Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 74


Differential daptomycin resistance development in Staphylococcus aureus strains with active and mutated gra regulatory systems.

Müller A, Grein F, Otto A, Gries K, Orlov D, Zarubaev V, Girard M, Sher X, Shamova O, Roemer T, François P, Becher D, Schneider T, Sahl HG.

Int J Med Microbiol. 2017 Dec 21. pii: S1438-4221(17)30395-8. doi: 10.1016/j.ijmm.2017.12.002. [Epub ahead of print]


Neutralization of Pathogenic Fungi with Small-Molecule Immunotherapeutics.

Chirkin E, Muthusamy V, Mann P, Roemer T, Nantermet PG, Spiegel DA.

Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13036-13040. doi: 10.1002/anie.201707536. Epub 2017 Sep 11.


Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.

Walker SS, Labroli M, Painter RE, Wiltsie J, Sherborne B, Murgolo N, Sher X, Mann P, Zuck P, Garlisi CG, Su J, Kargman S, Xiao L, Scapin G, Salowe S, Devito K, Sheth P, Buist N, Tan CM, Black TA, Roemer T.

PLoS One. 2017 Jul 10;12(7):e0180965. doi: 10.1371/journal.pone.0180965. eCollection 2017.


Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.

Wang H, Mann PA, Xiao L, Gill C, Galgoci AM, Howe JA, Villafania A, Barbieri CM, Malinverni JC, Sher X, Mayhood T, McCurry MD, Murgolo N, Flattery A, Mack M, Roemer T.

Cell Chem Biol. 2017 May 18;24(5):576-588.e6. doi: 10.1016/j.chembiol.2017.03.014. Epub 2017 Apr 20.


Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

Mandal M, Tan Z, Madsen-Duggan C, Buevich AV, Caldwell JP, Dejesus R, Flattery A, Garlisi CG, Gill C, Ha SN, Ho G, Koseoglu S, Labroli M, Basu K, Lee SH, Liang L, Liu J, Mayhood T, McGuinness D, McLaren DG, Wen X, Parmee E, Rindgen D, Roemer T, Sheth P, Tawa P, Tata J, Yang C, Yang SW, Xiao L, Wang H, Tan C, Tang H, Walsh P, Walsh E, Wu J, Su J.

J Med Chem. 2017 May 11;60(9):3851-3865. doi: 10.1021/acs.jmedchem.7b00113. Epub 2017 Mar 29.


FtsZ-Dependent Elongation of a Coccoid Bacterium.

Pereira AR, Hsin J, Król E, Tavares AC, Flores P, Hoiczyk E, Ng N, Dajkovic A, Brun YV, VanNieuwenhze MS, Roemer T, Carballido-Lopez R, Scheffers DJ, Huang KC, Pinho MG.

MBio. 2016 Sep 6;7(5). pii: e00908-16. doi: 10.1128/mBio.00908-16.


Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

Yang SW, Pan J, Yang C, Labroli M, Pan W, Caldwell J, Ha S, Koseoglu S, Xiao JC, Mayhood T, Sheth PR, Garlisi CG, Wu J, Lee SH, Wang H, Tan CM, Roemer T, Su J.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4743-4747. doi: 10.1016/j.bmcl.2016.08.036. Epub 2016 Aug 16.


The GPI anchor pathway: a promising antifungal target?

Mutz M, Roemer T.

Future Med Chem. 2016 Aug;8(12):1387-91. doi: 10.4155/fmc-2016-0110. No abstract available.


Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch.

Howe JA, Xiao L, Fischmann TO, Wang H, Tang H, Villafania A, Zhang R, Barbieri CM, Roemer T.

RNA Biol. 2016 Oct 2;13(10):946-954. Epub 2016 Aug 2.


Discovery of potent wall teichoic acid early stage inhibitors.

Labroli MA, Caldwell JP, Yang C, Lee SH, Wang H, Koseoglu S, Mann P, Yang SW, Xiao J, Garlisi CG, Tan C, Roemer T, Su J.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3999-4002. doi: 10.1016/j.bmcl.2016.06.090. Epub 2016 Jun 30.


Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.

Mann PA, Müller A, Wolff KA, Fischmann T, Wang H, Reed P, Hou Y, Li W, Müller CE, Xiao J, Murgolo N, Sher X, Mayhood T, Sheth PR, Mirza A, Labroli M, Xiao L, McCoy M, Gill CJ, Pinho MG, Schneider T, Roemer T.

