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Items: 1 to 50 of 472

1.

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells.

Kim HS, Tan Y, Ma W, Merkurjev D, Destici E, Ma Q, Suter T, Ohgi K, Friedman M, Skowronska-Krawczyk D, Rosenfeld MG.

Nature. 2018 Apr 18. doi: 10.1038/s41586-018-0048-8. [Epub ahead of print]

PMID:
29670286
2.

JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.

Gao WW, Xiao RQ, Zhang WJ, Hu YR, Peng BL, Li WJ, He YH, Shen HF, Ding JC, Huang QX, Ye TY, Li Y, Liu ZY, Ding R, Rosenfeld MG, Liu W.

Mol Cell. 2018 Apr 19;70(2):340-357.e8. doi: 10.1016/j.molcel.2018.03.006. Epub 2018 Apr 5.

PMID:
29628309
3.

Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.

Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V.

Mol Cell. 2018 Mar 1;69(5):757-772.e7. doi: 10.1016/j.molcel.2018.01.037.

PMID:
29499132
4.

Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock.

Wang J, Saijo K, Skola D, Jin C, Ma Q, Merkurjev D, Glass CK, Rosenfeld MG.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E244-E252. doi: 10.1073/pnas.1718759114. Epub 2017 Dec 20.

PMID:
29263096
5.

Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis.

Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen B.

Nat Neurosci. 2017 Nov;20(11):1520-1528. doi: 10.1038/nn.4638. Epub 2017 Sep 11.

PMID:
28892058
6.

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.

Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10107-10112. doi: 10.1073/pnas.1711058114. Epub 2017 Sep 1.

7.

Physiological functions of programmed DNA breaks in signal-induced transcription.

Puc J, Aggarwal AK, Rosenfeld MG.

Nat Rev Mol Cell Biol. 2017 Aug;18(8):471-476. doi: 10.1038/nrm.2017.43. Epub 2017 May 24. Review.

8.

Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.

Yang F, Ma Q, Liu Z, Li W, Tan Y, Jin C, Ma W, Hu Y, Shen J, Ohgi KA, Telese F, Liu W, Rosenfeld MG.

Mol Cell. 2017 May 4;66(3):321-331.e6. doi: 10.1016/j.molcel.2017.03.019.

PMID:
28475868
9.

Corrigendum: The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

Füllgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, Hermanson O, Rosenfeld MG, Klionsky DJ, Joseph B.

Nature. 2017 Mar 30;543(7647):742. doi: 10.1038/nature22027. Epub 2017 Mar 15. No abstract available.

PMID:
28297710
10.

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy.

Cucchiara V, Yang JC, Mirone V, Gao AC, Rosenfeld MG, Evans CP.

Cancers (Basel). 2017 Jan 16;9(1). pii: E9. doi: 10.3390/cancers9010009. Review.

11.

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.

Monaghan CE, Nechiporuk T, Jeng S, McWeeney SK, Wang J, Rosenfeld MG, Mandel G.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E406-E415. doi: 10.1073/pnas.1620230114. Epub 2017 Jan 3.

12.

Epithelial cell integrin β1 is required for developmental angiogenesis in the pituitary gland.

Scully KM, Skowronska-Krawczyk D, Krawczyk M, Merkurjev D, Taylor H, Livolsi A, Tollkuhn J, Stan RV, Rosenfeld MG.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13408-13413. Epub 2016 Nov 3.

13.

CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins.

Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld MG, Fu XD, Chisholm AD, Jin Y.

Elife. 2016 Jun 2;5. pii: e16072. doi: 10.7554/eLife.16072.

14.

Enhancers as non-coding RNA transcription units: recent insights and future perspectives.

Li W, Notani D, Rosenfeld MG.

Nat Rev Genet. 2016 Apr;17(4):207-23. doi: 10.1038/nrg.2016.4. Epub 2016 Mar 7. Review.

PMID:
26948815
15.

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.

Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A.

