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Items: 1 to 50 of 369

1.

CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers.

Galperin M, Farenc C, Mukhopadhyay M, Jayasinghe D, Decroos A, Benati D, Tan LL, Ciacchi L, Reid HH, Rossjohn J, Chakrabarti LA, Gras S.

Sci Immunol. 2018 Jun 8;3(24). pii: eaat0687. doi: 10.1126/sciimmunol.aat0687.

PMID:
29884618
2.

Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes.

Rouxel O, DaSilva J, Beaudoin L, Nel I, Tard C, Cagninacci L, Kiaf B, Oshima M, Diedisheim M, Salou M, Corbett A, Rossjohn J, McCluskey J, Scharfmann R, Battaglia M, Polak M, Lantz O, Beltrand J, Lehuen A.

Nat Immunol. 2018 Jun 7. doi: 10.1038/s41590-017-0023-9. [Epub ahead of print]

PMID:
29880894
3.

Lipids hide or step aside for CD1-autoreactive T cell receptors.

Cotton RN, Shahine A, Rossjohn J, Moody DB.

Curr Opin Immunol. 2018 Jun;52:93-99. doi: 10.1016/j.coi.2018.04.013. Epub 2018 May 5. Review.

PMID:
29738961
4.

Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses.

Rowntree LC, Nguyen THO, Halim H, Purcell AW, Rossjohn J, Gras S, Kotsimbos TC, Mifsud NA.

J Immunol. 2018 Jun 15;200(12):3993-4003. doi: 10.4049/jimmunol.1800010. Epub 2018 May 7.

PMID:
29735483
5.

Reply to Roudier et al.: HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis.

Ting YT, Purcell AW, Reid HH, Rossjohn J.

J Biol Chem. 2018 May 4;293(18):7039. doi: 10.1074/jbc.RL118.003013. No abstract available.

PMID:
29728533
6.

Phospholipid signaling in innate immune cells.

O'Donnell VB, Rossjohn J, Wakelam MJ.

J Clin Invest. 2018 Apr 23. pii: 97944. doi: 10.1172/JCI97944. [Epub ahead of print]

7.

An overview on the identification of MAIT cell antigens.

Kjer-Nielsen L, Corbett AJ, Chen Z, Liu L, Mak JY, Godfrey DI, Rossjohn J, Fairlie DP, McCluskey J, Eckle SB.

Immunol Cell Biol. 2018 Apr 14. doi: 10.1111/imcb.12057. [Epub ahead of print] Review.

PMID:
29656544
8.

Understanding the drivers of MHC restriction of T cell receptors.

La Gruta NL, Gras S, Daley SR, Thomas PG, Rossjohn J.

Nat Rev Immunol. 2018 Apr 10. doi: 10.1038/s41577-018-0007-5. [Epub ahead of print] Review.

PMID:
29636542
9.

Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.

J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.

10.

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.

Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR.

Cell Chem Biol. 2018 May 17;25(5):571-584.e8. doi: 10.1016/j.chembiol.2018.02.009. Epub 2018 Mar 22.

PMID:
29576533
11.

Unconventional T Cell Targets for Cancer Immunotherapy.

Godfrey DI, Le Nours J, Andrews DM, Uldrich AP, Rossjohn J.

Immunity. 2018 Mar 20;48(3):453-473. doi: 10.1016/j.immuni.2018.03.009. Review.

PMID:
29562195
12.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J.

Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.

PMID:
29531339
13.

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.

Chan KF, Gully BS, Gras S, Beringer DX, Kjer-Nielsen L, Cebon J, McCluskey J, Chen W, Rossjohn J.

Nat Commun. 2018 Mar 12;9(1):1026. doi: 10.1038/s41467-018-03321-w.

14.

