Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32


Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo.

Schilders K, Eenjes E, Edel G, de Munck AB, van Kempen MB, Demmers J, Wijnen R, Tibboel D, Rottier RJ.

Transgenic Res. 2018 Feb;27(1):75-85. doi: 10.1007/s11248-018-0058-1. Epub 2018 Jan 30.


Pulmonary vascular development in congenital diaphragmatic hernia.

Mous DS, Kool HM, Wijnen R, Tibboel D, Rottier RJ.

Eur Respir Rev. 2018 Jan 24;27(147). pii: 170104. doi: 10.1183/16000617.0104-2017. Print 2018 Mar 31. Review.


Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy.

Mous DS, Buscop-van Kempen MJ, Wijnen RMH, Tibboel D, Rottier RJ.

Respir Res. 2017 Nov 7;18(1):187. doi: 10.1186/s12931-017-0670-2.


Early Identification of Bronchopulmonary Dysplasia Using Novel Biomarkers by Proteomic Screening.

Förster K, Sass S, Ehrhardt H, Mous DS, Rottier RJ, Oak P, Schulze A, Flemmer AW, Gronbach J, Hübener C, Desai T, Eickelberg O, Theis FJ, Hilgendorff A.

Am J Respir Crit Care Med. 2017 Oct 20. doi: 10.1164/rccm.201706-1218LE. [Epub ahead of print] No abstract available.


Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.

Oak P, Pritzke T, Thiel I, Koschlig M, Mous DS, Windhorst A, Jain N, Eickelberg O, Foerster K, Schulze A, Goepel W, Reicherzer T, Ehrhardt H, Rottier RJ, Ahnert P, Gortner L, Desai TJ, Hilgendorff A.

EMBO Mol Med. 2017 Nov;9(11):1504-1520. doi: 10.15252/emmm.201607308.


The Future of Bronchopulmonary Dysplasia: Emerging Pathophysiological Concepts and Potential New Avenues of Treatment.

Collins JJP, Tibboel D, de Kleer IM, Reiss IKM, Rottier RJ.

Front Med (Lausanne). 2017 May 22;4:61. doi: 10.3389/fmed.2017.00061. eCollection 2017. Review.


Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia.

Mous DS, Kool HM, Buscop-van Kempen MJ, Koning AH, Dzyubachyk O, Wijnen RM, Tibboel D, Rottier RJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L734-L742. doi: 10.1152/ajplung.00180.2016. Epub 2016 Aug 12.


Regeneration of the lung: Lung stem cells and the development of lung mimicking devices.

Schilders KA, Eenjes E, van Riet S, Poot AA, Stamatialis D, Truckenmüller R, Hiemstra PS, Rottier RJ.

Respir Res. 2016 Apr 23;17:44. doi: 10.1186/s12931-016-0358-z. Review.


Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia.

Pereira-Terra P, Deprest JA, Kholdebarin R, Khoshgoo N, DeKoninck P, Munck AA, Wang J, Zhu F, Rottier RJ, Iwasiow BM, Correia-Pinto J, Tibboel D, Post M, Keijzer R.

Ann Surg. 2015 Dec;262(6):1130-40. doi: 10.1097/SLA.0000000000001054.


Pulmonary vascular development goes awry in congenital lung abnormalities.

Kool H, Mous D, Tibboel D, de Klein A, Rottier RJ.

Birth Defects Res C Embryo Today. 2014 Dec;102(4):343-58. doi: 10.1002/bdrc.21085. Epub 2014 Nov 26. Review.


Metabolic disturbances of the vitamin A pathway in human diaphragmatic hernia.

Coste K, Beurskens LW, Blanc P, Gallot D, Delabaere A, Blanchon L, Tibboel D, Labbé A, Rottier RJ, Sapin V.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L147-57.


Differentiated type II pneumocytes can be reprogrammed by ectopic Sox2 expression.

Kapere Ochieng J, Schilders K, Kool H, Buscop-van Kempen M, Boerema-De Munck A, Grosveld F, Wijnen R, Tibboel D, Rottier RJ.

PLoS One. 2014 Sep 11;9(9):e107248. doi: 10.1371/journal.pone.0107248. eCollection 2014.


Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression.

Raghoebir L, Biermann K, Kempen MB, Dubbink HJ, Dinjens WN, Hersmus R, Looijenga LH, Bruno MJ, Tibboel D, Rottier RJ, Smits R.

Virchows Arch. 2014 Oct;465(4):395-400. doi: 10.1007/s00428-014-1638-y. Epub 2014 Aug 10.


Clinical and etiological heterogeneity in patients with tracheo-esophageal malformations and associated anomalies.

Brosens E, Ploeg M, van Bever Y, Koopmans AE, IJsselstijn H, Rottier RJ, Wijnen R, Tibboel D, de Klein A.

Eur J Med Genet. 2014 Aug;57(8):440-52. doi: 10.1016/j.ejmg.2014.05.009. Epub 2014 Jun 13. Review.


Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63.

Ochieng JK, Schilders K, Kool H, Boerema-De Munck A, Buscop-Van Kempen M, Gontan C, Smits R, Grosveld FG, Wijnen RM, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):311-22. doi: 10.1165/rcmb.2013-0419OC.


Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.

Pan W, Jin Y, Chen J, Rottier RJ, Steel KP, Kiernan AE.

J Neurosci. 2013 Oct 9;33(41):16146-57. doi: 10.1523/JNEUROSCI.3150-12.2013.


Disturbed balance between SOX2 and CDX2 in human vitelline duct anomalies and intestinal duplications.

Raghoebir L, Biermann K, Buscop-van Kempen M, Wijnen RM, Tibboel D, Smits R, Rottier RJ.

Virchows Arch. 2013 May;462(5):515-22. doi: 10.1007/s00428-013-1405-5. Epub 2013 Apr 9.


Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.

Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ.

PLoS One. 2013;8(2):e57695. doi: 10.1371/journal.pone.0057695. Epub 2013 Feb 25. Erratum in: PLoS One. 2015;10(3):e0119359.


Premature differentiation of vascular smooth muscle cells in human congenital diaphragmatic hernia.

Sluiter I, van der Horst I, van der Voorn P, Boerema-de Munck A, Buscop-van Kempen M, de Krijger R, Tibboel D, Reiss I, Rottier RJ.

Exp Mol Pathol. 2013 Feb;94(1):195-202. doi: 10.1016/j.yexmp.2012.09.010. Epub 2012 Sep 24.


Induced Wnt5a expression perturbs embryonic outgrowth and intestinal elongation, but is well-tolerated in adult mice.

Bakker ER, Raghoebir L, Franken PF, Helvensteijn W, van Gurp L, Meijlink F, van der Valk MA, Rottier RJ, Kuipers EJ, van Veelen W, Smits R.

Dev Biol. 2012 Sep 1;369(1):91-100. doi: 10.1016/j.ydbio.2012.06.007. Epub 2012 Jun 9.


SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.

Raghoebir L, Bakker ER, Mills JC, Swagemakers S, Kempen MB, Munck AB, Driegen S, Meijer D, Grosveld F, Tibboel D, Smits R, Rottier RJ.

J Mol Cell Biol. 2012 Dec;4(6):377-85. doi: 10.1093/jmcb/mjs030. Epub 2012 Jun 7.


Reversal of pulmonary vascular remodeling in pulmonary hypertensive rats.

Sluiter I, van Heijst A, Haasdijk R, Kempen MB, Boerema-de Munck A, Reiss I, Tibboel D, Rottier RJ.

Exp Mol Pathol. 2012 Aug;93(1):66-73. doi: 10.1016/j.yexmp.2012.03.010. Epub 2012 Mar 27.


Hypoxia-inducible factor 2α plays a critical role in the formation of alveoli and surfactant.

Huang Y, Kempen MB, Munck AB, Swagemakers S, Driegen S, Mahavadi P, Meijer D, van Ijcken W, van der Spek P, Grosveld F, Günther A, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2012 Feb;46(2):224-32. doi: 10.1165/rcmb.2011-0024OC.


Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.

Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van Ijcken W, Dekkers DH, Demmers J, Rijkers EJ, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA.

Nat Genet. 2011 Jun;43(6):607-11. doi: 10.1038/ng.825. Epub 2011 May 1.


Vascular abnormalities in human newborns with pulmonary hypertension.

Sluiter I, Reiss I, Kraemer U, Krijger Rd, Tibboel D, Rottier RJ.

Expert Rev Respir Med. 2011 Apr;5(2):245-56. doi: 10.1586/ers.11.8. Review.


Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants.

Rajatapiti P, de Rooij JD, Beurskens LW, Keijzer R, Tibboel D, Rottier RJ, de Krijger RR.

Neonatology. 2010 Jun;97(4):346-54. doi: 10.1159/000261018. Epub 2009 Nov 25.


Genetic and environmental factors in the etiology of esophageal atresia and/or tracheoesophageal fistula: an overview of the current concepts.

Felix JF, de Jong EM, Torfs CP, de Klein A, Rottier RJ, Tibboel D.

Birth Defects Res A Clin Mol Teratol. 2009 Sep;85(9):747-54. doi: 10.1002/bdra.20592. Review.


Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors.

Gontan C, Güttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, Tibboel D, Görlich D, Poot RA, Rottier RJ.

J Cell Biol. 2009 Apr 6;185(1):27-34. doi: 10.1083/jcb.200810106.


Genetics and developmental biology of oesophageal atresia and tracheo-oesophageal fistula: lessons from mice relevant for paediatric surgeons.

Felix JF, Keijzer R, van Dooren MF, Rottier RJ, Tibboel D.

Pediatr Surg Int. 2004 Oct;20(10):731-6. Review.


A point mutation in the neu-1 locus causes the neuraminidase defect in the SM/J mouse.

Rottier RJ, Bonten E, d'Azzo A.

Hum Mol Genet. 1998 Feb;7(2):313-21.


Identification of the promoters for the human and murine protective protein/cathepsin A genes.

Rottier RJ, D'Azzo A.

DNA Cell Biol. 1997 May;16(5):599-610.


Supplemental Content

Loading ...
Support Center