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Items: 1 to 50 of 212

1.

Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.

Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Yang K, Guberski DL, Mordes JP, Greiner DL, Rossini AA, Bortell R.

Exp Biol Med (Maywood). 2010 Nov;235(11):1328-37. doi: 10.1258/ebm.2010.010150.

2.

Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.

Jurczyk A, Roy N, Bajwa R, Gut P, Lipson K, Yang C, Covassin L, Racki WJ, Rossini AA, Phillips N, Stainier DY, Greiner DL, Brehm MA, Bortell R, diIorio P.

Gen Comp Endocrinol. 2011 Jan 15;170(2):334-45. doi: 10.1016/j.ygcen.2010.10.010. Epub 2010 Oct 20.

3.

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats.

Kruger AJ, Yang C, Lipson KL, Pino SC, Leif JH, Hogan CM, Whalen BJ, Guberski DL, Lee Y, Unger RH, Greiner DL, Rossini AA, Bortell R.

Autoimmunity. 2011 Mar;44(2):137-48. doi: 10.3109/08916934.2010.482116. Epub 2010 Aug 9.

4.

A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.

Jurczyk A, Pino SC, O'Sullivan-Murphy B, Addorio M, Lidstone EA, Diiorio P, Lipson KL, Standley C, Fogarty K, Lifshitz L, Urano F, Mordes JP, Greiner DL, Rossini AA, Bortell R.

PLoS One. 2010 Jul 27;5(7):e11812. doi: 10.1371/journal.pone.0011812.

5.

Allografts stimulate cross-reactive virus-specific memory CD8 T cells with private specificity.

Brehm MA, Daniels KA, Priyadharshini B, Thornley TB, Greiner DL, Rossini AA, Welsh RM.

Am J Transplant. 2010 Aug;10(8):1738-48. doi: 10.1111/j.1600-6143.2010.03161.x.

6.

NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.

Racki WJ, Covassin L, Brehm M, Pino S, Ignotz R, Dunn R, Laning J, Graves SK, Rossini AA, Shultz LD, Greiner DL.

Transplantation. 2010 Mar 15;89(5):527-36. doi: 10.1097/TP.0b013e3181c90242.

7.

Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.

Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL.

Clin Immunol. 2010 Apr;135(1):84-98. doi: 10.1016/j.clim.2009.12.008. Epub 2010 Jan 21.

8.

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

King MA, Covassin L, Brehm MA, Racki W, Pearson T, Leif J, Laning J, Fodor W, Foreman O, Burzenski L, Chase TH, Gott B, Rossini AA, Bortell R, Shultz LD, Greiner DL.

Clin Exp Immunol. 2009 Jul;157(1):104-18. doi: 10.1111/j.1365-2249.2009.03933.x.

9.

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Yang C, Lipson KL, Jurczyk A, diIorio P, Brehm MA, Mordes JP, Greiner DL, Rossini AA, Bortell R.

PLoS One. 2009;4(5):e5468. doi: 10.1371/journal.pone.0005468. Epub 2009 May 8.

10.

Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.

Chopra P, Diiorio P, Pino SC, Wilson SB, Phillips NE, Mordes JP, Rossini AA, Greiner DL, Shultz LD, Bortell R.

In Vivo. 2009 Mar-Apr;23(2):195-201.

11.

TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.

Miller DM, Thornley TB, Pearson T, Kruger AJ, Yamazaki M, Shultz LD, Welsh RM, Brehm MA, Rossini AA, Greiner DL.

J Immunol. 2009 May 1;182(9):5547-59. doi: 10.4049/jimmunol.0802077.

12.

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.

Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE.

Cell Immunol. 2009;256(1-2):86-91. doi: 10.1016/j.cellimm.2009.01.008. Epub 2009 Feb 23.

13.

Role of innate immunity in transplantation tolerance.

Miller DM, Rossini AA, Greiner DL.