Mol Psychiatry. 2016 Oct;21(10):1417-33. doi: 10.1038/mp.2015.207. Epub 2016 Feb 2.

16.

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.

Han Y, Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Schumacher FR, Berndt SI, Wang Z, Xu J, Rohland N, Reich D, Tandon A, Pasaniuc B, Allen A, Quinque D, Mallick S, Notani D, Rosenfeld MG, Jayani RS, Kolb S, Gapstur SM, Stevens VL, Pettaway CA, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, John EM, Murphy AB, Signorello LB, Carpten J, Leske MC, Wu SY, Hennis AJM, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Zheng SL, Witte JS, Casey G, Lubwama A, Pooler LC, Sheng X, Coetzee GA, Cook MB, Chanock SJ, Stram DO, Watya S, Blot WJ, Conti DV, Henderson BE, Haiman CA.

J Natl Cancer Inst. 2016 Jan 27;108(7). doi: 10.1093/jnci/djv431. Print 2016 Jul.

17.

Notch-Dependent Pituitary SOX2(+) Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland.

Zhu X, Tollkuhn J, Taylor H, Rosenfeld MG.

Stem Cell Reports. 2015 Dec 8;5(6):1196-1209. doi: 10.1016/j.stemcr.2015.11.001.

18.

P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma.

Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K.

Mol Cell. 2015 Sep 17;59(6):931-40. doi: 10.1016/j.molcel.2015.07.027. Epub 2015 Sep 10.

19.

An epigenomic role of Fe65 in the cellular response to DNA damage.

Ryu S, Teles F, Minopoli G, Russo T, Rosenfeld MG, Suh Y.

Mutat Res. 2015 Jun;776:40-7. doi: 10.1016/j.mrfmmm.2015.01.006. Epub 2015 Jan 28.

20.

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control.

Wang J, Telese F, Tan Y, Li W, Jin C, He X, Basnet H, Ma Q, Merkurjev D, Zhu X, Liu Z, Zhang J, Ohgi K, Taylor H, White RR, Tazearslan C, Suh Y, Macfarlan TS, Pfaff SL, Rosenfeld MG.

Nat Neurosci. 2015 Sep;18(9):1256-64. doi: 10.1038/nn.4069. Epub 2015 Jul 27.

21.

Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation.

Li W, Hu Y, Oh S, Ma Q, Merkurjev D, Song X, Zhou X, Liu Z, Tanasa B, He X, Chen AY, Ohgi K, Zhang J, Liu W, Rosenfeld MG.

Mol Cell. 2015 Jul 16;59(2):188-202. doi: 10.1016/j.molcel.2015.06.002. Epub 2015 Jul 9.

22.

Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation.

Gao WW, Xiao RQ, Peng BL, Xu HT, Shen HF, Huang MF, Shi TT, Yi J, Zhang WJ, Wu XN, Gao X, Lin XZ, Dorrestein PC, Rosenfeld MG, Liu W.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3327-36. doi: 10.1073/pnas.1509658112. Epub 2015 Jun 16.

23.

Nuclear matrix revisited?

Skowronska-Krawczyk D, Rosenfeld MG.

Cell Cycle. 2015;14(10):1487-8. doi: 10.1080/15384101.2015.1032643. No abstract available.

24.

LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.

Telese F, Ma Q, Perez PM, Notani D, Oh S, Li W, Comoletti D, Ohgi KA, Taylor H, Rosenfeld MG.

Neuron. 2015 May 6;86(3):696-710. doi: 10.1016/j.neuron.2015.03.033. Epub 2015 Apr 16.

25.

The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.

Lee JY, Skon CN, Lee YJ, Oh S, Taylor JJ, Malhotra D, Jenkins MK, Rosenfeld MG, Hogquist KA, Jameson SC.

Immunity. 2015 Feb 17;42(2):252-264. doi: 10.1016/j.immuni.2015.01.013.

26.

Ligand-dependent enhancer activation regulated by topoisomerase-I activity.