PLoS Pathog. 2016 May 4;12(5):e1005585. doi: 10.1371/journal.ppat.1005585. eCollection 2016 May.


NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.

Hou Y, Mayhood T, Sheth P, Tan CM, Labroli M, Su J, Wyss DF, Roemer T, McCoy MA.

J Biomol Screen. 2016 Jul;21(6):579-89. doi: 10.1177/1087057116640199. Epub 2016 Mar 29.


TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Lee SH, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, Gill C, Mann P, Sher X, Ha S, Yang SW, Mandal M, Yang C, Liang L, Tan Z, Tawa P, Hou Y, Kuvelkar R, DeVito K, Wen X, Xiao J, Batchlett M, Balibar CJ, Liu J, Xiao J, Murgolo N, Garlisi CG, Sheth PR, Flattery A, Su J, Tan C, Roemer T.

Sci Transl Med. 2016 Mar 9;8(329):329ra32. doi: 10.1126/scitranslmed.aad7364.


Residual Ductility and Microstructural Evolution in Continuous-Bending-under-Tension of AA-6022-T4.

Zecevic M, Roemer TJ, Knezevic M, Korkolis YP, Kinsey BL.

Materials (Basel). 2016 Feb 26;9(3). pii: E130. doi: 10.3390/ma9030130.


Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T.

ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12.


Prevalence of uterine myomas in women in Germany: data of an epidemiological study.

Ahrendt HJ, Tylkoski H, Rabe T, Szczes A, Friedrich C, Roehl FW, Kitay A, Roemer T, Foth D.

Arch Gynecol Obstet. 2016 Jun;293(6):1243-53. doi: 10.1007/s00404-015-3930-8. Epub 2015 Nov 2.


Yeast: a microbe with macro-implications to antimicrobial drug discovery.

Balibar CJ, Roemer T.

Brief Funct Genomics. 2016 Mar;15(2):147-54. doi: 10.1093/bfgp/elv038. Epub 2015 Oct 5. Review.


Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T.

Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30.


Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance.

Reed P, Atilano ML, Alves R, Hoiczyk E, Sher X, Reichmann NT, Pereira PM, Roemer T, Filipe SR, Pereira-Leal JB, Ligoxygakis P, Pinho MG.

PLoS Pathog. 2015 May 7;11(5):e1004891. doi: 10.1371/journal.ppat.1004891. eCollection 2015 May.


Global analysis of fungal morphology exposes mechanisms of host cell escape.

O'Meara TR, Veri AO, Ketela T, Jiang B, Roemer T, Cowen LE.

Nat Commun. 2015 Mar 31;6:6741. doi: 10.1038/ncomms7741.


Economic and clinical benefits of radiofrequency ablation versus hysterectomy in patients suffering from menorrhagia: a retrospective analysis with German health claims data.

Kessel S, Hucke J, Goergen C, Soeder R, Roemer T.

Expert Rev Med Devices. 2015 May;12(3):365-72. doi: 10.1586/17434440.2015.1015988. Epub 2015 Feb 23.


Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola.

Ortíz-López FJ, Monteiro MC, González-Menéndez V, Tormo JR, Genilloud O, Bills GF, Vicente F, Zhang C, Roemer T, Singh SB, Reyes F.

J Nat Prod. 2015 Mar 27;78(3):468-75. doi: 10.1021/np500854j. Epub 2015 Jan 30.


Discovery, isolation, and structure elucidation of dretamycin.

Wilson KE, Smith SK, Kelly R, Masurekar P, Xu D, Parish CA, Wang H, Zink DL, Davies JE, Roemer T.

J Nat Prod. 2014 Jun 27;77(6):1280-6. doi: 10.1021/np401019t. Epub 2014 Jun 16.


Antifungal drug development: challenges, unmet clinical needs, and new approaches.

Roemer T, Krysan DJ.

Cold Spring Harb Perspect Med. 2014 May 1;4(5). pii: a019703. doi: 10.1101/cshperspect.a019703. Review.


Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

Mann PA, Müller A, Xiao L, Pereira PM, Yang C, Ho Lee S, Wang H, Trzeciak J, Schneeweis J, Dos Santos MM, Murgolo N, She X, Gill C, Balibar CJ, Labroli M, Su J, Flattery A, Sherborne B, Maier R, Tan CM, Black T, Onder K, Kargman S, Monsma FJ Jr, Pinho MG, Schneider T, Roemer T.