Crit Rev Immunol. 2008;28(5):403-39. Review.

PMID:
19166387
14.

TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.

Miller DM, Thornley T, Pearson T, Yamazaki M, Brehm MA, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2008 Dec;1150:149-51. doi: 10.1196/annals.1447.034.

15.

Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes.

Bortell R, Pino SC, Greiner DL, Zipris D, Rossini AA.

Ann N Y Acad Sci. 2008 Dec;1150:112-22. doi: 10.1196/annals.1447.025. Review.

16.

Humanized mice for the study of type 1 diabetes and beta cell function.

King M, Pearson T, Rossini AA, Shultz LD, Greiner DL.

Ann N Y Acad Sci. 2008 Dec;1150:46-53. doi: 10.1196/annals.1447.009. Review.

17.

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Mangada J, Pearson T, Brehm MA, Wicker LS, Peterson LB, Shultz LD, Serreze DV, Rossini AA, Greiner DL.

Diabetes. 2009 Jan;58(1):165-73. doi: 10.2337/db08-0275. Epub 2008 Nov 4.

18.

Viral infection: a potent barrier to transplantation tolerance.

Miller DM, Thornley TB, Greiner DL, Rossini AA.

Clin Dev Immunol. 2008;2008:742810. doi: 10.1155/2008/742810. Review.

19.

Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.

Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL.

Clin Exp Immunol. 2008 Nov;154(2):270-84. doi: 10.1111/j.1365-2249.2008.03753.x. Epub 2008 Sep 8.

20.

Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.

Giassi LJ, Pearson T, Shultz LD, Laning J, Biber K, Kraus M, Woda BA, Schmidt MR, Woodland RT, Rossini AA, Greiner DL.

Exp Biol Med (Maywood). 2008 Aug;233(8):997-1012. doi: 10.3181/0802-RM-70.

21.

A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.

Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL.

Diabetologia. 2008 Aug;51(8):1449-56. doi: 10.1007/s00125-008-1057-1. Epub 2008 Jun 19.

22.

The BB rat as a model of human insulin-dependent diabetes mellitus.

Whalen BJ, Mordes JP, Rossini AA.

Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.3. doi: 10.1002/0471142735.im1503s19.

PMID:
18432735
23.

Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.

Pino SC, O'Sullivan-Murphy B, Lidstone EA, Thornley TB, Jurczyk A, Urano F, Greiner DL, Mordes JP, Rossini AA, Bortell R.

Cell Stress Chaperones. 2008 Dec;13(4):421-34. doi: 10.1007/s12192-008-0038-0. Epub 2008 Apr 17.

24.

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.

PMID:
18096436
25.

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.

Thornley TB, Phillips NE, Beaudette-Zlatanova BC, Markees TG, Bahl K, Brehm MA, Shultz LD, Kurt-Jones EA, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2007 Nov 15;179(10):6620-9.

26.

Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.

Yamazaki M, Pearson T, Brehm MA, Miller DM, Mangada JA, Markees TG, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Am J Transplant. 2007 Jul;7(7):1710-21.

27.

Diabetes research in jeopardy: the extinction of clinical diabetes researchers.

Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:33-44. Epub 2007 Mar 21.

PMID:
17376823
28.

Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson M, Wasserfall C, Herold K, Mordes JP, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:90-3. Epub 2007 Mar 21.

PMID:
17376822
29.

Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.

Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL.

Ann N Y Acad Sci. 2007 Apr;1103:77-89. Epub 2007 Mar 1.

PMID:
17332083
30.

Passing the baton--to whom?

Rossini AA.

J Clin Invest. 2007 Feb;117(2):285-8.

31.

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.

Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2007 Jan 15;178(2):693-701.

32.

A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.

Hillebrands JL, Whalen B, Visser JT, Koning J, Bishop KD, Leif J, Rozing J, Mordes JP, Greiner DL, Rossini AA.

