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Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.

Kottyan LC, Maddox A, Braxton JR, Stucke EM, Mukkada V, Putnam PE, Abonia JP, Chehade M, Wood RA, Pesek RD, Vickery BP, Furuta GT, Dawson P, Sampson HA, Martin LJ, Kelly JA, Kimberly RP, Sivils K, Gaffney PM, Kaufman K, Harley JB, Rothenberg ME.

Genes Immun. 2018 Jun 8. doi: 10.1038/s41435-018-0034-z. [Epub ahead of print]


The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses.

Azouz NP, Ynga-Durand MA, Caldwell JM, Jain A, Rochman M, Fischesser DM, Ray LM, Bedard MC, Mingler MK, Forney C, Eilerman M, Kuhl JT, He H, Biagini Myers JM, Mukkada VA, Putnam PE, Khurana Hershey GK, Kottyan LC, Wen T, Martin LJ, Rothenberg ME.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaap9736. doi: 10.1126/scitranslmed.aap9736.


Alignment of Parent- and Child-Reported Outcomes and Histology in Eosinophilic Esophagitis Across Multiple CEGIR Sites.

Aceves SS, King E, Collins MH, Yang GY, Capocelli KE, Abonia JP, Atkins D, Bonis PA, Carpenter CL, Dellon ES, Eby MD, Falk GW, Gonsalves N, Gupta SK, Hirano I, Kocher K, Krischer JP, Leung J, Lipscomb J, Menard-Katcher P, Mukkada VA, Pan Z, Spergel JM, Sun Q, Wershil BK, Rothenberg ME, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

J Allergy Clin Immunol. 2018 May 28. pii: S0091-6749(18)30774-7. doi: 10.1016/j.jaci.2018.05.014. [Epub ahead of print]


New Developments in Eosinophilic Gastrointestinal Diseases Presented at the CEGIR/TIGERS Symposium at the 2018 AAAAI Meeting.

Spergel JM, Aceves SS, Kliewer K, Gonsalves N, Chehade M, Wechsler JB, Groetch M, Friedlander J, Dellon ES, Book W, Hirano I, Muir AB, Cianferoni A, Spencer L, Liacouras CA, Cheng E, Kottyan L, Wen T, Platts-Mills T, Rothenberg ME.

J Allergy Clin Immunol. 2018 May 24. pii: S0091-6749(18)30760-7. doi: 10.1016/j.jaci.2018.05.005. [Epub ahead of print] No abstract available.


Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis.

Rosenberg CE, Mingler MK, Caldwell JM, Collins MH, Fulkerson PC, Morris DW, Mukkada VA, Putnam PE, Shoda T, Wen T, Rothenberg ME.

Allergy. 2018 May 23. doi: 10.1111/all.13486. [Epub ahead of print]


Eosinophil Development, Disease Involvement, and Therapeutic Suppression.

Fulkerson PC, Rothenberg ME.

Adv Immunol. 2018;138:1-34. doi: 10.1016/ Epub 2018 Apr 22.


Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study.

Shoda T, Wen T, Aceves SS, Abonia JP, Atkins D, Bonis PA, Caldwell JM, Capocelli KE, Carpenter CL, Collins MH, Dellon ES, Eby MD, Gonsalves N, Gupta SK, Falk GW, Hirano I, Menard-Katcher P, Kuhl JT, Krischer JP, Leung J, Mukkada VA, Spergel JM, Trimarchi MP, Yang GY, Zimmermann N, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

Lancet Gastroenterol Hepatol. 2018 Jul;3(7):477-488. doi: 10.1016/S2468-1253(18)30096-7. Epub 2018 May 3.


Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis.

Zeng C, Vanoni S, Wu D, Caldwell JM, Wheeler JC, Arora K, Noah TK, Waggoner L, Besse JA, Yamani AN, Uddin J, Rochman M, Wen T, Chehade M, Collins MH, Mukkada VA, Putnam PE, Naren AP, Rothenberg ME, Hogan SP.

J Allergy Clin Immunol. 2018 May 4. pii: S0091-6749(18)30633-X. doi: 10.1016/j.jaci.2018.03.017. [Epub ahead of print]


Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD).

Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD.

J Leukoc Biol. 2018 Apr 19. doi: 10.1002/JLB.5MR0118-028R. [Epub ahead of print] Review.


Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.

