.

Pachl F, Ruprecht B, Lemeer S, Kuster B.

Proteomics. 2013 Sep;13(17):2552-62. doi: 10.1002/pmic.201300076. Epub 2013 Jul 30.

PMID:
23836775
20.

Characterization of a chemical affinity probe targeting Akt kinases.

Pachl F, Plattner P, Ruprecht B, Médard G, Sewald N, Kuster B.

J Proteome Res. 2013 Aug 2;12(8):3792-800. doi: 10.1021/pr400455j. Epub 2013 Jul 3.

PMID:
23795919
21.

Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity.

Lemeer S, Zörgiebel C, Ruprecht B, Kohl K, Kuster B.

J Proteome Res. 2013 Apr 5;12(4):1723-31. doi: 10.1021/pr301073j. Epub 2013 Mar 28.

PMID:
23495751
22.

Extremely slow Li ion dynamics in monoclinic Li2TiO3--probing macroscopic jump diffusion via 7Li NMR stimulated echoes.

Ruprecht B, Wilkening M, Uecker R, Heitjans P.

Phys Chem Chem Phys. 2012 Sep 14;14(34):11974-80. doi: 10.1039/c2cp41662j. Epub 2012 Jul 26.

PMID:
22836957
23.

Li self-diffusion in lithium niobate single crystals at low temperatures.

Rahn J, Hüger E, Dörrer L, Ruprecht B, Heitjans P, Schmidt H.

Phys Chem Chem Phys. 2012 Feb 21;14(7):2427-33. doi: 10.1039/c2cp23548j. Epub 2012 Jan 16.

PMID:
22246110
24.

Ultra-slow Li ion dynamics in Li(2)C(2)--on the similarities of results from (7)Li spin-alignment echo NMR and impedance spectroscopy.

Ruprecht B, Billetter H, Ruschewitz U, Wilkening M.

J Phys Condens Matter. 2010 Jun 23;22(24):245901. doi: 10.1088/0953-8984/22/24/245901. Epub 2010 May 26.

PMID:
21393791
25.

Gene polymorphisms of ACE and the angiotensin receptor AT2R1 influence serum ACE levels in sarcoidosis.

Biller H, Ruprecht B, Gaede KI, Müller-Quernheim J, Zissel G.

Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):139-46.

PMID:
20560294
26.

High anion conductivity in a ternary non-equilibrium phase of BaF(2) and CaF(2) with mixed cations.

Ruprecht B, Wilkening M, Feldhoff A, Steuernagel S, Heitjans P.

Phys Chem Chem Phys. 2009 May 7;11(17):3071-81. doi: 10.1039/b901293a. Epub 2009 Mar 19.

PMID:
19370201
27.

Genotype-corrected reference values for serum angiotensin-converting enzyme.

Biller H, Zissel G, Ruprecht B, Nauck M, Busse Grawitz A, Müller-Quernheim J.

Eur Respir J. 2006 Dec;28(6):1085-90.

28.

[Subacute sclerosing panencephalitis: fulminant form].

Grippo J, Cáceres L, Asís A, Grippo T, Ruprecht B, López M.

Rev Neurol. 2003 Mar 16-31;36(6):536-9. Spanish.

29.

Gene polymorphisms of immunoregulatory cytokines and angiotensin-converting enzyme in Wegener's granulomatosis.

Muraközy G, Gaede KI, Ruprecht B, Gutzeit O, Schürmann M, Schnabel A, Schlaak M, Gross WL, Müller-Quernheim J.

J Mol Med (Berl). 2001 Nov;79(11):665-70.

PMID:
11715070
30.

[Corrected normal values for serum ACE by genotyping the deletion-/insertion-polymorphism of the ACE gene].

Ruprecht B, Schürmann M, Ziegenhagen MW, vom Bauer E, Meier D, Schlaak M, Müller-Quernheim J.

Pneumologie. 2001 Jul;55(7):326-32. German.

PMID:
11481579

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