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A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL.

EMBO J. 2018 Feb 9. pii: e97452. doi: 10.15252/embj.201797452. [Epub ahead of print]


G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R.

Sci Signal. 2018 Feb 6;11(516). pii: eaao5749. doi: 10.1126/scisignal.aao5749.


R-spondins can potentiate WNT signaling without LGRs.

Lebensohn AM, Rohatgi R.

Elife. 2018 Feb 6;7. pii: e33126. doi: 10.7554/eLife.33126.


CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R.

Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002. No abstract available.


CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R.

Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. Erratum in: Dev Cell. 2018 Jan 22;44(2):271.


Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.

Byrne EF, Luchetti G, Rohatgi R, Siebold C.

Curr Opin Cell Biol. 2017 Dec 18;51:81-88. doi: 10.1016/ [Epub ahead of print] Review.


Architectural T-Wave Analysis and Identification of On-Therapy Breakthrough Arrhythmic Risk in Type 1 and Type 2 Long-QT Syndrome.

Sugrue A, Rohatgi RK, Noseworthy PA, Kremen V, Bos JM, Qiang B, Sapir Y, Attia ZI, Scott CG, Brady P, Asirvatham SJ, Friedman PA, Ackerman MJ.

Circ Arrhythm Electrophysiol. 2017 Nov;10(11). pii: e005648. doi: 10.1161/CIRCEP.117.005648.


Telenephrology: current perspectives and future directions.

Rohatgi R, Ross MJ, Majoni SW.

Kidney Int. 2017 Dec;92(6):1328-1333. doi: 10.1016/j.kint.2017.06.032. Epub 2017 Oct 12.


Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?

Roberts JD, Krahn AD, Ackerman MJ, Rohatgi RK, Moss AJ, Nazer B, Tadros R, Gerull B, Sanatani S, Wijeyeratne YD, Baruteau AE, Muir AR, Pang B, Cadrin-Tourigny J, Talajic M, Rivard L, Tester DJ, Liu T, Whitman IR, Wojciak J, Conacher S, Gula LJ, Leong-Sit P, Manlucu J, Green MS, Hamilton R, Healey JS, Lopes CM, Behr ER, Wilde AA, Gollob MH, Scheinman MM.

Circ Arrhythm Electrophysiol. 2017 Aug;10(8). pii: e005282. doi: 10.1161/CIRCEP.117.005282.


Contemporary Outcomes in Patients With Long QT Syndrome.

Rohatgi RK, Sugrue A, Bos JM, Cannon BC, Asirvatham SJ, Moir C, Owen HJ, Bos KM, Kruisselbrink T, Ackerman MJ.

J Am Coll Cardiol. 2017 Jul 25;70(4):453-462. doi: 10.1016/j.jacc.2017.05.046.


Proposing a Hybrid Model Based on Robson's Classification for Better Impact on Trends of Cesarean Deliveries.

Hans P, Rohatgi R.

J Obstet Gynaecol India. 2017 Jun;67(3):183-189. doi: 10.1007/s13224-016-0953-4. Epub 2016 Nov 21.


Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome.

Sugrue A, Noseworthy PA, Kremen V, Bos JM, Qiang B, Rohatgi RK, Sapir Y, Attia ZI, Brady P, Caraballo PJ, Asirvatham SJ, Friedman PA, Ackerman MJ.

Ann Noninvasive Electrocardiol. 2017 Nov;22(6). doi: 10.1111/anec.12455. Epub 2017 Apr 21.


Targeting Access to Kidney Care Via Telehealth: The VA Experience.

Crowley ST, Belcher J, Choudhury D, Griffin C, Pichler R, Robey B, Rohatgi R, Mielcarek B.

Adv Chronic Kidney Dis. 2017 Jan;24(1):22-30. doi: 10.1053/j.ackd.2016.11.005. Review.


Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T.

Cell. 2017 Jan 12;168(1-2):264-279.e15. doi: 10.1016/j.cell.2016.12.032. Epub 2017 Jan 12.


Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling.

Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R.

Elife. 2016 Dec 20;5. pii: e21459. doi: 10.7554/eLife.21459.


Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R.

Elife. 2016 Oct 5;5. pii: e20304. doi: 10.7554/eLife.20304.


Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1.

Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R.

Cancer Res. 2016 Oct 1;76(19):5810-5821. Epub 2016 Aug 8.


In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes.