ACS Chem Biol. 2013 Nov 15;8(11):2442-51. doi: 10.1021/cb400487f. Epub 2013 Sep 5.


Auxiliary factors: a chink in the armor of MRSA resistance to β-lactam antibiotics.

Roemer T, Schneider T, Pinho MG.

Curr Opin Microbiol. 2013 Oct;16(5):538-48. doi: 10.1016/j.mib.2013.06.012. Epub 2013 Jul 26. Review.


Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages.

Josten M, Reif M, Szekat C, Al-Sabti N, Roemer T, Sparbier K, Kostrzewa M, Rohde H, Sahl HG, Bierbaum G.

J Clin Microbiol. 2013 Jun;51(6):1809-17. doi: 10.1128/JCM.00518-13. Epub 2013 Apr 3.


Systems-level antimicrobial drug and drug synergy discovery.

Roemer T, Boone C.

Nat Chem Biol. 2013 Apr;9(4):222-31. doi: 10.1038/nchembio.1205.


Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

Wang H, Gill CJ, Lee SH, Mann P, Zuck P, Meredith TC, Murgolo N, She X, Kales S, Liang L, Liu J, Wu J, Santa Maria J, Su J, Pan J, Hailey J, Mcguinness D, Tan CM, Flattery A, Walker S, Black T, Roemer T.

Chem Biol. 2013 Feb 21;20(2):272-84. doi: 10.1016/j.chembiol.2012.11.013.


Isolation, structure, and biological activity of Phaeofungin, a cyclic lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test.

Singh SB, Ondeyka J, Harris G, Herath K, Zink D, Vicente F, Bills G, Collado J, Platas G, González del Val A, Martin J, Reyes F, Wang H, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Roemer T, Xu D.

J Nat Prod. 2013 Mar 22;76(3):334-45. doi: 10.1021/np300704s. Epub 2012 Dec 24.


Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation.

Meredith TC, Wang H, Beaulieu P, Gründling A, Roemer T.

Mob Genet Elements. 2012 Jul 1;2(4):171-178.


Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.

Tan CM, Therien AG, Lu J, Lee SH, Caron A, Gill CJ, Lebeau-Jacob C, Benton-Perdomo L, Monteiro JM, Pereira PM, Elsen NL, Wu J, Deschamps K, Petcu M, Wong S, Daigneault E, Kramer S, Liang L, Maxwell E, Claveau D, Vaillancourt J, Skorey K, Tam J, Wang H, Meredith TC, Sillaots S, Wang-Jarantow L, Ramtohul Y, Langlois E, Landry F, Reid JC, Parthasarathy G, Sharma S, Baryshnikova A, Lumb KJ, Pinho MG, Soisson SM, Roemer T.

Sci Transl Med. 2012 Mar 21;4(126):126ra35. doi: 10.1126/scitranslmed.3003592.


The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.

Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, Mitchell A, Roemer T, Hannun YA, Cammue BP.

Mol Microbiol. 2012 Apr;84(1):166-80. doi: 10.1111/j.1365-2958.2012.08017.x. Epub 2012 Mar 5.


Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus.

Münch D, Roemer T, Lee SH, Engeser M, Sahl HG, Schneider T.

PLoS Pathog. 2012 Jan;8(1):e1002509. doi: 10.1371/journal.ppat.1002509. Epub 2012 Jan 26.


Bugs, drugs and chemical genomics.

Roemer T, Davies J, Giaever G, Nislow C.

Nat Chem Biol. 2011 Dec 15;8(1):46-56. doi: 10.1038/nchembio.744. Review.


Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics.

Lee SH, Jarantow LW, Wang H, Sillaots S, Cheng H, Meredith TC, Thompson J, Roemer T.

Chem Biol. 2011 Nov 23;18(11):1379-89. doi: 10.1016/j.chembiol.2011.08.015.


Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, Giaever G.

Chem Biol. 2011 Oct 28;18(10):1273-83. doi: 10.1016/j.chembiol.2011.07.018.


High-frequency transposition for determining antibacterial mode of action.

Wang H, Claveau D, Vaillancourt JP, Roemer T, Meredith TC.