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

Miles JJ, Tan MP, Dolton G, Edwards ES, Galloway SA, Laugel B, Clement M, Makinde J, Ladell K, Matthews KK, Watkins TS, Tungatt K, Wong Y, Lee HS, Clark RJ, Pentier JM, Attaf M, Lissina A, Ager A, Gallimore A, Rizkallah PJ, Gras S, Rossjohn J, Burrows SR, Cole DK, Price DA, Sewell AK.

J Clin Invest. 2018 Apr 2;128(4):1569-1580. doi: 10.1172/JCI91512. Epub 2018 Mar 12.

15.

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.

Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, Gao X, Thomas R, Brumme ZL, Carlson JM, Wolinsky SM, Goedert JJ, Walker BD, Segal FP, Deeks SG, Haas DW, Migueles SA, Connors M, Michael N, Fellay J, Gostick E, Llewellyn-Lacey S, Price DA, Lafont BA, Pymm P, Saunders PM, Widjaja J, Wong SC, Vivian JP, Rossjohn J, Brooks AG, Carrington M.

J Clin Invest. 2018 May 1;128(5):1903-1912. doi: 10.1172/JCI98463. Epub 2018 Apr 3.

16.

Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics.

Ramarathinam SH, Gras S, Alcantara S, Yeung AWS, Mifsud NA, Sonza S, Illing PT, Glaros EN, Center RJ, Thomas SR, Kent SJ, Ternette N, Purcell DFJ, Rossjohn J, Purcell AW.

Proteomics. 2018 Feb 13:e1700253. doi: 10.1002/pmic.201700253. [Epub ahead of print]

PMID:
29437277
17.

Editorial.

Rossjohn J, Godfrey DI.

Semin Cell Dev Biol. 2018 Feb 28. pii: S1084-9521(18)30029-6. doi: 10.1016/j.semcdb.2018.02.008. [Epub ahead of print] No abstract available.

PMID:
29432950
18.

Flow Cytometric Clinical Immunomonitoring Using Peptide-MHC Class II Tetramers: Optimization of Methods and Protocol Development.

Jansen DTSL, Ramnoruth N, Loh KL, Rossjohn J, Reid HH, Nel HJ, Thomas R.

Front Immunol. 2018 Jan 22;9:8. doi: 10.3389/fimmu.2018.00008. eCollection 2018.

19.

Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1.

Awad W, Le Nours J, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Immunol Cell Biol. 2018 Feb 2. doi: 10.1111/imcb.12017. [Epub ahead of print] Review.

PMID:
29393543
20.

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection.

D'Souza C, Pediongco T, Wang H, Scheerlinck JY, Kostenko L, Esterbauer R, Stent AW, Eckle SBG, Meehan BS, Strugnell RA, Cao H, Liu L, Mak JYW, Lovrecz G, Lu L, Fairlie DP, Rossjohn J, McCluskey J, Every AL, Chen Z, Corbett AJ.

J Immunol. 2018 Mar 1;200(5):1901-1916. doi: 10.4049/jimmunol.1701512. Epub 2018 Jan 29.

PMID:
29378910
21.

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function.

Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. doi: 10.1073/pnas.1716669115. Epub 2018 Jan 19.

PMID:
29351991
22.

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.

Ting YT, Petersen J, Ramarathinam SH, Scally SW, Loh KL, Thomas R, Suri A, Baker DG, Purcell AW, Reid HH, Rossjohn J.

J Biol Chem. 2018 Mar 2;293(9):3236-3251. doi: 10.1074/jbc.RA117.001013. Epub 2018 Jan 9.

23.

HLA variation and disease.

Dendrou CA, Petersen J, Rossjohn J, Fugger L.

Nat Rev Immunol. 2018 May;18(5):325-339. doi: 10.1038/nri.2017.143. Epub 2018 Jan 2. Review.

PMID:
29292391
24.

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.

Van Braeckel-Budimir N, Gras S, Ladell K, Josephs TM, Pewe L, Urban SL, Miners KL, Farenc C, Price DA, Rossjohn J, Harty JT.

