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Items: 1 to 50 of 51

1.

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.

Pettersson-Klein AT, Izadi M, Ferreira DMS, Cervenka I, Correia JC, Martinez-Redondo V, Southern M, Cameron M, Kamenecka T, Agudelo LZ, Porsmyr-Palmertz M, Martens U, Lundgren B, Otrocka M, Jenmalm-Jensen A, Griffin PR, Ruas JL.

Mol Metab. 2018 Mar;9:28-42. doi: 10.1016/j.molmet.2018.01.017. Epub 2018 Feb 3.

2.

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren PO, Ruas JL.

Cell Metab. 2018 Feb 6;27(2):378-392.e5. doi: 10.1016/j.cmet.2018.01.004.

PMID:
29414686
3.

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.

Mills R, Taylor-Weiner H, Correia JC, Agudelo LZ, Allodi I, Kolonelou C, Martinez-Redondo V, Ferreira DMS, Nichterwitz S, Comley LH, Lundin V, Hedlund E, Ruas JL, Teixeira AI.

Mol Metab. 2018 Jan;7:12-22. doi: 10.1016/j.molmet.2017.11.001. Epub 2017 Nov 7.

4.

Multiple anthelmintic resistance in Southern Brazil sheep flocks.

Oliveira PA, Riet-Correa B, Estima-Silva P, Coelho ACB, Santos BLD, Costa MAP, Ruas JL, Schild AL.

Rev Bras Parasitol Vet. 2017 Oct-Dec;26(4):427-432. doi: 10.1590/S1984-29612017058. Epub 2017 Oct 23.

5.

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.

Cervenka I, Agudelo LZ, Ruas JL.

Science. 2017 Jul 28;357(6349). pii: eaaf9794. doi: 10.1126/science.aaf9794. Review.

PMID:
28751584
6.

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR.

Cell Rep. 2017 Jan 17;18(3):636-646. doi: 10.1016/j.celrep.2016.12.070.

7.

The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.

Cipriano M, Correia JC, Camões SP, Oliveira NG, Cruz P, Cruz H, Castro M, Ruas JL, Santos JM, Miranda JP.

Arch Toxicol. 2017 Jun;91(6):2469-2489. doi: 10.1007/s00204-016-1901-x. Epub 2016 Dec 1.

PMID:
27909741
8.

Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling.

Mutikainen M, Tuomainen T, Naumenko N, Huusko J, Smirin B, Laidinen S, Kokki K, Hynynen H, Ylä-Herttuala S, Heinäniemi M, Ruas JL, Tavi P.

J Physiol. 2016 Dec 1;594(23):7049-7071. doi: 10.1113/JP272847.

9.

Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.

Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, Rodrigues CM, Björkhem I, Ruas JL, Rodrigues E.

Sci Rep. 2016 Aug 5;6:30928. doi: 10.1038/srep30928.

10.

Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise.

Jannig PR, Ruas JL.

Acta Physiol (Oxf). 2017 Jan;219(1):14-16. doi: 10.1111/apha.12752. Epub 2016 Jul 25. No abstract available.

PMID:
27419811
11.

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.

Martínez-Redondo V, Jannig PR, Correia JC, Ferreira DM, Cervenka I, Lindvall JM, Sinha I, Izadi M, Pettersson-Klein AT, Agudelo LZ, Gimenez-Cassina A, Brum PC, Dahlman-Wright K, Ruas JL.

J Biol Chem. 2016 Jul 15;291(29):15169-84. doi: 10.1074/jbc.M115.705822. Epub 2016 May 26.

12.

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.

Schlittler M, Goiny M, Agudelo LZ, Venckunas T, Brazaitis M, Skurvydas A, Kamandulis S, Ruas JL, Erhardt S, Westerblad H, Andersson DC.

Am J Physiol Cell Physiol. 2016 May 15;310(10):C836-40. doi: 10.1152/ajpcell.00053.2016. Epub 2016 Mar 30.

13.

Mechano-signalling pathways in an experimental intensive critical illness myopathy model.

Corpeno Kalamgi R, Salah H, Gastaldello S, Martinez-Redondo V, Ruas JL, Fury W, Bai Y, Gromada J, Sartori R, Guttridge DC, Sandri M, Larsson L.

J Physiol. 2016 Aug 1;594(15):4371-88. doi: 10.1113/JP271973. Epub 2016 Apr 24.

