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Improved Murine-MHC-Deficient HLA-Transgenic NOD-Mouse Models for Type 1 Diabetes Therapy Development.

Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, DiLorenzo TP, Serreze DV.

Diabetes. 2018 Feb 22. pii: db171467. doi: 10.2337/db17-1467. [Epub ahead of print]


A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT.

Nat Commun. 2018 Feb 12;9(1):621. doi: 10.1038/s41467-018-03061-x.


Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.

Marnik EA, Wang X, Sproule TJ, Park G, Christianson GJ, Lane-Reticker SK, Jain S, Duffy T, Wang H, Carter GW, Morse HC 3rd, Roopenian DC.

Cell Rep. 2017 Oct 3;21(1):208-221. doi: 10.1016/j.celrep.2017.09.036.


Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.

Denzin LK, Khan AA, Virdis F, Wilks J, Kane M, Beilinson HA, Dikiy S, Case LK, Roopenian D, Witkowski M, Chervonsky AV, Golovkina TV.

Immunity. 2017 Aug 15;47(2):310-322.e7. doi: 10.1016/j.immuni.2017.07.013.


Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22.


Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ.

Herbert Pratt C, Potter CS, Kuiper RV, Karst SY, Dadras SS, Roopenian DC, Sundberg JP.

Exp Mol Pathol. 2017 Feb;102(1):128-132. doi: 10.1016/j.yexmp.2016.12.009. Epub 2016 Dec 28.


Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.

Roopenian DC, Christianson GJ, Proetzel G, Sproule TJ.

Methods Mol Biol. 2016;1438:103-14. doi: 10.1007/978-1-4939-3661-8_6.


Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice.

Jain S, Park G, Sproule TJ, Christianson GJ, Leeth CM, Wang H, Roopenian DC, Morse HC 3rd.

PLoS One. 2016 Apr 6;11(4):e0153059. doi: 10.1371/journal.pone.0153059. eCollection 2016.


IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma.

Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, Roopenian DC, Morse HC 3rd.

Am J Pathol. 2015 Nov;185(11):3102-14. doi: 10.1016/j.ajpath.2015.07.021. Epub 2015 Sep 9.


Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help.

Kim J, Ryu SJ, Oh K, Ju JM, Jeon JY, Nam G, Lee DS, Kim HR, Kim JY, Chang J, Sproule T, Choi K, Roopenian D, Choi EY.

Nat Commun. 2015 Aug 14;6:7994. doi: 10.1038/ncomms8994.


Minor genomic differences between related B6 and B10 mice affect severity of schistosome infection by governing the mode of dendritic cell activation.

Smith PM, Sproule TJ, Philip VM, Roopenian DC, Stadecker MJ.

Eur J Immunol. 2015 Aug;45(8):2312-23. doi: 10.1002/eji.201545547. Epub 2015 Jun 9.


Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs.

Roopenian DC, Low BE, Christianson GJ, Proetzel G, Sproule TJ, Wiles MV.

MAbs. 2015;7(2):344-51. doi: 10.1080/19420862.2015.1008345.


Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies.

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT.

J Biol Chem. 2014 Jun 13;289(24):17228-39. doi: 10.1074/jbc.M113.522565. Epub 2014 Apr 24.


Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice.

Sproule TJ, Bubier JA, Grandi FC, Sun VZ, Philip VM, McPhee CG, Adkins EB, Sundberg JP, Roopenian DC.

PLoS Genet. 2014 Feb 13;10(2):e1004068. doi: 10.1371/journal.pgen.1004068. eCollection 2014 Feb.


Expression of neonatal Fc receptor in the eye.

Powner MB, McKenzie JA, Christianson GJ, Roopenian DC, Fruttiger M.

Invest Ophthalmol Vis Sci. 2014 Mar 19;55(3):1607-15. doi: 10.1167/iovs.13-12574.


A methods paper that led to much more.

Roopenian D.

J Immunol. 2014 Jan 1;192(1):3-4. doi: 10.4049/jimmunol.1303010. No abstract available.


Genetically engineered humanized mouse models for preclinical antibody studies.

Proetzel G, Wiles MV, Roopenian DC.

BioDrugs. 2014 Apr;28(2):171-80. doi: 10.1007/s40259-013-0071-0. Review.


IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice.

McPhee CG, Bubier JA, Sproule TJ, Park G, Steinbuck MP, Schott WH, Christianson GJ, Morse HC 3rd, Roopenian DC.