Nat Chem Biol. 2011 Sep 4;7(10):720-9. doi: 10.1038/nchembio.643.


Isolation, structure, and biological activities of Fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test.

Xu D, Ondeyka J, Harris GH, Zink D, Kahn JN, Wang H, Bills G, Platas G, Wang W, Szewczak AA, Liberator P, Roemer T, Singh SB.

J Nat Prod. 2011 Aug 26;74(8):1721-30. doi: 10.1021/np2001573. Epub 2011 Jul 13.


Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery.

Trew G, Pistofidis G, Pados G, Lower A, Mettler L, Wallwiener D, Korell M, Pouly JL, Coccia ME, Audebert A, Nappi C, Schmidt E, McVeigh E, Landi S, Degueldre M, Konincxk P, Rimbach S, Chapron C, Dallay D, Röemer T, McConnachie A, Ford I, Crowe A, Knight A, Dizerega G, Dewilde R.

Hum Reprod. 2011 Aug;26(8):2015-27. doi: 10.1093/humrep/der135. Epub 2011 Jun 1.


Endometrial safety of an oral contraceptive containing estradiol valerate and dienogest.

Bitzer J, Parke S, Roemer T, Serrani M.

Int J Womens Health. 2011 Apr 18;3:127-32. doi: 10.2147/IJWH.S18735.


Confronting the challenges of natural product-based antifungal discovery.

Roemer T, Xu D, Singh SB, Parish CA, Harris G, Wang H, Davies JE, Bills GF.

Chem Biol. 2011 Feb 25;18(2):148-64. doi: 10.1016/j.chembiol.2011.01.009. Review.


Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model.

Becker JM, Kauffman SJ, Hauser M, Huang L, Lin M, Sillaots S, Jiang B, Xu D, Roemer T.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22044-9. doi: 10.1073/pnas.1009845107. Epub 2010 Dec 6.


Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

Xu HH, Trawick JD, Haselbeck RJ, Forsyth RA, Yamamoto RT, Archer R, Patterson J, Allen M, Froelich JM, Taylor I, Nakaji D, Maile R, Kedar GC, Pilcher M, Brown-Driver V, McCarthy M, Files A, Robbins D, King P, Sillaots S, Malone C, Zamudio CS, Roemer T, Wang L, Youngman PJ, Wall D.

Antimicrob Agents Chemother. 2010 Sep;54(9):3659-70. doi: 10.1128/AAC.00308-10. Epub 2010 Jun 14.


Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus.

Huber J, Donald RG, Lee SH, Jarantow LW, Salvatore MJ, Meng X, Painter R, Onishi RH, Occi J, Dorso K, Young K, Park YW, Skwish S, Szymonifka MJ, Waddell TS, Miesel L, Phillips JW, Roemer T.

Chem Biol. 2009 Aug 28;16(8):837-48. doi: 10.1016/j.chembiol.2009.05.012.


Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

Bills GF, Platas G, Overy DP, Collado J, Fillola A, Jiménez MR, Martín J, del Val AG, Vicente F, Tormo JR, Peláez F, Calati K, Harris G, Parish C, Xu D, Roemer T.

Mycologia. 2009 Jul-Aug;101(4):449-72.


Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.

Xu D, Sillaots S, Davison J, Hu W, Jiang B, Kauffman S, Martel N, Ocampo P, Oh C, Trosok S, Veillette K, Wang H, Yang M, Zhang L, Becker J, Martin CE, Roemer T.

J Biol Chem. 2009 Jul 17;284(29):19754-64. doi: 10.1074/jbc.M109.019877. Epub 2009 Jun 1.


Influence of anaesthesia resident training on the duration of three common surgical operations.

Hanss R, Roemer T, Hedderich J, Roesler L, Steinfath M, Bein B, Scholz J, Bauer M.

Anaesthesia. 2009 Jun;64(6):632-7. doi: 10.1111/j.1365-2044.2008.05853.x.


A whale of a library.

Xu D, Roemer T.

Nat Biotechnol. 2009 Apr;27(4):342-4. doi: 10.1038/nbt0409-342. No abstract available.


Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.

Trunk K, Gendron P, Nantel A, Lemieux S, Roemer T, Raymond M.

Eukaryot Cell. 2009 May;8(5):756-67. doi: 10.1128/EC.00332-08. Epub 2009 Mar 6.

Supplemental Content

Loading ...
Support Center