Puc J, Kozbial P, Li W, Tan Y, Liu Z, Suter T, Ohgi KA, Zhang J, Aggarwal AK, Rosenfeld MG.

Cell. 2015 Jan 29;160(3):367-80. doi: 10.1016/j.cell.2014.12.023. Epub 2015 Jan 22. Erratum in: Cell. 2015 Oct 8;163(2):520-2.

27.

Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.

Zhang F, Tanasa B, Merkurjev D, Lin C, Song X, Li W, Tan Y, Liu Z, Zhang J, Ohgi KA, Krones A, Skowronska-Krawczyk D, Rosenfeld MG.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1380-5. doi: 10.1073/pnas.1424228112. Epub 2015 Jan 20.

28.

Enhancer activation requires trans-recruitment of a mega transcription factor complex.

Liu Z, Merkurjev D, Yang F, Li W, Oh S, Friedman MJ, Song X, Zhang F, Ma Q, Ohgi KA, Krones A, Rosenfeld MG.

Cell. 2014 Oct 9;159(2):358-73. doi: 10.1016/j.cell.2014.08.027.

29.

Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation.

Basnet H, Su XB, Tan Y, Meisenhelder J, Merkurjev D, Ohgi KA, Hunter T, Pillus L, Rosenfeld MG.

Nature. 2014 Dec 11;516(7530):267-71. doi: 10.1038/nature13736. Epub 2014 Sep 24.

30.

Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases.

Castelo-Branco G, Lilja T, Wallenborg K, Falcão AM, Marques SC, Gracias A, Solum D, Paap R, Walfridsson J, Teixeira AI, Rosenfeld MG, Jepsen K, Hermanson O.

Stem Cell Reports. 2014 Sep 9;3(3):502-15. doi: 10.1016/j.stemcr.2014.07.008. Epub 2014 Aug 28.

31.

Required enhancer-matrin-3 network interactions for a homeodomain transcription program.

Skowronska-Krawczyk D, Ma Q, Schwartz M, Scully K, Li W, Liu Z, Taylor H, Tollkuhn J, Ohgi KA, Notani D, Kohwi Y, Kohwi-Shigematsu T, Rosenfeld MG.

Nature. 2014 Oct 9;514(7521):257-61. doi: 10.1038/nature13573. Epub 2014 Aug 3.

32.

CtBPs sense microenvironmental oxygen levels to regulate neural stem cell state.

Dias JM, Ilkhanizadeh S, Karaca E, Duckworth JK, Lundin V, Rosenfeld MG, Ericson J, Hermanson O, Teixeira AI.

Cell Rep. 2014 Aug 7;8(3):665-70. doi: 10.1016/j.celrep.2014.06.057. Epub 2014 Jul 31.

33.

Complexity of the RAR-mediated transcriptional regulatory programs.

Liu Z, Hu Q, Rosenfeld MG.

Subcell Biochem. 2014;70:203-25. doi: 10.1007/978-94-017-9050-5_10. Review.

PMID:
24962887
34.

GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ.

Cardamone MD, Tanasa B, Chan M, Cederquist CT, Andricovich J, Rosenfeld MG, Perissi V.

Cell Rep. 2014 Jul 10;8(1):163-76. doi: 10.1016/j.celrep.2014.05.041. Epub 2014 Jun 19.

35.

Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.

Jin C, Yang L, Xie M, Lin C, Merkurjev D, Yang JC, Tanasa B, Oh S, Zhang J, Ohgi KA, Zhou H, Li W, Evans CP, Ding S, Rosenfeld MG.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9235-40. doi: 10.1073/pnas.1404303111. Epub 2014 Jun 13.

36.

Enhancer RNAs and regulated transcriptional programs.

Lam MT, Li W, Rosenfeld MG, Glass CK.

Trends Biochem Sci. 2014 Apr;39(4):170-82. doi: 10.1016/j.tibs.2014.02.007. Epub 2014 Mar 24. Review.