J Immunol. 2013 Nov 1;191(9):4581-8. doi: 10.4049/jimmunol.1300439. Epub 2013 Sep 27.


Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies.

Proetzel G, Roopenian DC.

Methods. 2014 Jan 1;65(1):148-53. doi: 10.1016/j.ymeth.2013.07.005. Epub 2013 Jul 16.


The Cinderella effect: searching for the best fit between mouse models and human diseases.

Sundberg JP, Roopenian DC, Liu ET, Schofield PN.

J Invest Dermatol. 2013 Nov;133(11):2509-2513. doi: 10.1038/jid.2013.238. Epub 2013 Jun 27.


IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R.

Martin CE, van Leeuwen EM, Im SJ, Roopenian DC, Sung YC, Surh CD.

Blood. 2013 May 30;121(22):4484-92. doi: 10.1182/blood-2012-08-449215. Epub 2013 Apr 22.


The immunologic functions of the neonatal Fc receptor for IgG.

Rath T, Kuo TT, Baker K, Qiao SW, Kobayashi K, Yoshida M, Roopenian D, Fiebiger E, Lencer WI, Blumberg RS.

J Clin Immunol. 2013 Jan;33 Suppl 1:S9-17. doi: 10.1007/s10875-012-9768-y. Epub 2012 Sep 5. Review.


Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life.

Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I.

J Biol Chem. 2012 Jun 29;287(27):22927-37. doi: 10.1074/jbc.M112.355131. Epub 2012 May 8.


A direct method to determine the strength of the dermal-epidermal junction in a mouse model for epidermolysis bullosa.

Sproule TJ, Roopenian DC, Sundberg JP.

Exp Dermatol. 2012 Jun;21(6):453-5. doi: 10.1111/j.1600-0625.2012.01482.x. Epub 2012 Apr 16.


Monoclonal antibodies directed against human FcRn and their applications.

Christianson GJ, Sun VZ, Akilesh S, Pesavento E, Proetzel G, Roopenian DC.

MAbs. 2012 Mar-Apr;4(2):208-16. doi: 10.4161/mabs.4.2.19397. Epub 2012 Mar 1.


A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment.

Ryu SJ, Jeon JY, Chang J, Sproule TJ, Roopenian DC, Choi EY.

Mol Cells. 2012 Apr;33(4):393-9. doi: 10.1007/s10059-012-0008-3. Epub 2012 Mar 21.


Increased expression of Cxcr3 and its ligands, Cxcl9 and Cxcl10, during the development of alopecia areata in the mouse.

McPhee CG, Duncan FJ, Silva KA, King LE Jr, Hogenesch H, Roopenian DC, Everts HB, Sundberg JP.

J Invest Dermatol. 2012 Jun;132(6):1736-8. doi: 10.1038/jid.2012.17. Epub 2012 Feb 23. No abstract available.


Clinical chemistry of human FcRn transgenic mice.

Stein C, Kling L, Proetzel G, Roopenian DC, de Angelis MH, Wolf E, Rathkolb B.

Mamm Genome. 2012 Apr;23(3-4):259-69. doi: 10.1007/s00335-011-9379-6. Epub 2011 Dec 23.


Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport.

Bai Y, Ye L, Tesar DB, Song H, Zhao D, Björkman PJ, Roopenian DC, Zhu X.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18406-11. doi: 10.1073/pnas.1115348108. Epub 2011 Oct 31.


Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.

Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlén M, Ekström TJ, Davisson MT, Hökfelt TG, Schalling M, Johansen JE.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18108-13. doi: 10.1073/pnas.1114863108. Epub 2011 Oct 24.


MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.

McPhee CG, Sproule TJ, Shin DM, Bubier JA, Schott WH, Steinbuck MP, Avenesyan L, Morse HC 3rd, Roopenian DC.

J Immunol. 2011 Nov 1;187(9):4695-704. doi: 10.4049/jimmunol.1101776. Epub 2011 Sep 30.


Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation.

Wang X, Li H, Matte-Martone C, Cui W, Li N, Tan HS, Roopenian D, Shlomchik WD.

Blood. 2011 Dec 8;118(24):6426-37. doi: 10.1182/blood-2011-06-358747. Epub 2011 Sep 30.


Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.

Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD.

Blood. 2011 Nov 24;118(22):5965-76. doi: 10.1182/blood-2011-07-367011. Epub 2011 Sep 13.


A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection.