Sherrill JD, Kc K, Wang X, Wen T, Chamberlin A, Stucke EM, Collins MH, Abonia JP, Peng Y, Wu Q, Putnam PE, Dexheimer PJ, Aronow BJ, Kottyan LC, Kaufman KM, Harley JB, Huang T, Rothenberg ME.

JCI Insight. 2018 Apr 19;3(8). pii: 99922. doi: 10.1172/jci.insight.99922. [Epub ahead of print]


Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care.

Hiremath G, Kodroff E, Strobel MJ, Scott M, Book W, Reidy C, Kyle S, Mack D, Sable K, Abonia P, Spergel J, Gupta SK, Furuta TG, Rothenberg ME, Dellon ES.

Clin Res Hepatol Gastroenterol. 2018 Mar 31. pii: S2210-7401(18)30042-1. doi: 10.1016/j.clinre.2018.03.003. [Epub ahead of print]


DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.

Peinhaupt M, Roula D, Theiler A, Sedej M, Schicho R, Marsche G, Sturm EM, Sabroe I, Rothenberg ME, Heinemann A.

J Leukoc Biol. 2018 Apr 1. doi: 10.1002/JLB.3MA1017-404R. [Epub ahead of print]


Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333.


News Beyond Our Pages.

Rothenberg ME, Bousquet J.

J Allergy Clin Immunol. 2018 Feb;141(2):520-521. doi: 10.1016/j.jaci.2017.12.977. No abstract available.


Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

Cheng K, Gupta SK, Kantor S, Kuhl JT, Aceves SS, Bonis PA, Capocelli KE, Carpenter C, Chehade M, Collins MH, Dellon ES, Falk GW, Gopal-Srivastava R, Gonsalves N, Hirano I, King EC, Leung J, Krischer JP, Mukkada VA, Schoepfer A, Spergel JM, Straumann A, Yang GY, Furuta GT, Rothenberg ME.

Transl Sci Rare Dis. 2017 Dec 18;2(3-4):141-155. doi: 10.3233/TRD-170016.


IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis.

Travers J, Rochman M, Caldwell JM, Besse JA, Miracle CE, Rothenberg ME.

Sci Rep. 2017 Dec 14;7(1):17563. doi: 10.1038/s41598-017-17541-5.


Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci.

Martin LJ, He H, Collins MH, Abonia JP, Biagini Myers JM, Eby M, Johansson H, Kottyan LC, Khurana Hershey GK, Rothenberg ME.

J Allergy Clin Immunol. 2018 May;141(5):1690-1698. doi: 10.1016/j.jaci.2017.09.046. Epub 2017 Nov 10.



Lu TX, Rothenberg ME.

J Allergy Clin Immunol. 2018 Apr;141(4):1202-1207. doi: 10.1016/j.jaci.2017.08.034. Epub 2017 Oct 23.


Disease-Related Predictors of Health-Related Quality of Life in Youth With Eosinophilic Esophagitis.

Lynch MK, Barnes MJ, Dimmitt RA, Martin L, Rothenberg ME, Goodin BR.

J Pediatr Psychol. 2018 May 1;43(4):464-471. doi: 10.1093/jpepsy/jsx128.


Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity.

Rochman M, Travers J, Abonia JP, Caldwell JM, Rothenberg ME.

JCI Insight. 2017 Oct 19;2(20). pii: 96789. doi: 10.1172/jci.insight.96789. [Epub ahead of print]


Advances in mechanisms of allergic disease in 2016.

Rothenberg ME, Saito H, Peebles RS Jr.

J Allergy Clin Immunol. 2017 Dec;140(6):1622-1631. doi: 10.1016/j.jaci.2017.08.029. Epub 2017 Oct 13. Review.


Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.

Jensen ET, Kuhl JT, Martin LJ, Langefeld CD, Dellon ES, Rothenberg ME.

J Allergy Clin Immunol. 2018 Feb;141(2):632-637.e5. doi: 10.1016/j.jaci.2017.07.010. Epub 2017 Oct 10.


Novel immunologic mechanisms in eosinophilic esophagitis.

Caldwell JM, Paul M, Rothenberg ME.

Curr Opin Immunol. 2017 Oct;48:114-121. doi: 10.1016/j.coi.2017.08.006. Epub 2017 Sep 29. Review. No abstract available.