Immunity. 2017 Nov 21;47(5):835-847.e4. doi: 10.1016/j.immuni.2017.10.013. Epub 2017 Nov 14.

PMID:
29150238
25.

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.

Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaao1384. doi: 10.1126/sciimmunol.aao1384.

PMID:
29054999
26.

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes.

Rouxel O, Da Silva J, Beaudoin L, Nel I, Tard C, Cagninacci L, Kiaf B, Oshima M, Diedisheim M, Salou M, Corbett A, Rossjohn J, McCluskey J, Scharfmann R, Battaglia M, Polak M, Lantz O, Beltrand J, Lehuen A.

Nat Immunol. 2017 Dec;18(12):1321-1331. doi: 10.1038/ni.3854. Epub 2017 Oct 9. Erratum in: Nat Immunol. 2018 Jun 7;:.

PMID:
28991267
27.

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors.

Sullivan LC, Walpole NG, Farenc C, Pietra G, Sum MJW, Clements CS, Lee EJ, Beddoe T, Falco M, Mingari MC, Moretta L, Gras S, Rossjohn J, Brooks AG.

J Biol Chem. 2017 Dec 22;292(51):21149-21158. doi: 10.1074/jbc.M117.807719. Epub 2017 Sep 25.

PMID:
28972140
28.

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response.

Culshaw A, Ladell K, Gras S, McLaren JE, Miners KL, Farenc C, van den Heuvel H, Gostick E, Dejnirattisai W, Wangteeraprasert A, Duangchinda T, Chotiyarnwong P, Limpitikul W, Vasanawathana S, Malasit P, Dong T, Rossjohn J, Mongkolsapaya J, Price DA, Screaton GR.

Nat Immunol. 2017 Nov;18(11):1228-1237. doi: 10.1038/ni.3850. Epub 2017 Sep 25.

29.

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule.

Mobbs JI, Illing PT, Dudek NL, Brooks AG, Baker DG, Purcell AW, Rossjohn J, Vivian JP.

J Biol Chem. 2017 Oct 20;292(42):17203-17215. doi: 10.1074/jbc.M117.806976. Epub 2017 Aug 30.

PMID:
28855257
30.

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.

Scally SW, Law SC, Ting YT, Heemst JV, Sokolove J, Deutsch AJ, Bridie Clemens E, Moustakas AK, Papadopoulos GK, van der Woude D, Smolik I, Hitchon CA, Robinson DB, Ferucci ED, Bernstein CN, Meng X, Anaparti V, Huizinga T, Kedzierska K, Reid HH, Raychaudhuri S, Toes RE, Rossjohn J, El-Gabalawy H, Thomas R.

Ann Rheum Dis. 2017 Nov;76(11):1915-1923. doi: 10.1136/annrheumdis-2017-211300. Epub 2017 Aug 11.

PMID:
28801345
31.

Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians.

Clemens EB, Grant EJ, Wang Z, Gras S, Tipping P, Rossjohn J, Miller A, Tong SYC, Kedzierska K.

Immunol Cell Biol. 2017 Aug;95(7):648. doi: 10.1038/icb.2017.47.

32.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8348-8353. doi: 10.1073/pnas.1705882114. Epub 2017 Jul 17.

33.

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.

Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T.

J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29.

34.

Structural and regulatory diversity shape HLA-C protein expression levels.

Kaur G, Gras S, Mobbs JI, Vivian JP, Cortes A, Barber T, Kuttikkatte SB, Jensen LT, Attfield KE, Dendrou CA, Carrington M, McVean G, Purcell AW, Rossjohn J, Fugger L.

Nat Commun. 2017 Jun 26;8:15924. doi: 10.1038/ncomms15924.

35.

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.

Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SMM.

PLoS Biol. 2017 Jun 20;15(6):e2001930. doi: 10.1371/journal.pbio.2001930. eCollection 2017 Jun.

36.

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).

Deuss FA, Gully BS, Rossjohn J, Berry R.