Lu L, Palaniyandi S, Zeng R, Bai Y, Liu X, Wang Y, Pauza CD, Roopenian DC, Zhu X.

J Virol. 2011 Oct;85(20):10542-53. doi: 10.1128/JVI.05441-11. Epub 2011 Aug 17.


Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens.

Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian DC, Van Kaer L, Joyce S.

J Immunol. 2011 Jun 15;186(12):6683-92. doi: 10.4049/jimmunol.1100525. Epub 2011 May 13.


Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration.

Derbyshire K, Addey C, Coe D, Stuckey DW, Muezzin H, Bubier JA, Shaffer DJ, Roopenian DC, Chai JG, Scott DM.

J Immunol. 2011 May 15;186(10):5719-28. doi: 10.4049/jimmunol.1002444. Epub 2011 Apr 13.


The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells.

Liu X, Lu L, Yang Z, Palaniyandi S, Zeng R, Gao LY, Mosser DM, Roopenian DC, Zhu X.

J Immunol. 2011 Apr 15;186(8):4674-86. doi: 10.4049/jimmunol.1003584. Epub 2011 Mar 14.


Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts.

Russell PS, Chase CM, Madsen JC, Hirohashi T, Cornell LD, Sproule TJ, Colvin RB, Roopenian DC.

Transplantation. 2011 Apr 27;91(8):847-52. doi: 10.1097/TP.0b013e3182122f82.


Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection.

Li Z, Palaniyandi S, Zeng R, Tuo W, Roopenian DC, Zhu X.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4388-93. doi: 10.1073/pnas.1012861108. Epub 2011 Feb 28.


Efficient mucosal vaccination mediated by the neonatal Fc receptor.

Ye L, Zeng R, Bai Y, Roopenian DC, Zhu X.

Nat Biotechnol. 2011 Feb;29(2):158-63. doi: 10.1038/nbt.1742. Epub 2011 Jan 16.


CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice.

Kim HJ, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2010-5. doi: 10.1073/pnas.1018974108. Epub 2011 Jan 13.


A mouse model of heritable cerebrovascular disease.

Sproule TJ, Sled JG, Wentzell J, Wang B, Henkelman RM, Roopenian DC, Burgess RW.

PLoS One. 2010 Dec 31;5(12):e15327. doi: 10.1371/journal.pone.0015327.


Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans.

Sundberg JP, Taylor D, Lorch G, Miller J, Silva KA, Sundberg BA, Roopenian D, Sperling L, Ong D, King LE, Everts H.

Vet Pathol. 2011 Mar;48(2):513-24. doi: 10.1177/0300985810379431. Epub 2010 Sep 22.


Clinical ramifications of the MHC family Fc receptor FcRn.

Roopenian DC, Sun VZ.

J Clin Immunol. 2010 Nov;30(6):790-7. doi: 10.1007/s10875-010-9458-6. Epub 2010 Sep 17. Review.


Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice.

Wu B, Potter CS, Silva KA, Liang Y, Reinholdt LG, Alley LM, Rowe LB, Roopenian DC, Awgulewitsch A, Sundberg JP.

J Invest Dermatol. 2010 Nov;130(11):2666-8. doi: 10.1038/jid.2010.168. Epub 2010 Jun 24. No abstract available.


A mouse model of generalized non-Herlitz junctional epidermolysis bullosa.

Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, Sundberg JP.

J Invest Dermatol. 2010 Jul;130(7):1819-28. doi: 10.1038/jid.2010.46. Epub 2010 Mar 25.


Enhanced antibody half-life improves in vivo activity.

Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR.

Nat Biotechnol. 2010 Feb;28(2):157-9. doi: 10.1038/nbt.1601. Epub 2010 Jan 17.


Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies.

Roopenian DC, Christianson GJ, Sproule TJ.

Methods Mol Biol. 2010;602:93-104. doi: 10.1007/978-1-60761-058-8_6.


B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection.

Baker PJ, Boutaugh NR, Tiffany M, Roopenian DC.

Interdiscip Perspect Infect Dis. 2009;2009:864359. doi: 10.1155/2009/864359. Epub 2009 Oct 25.


Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity.

Bleich A, Büchler G, Beckwith J, Petell LM, Affourtit JP, King BL, Shaffer DJ, Roopenian DC, Hedrich HJ, Sundberg JP, Leiter EH.

Inflamm Bowel Dis. 2010 May;16(5):765-75. doi: 10.1002/ibd.21146.

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