A flow cytometry-based diagnosis of eosinophilic esophagitis.

Wen T, Kuhl J, Putnam P, Mukkada V, Farrell M, Kaul A, Cole C, Rothenberg ME.

J Allergy Clin Immunol. 2017 Dec;140(6):1736-1739.e3. doi: 10.1016/j.jaci.2017.07.022. Epub 2017 Aug 19. No abstract available.


MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism.

Miguel-Hidalgo JJ, Hall KO, Bonner H, Roller AM, Syed M, Park CJ, Ball JP, Rothenberg ME, Stockmeier CA, Romero DG.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):503-514. doi: 10.1016/j.pnpbp.2017.08.009. Epub 2017 Aug 9.


Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel.

Wen T, Rothenberg ME.

Front Med (Lausanne). 2017 Jul 14;4:108. doi: 10.3389/fmed.2017.00108. eCollection 2017. Review.


Pathophysiology of Eosinophilic Esophagitis.

O'Shea KM, Aceves SS, Dellon ES, Gupta SK, Spergel JM, Furuta GT, Rothenberg ME.

Gastroenterology. 2018 Jan;154(2):333-345. doi: 10.1053/j.gastro.2017.06.065. Epub 2017 Jul 27. Review.


CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

Rozenberg P, Reichman H, Zab-Bar I, Itan M, Pasmanik-Chor M, Bouffi C, Qimron U, Bachelet I, Fulkerson PC, Rothenberg ME, Munitz A.

Sci Rep. 2017 Jul 19;7(1):5922. doi: 10.1038/s41598-017-06397-4.


Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor.

Qin M, Wang L, Li F, Yang M, Song L, Tian F, Yukht A, Shah PK, Rothenberg ME, Sharifi BG.

Atherosclerosis. 2017 Aug;263:82-91. doi: 10.1016/j.atherosclerosis.2017.05.011. Epub 2017 May 20.


Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis.

Jensen ET, Kuhl JT, Martin LJ, Rothenberg ME, Dellon ES.

J Allergy Clin Immunol. 2018 Jan;141(1):214-222. doi: 10.1016/j.jaci.2017.05.018. Epub 2017 Jun 7.


In Memory and Celebration: Dr. James J. Lee.

Rosenberg HF, Fryer AD, Munitz A, Bochner BS, Jacoby DB, Levi-Schaffer F, Gleich GJ, Furuta GT, Rothenberg ME, Lacy P, Fulkerson PC, Hogan SP, Ackerman SJ, Foster PS.

Clin Exp Allergy. 2017 Jul;47(7):980-981. doi: 10.1111/cea.12959. No abstract available.


Infant feeding: Swinging the Pendulum from Late to Early Introduction of Food.

Katz Y, Rothenberg ME.

Isr Med Assoc J. 2016 Nov;18(11):684-688. Review. No abstract available.


News Beyond Our Pages.

Rothenberg ME, Bousquet J.

J Allergy Clin Immunol. 2017 Mar;139(3):762-763. doi: 10.1016/j.jaci.2017.01.002. No abstract available.


Correction: ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD.

J Exp Med. 2017 Apr 3;214(4):1201. doi: 10.1084/jem.2016143503082017c. Epub 2017 Mar 13. No abstract available.


Genetics of eosinophilic esophagitis.

Kottyan LC, Rothenberg ME.

Mucosal Immunol. 2017 May;10(3):580-588. doi: 10.1038/mi.2017.4. Epub 2017 Feb 22. Review.


Calpain-14 and its association with eosinophilic esophagitis.

Litosh VA, Rochman M, Rymer JK, Porollo A, Kottyan LC, Rothenberg ME.

J Allergy Clin Immunol. 2017 Jun;139(6):1762-1771.e7. doi: 10.1016/j.jaci.2016.09.027. Epub 2017 Jan 25. Review.


ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Lyons JJ, Liu Y, Ma CA, Yu X, O'Connell MP, Lawrence MG, Zhang Y, Karpe K, Zhao M, Siegel AM, Stone KD, Nelson C, Jones N, DiMaggio T, Darnell DN, Mendoza-Caamal E, Orozco L, Hughes JD, McElwee J, Hohman RJ, Frischmeyer-Guerrerio PA, Rothenberg ME, Freeman AF, Holland SM, Milner JD.

