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Items: 1 to 50 of 193

1.

Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Broekman W, Khedoe PPSJ, Schepers K, Roelofs H, Stolk J, Hiemstra PS.

Thorax. 2018 Jun;73(6):565-574. doi: 10.1136/thoraxjnl-2017-210672. Epub 2018 Apr 13.

2.

The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine.

Broekman MMTJ, Wong DR, Wanten GJA, Roelofs HM, van Marrewijk CJ, Klungel OH, Verbeek ALM, Hooymans PM, Guchelaar HJ, Scheffer H, Derijks LJJ, Coenen MJH, de Jong DJ.

Pharmacogenomics J. 2018 Jan;18(1):160-166. doi: 10.1038/tpj.2016.87. Epub 2017 Jan 3.

PMID:
28045129
3.

Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients.

Broekman W, Roelofs H, Zarcone MC, Taube C, Stolk J, Hiemstra PS.

ERJ Open Res. 2016 Jun 28;2(2). pii: 00045-2015. eCollection 2016 Apr.

4.

Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough?

den Haan MC, van Zuylen VL, Pluijmert NJ, Schutte CI, Fibbe WE, Schalij MJ, Roelofs H, Atsma DE.

PLoS One. 2016 Apr 6;11(4):e0152938. doi: 10.1371/journal.pone.0152938. eCollection 2016.

5.

A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema.

Stolk J, Broekman W, Mauad T, Zwaginga JJ, Roelofs H, Fibbe WE, Oostendorp J, Bajema I, Versteegh MI, Taube C, Hiemstra PS.

QJM. 2016 May;109(5):331-6. doi: 10.1093/qjmed/hcw001. Epub 2016 Jan 27.

6.

TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor.

Broekman W, Amatngalim GD, de Mooij-Eijk Y, Oostendorp J, Roelofs H, Taube C, Stolk J, Hiemstra PS.

Respir Res. 2016 Jan 11;17:3. doi: 10.1186/s12931-015-0316-1.

7.

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study.

Reinders ME, Dreyer GJ, Bank JR, Roelofs H, Heidt S, Roelen DL, Zandvliet ML, Huurman VA, Fibbe WE, van Kooten C, Claas FH, Rabelink TJ, de Fijter JW.

J Transl Med. 2015 Nov 4;13:344. doi: 10.1186/s12967-015-0700-0.

8.

Direct Comparison of Wharton's Jelly and Bone Marrow-Derived Mesenchymal Stromal Cells to Enhance Engraftment of Cord Blood CD34(+) Transplants.

van der Garde M, van Pel M, Millán Rivero JE, de Graaf-Dijkstra A, Slot MC, Kleinveld Y, Watt SM, Roelofs H, Zwaginga JJ.

Stem Cells Dev. 2015 Nov 15;24(22):2649-59. doi: 10.1089/scd.2015.0138. Epub 2015 Oct 8.

9.

Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit.

Jansen D, Peters E, Heemskerk S, Koster-Kamphuis L, Bouw MP, Roelofs HM, van Oeveren W, van Heijst AF, Pickkers P.

Am J Perinatol. 2016 Jan;33(2):180-7. doi: 10.1055/s-0035-1563714. Epub 2015 Sep 7.

PMID:
26344007
10.

LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease.

Broekman MM, Roelofs HM, Hoentjen F, Wiegertjes R, Stoel N, Joosten LA, de Jong DJ, Wanten GJ.

PLoS One. 2015 Jul 24;10(7):e0133932. doi: 10.1371/journal.pone.0133932. eCollection 2015.

11.

Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial.

van Poppel PC, Breedveld P, Abbink EJ, Roelofs H, van Heerde W, Smits P, Lin W, Tan AH, Russel FG, Donders R, Tack CJ, Rongen GA.

PLoS One. 2015 Jul 20;10(7):e0128695. doi: 10.1371/journal.pone.0128695. eCollection 2015.

12.

Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia-reperfusion.

van Zuylen VL, den Haan MC, Roelofs H, Fibbe WE, Schalij MJ, Atsma DE.

Springerplus. 2015 Jul 10;4:336. doi: 10.1186/s40064-015-1128-y. eCollection 2015.

13.

Immune activation by medium-chain triglyceride-containing lipid emulsions is not modulated by n-3 lipids or toll-like receptor 4.

Olthof ED, Gülich AF, Renne MF, Landman S, Joosten LA, Roelofs HM, Wanten GJ.

Toxicol In Vitro. 2015 Oct;29(7):1851-8. doi: 10.1016/j.tiv.2015.07.004. Epub 2015 Jul 7.