37.

Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release.

Liu W, Ma Q, Wong K, Li W, Ohgi K, Zhang J, Aggarwal A, Rosenfeld MG.

Cell. 2013 Dec 19;155(7):1581-1595. doi: 10.1016/j.cell.2013.10.056.

38.

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.

Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, Merkurjev D, Ohgi KA, Meng D, Zhang J, Evans CP, Rosenfeld MG.

Nature. 2013 Aug 29;500(7464):598-602. doi: 10.1038/nature12451. Epub 2013 Aug 14.

39.

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

Füllgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, Hermanson O, Rosenfeld MG, Klionsky DJ, Joseph B.

Nature. 2013 Aug 22;500(7463):468-71. doi: 10.1038/nature12313. Epub 2013 Jul 17. Erratum in: Nature. 2017 Mar 30;543(7647):742.

40.

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.

Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK.

Nature. 2013 Jun 27;498(7455):511-5. doi: 10.1038/nature12209. Epub 2013 Jun 2.

41.

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation.

Li W, Notani D, Ma Q, Tanasa B, Nunez E, Chen AY, Merkurjev D, Zhang J, Ohgi K, Song X, Oh S, Kim HS, Glass CK, Rosenfeld MG.

Nature. 2013 Jun 27;498(7455):516-20. doi: 10.1038/nature12210. Epub 2013 Jun 2.

42.

The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.

Scafoglio C, Smolka M, Zhou H, Perissi V, Rosenfeld MG.

PLoS One. 2013 May 17;8(5):e59986. doi: 10.1371/journal.pone.0059986. Print 2013.

43.

"Seq-ing" insights into the epigenetics of neuronal gene regulation.

Telese F, Gamliel A, Skowronska-Krawczyk D, Garcia-Bassets I, Rosenfeld MG.

Neuron. 2013 Feb 20;77(4):606-23. doi: 10.1016/j.neuron.2013.01.034. Review.

44.

TCF7L2 variation and proliferative diabetic retinopathy.

Luo J, Zhao L, Chen AY, Zhang X, Zhu J, Zhao J, Ouyang H, Luo H, Song Y, Lee J, Patel SH, Shaw PX, Sadda S, Zhuo Y, Rosenfeld MG, Zhang K.

Diabetes. 2013 Jul;62(7):2613-7. doi: 10.2337/db12-1093. Epub 2013 Feb 22.

45.

Epigenetic regulation of human embryonic stem cells.

Hu Q, Rosenfeld MG.

Front Genet. 2012 Nov 5;3:238. doi: 10.3389/fgene.2012.00238. eCollection 2012.

46.

DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation.

Hu Q, Tanasa B, Trabucchi M, Li W, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG.

Nat Struct Mol Biol. 2012 Nov;19(11):1168-75. doi: 10.1038/nsmb.2400. Epub 2012 Oct 14.

47.

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

Stender JD, Pascual G, Liu W, Kaikkonen MU, Do K, Spann NJ, Boutros M, Perrimon N, Rosenfeld MG, Glass CK.

Mol Cell. 2012 Oct 12;48(1):28-38. doi: 10.1016/j.molcel.2012.07.020. Epub 2012 Aug 23.

48.

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.

Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381-6. doi: 10.1073/pnas.1212366109. Epub 2012 Aug 20.

49.

Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.

Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M.

PLoS Genet. 2012;8(7):e1002823. doi: 10.1371/journal.pgen.1002823. Epub 2012 Jul 26. Erratum in: PLoS Genet. 2012 Sep;8(9). doi:10.1371/annotation/c93e4b67-d237-48fb-aec7-0db398407bb4.

50.

The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.

Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, Li H, Hu Q, Ghosh G, Adams JA, Rosenfeld MG, Fu XD.

Mol Cell. 2012 Aug 10;47(3):422-33. doi: 10.1016/j.molcel.2012.05.014. Epub 2012 Jun 21.

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