J Immunol. 2006 Dec 1;177(11):7820-32.

33.

Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation.

Phillips NE, Greiner DL, Mordes JP, Rossini AA.

Transplantation. 2006 Oct 27;82(8):1085-92.

PMID:
17060858
34.

Autoimmunity after islet-cell allotransplantation.

Worcester Human Islet Transplantation Group, Sharma V, Andersen D, Thompson M, Woda BA, Stoff JS, Hartigan C, Rastellini C, Phillips D, Mordes JP, Rossini AA.

N Engl J Med. 2006 Sep 28;355(13):1397-9. No abstract available.

35.

Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.

Brehm MA, Mangada J, Markees TG, Pearson T, Daniels KA, Thornley TB, Welsh RM, Rossini AA, Greiner DL.

Blood. 2007 Jan 15;109(2):819-26. Epub 2006 Sep 14.

36.

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA, Urano F.

Cell Metab. 2006 Sep;4(3):245-54.

37.

ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).

Morrison AR, Moss J, Stevens LA, Evans JE, Farrell C, Merithew E, Lambright DG, Greiner DL, Mordes JP, Rossini AA, Bortell R.

J Biol Chem. 2006 Nov 3;281(44):33363-72. Epub 2006 Aug 24.

38.

Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.

Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA.

Xenotransplantation. 2006 May;13(3):224-32.

PMID:
16756565
39.

Costimulation and autoimmune diabetes in BB rats.

Beaudette-Zlatanova BC, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, Benjamin CD, Hunig T, Drexhage HA, Ansari MJ, Leif J, Mordes JP, Greiner DL, Sayegh MH, Rossini AA.

Am J Transplant. 2006 May;6(5 Pt 1):894-902.

40.

TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.

Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL.

J Immunol. 2006 Feb 1;176(3):1561-70.

41.

A comprehensive review of interventions in the NOD mouse and implications for translation.

Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, Bluestone JA, Eisenbarth GS, Mathis D, Rossini AA, Campbell SE, Kahn R, Kreuwel HT.

Immunity. 2005 Aug;23(2):115-26. Review.

42.

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.

Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6931-5. Epub 2005 May 2.

43.

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.

Gordon EJ, Wicker LS, Peterson LB, Serreze DV, Markees TG, Shultz LD, Rossini AA, Greiner DL, Mordes JP.

Diabetes. 2005 Jan;54(1):107-15.

44.

TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats.

Zipris D, Lien E, Xie JX, Greiner DL, Mordes JP, Rossini AA.

J Immunol. 2005 Jan 1;174(1):131-42.

45.

Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.

Markees TG, Pearson T, Cuthbert A, Pearson AL, Shultz LD, Leif J, Phillips NE, Mordes JP, Greiner DL, Rossini AA.

Transplantation. 2004 Dec 15;78(11):1601-8.

PMID:
15591948
46.

Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.

Harris JE, Bishop KD, Phillips NE, Mordes JP, Greiner DL, Rossini AA, Czech MP.

J Immunol. 2004 Dec 15;173(12):7331-8.

47.

From beast to bedside: a commentary.

Rossini AA.

Diabetologia. 2004 Oct;47(10):1647-9. Epub 2004 Oct 22. Review. No abstract available.

PMID:
15502928
48.

Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.

Banuelos SJ, Markees TG, Phillips NE, Appel MC, Cuthbert A, Leif J, Mordes JP, Shultz LD, Rossini AA, Greiner DL.

Transplantation. 2004 Sep 15;78(5):660-7.

PMID:
15371665
49.

Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.

Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC.

Clin Immunol. 2004 Sep;112(3):273-83.

PMID:
15308121
50.

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

Pearson T, Weiser P, Markees TG, Serreze DV, Wicker LS, Peterson LB, Cumisky AM, Shultz LD, Mordes JP, Rossini AA, Greiner DL.

Diabetes. 2004 Aug;53(8):1972-8.

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