Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 21

1.

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B.

EMBO J. 2018 Jun 6. pii: e98697. doi: 10.15252/embj.201798697. [Epub ahead of print]

2.

Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.

Nettekoven M, Adam JM, Bendels S, Bissantz C, Fingerle J, Grether U, Grüner S, Guba W, Kimbara A, Ottaviani G, Püllmann B, Rogers-Evans M, Röver S, Rothenhäusler B, Schmitt S, Schuler F, Schulz-Gasch T, Ullmer C.

ChemMedChem. 2016 Jan 19;11(2):179-89. doi: 10.1002/cmdc.201500218. Epub 2015 Jul 21.

PMID:
26228928
3.

Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P.

J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18.

PMID:
25654260
4.

Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!

Rogers-Evans M, Knust H, Plancher JM, Carreira EM, Wuitschik G, Burkhard J, Li DB, Guérot C.

Chimia (Aarau). 2014;68(7-8):492-9. doi: 10.2533/chimia.2014.492.

PMID:
25437389
5.

Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.

Li DB, Rogers-Evans M, Carreira EM.

Org Lett. 2013 Sep 20;15(18):4766-9. doi: 10.1021/ol402127b. Epub 2013 Aug 30.

PMID:
23991674
6.

Synthesis and stability of oxetane analogs of thalidomide and lenalidomide.

Burkhard JA, Wuitschik G, Plancher JM, Rogers-Evans M, Carreira EM.

Org Lett. 2013 Sep 6;15(17):4312-5. doi: 10.1021/ol401705a. Epub 2013 Aug 12.

PMID:
23937240
7.

BACE1 inhibitors: a head group scan on a series of amides.

Woltering TJ, Wostl W, Hilpert H, Rogers-Evans M, Pinard E, Mayweg A, Göbel M, Banner DW, Benz J, Travagli M, Pollastrini M, Marconi G, Gabellieri E, Guba W, Mauser H, Andreini M, Jacobsen H, Power E, Narquizian R.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4239-43. doi: 10.1016/j.bmcl.2013.05.003. Epub 2013 May 18.

PMID:
23735744
8.

β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.

Hilpert H, Guba W, Woltering TJ, Wostl W, Pinard E, Mauser H, Mayweg AV, Rogers-Evans M, Humm R, Krummenacher D, Muser T, Schnider C, Jacobsen H, Ozmen L, Bergadano A, Banner DW, Hochstrasser R, Kuglstatter A, David-Pierson P, Fischer H, Polara A, Narquizian R.

J Med Chem. 2013 May 23;56(10):3980-95. doi: 10.1021/jm400225m. Epub 2013 May 2.

PMID:
23590342
9.

Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.

Nettekoven M, Fingerle J, Grether U, Grüner S, Kimbara A, Püllmann B, Rogers-Evans M, Röver S, Schuler F, Schulz-Gasch T, Ullmer C.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1177-81. doi: 10.1016/j.bmcl.2013.01.044. Epub 2013 Jan 23.

PMID:
23380378
10.

Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery.

Li DB, Rogers-Evans M, Carreira EM.

Org Lett. 2011 Nov 18;13(22):6134-6. doi: 10.1021/ol2025313. Epub 2011 Oct 18.

PMID:
22007769
11.

Oxetanes as versatile elements in drug discovery and synthesis.

Burkhard JA, Wuitschik G, Rogers-Evans M, Müller K, Carreira EM.

Angew Chem Int Ed Engl. 2010 Nov 22;49(48):9052-67. doi: 10.1002/anie.200907155. Review.

PMID:
21031377
12.

Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.

Burkhard JA, Guérot C, Knust H, Rogers-Evans M, Carreira EM.

Org Lett. 2010 May 7;12(9):1944-7. doi: 10.1021/ol1003302.

PMID:
20356106
13.

Oxetanes in drug discovery: structural and synthetic insights.

Wuitschik G, Carreira EM, Wagner B, Fischer H, Parrilla I, Schuler F, Rogers-Evans M, Müller K.

J Med Chem. 2010 Apr 22;53(8):3227-46. doi: 10.1021/jm9018788.

PMID:
20349959
14.

Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.

Malherbe P, Borroni E, Gobbi L, Knust H, Nettekoven M, Pinard E, Roche O, Rogers-Evans M, Wettstein JG, Moreau JL.

Br J Pharmacol. 2009 Apr;156(8):1326-41. doi: 10.1111/j.1476-5381.2009.00127.x.

15.

Spirocyclic oxetanes: synthesis and properties.

Wuitschik G, Rogers-Evans M, Buckl A, Bernasconi M, Märki M, Godel T, Fischer H, Wagner B, Parrilla I, Schuler F, Schneider J, Alker A, Schweizer WB, Müller K, Carreira EM.

Angew Chem Int Ed Engl. 2008;47(24):4512-5. doi: 10.1002/anie.200800450. No abstract available.

PMID:
18465828
16.

Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.

Alig L, Alsenz J, Andjelkovic M, Bendels S, Bénardeau A, Bleicher K, Bourson A, David-Pierson P, Guba W, Hildbrand S, Kube D, Lübbers T, Mayweg AV, Narquizian R, Neidhart W, Nettekoven M, Plancher JM, Rocha C, Rogers-Evans M, Röver S, Schneider G, Taylor S, Waldmeier P.

J Med Chem. 2008 Apr 10;51(7):2115-27. doi: 10.1021/jm701487t. Epub 2008 Mar 13.

PMID:
18335976
17.

Oxetanes as promising modules in drug discovery.

Wuitschik G, Rogers-Evans M, Müller K, Fischer H, Wagner B, Schuler F, Polonchuk L, Carreira EM.

Angew Chem Int Ed Engl. 2006 Nov 27;45(46):7736-9. No abstract available.

PMID:
17013952
18.

Synthesis of 1,4-benzodiazepine-3,5-diones.

Wiklund P, Rogers-Evans M, Bergman J.

J Org Chem. 2004 Sep 17;69(19):6371-6.

PMID:
15357597
19.

Ligand identification for G-protein-coupled receptors: a lead generation perspective.

Bleicher KH, Green LG, Martin RE, Rogers-Evans M.

Curr Opin Chem Biol. 2004 Jun;8(3):287-96. Review.

PMID:
15183327
20.

A concise asymmetric route to the bridged bicyclic tropane alkaloid ferruginine using enyne ring-closing metathesis.

Aggarwal VK, Astle CJ, Rogers-Evans M.

Org Lett. 2004 Apr 29;6(9):1469-71.

PMID:
15101769
21.

Development of a virtual screening method for identification of "frequent hitters" in compound libraries.

Roche O, Schneider P, Zuegge J, Guba W, Kansy M, Alanine A, Bleicher K, Danel F, Gutknecht EM, Rogers-Evans M, Neidhart W, Stalder H, Dillon M, Sjögren E, Fotouhi N, Gillespie P, Goodnow R, Harris W, Jones P, Taniguchi M, Tsujii S, von der Saal W, Zimmermann G, Schneider G.

J Med Chem. 2002 Jan 3;45(1):137-42.

PMID:
11754585

Supplemental Content

Loading ...
Support Center