J Biol Chem. 2017 Jul 7;292(27):11413-11422. doi: 10.1074/jbc.M117.786483. Epub 2017 May 17.

PMID:
28515320
37.

MAIT cells and MR1-antigen recognition.

Keller AN, Corbett AJ, Wubben JM, McCluskey J, Rossjohn J.

Curr Opin Immunol. 2017 Jun;46:66-74. doi: 10.1016/j.coi.2017.04.002. Epub 2017 May 8. Review.

PMID:
28494326
38.

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR.

Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3.

39.

A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popović B, Tanaka M, Fu Z, Balaji GR, Lau TNH, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpotić A, Allan DSJ, Makrigiannis AP, Jonjić S, Rossjohn J, Carlyle JR.

Cell. 2017 Mar 23;169(1):58-71.e14. doi: 10.1016/j.cell.2017.03.002.

40.

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling.

de Weerd NA, Matthews AY, Pattie PR, Bourke NM, Lim SS, Vivian JP, Rossjohn J, Hertzog PJ.

J Biol Chem. 2017 May 5;292(18):7554-7565. doi: 10.1074/jbc.M116.773788. Epub 2017 Mar 13.

41.

Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease.

Cook L, Munier CML, Seddiki N, van Bockel D, Ontiveros N, Hardy MY, Gillies JK, Levings MK, Reid HH, Petersen J, Rossjohn J, Anderson RP, Zaunders JJ, Tye-Din JA, Kelleher AD.

J Allergy Clin Immunol. 2017 Dec;140(6):1592-1603.e8. doi: 10.1016/j.jaci.2017.02.015. Epub 2017 Mar 8.

42.

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

Mak JY, Xu W, Reid RC, Corbett AJ, Meehan BS, Wang H, Chen Z, Rossjohn J, McCluskey J, Liu L, Fairlie DP.

Nat Commun. 2017 Mar 8;8:14599. doi: 10.1038/ncomms14599.

43.

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.

Pymm P, Illing PT, Ramarathinam SH, O'Connor GM, Hughes VA, Hitchen C, Price DA, Ho BK, McVicar DW, Brooks AG, Purcell AW, Rossjohn J, Vivian JP.

Nat Struct Mol Biol. 2017 Apr;24(4):387-394. doi: 10.1038/nsmb.3381. Epub 2017 Feb 20.

PMID:
28218747
44.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP, McCluskey J, Rossjohn J.

Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.

PMID:
28166217
45.

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ.

Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18.

PMID:
27925318
46.

Crystal structure of fuculose aldolase from the Antarctic psychrophilic yeast Glaciozyma antarctica PI12.

Jaafar NR, Littler D, Beddoe T, Rossjohn J, Illias RM, Mahadi NM, Mackeen MM, Murad AM, Abu Bakar FD.

Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):831-839. Epub 2016 Oct 27.

PMID:
27827354
47.

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.

48.

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Gras S, Chadderton J, Del Campo CM, Farenc C, Wiede F, Josephs TM, Sng XYX, Mirams M, Watson KA, Tiganis T, Quinn KM, Rossjohn J, La Gruta NL.

Immunity. 2016 Oct 18;45(4):749-760. doi: 10.1016/j.immuni.2016.09.007. Epub 2016 Oct 4.

49.

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

Koay HF, Gherardin NA, Enders A, Loh L, Mackay LK, Almeida CF, Russ BE, Nold-Petry CA, Nold MF, Bedoui S, Chen Z, Corbett AJ, Eckle SB, Meehan B, d'Udekem Y, Konstantinov IE, Lappas M, Liu L, Goodnow CC, Fairlie DP, Rossjohn J, Chong MM, Kedzierska K, Berzins SP, Belz GT, McCluskey J, Uldrich AP, Godfrey DI, Pellicci DG.

Nat Immunol. 2016 Nov;17(11):1300-1311. doi: 10.1038/ni.3565. Epub 2016 Sep 26.

PMID:
27668799
50.

Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.

Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L.

Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332.

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