14.

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.

Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, Ruas JL.

Mol Metab. 2015 Sep 26;4(12):891-902. doi: 10.1016/j.molmet.2015.09.005. eCollection 2015 Dec.

15.

Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle.

Zepf FD, Stewart RM, Guillemin G, Ruas JL.

Acta Neuropsychiatr. 2016 Aug;28(4):244-5. doi: 10.1017/neu.2015.69. Epub 2016 Feb 2. No abstract available.

PMID:
26832995
16.

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.

Place N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng AJ, Ochala J, Kamandulis S, Girard S, Volungevičius G, Paužas H, Mekideche A, Kayser B, Martinez-Redondo V, Ruas JL, Bruton J, Truffert A, Lanner JT, Skurvydas A, Westerblad H.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15492-7. doi: 10.1073/pnas.1507176112. Epub 2015 Nov 2.

17.

The hitchhiker's guide to PGC-1α isoform structure and biological functions.

Martínez-Redondo V, Pettersson AT, Ruas JL.

Diabetologia. 2015 Sep;58(9):1969-77. doi: 10.1007/s00125-015-3671-z. Epub 2015 Jun 25. Review.

PMID:
26109214
18.

Intercellular: local and systemic actions of skeletal muscle PGC-1s.

Correia JC, Ferreira DM, Ruas JL.

Trends Endocrinol Metab. 2015 Jun;26(6):305-14. doi: 10.1016/j.tem.2015.03.010. Epub 2015 Apr 28. Review.

PMID:
25934582
19.

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.

White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15756-61. doi: 10.1073/pnas.1417898111. Epub 2014 Oct 21.

20.

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DMS, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL.

Cell. 2014 Sep 25;159(1):33-45. doi: 10.1016/j.cell.2014.07.051.

21.

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM.

Cell. 2014 Jun 5;157(6):1279-91. doi: 10.1016/j.cell.2014.03.065.

22.

Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways.

Aesoy R, Gradin K, Aasrud KS, Hoivik EA, Ruas JL, Poellinger L, Bakke M.

Mol Cancer. 2014 Mar 11;13:54. doi: 10.1186/1476-4598-13-54.

23.

Isolation and pathogenicity of Toxoplasma gondii in naturally infected (rustic farm) pigs in southern Brazil.

Cademartori BG, Santos LM, Oliveira FC, Quevedo P, Oliveira PA, Ramos TS, Rocha AS, Ruas JL, Farias NA.

Vet Parasitol. 2014 Jun 16;203(1-2):207-11. doi: 10.1016/j.vetpar.2014.02.009. Epub 2014 Feb 18.

PMID:
24612744
24.

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.

Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B, Estall JL.

Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E157-67. doi: 10.1152/ajpendo.00578.2013. Epub 2013 Nov 26.

25.

Occurrence of antibodies to Toxoplasma gondii in water buffaloes and meat cattle in Rio Grande do Sul State, southern Brazil.

Santos LM, Damé MC, Cademartori BG, da Cunha Filho NA, Farias NA, Ruas JL.

Acta Parasitol. 2013 Sep;58(3):334-6. doi: 10.2478/s11686-013-0148-4. Epub 2013 Aug 29.

PMID:
23990431
26.

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.

Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM.

Cell. 2012 Dec 7;151(6):1319-31. doi: 10.1016/j.cell.2012.10.050.

27.

Subacute and acute fasciolosis in sheep in southern Brazil.

Fiss L, de Lourdes Adrien M, Marcolongo-Pereira C, Assis-Brasil ND, Sallis ES, Riet-Correa F, Ruas JL, Schild AL.

Parasitol Res. 2013 Feb;112(2):883-7. doi: 10.1007/s00436-012-3096-2. Epub 2012 Sep 2.

PMID:
22941529
28.

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.

Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM.

Genes Dev. 2011 Jun 15;25(12):1232-44. doi: 10.1101/gad.2054711. Epub 2011 Jun 6.

29.

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.

Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM.

Cell Metab. 2011 Feb 2;13(2):160-9. doi: 10.1016/j.cmet.2011.01.003.

30.

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.

Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21866-71. doi: 10.1073/pnas.1016089107. Epub 2010 Nov 24.

31.

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.

Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR.

Development. 2010 Oct;137(20):3489-99. doi: 10.1242/dev.053348. Epub 2010 Sep 15.