Schmidt HB, Rohatgi R.

Cell Rep. 2016 Aug 2;16(5):1228-1236. doi: 10.1016/j.celrep.2016.06.088. Epub 2016 Jul 21.


Structural basis of Smoothened regulation by its extracellular domains.

Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C.

Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20.


Identification of Concealed and Manifest Long QT Syndrome Using a Novel T Wave Analysis Program.

Sugrue A, Noseworthy PA, Kremen V, Bos JM, Qiang B, Rohatgi RK, Sapir Y, Attia ZI, Brady P, Asirvatham SJ, Friedman PA, Ackerman MJ.

Circ Arrhythm Electrophysiol. 2016 Jul;9(7). pii: e003830. doi: 10.1161/CIRCEP.115.003830.


Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb.

Zhuang Y, Jia Z, Hu C, Ding G, Zhang X, Zhang Y, Yang G, Rohatgi R, Huang S, He JC, Zhang A.

Oncotarget. 2016 Jun 23;8(44):75808-75821. doi: 10.18632/oncotarget.10257. eCollection 2017 Sep 29.


Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis.

Jia Z, Zhuang Y, Hu C, Zhang X, Ding G, Zhang Y, Rohatgi R, Hua H, Huang S, He JC, Zhang A.

Oncotarget. 2016 Jul 26;7(30):47134-47144. doi: 10.18632/oncotarget.9972.


Selective Serotonin Re-uptake Inhibitors (SSRIs) Induced Weight Changes: A Dose and Duration Dependent Study on Albino Rats.

Aggarwal A, Jethani SL, Rohatgi RK, Kalra J.

J Clin Diagn Res. 2016 Mar;10(3):AF01-3. doi: 10.7860/JCDR/2016/16482.7376. Epub 2016 Mar 1.


An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.

Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW.

EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4.


An autophagy-independent function for Beclin 1 in cancer.

Rohatgi RA, Shaw LM.

Mol Cell Oncol. 2016 Jan 2;3(1). pii: e1030539. Epub 2015 Apr 14.


Left ventricular outflow track obstruction and mitral valve regurgitation in a patient with takotsubo cardiomyopathy.

Wu Y, Fan W, Chachula L, Costacurta G, Rohatgi R, Elmi F.

J Community Hosp Intern Med Perspect. 2015 Dec 11;5(6):29419. doi: 10.3402/jchimp.v5.29419. eCollection 2015.


Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling.

Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT, Rohatgi R, McCormick PJ, Ogden SK.

PLoS Genet. 2015 Aug 20;11(8):e1005473. doi: 10.1371/journal.pgen.1005473. eCollection 2015 Aug.


Rapid Screening of Gli2/3 Mutants Using the Flp-In System.

Niewiadomski P, Rohatgi R.

Methods Mol Biol. 2015;1322:125-30. doi: 10.1007/978-1-4939-2772-2_11.


Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry.

Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R.

Methods Mol Biol. 2015;1322:105-23. doi: 10.1007/978-1-4939-2772-2_10.


Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR.

Niewiadomski P, Rohatgi R.

Methods Mol Biol. 2015;1322:81-92. doi: 10.1007/978-1-4939-2772-2_8.


Stimulant therapy in children with attention-deficit/hyperactivity disorder and concomitant long QT syndrome: A safe combination?

Rohatgi RK, Bos JM, Ackerman MJ.

Heart Rhythm. 2015 Aug;12(8):1807-12. doi: 10.1016/j.hrthm.2015.04.043. Epub 2015 May 5.


Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.

Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG.

Dev Cell. 2015 May 26;33(4):373-87. doi: 10.1016/j.devcel.2015.03.005. Epub 2015 Apr 30.


Cholesterol affects flow-stimulated cyclooxygenase-2 expression and prostanoid secretion in the cortical collecting duct.

Liu Y, Flores D, Carrisoza-Gaytán R, Rohatgi R.

Am J Physiol Renal Physiol. 2015 Jun 1;308(11):F1229-37. doi: 10.1152/ajprenal.00635.2014. Epub 2015 Mar 11.


Beclin 1 regulates growth factor receptor signaling in breast cancer.

Rohatgi RA, Janusis J, Leonard D, Bellvé KD, Fogarty KE, Baehrecke EH, Corvera S, Shaw LM.

Oncogene. 2015 Oct 16;34(42):5352-62. doi: 10.1038/onc.2014.454. Epub 2015 Feb 2.


