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Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY.

Immunity. 2018 May 21. pii: S1074-7613(18)30182-1. doi: 10.1016/j.immuni.2018.04.013. [Epub ahead of print]


ZFP36 RNA-binding proteins restrain T-cell activation and anti-viral immunity.

Moore MJ, Blachere NE, Fak JJ, Park CY, Sawicka K, Parveen S, Zucker-Scharff I, Moltedo B, Rudensky AY, Darnell RB.

Elife. 2018 May 31;7. pii: e33057. doi: 10.7554/eLife.33057. [Epub ahead of print]


Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.

Ariyan CE, Brady MS, Siegelbaum RH, Hu J, Bello DM, Rand J, Fisher C, Lefkowitz RA, Panageas KS, Pulitzer M, Vignali M, Emerson R, Tipton C, Robins H, Merghoub T, Yuan J, Jungbluth A, Blando J, Sharma P, Rudensky AY, Wolchok JD, Allison JP.

Cancer Immunol Res. 2018 Feb;6(2):189-200. doi: 10.1158/2326-6066.CIR-17-0356. Epub 2018 Jan 16.


Comparative analysis of murine T-cell receptor repertoires.

Izraelson M, Nakonechnaya TO, Moltedo B, Egorov ES, Kasatskaya SA, Putintseva EV, Mamedov IZ, Staroverov DB, Shemiakina II, Zakharova MY, Davydov AN, Bolotin DA, Shugay M, Chudakov DM, Rudensky AY, Britanova OV.

Immunology. 2018 Feb;153(2):133-144. doi: 10.1111/imm.12857. Epub 2017 Nov 27. Review.


A nonimmune function of T cells in promoting lung tumor progression.

Green JA, Arpaia N, Schizas M, Dobrin A, Rudensky AY.

J Exp Med. 2017 Dec 4;214(12):3565-3575. doi: 10.1084/jem.20170356. Epub 2017 Oct 16.


Antigen receptor repertoire profiling from RNA-seq data.

Bolotin DA, Poslavsky S, Davydov AN, Frenkel FE, Fanchi L, Zolotareva OI, Hemmers S, Putintseva EV, Obraztsova AS, Shugay M, Ataullakhanov RI, Rudensky AY, Schumacher TN, Chudakov DM.

Nat Biotechnol. 2017 Oct 11;35(10):908-911. doi: 10.1038/nbt.3979. No abstract available.


Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet.

Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY.

Nature. 2017 Sep 20;550(7674):142. doi: 10.1038/nature24013.


BRCT-domain protein BRIT1 influences class switch recombination.

Yen WF, Chaudhry A, Vaidyanathan B, Yewdell WT, Pucella JN, Sharma R, Liang Y, Li K, Rudensky AY, Chaudhuri J.

Proc Natl Acad Sci U S A. 2017 Jul 19. pii: 201708211. doi: 10.1073/pnas.1708211114. [Epub ahead of print]


Stability and function of regulatory T cells expressing the transcription factor T-bet.

Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY.

Nature. 2017 Jun 15;546(7658):421-425. doi: 10.1038/nature22360. Epub 2017 Jun 7. Erratum in: Nature. 2017 Sep 20;:.


Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.

Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY.

J Exp Med. 2017 Mar 6;214(3):609-622. doi: 10.1084/jem.20161318. Epub 2017 Jan 27.


Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330-336.

Fontenot JD, Gavin MA, Rudensky AY.

J Immunol. 2017 Feb 1;198(3):986-992. No abstract available.


The aryl hydrocarbon receptor controls cell-fate decisions in B cells.

Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J.

J Exp Med. 2017 Jan;214(1):197-208. doi: 10.1084/jem.20160789. Epub 2016 Dec 23.


Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells.

Sektioglu IM, Carretero R, Bulbuc N, Bald T, Tüting T, Rudensky AY, Hämmerling GJ.

Cancer Res. 2017 Jan 15;77(2):291-302. doi: 10.1158/0008-5472.CAN-16-0993. Epub 2016 Nov 22.


Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer.

Plitas G, Konopacki C, Wu K, Bos PD, Morrow M, Putintseva EV, Chudakov DM, Rudensky AY.