32.

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM.

Nature. 2010 Jul 22;466(7305):451-6. doi: 10.1038/nature09291.

33.

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.

Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22510-5. doi: 10.1073/pnas.0912533106. Epub 2009 Dec 14.

34.

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

Ruas JL, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder RG, Pereira T, Poellinger L.

J Biol Chem. 2010 Jan 22;285(4):2601-9. doi: 10.1074/jbc.M109.021824. Epub 2009 Oct 30.

35.

[Helminths of Pampas fox, Pseudalopex gymnocercus (Fischer, 1814) and of Crab-eating fox, Cerdocyon thous (Linnaeus, 1766) in the South of the State of Rio Grande do Sul, Brazil].

Ruas JL, Muller G, Farias NA, Gallina T, Lucas AS, Pappen FG, Sinkoc AL, Brum JG.

Rev Bras Parasitol Vet. 2008 Apr-Jun;17(2):87-92. Portuguese.

PMID:
18823576
36.

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.

Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM.

Genes Dev. 2008 May 15;22(10):1397-409. doi: 10.1101/gad.1666108.

37.

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368-73. doi: 10.1073/pnas.0711591105. Epub 2008 Feb 25.

38.

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.

Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM.

Nature. 2008 Feb 21;451(7181):1008-12. doi: 10.1038/nature06613.

PMID:
18288196
39.

Development and evaluation of a quantitative PCR assay for detection of Hepatozoon sp.

Criado-Fornelio A, Buling A, Cunha-Filho NA, Ruas JL, Farias NA, Rey-Valeiron C, Pingret JL, Etievant M, Barba-Carretero JC.

Vet Parasitol. 2007 Dec 25;150(4):352-6. Epub 2007 Nov 5.

PMID:
17983705
40.

Modulation of vascular gene expression by hypoxia.

Ruas JL, Lendahl U, Poellinger L.

Curr Opin Lipidol. 2007 Oct;18(5):508-14. Review.

PMID:
17885420
41.

Hypoxia inducible factor regulates the cardiac expression and secretion of apelin.

Ronkainen VP, Ronkainen JJ, Hänninen SL, Leskinen H, Ruas JL, Pereira T, Poellinger L, Vuolteenaho O, Tavi P.

FASEB J. 2007 Jun;21(8):1821-30. Epub 2007 Mar 6.

PMID:
17341685
42.

Seasonal allergic dermatitis in sheep in southern Brazil caused by Culicoides insignis (Diptera: Ceratopogonidae).

Corrêa TG, Ferreira JM, Riet-Correa G, Ruas JL, Schild AL, Riet-Correa F, Guimarães A, Felippe-Bauer ML.

Vet Parasitol. 2007 Apr 10;145(1-2):181-5. Epub 2006 Nov 28.

PMID:
17127007
43.

Biologic and genetic comparison of Toxoplasma gondii isolates in free-range chickens from the northern Pará state and the southern state Rio Grande do Sul, Brazil revealed highly diverse and distinct parasite populations.

Dubey JP, Sundar N, Gennari SM, Minervino AH, Farias NA, Ruas JL, dos Santos TR, Cavalcante GT, Kwok OC, Su C.

Vet Parasitol. 2007 Jan 31;143(2):182-8. Epub 2006 Sep 18.

PMID:
16982151
44.

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.

Zheng X, Ruas JL, Cao R, Salomons FA, Cao Y, Poellinger L, Pereira T.

Mol Cell Biol. 2006 Jun;26(12):4628-41.

45.

New molecular data on mammalian Hepatozoon species (Apicomplexa: Adeleorina) from Brazil and Spain.

Criado-Fornelio A, Ruas JL, Casado N, Farias NA, Soares MP, Müller G, Brumt JG, Berne ME, Buling-Saraña A, Barba-Carretero JC.

J Parasitol. 2006 Feb;92(1):93-9.

PMID:
16629322
46.

Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M.

Dev Cell. 2005 Nov;9(5):617-28.

47.

Hypoxia-dependent activation of HIF into a transcriptional regulator.

Ruas JL, Poellinger L.

Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):514-22. Review.

PMID:
15908239
48.

Role of CBP in regulating HIF-1-mediated activation of transcription.

Ruas JL, Poellinger L, Pereira T.

J Cell Sci. 2005 Jan 15;118(Pt 2):301-11. Epub 2004 Dec 22.

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