PMID:
26162596
14.

Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.

Molendijk I, Bonsing BA, Roelofs H, Peeters KC, Wasser MN, Dijkstra G, van der Woude CJ, Duijvestein M, Veenendaal RA, Zwaginga JJ, Verspaget HW, Fibbe WE, van der Meulen-de Jong AE, Hommes DW.

Gastroenterology. 2015 Oct;149(4):918-27.e6. doi: 10.1053/j.gastro.2015.06.014. Epub 2015 Jun 25.

PMID:
26116801
15.

Mesenchymal stromal cells of osteosarcoma patients do not show evidence of neoplastic changes during long-term culture.

Buddingh EP, Ruslan SEN, Reijnders CMA, Szuhai K, Kuijjer ML, Roelofs H, Hogendoorn PCW, Maarten Egeler R, Cleton-Jansen AM, Lankester AC.

Clin Sarcoma Res. 2015 Jun 23;5:16. doi: 10.1186/s13569-015-0031-1. eCollection 2015.

16.

The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo.

Suijker J, Baelde HJ, Roelofs H, Cleton-Jansen AM, Bovée JV.

Oncotarget. 2015 Jun 20;6(17):14832-42.

17.

Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro.

Broekman MM, Roelofs HM, Wong DR, Kerstholt M, Leijten A, Hoentjen F, Peters WH, Wanten GJ, de Jong DJ.

Cell Biol Toxicol. 2015 Jun;31(3):161-71. doi: 10.1007/s10565-015-9301-1. Epub 2015 Apr 28.

18.

Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and the risk for benign Warthin's tumors of the parotid gland.

Lacko M, Voogd AC, van de Goor RC, Roelofs HM, Te Morsche RH, Bouvy ND, Peters WH, Manni JJ.

Head Neck. 2016 Apr;38 Suppl 1:E717-23. doi: 10.1002/hed.24077. Epub 2015 Jul 29.

PMID:
25899702
19.

No Clinical or Biochemical Evidence for Essential Fatty Acid Deficiency in Home Patients Who Depend on Long-Term Mixed Olive Oil- and Soybean Oil-Based Parenteral Nutrition.

Olthof ED, Roelofs HM, Fisk HL, Calder PC, Wanten GJ.

JPEN J Parenter Enteral Nutr. 2016 Sep;40(7):982-8. doi: 10.1177/0148607115581375. Epub 2015 Apr 17.

PMID:
25888677
20.

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival.

Derhovanessian E, Chen S, Maier AB, Hähnel K, de Craen AJ, Roelofs H, Westendorp R, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):917-23. doi: 10.1093/gerona/glu128. Epub 2015 Apr 7.

PMID:
25852090
21.

Post-myocardial infarct inflammation and the potential role of cell therapy.

van Zuylen VL, den Haan MC, Geutskens SB, Roelofs H, Fibbe WE, Schalij MJ, Atsma DE.

Cardiovasc Drugs Ther. 2015 Feb;29(1):59-73. doi: 10.1007/s10557-014-6568-z. Review.

PMID:
25583678
22.

Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients.

Reinders ME, Bank JR, Dreyer GJ, Roelofs H, Heidt S, Roelen DL, Al Huurman V, Lindeman J, van Kooten C, Claas FH, Fibbe WE, Rabelink TJ, de Fijter JW.

J Transl Med. 2014 Dec 10;12:331. doi: 10.1186/s12967-014-0331-x.

23.

GST Theta null genotype is associated with an increased risk for ulcerative colitis: a case-control study and meta-analysis of GST Mu and GST Theta polymorphisms in inflammatory bowel disease.

Broekman MM, Bos C, Te Morsche RH, Hoentjen F, Roelofs HM, Peters WH, Wanten GJ, de Jong DJ.

J Hum Genet. 2014 Oct;59(10):575-80. doi: 10.1038/jhg.2014.77. Epub 2014 Sep 4.

PMID:
25186055
24.

Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.

Freriksen JJ, Salomon J, Roelofs HM, Te Morsche RH, van der Stappen JW, Dura P, Witteman BJ, Lacko M, Peters WH.

J Hum Genet. 2014 Jul;59(7):381-6. doi: 10.1038/jhg.2014.38. Epub 2014 May 15.

PMID:
24830960
25.

Human Allogeneic Bone Marrow and Adipose Tissue Derived Mesenchymal Stromal Cells Induce CD8+ Cytotoxic T Cell Reactivity.