Immunity. 2016 Nov 15;45(5):1122-1134. doi: 10.1016/j.immuni.2016.10.032.


An essential role for the IL-2 receptor in Treg cell function.

Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY.

Nat Immunol. 2016 Nov;17(11):1322-1333. doi: 10.1038/ni.3540. Epub 2016 Sep 5.


Regulatory T Cells: Differentiation and Function.

Plitas G, Rudensky AY.

Cancer Immunol Res. 2016 Sep 2;4(9):721-5. doi: 10.1158/2326-6066.CIR-16-0193. Review.


Memory of Inflammation in Regulatory T Cells.

van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY.

Cell. 2016 Aug 11;166(4):977-990. doi: 10.1016/j.cell.2016.07.006. Epub 2016 Aug 4.


T cell receptor signalling in the control of regulatory T cell differentiation and function.

Li MO, Rudensky AY.

Nat Rev Immunol. 2016 Apr;16(4):220-33. doi: 10.1038/nri.2016.26. Review.


Hallmarks of Tissue-Resident Lymphocytes.

Fan X, Rudensky AY.

Cell. 2016 Mar 10;164(6):1198-1211. doi: 10.1016/j.cell.2016.02.048. Review.


miR-23∼27∼24 clusters control effector T cell differentiation and function.

Cho S, Wu CJ, Yasuda T, Cruz LO, Khan AA, Lin LL, Nguyen DT, Miller M, Lee HM, Kuo ML, Broide DH, Rajewsky K, Rudensky AY, Lu LF.

J Exp Med. 2016 Feb 8;213(2):235-49. doi: 10.1084/jem.20150990. Epub 2016 Feb 1.


Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627.

Rudensky AY, Preston-Hurlburt P, Hong SC, Barlow A, Janeway CA Jr.

J Immunol. 2016 Feb 1;196(3):941-6. No abstract available.


A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

Feng Y, van der Veeken J, Shugay M, Putintseva EV, Osmanbeyoglu HU, Dikiy S, Hoyos BE, Moltedo B, Hemmers S, Treuting P, Leslie CS, Chudakov DM, Rudensky AY.

Nature. 2015 Dec 3;528(7580):132-136. doi: 10.1038/nature16141. Epub 2015 Nov 25.


Immune homeostasis enforced by co-localized effector and regulatory T cells.

Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN.

Nature. 2015 Dec 10;528(7581):225-30. doi: 10.1038/nature16169. Epub 2015 Nov 25.


Genetic and epigenetic variation in the lineage specification of regulatory T cells.

Arvey A, van der Veeken J, Plitas G, Rich SS, Concannon P, Rudensky AY.

Elife. 2015 Oct 28;4:e07571. doi: 10.7554/eLife.07571.


Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs.

Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY.

Science. 2015 Nov 20;350(6263):981-5. doi: 10.1126/science.aac9593. Epub 2015 Oct 15.


Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH.

J Exp Med. 2015 Sep 21;212(10):1603-21. doi: 10.1084/jem.20141030. Epub 2015 Sep 14.


A Distinct Function of Regulatory T Cells in Tissue Protection.

Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting PM, Rudensky AY.

Cell. 2015 Aug 27;162(5):1078-89. doi: 10.1016/j.cell.2015.08.021.


A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner.

Lu LF, Gasteiger G, Yu IS, Chaudhry A, Hsin JP, Lu Y, Bos PD, Lin LL, Zawislak CL, Cho S, Sun JC, Leslie CS, Lin SW, Rudensky AY.

Immunity. 2015 Jul 21;43(1):52-64. doi: 10.1016/j.immuni.2015.04.022. Epub 2015 Jul 7.


DNA methylation secures CD4(+) and CD8(+) T cell lineage borders.

Feng Y, Rudensky AY.

Nat Immunol. 2015 Jul;16(7):681-3. doi: 10.1038/ni.3207. No abstract available.


The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function.

Hemmers S, Rudensky AY.

Cell Rep. 2015 Jun 9;11(9):1339-49. doi: 10.1016/j.celrep.2015.04.058. Epub 2015 May 21.


Continuous requirement for the TCR in regulatory T cell function.

Levine AG, Arvey A, Jin W, Rudensky AY.

Nat Immunol. 2014 Nov;15(11):1070-8. doi: 10.1038/ni.3004. Epub 2014 Sep 28.