J Exp Med. 2017 Mar 6;214(3):669-680. doi: 10.1084/jem.20161435. Epub 2017 Jan 26. Erratum in: J Exp Med. 2017 Apr 3;214(4):1201.


Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis.

Rochman M, Travers J, Miracle CE, Bedard MC, Wen T, Azouz NP, Caldwell JM, Kc K, Sherrill JD, Davis BP, Rymer JK, Kaufman KM, Aronow BJ, Rothenberg ME.

J Allergy Clin Immunol. 2017 Sep;140(3):738-749.e3. doi: 10.1016/j.jaci.2016.11.042. Epub 2017 Jan 17.


SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

Hoffman AF, Simpson KJ, Horvath P, Lovitt C, Silver S, Easton E, LaBarbera DV, Mendez M, Rothenberg ME, Seldin J, Wardwell-Swanson J, Fennell M.

Assay Drug Dev Technol. 2017 Jan;15(1):1-7. doi: 10.1089/adt.2016.29054.afh. No abstract available.


Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.

Caldwell JM, Collins MH, Kemme KA, Sherrill JD, Wen T, Rochman M, Stucke EM, Amin L, Tai H, Putnam PE, Jiménez-Dalmaroni MJ, Wormald MR, Porollo A, Abonia JP, Rothenberg ME.

Mucosal Immunol. 2017 Sep;10(5):1190-1201. doi: 10.1038/mi.2016.120. Epub 2017 Jan 4.


Oral immunotherapy-induced gastrointestinal symptoms and peripheral blood eosinophil responses.

Goldberg MR, Elizur A, Nachshon L, Appel MY, Levy MB, Golobov K, Goldberg R, Stein M, Rothenberg ME, Katz Y.

J Allergy Clin Immunol. 2017 Apr;139(4):1388-1390.e4. doi: 10.1016/j.jaci.2016.09.053. Epub 2016 Nov 29. No abstract available.


Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

Lee JJ, Rothenberg ME, Seeley ES, Zimdahl B, Kawano S, Lu WJ, Shin K, Sakata-Kato T, Chen JK, Diehn M, Clarke MF, Beachy PA.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7545-E7553. Epub 2016 Nov 4.


Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.

Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD.

Nat Genet. 2016 Dec;48(12):1564-1569. doi: 10.1038/ng.3696. Epub 2016 Oct 17.


The Regulatory Function of Eosinophils.

Wen T, Rothenberg ME.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.MCHD-0020-2015. Review.


CRISPR/Cas9 in allergic and immunologic diseases.

Goodman MA, Moradi Manesh D, Malik P, Rothenberg ME.

Expert Rev Clin Immunol. 2017 Jan;13(1):5-9. Epub 2016 Oct 24. No abstract available.


Linking impaired skin barrier function to esophageal allergic inflammation via IL-33.

Travers J, Rochman M, Miracle CE, Cohen JP, Rothenberg ME.

J Allergy Clin Immunol. 2016 Nov;138(5):1381-1383. doi: 10.1016/j.jaci.2016.09.001. Epub 2016 Sep 21. No abstract available.


A hidden residential cell in the lung.

Rothenberg ME.

J Clin Invest. 2016 Sep 1;126(9):3185-7. doi: 10.1172/JCI89768. Epub 2016 Aug 22.


Paired Ig-like Receptor B Inhibits IL-13-Driven Eosinophil Accumulation and Activation in the Esophagus.

Ben Baruch-Morgenstern N, Mingler MK, Stucke E, Besse JA, Wen T, Reichman H, Munitz A, Rothenberg ME.

J Immunol. 2016 Aug 1;197(3):707-14. doi: 10.4049/jimmunol.1501873. Epub 2016 Jun 20.


Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry.

Gupta J, Johansson E, Bernstein JA, Chakraborty R, Khurana Hershey GK, Rothenberg ME, Mersha TB.

J Allergy Clin Immunol. 2016 Sep;138(3):676-699. doi: 10.1016/j.jaci.2016.02.045. Epub 2016 Jun 11. Review.


Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis.

Morris DW, Stucke EM, Martin LJ, Abonia JP, Mukkada VA, Putnam PE, Rothenberg ME, Fulkerson PC.

J Allergy Clin Immunol. 2016 Sep;138(3):915-918.e5. doi: 10.1016/j.jaci.2016.03.027. Epub 2016 May 16. No abstract available.

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