Flow regulation of endothelin-1 production in the inner medullary collecting duct.

Pandit MM, Inscho EW, Zhang S, Seki T, Rohatgi R, Gusella L, Kishore B, Kohan DE.

Am J Physiol Renal Physiol. 2015 Mar 15;308(6):F541-52. doi: 10.1152/ajprenal.00456.2014. Epub 2015 Jan 13.


Angiotensin II type 2 receptor regulates ROMK-like K⁺ channel activity in the renal cortical collecting duct during high dietary K⁺ adaptation.

Wei Y, Liao Y, Zavilowitz B, Ren J, Liu W, Chan P, Rohatgi R, Estilo G, Jackson EK, Wang WH, Satlin LM.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F833-43. doi: 10.1152/ajprenal.00141.2014. Epub 2014 Aug 6.


Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia.

Pusapati GV, Rohatgi R.

EMBO J. 2014 Sep 1;33(17):1852-4. doi: 10.15252/embj.201489294. Epub 2014 Jul 17. No abstract available.


Frontiers in hedgehog signal transduction.

Guerrero I, Rohatgi R.

Semin Cell Dev Biol. 2014 Sep;33:50-1. doi: 10.1016/j.semcdb.2014.06.009. Epub 2014 Jun 16. No abstract available.


Effects of biomechanical forces on signaling in the cortical collecting duct (CCD).

Carrisoza-Gaytan R, Liu Y, Flores D, Else C, Lee HG, Rhodes G, Sandoval RM, Kleyman TR, Lee FY, Molitoris B, Satlin LM, Rohatgi R.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F195-204. doi: 10.1152/ajprenal.00634.2013. Epub 2014 May 28.


G-protein-coupled receptors, Hedgehog signaling and primary cilia.

Mukhopadhyay S, Rohatgi R.

Semin Cell Dev Biol. 2014 Sep;33:63-72. doi: 10.1016/j.semcdb.2014.05.002. Epub 2014 May 17. Review.


Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.

Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R.

J Biol Chem. 2014 Apr 18;289(16):11095-110. doi: 10.1074/jbc.M113.540351. Epub 2014 Mar 4.


A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding.

Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F.

J Bone Miner Res. 2014 Aug;29(8):1872-85. doi: 10.1002/jbmr.2213.


EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R.

Dev Cell. 2014 Mar 10;28(5):483-96. doi: 10.1016/j.devcel.2014.01.021. Epub 2014 Feb 27.


Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling.

Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R.

Cell Rep. 2014 Jan 16;6(1):168-181. doi: 10.1016/j.celrep.2013.12.003. Epub 2013 Dec 27.


Biomechanical regulation of cyclooxygenase-2 in the renal collecting duct.

Liu Y, Flores D, Carrisoza-Gaytán R, Rohatgi R.

Am J Physiol Renal Physiol. 2014 Jan;306(2):F214-23. doi: 10.1152/ajprenal.00327.2013. Epub 2013 Nov 13.


Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling.

Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R.

Elife. 2013 Oct 29;2:e01340. doi: 10.7554/eLife.01340.


Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis.

Carragee EJ, Chu G, Rohatgi R, Hurwitz EL, Weiner BK, Yoon ST, Comer G, Kopjar B.

J Bone Joint Surg Am. 2013 Sep 4;95(17):1537-45. doi: 10.2106/JBJS.L.01483.


Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips.

Earhart CM, Hughes CE, Gaster RS, Ooi CC, Wilson RJ, Zhou LY, Humke EW, Xu L, Wong DJ, Willingham SB, Schwartz EJ, Weissman IL, Jeffrey SS, Neal JW, Rohatgi R, Wakelee HA, Wang SX.

Lab Chip. 2014 Jan 7;14(1):78-88. doi: 10.1039/c3lc50580d.


Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier.

Lin YC, Niewiadomski P, Lin B, Nakamura H, Phua SC, Jiao J, Levchenko A, Inoue T, Rohatgi R, Inoue T.

Nat Chem Biol. 2013 Jul;9(7):437-43. doi: 10.1038/nchembio.1252. Epub 2013 May 12.


A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia.

Dorn KV, Hughes CE, Rohatgi R.

Dev Cell. 2012 Oct 16;23(4):823-35. doi: 10.1016/j.devcel.2012.07.004. Epub 2012 Sep 13.

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