Interactions between innate and adaptive lymphocytes.

Gasteiger G, Rudensky AY.

Nat Rev Immunol. 2014 Sep;14(9):631-9. doi: 10.1038/nri3726. Epub 2014 Aug 18. Review.


Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.

Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.

Cell. 2014 Aug 14;158(4):749-763. doi: 10.1016/j.cell.2014.07.031.


Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.

Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R.

J Exp Med. 2014 Aug 25;211(9):1905-18. doi: 10.1084/jem.20132577. Epub 2014 Aug 11.


Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells.

Arvey A, van der Veeken J, Samstein RM, Feng Y, Stamatoyannopoulos JA, Rudensky AY.

Nat Immunol. 2014 Jun;15(6):580-587. doi: 10.1038/ni.2868. Epub 2014 Apr 13.


Regulatory T cell ablation causes acute T cell lymphopenia.

Moltedo B, Hemmers S, Rudensky AY.

PLoS One. 2014 Jan 23;9(1):e86762. doi: 10.1371/journal.pone.0086762. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e99340. Dosage error in article text.


Microbial metabolites control gut inflammatory responses.

Arpaia N, Rudensky AY.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2058-9. doi: 10.1073/pnas.1323183111. Epub 2014 Jan 16. No abstract available.


Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY.

Nature. 2013 Dec 19;504(7480):451-5. doi: 10.1038/nature12726. Epub 2013 Nov 13.


Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy.

Bos PD, Plitas G, Rudra D, Lee SY, Rudensky AY.

J Exp Med. 2013 Oct 21;210(11):2435-66. doi: 10.1084/jem.20130762. Epub 2013 Oct 14.


The plasticity and stability of regulatory T cells.

Sakaguchi S, Vignali DA, Rudensky AY, Niec RE, Waldmann H.

Nat Rev Immunol. 2013 Jun;13(6):461-7. doi: 10.1038/nri3464. Epub 2013 May 17.


IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.

Gasteiger G, Hemmers S, Firth MA, Le Floc'h A, Huse M, Sun JC, Rudensky AY.

J Exp Med. 2013 Jun 3;210(6):1167-78. doi: 10.1084/jem.20122462. Epub 2013 May 6.


IL-2-dependent adaptive control of NK cell homeostasis.

Gasteiger G, Hemmers S, Bos PD, Sun JC, Rudensky AY.

J Exp Med. 2013 Jun 3;210(6):1179-87. doi: 10.1084/jem.20122571. Epub 2013 May 6.


Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155.

Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6967-72. doi: 10.1073/pnas.1304410110. Epub 2013 Apr 9.


Control of inflammation by integration of environmental cues by regulatory T cells.

Chaudhry A, Rudensky AY.

J Clin Invest. 2013 Mar;123(3):939-44. doi: 10.1172/JCI57175. Epub 2013 Mar 1. Review.


Treg cells in cancer: a case of multiple personality disorder.

Bos PD, Rudensky AY.

Sci Transl Med. 2012 Dec 12;4(164):164fs44. doi: 10.1126/scitranslmed.3005283.


Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting.

Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY.

Mol Cell. 2012 Dec 14;48(5):760-70. doi: 10.1016/j.molcel.2012.10.002. Epub 2012 Nov 8.


Novel Foxo1-dependent transcriptional programs control T(reg) cell function.

Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, Li MO.

Nature. 2012 Nov 22;491(7425):554-9. doi: 10.1038/nature11581. Epub 2012 Nov 7.


Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.

Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY.

Cell. 2012 Sep 28;151(1):153-66. doi: 10.1016/j.cell.2012.06.053.


Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.

Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, Xiong H, Dolpady J, Frey AB, Ruocco MG, Yang Y, Floess S, Huehn J, Oh S, Li MO, Niec RE, Rudensky AY, Dustin ML, Littman DR, Lafaille JJ.

J Exp Med. 2012 Sep 24;209(10):1723-42, S1. Epub 2012 Sep 10.


Transcription factor Foxp3 and its protein partners form a complex regulatory network.

Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY.

Nat Immunol. 2012 Oct;13(10):1010-9. doi: 10.1038/ni.2402. Epub 2012 Aug 26.

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