Roemeling-van Rhijn M, Reinders ME, Franquesa M, Engela AU, Korevaar SS, Roelofs H, Genever PG, Ijzermans JN, Betjes MG, Baan CC, Weimar W, Hoogduijn MJ.

J Stem Cell Res Ther. 2013 Dec 12;3(Suppl 6):004.

26.

Human Bone Marrow- and Adipose Tissue-derived Mesenchymal Stromal Cells are Immunosuppressive In vitro and in a Humanized Allograft Rejection Model.

Roemeling-van Rhijn M, Khairoun M, Korevaar SS, Lievers E, Leuning DG, Ijzermans JN, Betjes MG, Genever PG, van Kooten C, de Fijter HJ, Rabelink TJ, Baan CC, Weimar W, Roelofs H, Hoogduijn MJ, Reinders ME.

J Stem Cell Res Ther. 2013 Nov 25;Suppl 6(1):20780.

27.

Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.

Ong J, Salomon J, te Morsche RH, Roelofs HM, Witteman BJ, Dura P, Lacko M, Peters WH.

PLoS One. 2014 Mar 7;9(3):e90916. doi: 10.1371/journal.pone.0090916. eCollection 2014.

28.

Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?

Moll G, Hult A, von Bahr L, Alm JJ, Heldring N, Hamad OA, Stenbeck-Funke L, Larsson S, Teramura Y, Roelofs H, Nilsson B, Fibbe WE, Olsson ML, Le Blanc K.

PLoS One. 2014 Jan 13;9(1):e85040. doi: 10.1371/journal.pone.0085040. eCollection 2014.

29.

Over-expression of COX-2 mRNA in colorectal cancer.

Roelofs HM, Te Morsche RH, van Heumen BW, Nagengast FM, Peters WH.

BMC Gastroenterol. 2014 Jan 2;14:1. doi: 10.1186/1471-230X-14-1.

30.

Duodenal mucosal risk markers in patients with familial adenomatous polyposis: effects of celecoxib/ursodeoxycholic acid co-treatment and comparison with patient controls.

van Heumen BW, Roelofs HM, te Morsche RH, Nagengast FM, Peters WH.

Orphanet J Rare Dis. 2013 Nov 19;8:181. doi: 10.1186/1750-1172-8-181.

31.

Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas.

Hoensch HP, Roelofs HM, Edler L, Kirch W, Peters WH.

World J Gastroenterol. 2013 Sep 28;19(36):6020-5. doi: 10.3748/wjg.v19.i36.6020.

32.

Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: a Dutch Caucasian case-control study.

Dura P, Berkers T, van Veen EM, Salomon J, te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, Witteman BJ, Tan AC, Drenth JP, Peters WH.

J Hum Genet. 2013 Nov;58(11):742-8. doi: 10.1038/jhg.2013.95. Epub 2013 Sep 19.

PMID:
24048263
33.

Multipotent stromal cells skew monocytes towards an anti-inflammatory function: the link with key immunoregulatory molecules.

Melief SM, Geutskens SB, Fibbe WE, Roelofs H.

Haematologica. 2013 Sep;98(9):e121-2. doi: 10.3324/haematol.2013.093864. No abstract available.

34.

Gastrointestinal acute graft-versus-host disease in children: histology for diagnosis, mesenchymal stromal cells for treatment, and biomarkers for prediction of response.

Calkoen FG, Jol-van der Zijde CM, Mearin ML, Schweizer JJ, Jansen-Hoogendijk AM, Roelofs H, van Halteren AG, Egeler RM, van Tol MJ, Ball LM.

Biol Blood Marrow Transplant. 2013 Nov;19(11):1590-9. doi: 10.1016/j.bbmt.2013.08.006. Epub 2013 Aug 28.

35.

Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease.

Ball LM, Bernardo ME, Roelofs H, van Tol MJ, Contoli B, Zwaginga JJ, Avanzini MA, Conforti A, Bertaina A, Giorgiani G, Jol-van der Zijde CM, Zecca M, Le Blanc K, Frassoni F, Egeler RM, Fibbe WE, Lankester AC, Locatelli F.

Br J Haematol. 2013 Nov;163(4):501-9. doi: 10.1111/bjh.12545. Epub 2013 Aug 31.

PMID:
23992039
36.

Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up.

Rodrigo SF, van Ramshorst J, Hoogslag GE, Boden H, Velders MA, Cannegieter SC, Roelofs H, Al Younis I, Dibbets-Schneider P, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE.

J Cardiovasc Transl Res. 2013 Oct;6(5):816-25. doi: 10.1007/s12265-013-9507-7. Epub 2013 Aug 28.

37.

Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial.

van Heumen BW, Roelofs HM, Vink-Börger ME, Dekker E, Mathus-Vliegen EM, Dees J, Koornstra JJ, Langers AM, Nagtegaal ID, Kampman E, Peters WH, Nagengast FM.

Orphanet J Rare Dis. 2013 Aug 6;8:118. doi: 10.1186/1750-1172-8-118.

38.

No role for glutathione S-transferase genotypes in Caucasian esophageal squamous cell or adenocarcinoma etiology: an European case-control study.

Dura P, Salomon J, Te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, Witteman BJ, Tan AC, Drenth JP, Peters WH.

BMC Gastroenterol. 2013 Jun 3;13:97. doi: 10.1186/1471-230X-13-97.

39.

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.

Melief SM, Schrama E, Brugman MH, Tiemessen MM, Hoogduijn MJ, Fibbe WE, Roelofs H.

Stem Cells. 2013 Sep;31(9):1980-91. doi: 10.1002/stem.1432.

40.

Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts.

Melief SM, Zwaginga JJ, Fibbe WE, Roelofs H.

Stem Cells Transl Med. 2013 Jun;2(6):455-63. doi: 10.5966/sctm.2012-0184. Epub 2013 May 21.

41.

Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk.

Dura P, van Veen EM, Salomon J, te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, Witteman BJ, Tan AC, Drenth JP, Peters WH.

Int J Cancer. 2013 Oct 1;133(7):1751-5. doi: 10.1002/ijc.28160. Epub 2013 Apr 16.

42.

Bone marrow-derived mesenchymal stromal cells from patients with end-stage renal disease are suitable for autologous therapy.

Reinders ME, Roemeling-van Rhijn M, Khairoun M, Lievers E, de Vries DK, Schaapherder AF, Wong SW, Zwaginga JJ, Duijs JM, van Zonneveld AJ, Hoogduijn MJ, Fibbe WE, de Fijter JW, van Kooten C, Rabelink TJ, Roelofs H.

Cytotherapy. 2013 Jun;15(6):663-72. doi: 10.1016/j.jcyt.2013.01.010. Epub 2013 Feb 16.

PMID:
23419679
43.

Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study.

Reinders ME, de Fijter JW, Roelofs H, Bajema IM, de Vries DK, Schaapherder AF, Claas FH, van Miert PP, Roelen DL, van Kooten C, Fibbe WE, Rabelink TJ.

Stem Cells Transl Med. 2013 Feb;2(2):107-11. doi: 10.5966/sctm.2012-0114. Epub 2013 Jan 24.

44.

Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6.

Melief SM, Geutskens SB, Fibbe WE, Roelofs H.

Haematologica. 2013 Jun;98(6):888-95. doi: 10.3324/haematol.2012.078055. Epub 2013 Jan 24.

45.

GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology.

Dura P, Bregitha CV, te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, Witteman BJ, Tan AC, Drenth JP, Peters WH.

Eur J Cancer Prev. 2013 Sep;22(5):417-9. doi: 10.1097/CEJ.0b013e32835c7f53.

PMID:
23222411
46.

The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells.

Torensma R, Prins HJ, Schrama E, Verwiel ET, Martens AC, Roelofs H, Jansen BJ.

Stem Cells Dev. 2013 Apr 1;22(7):1086-96. doi: 10.1089/scd.2012.0384. Epub 2012 Dec 21.

47.

Long-term olive oil-based parenteral nutrition sustains innate immune function in home patients without active underlying disease.

Olthof ED, Roelofs HM, Versleijen MW, Te Morsche RH, Simonetti ER, Hermans PW, Wanten GJ.

Clin Nutr. 2013 Aug;32(4):643-9. doi: 10.1016/j.clnu.2012.08.009. Epub 2012 Aug 23.

PMID:
22963880
48.

The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97.

Odenthal J, van Heumen BW, Roelofs HM, te Morsche RH, Marian B, Nagengast FM, Peters WH.

Nutr Cancer. 2012 Aug;64(6):856-63. doi: 10.1080/01635581.2012.700994. Epub 2012 Jul 25.

PMID:
22830632
49.

Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.

Lacko M, Voogd AC, Roelofs HM, te Morsche RH, Oude Ophuis MB, Peters WH, Manni JJ.

Head Neck. 2013 Jun;35(6):858-67. doi: 10.1002/hed.23054. Epub 2012 Jun 19.

PMID:
22715028
50.

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.

Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G.

Age (Dordr). 2013 Aug;35(4):1387-99. doi: 10.1007/s11357-012-9425-7. Epub 2012 Jun 4.

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